Explanipedia

Myelodysplastic Syndromes and Incident Cardiovascular Disease: A Nationwide, Real-World Cohort Study Open

Yuta Suzuki, Hidehiro Kaneko, Toshiyuki Ko, Akira Okada, Norifumi Takeda , et al. · 2025

MDS was independently associated with incident CVD, including IHD, stroke, HF, and AF. MDS should be recognized as an independent cardiovascular risk factor in both clinical practice and public health strategies.

Myocardial lipin1 protects the heart against ischemic injury by preserving lipid homeostasis Open

Jiaxi Guo, Kohei Karasaki, Kazutaka Ueda, Manami Katoh, Masaki Hashimoto , et al. · 2025

Impaired cardiac lipid metabolism has been reported to cause heart failure. Lipin1, a multifunctional protein, is a phosphatidate phosphatase that generates diacylglycerol from phosphatidic acid and a transcriptional cofactor that regulate…

Heart failure-specific cardiac fibroblasts contribute to cardiac dysfunction via the MYC–CXCL1–CXCR2 axis Open

Jin Komuro, Hisayuki Hashimoto, Toshiomi Katsuki, Dai Kusumoto, Manami Katoh , et al. · 2025

Heart failure (HF) is a growing global health issue. While most studies focus on cardiomyocytes, here we highlight the role of cardiac fibroblasts (CFs) in HF. Single-cell RNA sequencing of mouse hearts under pressure overload identified s…

Cardiovascular-kidney-metabolic syndrome stage predicts cardiovascular outcomes in cancer patients: a real-world data analysis of a nationwide epidemiological dataset Open

Toshiyuki Ko, Yuta Suzuki, Hidehiro Kaneko, Akira Okada, Takahiro Jimba , et al. · 2025

Aims Cancer survivors are at increased cardiovascular risk due to shared risk factors and treatment-related toxicity. The recently proposed cardiovascular-kidney-metabolic (CKM) syndrome framework provides a novel approach for cardiometabo…

Frailty and its components and cardiovascular outcomes in older adults: A nationwide epidemiological study Open

Kensuke Ueno, Toshiyuki Ko, Yuta Suzuki, Hidehiro Kaneko, Kentaro Kamiya , et al. · 2025

Aim Although frailty is the result of multifactorial vulnerability, such as physical, cognitive, and socio‐psychological factors, the association of multifactor‐defined frailty and its components with cardiovascular disease (CVD) has not b…

Genotype‐guided cardiac device intervention in LMNA‐related cardiac conduction disorder: The need for timely genetic testing Open

Shunsuke Inoue, Zhehao Dai, Tsukasa Oshima, Seitaro Nomura, Takashi Hiruma , et al. · 2025

Effect of SGLT2i on kidney outcomes of individuals with type 2 diabetes according to body mass index: nationwide cohort study Open

Takahiro Jimba, Hidehiro Kaneko, Yuta Suzuki, Akira Okada, Tatsuhiko Azegami , et al. · 2025

Aims To investigate the clinical significance of the modification of the kidney protective effects of sodium-glucose cotransporter-2 (SGLT2) inhibitors by baseline body mass index (BMI). Methods and results We included individuals with SGL…

Recent Trends in Achievement Rates and Time Required for Left Ventricular Reverse Remodeling in Dilated Cardiomyopathy Open

Masahiro Wanezaki, Tetsu Watanabe, Atsushi Iizuka, Tomoki Kobayashi, S Edamura , et al. · 2025

The LVRR achievement rate in DCM has been increasing, and the time to LVRR has been shortened in recent years. Beta-blocker dose and BNP levels at discharge may be strongly associated with LVRR.

Association of estimated glomerular filtration rate with the incidence of sleep apnea syndrome Open

Tatsuhiko Azegami, Hidehiro Kaneko, Akira Okada, Yuta Suzuki, Toshiyuki Ko , et al. · 2024

Study Objectives Sleep apnea syndrome (SAS) is potentially linked to life-threatening conditions. The decline in kidney function is involved in the development of various diseases; however, it remains unclear whether it is implicated in th…

TRAITER: transformer-guided diagnosis and prognosis of heart failure using cell nuclear morphology and DNA damage marker Open

Hiromu Hayashi, Toshiyuki Ko, Zhehao Dai, Kanna Fujita, Seitaro Nomura , et al. · 2024

Motivation Heart failure (HF), a major cause of morbidity and mortality, necessitates precise diagnostic and prognostic methods. Results This study presents a novel deep learning approach, Transformer-based Analysis of Images of Tissue for…

Dose‐dependent association between estimated glomerular filtration rate and the subsequent risk of depression: An analysis of a nationwide epidemiological dataset Open

Toshiyuki Ko, Hidehiro Kaneko, Yuta Suzuki, Akira Okada, Tatsuhiko Azegami , et al. · 2024

Background Although the risk of depression is well‐known in the patients with kidney dysfunction, especially at the late stages, little is known about the exact point at which the decline in estimated glomerular filtration rate (eGFR) begi…

Myocardial DNA Damage Is Responsible for the Relationship Between Genotype and Reverse Remodeling in Patients With Dilated Cardiomyopathy Open

Zhehao Dai, Toshiyuki Ko, Shunsuke Inoue, Seitaro Nomura, Kanna Fujita , et al. · 2024

Kidney outcomes with SGLT2 inhibitor versus DPP4 inhibitor use in older adults with diabetes Open

Yuta Suzuki, Hidehiro Kaneko, Akira Okada, Jin Komuro, Toshiyuki Ko , et al. · 2024

Background While the kidney-protective effects of sodium–glucose co-transporter 2 (SGLT2) inhibitors have attracted much attention, there are limited real-world clinical data examining the effects of SGLT2 inhibitors on kidney function in …

Association Between Clonal Hematopoiesis and Left Ventricular Reverse Remodeling in Nonischemic Dilated Cardiomyopathy Open

Shunsuke Inoue, Toshiyuki Ko, Akito Shindo, Seitaro Nomura, Takanobu Yamada , et al. · 2024

A Valuable Genetically Engineered Nonhuman Primate Model of Dilated Cardiomyopathy Open

Toshiyuki Ko, Issei Komuro · 2024

A Pathogenic LAMP2 Non-Canonical Splice Site Mutation Caused Danon Disease Requiring Heart Transplantation Open

Ryo Abe, Toshiyuki Ko, Shunsuke Inoue, Seitaro Nomura, Takahiro Jimba , et al. · 2024

Myocardial DNA Damage Predicts Heart Failure Outcome in Various Underlying Diseases Open

Zhehao Dai, Toshiyuki Ko, Kanna Fujita, Seitaro Nomura, Yukari Uemura , et al. · 2023

DNA damage determines the consequences of human heart failure. Assessment of DNA damage is useful to predict treatment efficacy and prognosis of heart failure patients with various underlying etiologies.

Myocardial DNA damage combined with genotype predicts heart failure outcome in various underlying diseases Open

Zhehao Dai, Toshiyuki Ko, Seitaro Nomura, Shunsuke Inoue, Kanna Fujita , et al. · 2023

Background Reliable predictors of treatment efficacy in heart failure have been long awaited. DNA damage has been implicated as a cause of heart failure. Purpose To investigate the association of DNA damage in myocardial tissue with treatm…

Alpha 7 nicotinic acetylcholine receptors signaling boosts cell-cell interactions in macrophages effecting anti-inflammatory and organ protection Open

Yasuna Nakamura, Hirotaka Matsumoto, Chia-Hsien Wu, Daichi Fukaya, Rie Uni , et al. · 2023

How Can We Survive the Heart Failure Pandemic Era? Basic Research for Understanding the Pathophysiology of Heart Failure and Development of Novel Therapies Open

Manami Katoh, Toshiyuki Ko, Mikako Katagiri, Shintaro Yamada, Masamichi Ito , et al. · 2023

Heart failure is caused by a variety of factors, and although many new drug and non-drug therapies have been developed for its treatment in the past decades, the number of patients with heart failure continues to increase and its prognosis…

TEAD1 trapping by the Q353R–Lamin A/C causes dilated cardiomyopathy Open

Shintaro Yamada, Toshiyuki Ko, Masamichi Ito, Tatsuro Sassa, Seitaro Nomura , et al. · 2023

Mutations in the LMNA gene encoding Lamin A and C (Lamin A/C), major components of the nuclear lamina, cause laminopathies including dilated cardiomyopathy (DCM), but the underlying molecular mechanisms have not been fully elucidated. Here…

Spatiotemporal transcriptome analysis reveals critical roles for mechano-sensing genes at the border zone in remodeling after myocardial infarction Open

Shintaro Yamada, Toshiyuki Ko, Satoshi Hatsuse, Seitaro Nomura, Bo Zhang , et al. · 2022

The underlying mechanisms of ventricular remodeling after myocardial infarction (MI) remain largely unknown. In this study, we performed an integrative analysis of spatial transcriptomics and single-nucleus RNA sequencing (snRNA-seq) in a …

Aberrant interaction between TEAD1 and Lamin A/C causes cardiomyopathy Open

Susumu Yamada, Toshiyuki Ko, M. Ito, Tatsuro Sassa, S. Nomura , et al. · 2022

Background Mutations in the LMNA gene encoding Lamin A/C, a major component of the nuclear lamina, cause laminopathies including dilated cardiomyopathy (DCM). DCM patients with LMNA mutations have particularly severe clinical courses such …

Molecular Genomic Autopsy　― Clues to Preventing Further Tragedy? ― Open

Toshiyuki Ko, Hiroyuki Morita · 2022

in which the cause of death is clarified by postmortem genetic testing is very important and has been already mentioned international guidelines or statements. 1,3,4n this issue of the Journal, Hata al report a study of postmortem genetic …

Takotsubo Cardiomyopathy and Peripartum Cardiomyopathy Open

Toshiyuki Ko, Hiroyuki Morita · 2022

Manipulating Cardiomyocyte Plasticity for Heart Regeneration Open

Toshiyuki Ko, Seitaro Nomura · 2022

Pathological heart injuries such as myocardial infarction induce adverse ventricular remodeling and progression to heart failure owing to widespread cardiomyocyte death. The adult mammalian heart is terminally differentiated unlike those o…

Cardiac fibroblasts regulate the development of heart failure via Htra3-TGF-β-IGFBP7 axis Open

Toshiyuki Ko, Seitaro Nomura, Shintaro Yamada, Kanna Fujita, Takanori Fujita , et al. · 2022

Heart Failure Pathogenesis Elucidation and New Treatment Method Development Open

Mikako Katagiri, Shintaro Yamada, Manami Katoh, Toshiyuki Ko, Masamichi Ito , et al. · 2022

Heart failure (HF) is a leading cause of death worldwide. In Japan, the number of HF patients has increased with its aging population, resulting in "HF pandemic." HF is the final stage of various cardiovascular diseases, including valvular…

Single-Cell Analysis Revealed the Role of CD8+ Effector T Cells in Preventing Cardioprotective Macrophage Differentiation in the Early Phase of Heart Failure Open

Kyoko Komai, Minako Ito, Seitaro Nomura, Shigeyuki Shichino, Manami Katoh , et al. · 2021

Heart failure is a complex clinical syndrome characterized by insufficient cardiac function. Heart-resident and infiltrated macrophages have been shown to play important roles in the cardiac remodeling that occurs in response to cardiac pr…

Spatiotemporal single-cell analysis reveals critical roles of mechano-sensing genes at the border zone in remodeling after myocardial infarction Open

Shintaro Yamada, Toshiyuki Ko, Satoshi Hatsuse, Seitaro Nomura, Bo Zhang , et al. · 2021

The left ventricular remodeling after myocardial infarction (MI) causes heart failure, but its underlying mechanisms remain largely unknown. Here, we performed an integrative analysis of spatial transcriptomics and single cell RNA-seq in m…

Toshiyuki Ko YOU? Author Swipe