Toshiyuki Mitsuyama
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View article: Tumor Cell Implantation from an Oral Advanced Cancer at the Rectal Endoscopic Submucosal Dissection Site: A Case Report and Literature Review
Tumor Cell Implantation from an Oral Advanced Cancer at the Rectal Endoscopic Submucosal Dissection Site: A Case Report and Literature Review Open
This report and literature review explores cases of tumor cell implantation at colorectal post-endoscopic resection sites. We detail a unique case in which advanced rectosigmoid colon cancer cells would implant into an endoscopic submucosa…
View article: Endoscopic ultrasound-guided pancreatic duct drainage with a two-step puncture technique for a non-dilated pancreatic duct
Endoscopic ultrasound-guided pancreatic duct drainage with a two-step puncture technique for a non-dilated pancreatic duct Open
Endoscopic ultrasound-guided pancreatic duct drainage (EUS-PD) has emerged as an option in patients with failure of standard transpapillary endoscopic retrograde access to the pancreatic duct (PD) or surgically altered anatomy [1]. The duc…
View article: Effective hemostasis under gel immersion endoscopy using inflated balloons on the tip of double balloon endoscope for active bleeding in the small intestine
Effective hemostasis under gel immersion endoscopy using inflated balloons on the tip of double balloon endoscope for active bleeding in the small intestine Open
View article: Advanced technical tips and recent insights in ERCP using balloon‐assisted endoscopy
Advanced technical tips and recent insights in ERCP using balloon‐assisted endoscopy Open
Pancreatobiliary endoscopic interventions using balloon‐assisted endoscopes have been widely acknowledged as the first‐line therapy for pancreatobiliary diseases in postoperative patients with reconstructed gastrointestinal anatomy (exclud…
View article: Perforation-free removal of gastric gastrointestinal stromal tumors: Endoscopic inversion and strangulation of muscle layer and resection (EISMR)
Perforation-free removal of gastric gastrointestinal stromal tumors: Endoscopic inversion and strangulation of muscle layer and resection (EISMR) Open
Endoscopic resection for GIST has become more widespread in recent years because it is less invasive than surgery. However, when endoscopic resection is performed, a full-layer resection of the gastric wall is often necessary, and extensiv…
View article: New Treatment for Completely Obstructed Pancreaticojejunal Anastomosis Using Gel-Immersion Double-Balloon ERP With Long Cap
New Treatment for Completely Obstructed Pancreaticojejunal Anastomosis Using Gel-Immersion Double-Balloon ERP With Long Cap Open
A 71-year-old woman who had undergone pancreatoduodenectomy with Braun anastomosis for lower biliary cancer 2 years before developed recurrent pancreatitis. Abdominal computed tomography revealed mildly dilated pancreatic duct (Figure A). …
View article: Cardiac 18F‑FDG uptake and new‑onset rectal cancer
Cardiac 18F‑FDG uptake and new‑onset rectal cancer Open
The present study aimed to investigate the factors affecting the cardiac uptake of 18F-fluorodeoxyglucose (18F-FDG) during 18F-FDG positron emission tomography (PET) for new-onset rectal cancer and new-onset colon cancer (ascending, transv…
View article: Gel immersion endoscopic papillectomy using a double-balloon endoscope to resect an ampullary tumor
Gel immersion endoscopic papillectomy using a double-balloon endoscope to resect an ampullary tumor Open
The usefulness of underwater endoscopic papillectomy for treating ampullary tumors in patients with surgically altered anatomy has been reported [1], but difficulties in managing the water flow in the gastrointestinal tract, and the nature…
View article: Long-term Outcomes after Steroid Pulse Therapy in Patients with Type 1 Autoimmune Pancreatitis
Long-term Outcomes after Steroid Pulse Therapy in Patients with Type 1 Autoimmune Pancreatitis Open
Objective Steroid pulse therapy is a regimen involving the intravenous administration of supra-pharmacological doses of corticosteroids in the short term. It is used to treat various inflammatory and autoimmune conditions. However, the str…
View article: Diagnostic rate and issues regarding the Japanese clinical diagnostic criteria for autoimmune pancreatitis 2018
Diagnostic rate and issues regarding the Japanese clinical diagnostic criteria for autoimmune pancreatitis 2018 Open
近年,わが国の自己免疫性膵炎(AIP)臨床診断基準の改訂版(JPS2018)が発表された.本研究の目的は,旧診断基準(JPS2011)および国際基準(ICDC)との比較からJPS2018が持つ1型AIPの診断率や課題を明らかにすることである.1型AIP(準確診/probable AIP以上)の診断率は,JPS2018では91%,JPS2011では83.4%,ICDCでは87.6%であり,JPS2018の診断率は他の診断基準に比べ高かった.JPS2018において診断率が改善し…
View article: Viral Infection in Esophageal, Gastric, and Colorectal Cancer
Viral Infection in Esophageal, Gastric, and Colorectal Cancer Open
The human gastrointestinal tract, which constitutes the digestive system, contains a large number of virus particles that maintain organizational homeostasis and health. Conversely, viral pathogens have also attracted attention for their i…
View article: Endoscopic approach for a pinhole-like benign stenosis in a pancreaticojejunal anastomosis using a double-balloon endoscope with a clear long cap attachment
Endoscopic approach for a pinhole-like benign stenosis in a pancreaticojejunal anastomosis using a double-balloon endoscope with a clear long cap attachment Open
The usefulness of therapeutic modalities using double-balloon endoscopy for biliary disease in postoperative patients has been widely reported [1] [2] [3], while papers published about its use in pancreatic disease are scarce, despite an i…
View article: Efficacy and safety of endoscopic stent placement for afferent loop obstruction using a short double‐balloon endoscopy
Efficacy and safety of endoscopic stent placement for afferent loop obstruction using a short double‐balloon endoscopy Open
Background Afferent loop obstruction (ALO) is a rare mechanical complication that occurs after gastrojejunostomy. Recently the use of double‐balloon endoscopy (DBE) can be useful for benign and malignant ALO. Methods We retrospectively ide…
View article: Gel Immersion Endoscopic Mucosal Resection (EMR) for Superficial Nonampullary Duodenal Epithelial Tumors May Reduce Procedure Time Compared with Underwater EMR (with Video)
Gel Immersion Endoscopic Mucosal Resection (EMR) for Superficial Nonampullary Duodenal Epithelial Tumors May Reduce Procedure Time Compared with Underwater EMR (with Video) Open
Background/Aims. Underwater endoscopic mucosal resection (UEMR) has recently attracted attention as a safe and effective method for superficial nonampullary duodenal epithelial tumors (SNADETs). However, water is a fluid and it does not re…
View article: Endoscopic retrieval of a migrated surgical clip in a choledochojejunal anastomosis using the rendezvous technique
Endoscopic retrieval of a migrated surgical clip in a choledochojejunal anastomosis using the rendezvous technique Open
It is a rare complication for a surgical clip to migrate into a bile duct [1] [2], and removing a migrated surgical clip endoscopically is technically challenging, particularly in patients with surgically altered anatomy. We report here th…
View article: Development of Severe Acute Pancreatitis Following Uncovered Metallic Stent Placement: A Rare Case Report
Development of Severe Acute Pancreatitis Following Uncovered Metallic Stent Placement: A Rare Case Report Open
Self-expandable metallic stents (SEMSs) are widely used for malignant biliary stricture (MBS). Acute pancreatitis is an early complication following SEMS placement. In the present case, the patient developed severe acute pancreatitis after…
View article: Internal biliary drainage using double‐balloon endoscopy in a patient with complete obstruction of the hepaticojejunostomy site
Internal biliary drainage using double‐balloon endoscopy in a patient with complete obstruction of the hepaticojejunostomy site Open
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View article: Recent advances of endoscopic retrograde cholangiopancreatography using balloon assisted endoscopy for pancreaticobiliary diseases in patients with surgically altered anatomy: Therapeutic strategy and management of difficult cases
Recent advances of endoscopic retrograde cholangiopancreatography using balloon assisted endoscopy for pancreaticobiliary diseases in patients with surgically altered anatomy: Therapeutic strategy and management of difficult cases Open
Endoscopic retrograde cholangiopancreatography (ERCP) is an endoscopic modality established for diagnosis and treatment of pancreaticobiliary diseases. However ERCP in patients with surgically altered anatomy (SAA) has been difficult, and …
View article: Usefulness of half‐covered metallic stent placement in preventing acute cholecystitis complication in pancreatic cancer‐induced distal biliary stricture
Usefulness of half‐covered metallic stent placement in preventing acute cholecystitis complication in pancreatic cancer‐induced distal biliary stricture Open
Background and Aim A self‐expandable metallic stent (SEMS) is commonly used for biliary stricture caused by pancreatic cancer. Covered SEMS may obstruct the cystic duct, causing acute cholecystitis. This study aimed to determine the outcom…
View article: Effectiveness of Photodynamic Screening Using 5-Aminolevulinic Acid for the Diagnosis of Pancreatic Cancer
Effectiveness of Photodynamic Screening Using 5-Aminolevulinic Acid for the Diagnosis of Pancreatic Cancer Open
The urinary levels of UP after ALA administration might serve as a promising biomarker for diagnosis and prognosis prediction of PaC.
View article: Diffuse Pancreatic Cancer Mimicking Autoimmune Pancreatitis
Diffuse Pancreatic Cancer Mimicking Autoimmune Pancreatitis Open
The characteristic finding of sausage-shaped pancreas or capsule-like rim facilitates the diagnosis of autoimmune pancreatitis. We herein report a case of a 67-year-old man showing a sausage-shaped, enlarged pancreas with a capsule-like ri…
View article: Neutrophil infiltrations compared between types 1 and 2 autoimmune pancreatitis
Neutrophil infiltrations compared between types 1 and 2 autoimmune pancreatitis Open
【背景】自己免疫性膵炎（Autoimmune pancreatitis; AIP）はわが国から提唱された疾患概念である．2011年に国際コンセンサス診断基準が作成されIgG4の関与するものを1型自己免疫性膵炎，好中球病変が主体とするものを2型自己免疫性膵炎と分類することとなった．2型自己免疫性膵炎の組織像として，好中球が膵管内腔や上皮に集簇し，管腔の破壊や閉塞をきたすことが特徴的である．2型自己免疫性膵炎は好中球が重要な役割を果たしていると言われているが，好中球が遊走される…
View article: Role of two‐step endoscopic ultrasonography‐guided antegrade treatment as an option for bile duct stones in patients with surgically altered anatomy
Role of two‐step endoscopic ultrasonography‐guided antegrade treatment as an option for bile duct stones in patients with surgically altered anatomy Open
This Editorial refers to the article by Y. Nakai, p125-127 of this issue.
View article: Smad2/3 Linker Phosphorylation Is a Possible Marker of Cancer Stem Cells and Correlates with Carcinogenesis in a Mouse Model of Colitis-Associated Colorectal Cancer
Smad2/3 Linker Phosphorylation Is a Possible Marker of Cancer Stem Cells and Correlates with Carcinogenesis in a Mouse Model of Colitis-Associated Colorectal Cancer Open
pSmad3L-Ser signalling is an early event in colitis-associated colorectal cancer, and pSmad2/3L-Thr immunostaining-positive cells might be cancer stem cells.
View article: Phosphorylation of Smad2/3 at the specific linker threonine residue indicates slow-cycling esophageal stem-like cells before re-entry to the cell cycle
Phosphorylation of Smad2/3 at the specific linker threonine residue indicates slow-cycling esophageal stem-like cells before re-entry to the cell cycle Open
Summary The stem cell compartment in the esophageal epithelium is possibly located in the basal layer. We have identified significant expression of Smad2/3, phosphorylated at specific linker threonine residues (pSmad2/3L-Thr), in the epith…