Toshiyuki Sumi
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View article: An Unexpected Cause of Tongue Deviation
An Unexpected Cause of Tongue Deviation Open
View article: A Case of Pelvic Lymphatic Effusion Managed with N-butyl-2-cyanoacrylate/Lipiodol Embolization through an Inguinal Lymph Node
A Case of Pelvic Lymphatic Effusion Managed with N-butyl-2-cyanoacrylate/Lipiodol Embolization through an Inguinal Lymph Node Open
Lymphatic ascites developed in a woman in her fifties after she underwent total hysterectomy, bilateral salpingo-oophorectomy, and lymph node dissection for endometrial carcinoma. Approximately 500-1,000 mL of opalescent fluid was drained …
View article: Long-term partial response after camrelizumab plus chemotherapy induction therapy and camrelizumab maintenance therapy beyond two years in squamous non-small cell lung cancer: a case report
Long-term partial response after camrelizumab plus chemotherapy induction therapy and camrelizumab maintenance therapy beyond two years in squamous non-small cell lung cancer: a case report Open
For squamous NSCLC patients without a CR to induction therapy, continuing ICI maintenance therapy beyond 2 years-rather than discontinuing treatment-may potentially extend overall survival.
View article: Prophylactic Interventions to Prevent Severe Skin Toxicities in Patients With Non–Small Cell Lung Cancer Treated With Nivolumab + Ipilimumab With or Without Chemotherapy
Prophylactic Interventions to Prevent Severe Skin Toxicities in Patients With Non–Small Cell Lung Cancer Treated With Nivolumab + Ipilimumab With or Without Chemotherapy Open
PURPOSE The frequent occurrence of immune-related adverse events during immune checkpoint inhibitor therapy for non–small cell lung cancer (NSCLC), particularly dermatologic toxicities, often necessitates treatment modifications and system…
View article: Significance of Platinum‐Based Chemotherapy With Programmed Death‐1 Blockade in Limited Disease Small Cell Lung Cancer: A Retrospective Study
Significance of Platinum‐Based Chemotherapy With Programmed Death‐1 Blockade in Limited Disease Small Cell Lung Cancer: A Retrospective Study Open
Main Problem The efficacy and safety of platinum‐based chemotherapy with programmed death‐1 (PD‐1) blockade after chemoradiotherapy (CRT) for the treatment of limited disease (LD) small cell lung cancer (SCLC) is unknown. This study aimed …
View article: Ramucirumab and erlotinib combination as first-line treatment for advanced or recurrent non-small cell lung cancer harboring <i>EGFR</i> Exon21 L858R mutation: a multicenter retrospective observational cohort study in Japan (REAL-SPEED)
Ramucirumab and erlotinib combination as first-line treatment for advanced or recurrent non-small cell lung cancer harboring <i>EGFR</i> Exon21 L858R mutation: a multicenter retrospective observational cohort study in Japan (REAL-SPEED) Open
Background: EGFR L858R mutation is associated with poorer efficacy of EGFR-tyrosine kinase inhibitors (TKIs) than EGFR Ex19del in patients with non-small cell lung cancer (NSCLC). However, ramucirumab (RAM) + erlotinib (ERL) therapy exhibi…
View article: 45P Durvalumab plus carboplatin/paclitaxel followed by durvalumab with/without olaparib as first-line treatment for endometrial cancer: Progression-free survival and safety by age above/below 70 years and with/without clinical obesity in the DUO-E trial
45P Durvalumab plus carboplatin/paclitaxel followed by durvalumab with/without olaparib as first-line treatment for endometrial cancer: Progression-free survival and safety by age above/below 70 years and with/without clinical obesity in the DUO-E trial Open
View article: Severe group A streptococcal pneumonia with multiple cavitary lesions
Severe group A streptococcal pneumonia with multiple cavitary lesions Open
View article: Visceral Pleural Perforation from within a Tumor during Ultrathin Bronchoscopy
Visceral Pleural Perforation from within a Tumor during Ultrathin Bronchoscopy Open
View article: Transbronchial Lung Cryobiopsy as a Diagnostic Tool for Gastric Cancer-induced Pulmonary Tumor Thrombotic Microangiopathy
Transbronchial Lung Cryobiopsy as a Diagnostic Tool for Gastric Cancer-induced Pulmonary Tumor Thrombotic Microangiopathy Open
View article: Loss of Tapasin in Tumors Potentiates T‐Cell Recognition and Anti‐Tumor Effects of Immune Checkpoint Blockade
Loss of Tapasin in Tumors Potentiates T‐Cell Recognition and Anti‐Tumor Effects of Immune Checkpoint Blockade Open
Tumors can evade host immune surveillance by compromising the intracellular antigen processing machinery (APM), such as beta 2 macroglobulin (β2m) or the transporter associated with antigen processing (TAP). Defects in the APM generally re…
View article: A Case of Repeated Cytokine Releasing Syndrome During Nivolumab Plus Ipilimumab Therapy, with Bacterial Infection Suspected as a Trigger for Relapse
A Case of Repeated Cytokine Releasing Syndrome During Nivolumab Plus Ipilimumab Therapy, with Bacterial Infection Suspected as a Trigger for Relapse Open
View article: Efficacy and safety of nivolumab and ipilimumab with or without chemotherapy for unresectable non-small cell lung cancer: a multicenter retrospective observational study
Efficacy and safety of nivolumab and ipilimumab with or without chemotherapy for unresectable non-small cell lung cancer: a multicenter retrospective observational study Open
NI and NICT showed comparable efficacies in PFS and OS. However, NICT had a higher incidence of severe irAEs and treatment-related mortality. High tumor burden and early high fever were predictors of severe irAEs. Further research is warra…
View article: EVALUATION OF WORKFORCE DEVELOPMENT INITIATIVES IN THE CONSTRUCTION INDUSTRY IN OITA PREFECTURE
EVALUATION OF WORKFORCE DEVELOPMENT INITIATIVES IN THE CONSTRUCTION INDUSTRY IN OITA PREFECTURE Open
View article: Fulminant Type 1 Diabetes Mellitus Leading to Diabetic Ketoacidosis and Mesenteric Ischemia With Necrosis Following Pembrolizumab Administration: A Case Report
Fulminant Type 1 Diabetes Mellitus Leading to Diabetic Ketoacidosis and Mesenteric Ischemia With Necrosis Following Pembrolizumab Administration: A Case Report Open
Immune checkpoint inhibitors (ICIs), such as pembrolizumab, have revolutionized cancer therapy but can lead to severe immune-related adverse events (irAEs). We present a case of fulminant type 1 diabetes mellitus (T1DM) with diabetic ketoa…
View article: Real-world data of first-line treatment with pembrolizumab for NSCLC with high PD-L1 expression in elderly patients: a subgroup analysis of HOT/NJLCG2001
Real-world data of first-line treatment with pembrolizumab for NSCLC with high PD-L1 expression in elderly patients: a subgroup analysis of HOT/NJLCG2001 Open
Background In the first-line treatment of elderly patients with advanced-stage non-small cell lung cancer (NSCLC) with high programmed death-ligand 1 (PD-L1) expression (tumor proportion score ≥ 50%), this study aimed to determine whether …
View article: Esophagomediastinal fistula during durvalumab plus tremelimumab with chemotherapy in angiotensin-converting enzyme 2-positive non-small cell lung cancer: a case report
Esophagomediastinal fistula during durvalumab plus tremelimumab with chemotherapy in angiotensin-converting enzyme 2-positive non-small cell lung cancer: a case report Open
Clinicians should be aware that COVID-19 might be associated with the development of severe irAEs and unexpectedly enhanced antitumor effects. The findings also suggest new fields of study regarding the interaction between viral infection …
View article: Role of Fyn expression in predicting the sensitivity to platinum‑based chemotherapy in patients with ovarian serous carcinoma
Role of Fyn expression in predicting the sensitivity to platinum‑based chemotherapy in patients with ovarian serous carcinoma Open
Ovarian serous carcinoma is a gynecological malignancy associated with a high mortality rate, which is commonly diagnosed in the first instance at a late stage and has a propensity to develop resistance to platinum-based chemotherapy. Iden…
View article: A Case of Pleurisy as Immune-related Adverse Events of Neoadjuvant Nivolumab and Chemotherapy After Lobectomy
A Case of Pleurisy as Immune-related Adverse Events of Neoadjuvant Nivolumab and Chemotherapy After Lobectomy Open
背景.近年,免疫チェックポイント阻害薬(immune checkpoint inhibitor:ICI)は非小細胞肺癌の術前補助化学療法(neoadjuvant chemotherapy:NAC)に使用されるようになった.肺癌診療医は過去に様々な免疫関連有害事象(immune-related adverse events:irAE)を経験してきたが,irAEとしての胸膜炎は稀であり,ICIを併用したNAC後に発症した報告はない.症例.63歳男性.右上葉肺扁平上皮癌(cT2a…
View article: A Newly Developed Anti-L1CAM Monoclonal Antibody Targets Small Cell Lung Carcinoma Cells
A Newly Developed Anti-L1CAM Monoclonal Antibody Targets Small Cell Lung Carcinoma Cells Open
Few effective treatments are available for small cell lung cancer (SCLC), indicating the need to explore new therapeutic options. Here, we focus on an antibody–drug conjugate (ADC) targeting the L1 cell adhesion molecule (L1CAM). Several p…
View article: Real‐world first‐line treatment with pembrolizumab for non‐small cell lung carcinoma with high <scp>PD</scp>‐<scp>L1</scp> expression: Updated analysis
Real‐world first‐line treatment with pembrolizumab for non‐small cell lung carcinoma with high <span>PD</span>‐<span>L1</span> expression: Updated analysis Open
Background Selecting pembrolizumab monotherapy (MONO) or pembrolizumab plus platinum‐based chemotherapy (COMB) for patients with nonsmall cell lung cancer (NSCLC) and high programmed death‐ligand 1 (PD‐L1) expression is an important issue …
View article: Predicting recurrence in intermediate‑ and high‑risk stage IB‑IIB cervical cancer treated with adjuvant cisplatin and paclitaxel chemotherapy post‑radical hysterectomy: The role of TBX2 expression
Predicting recurrence in intermediate‑ and high‑risk stage IB‑IIB cervical cancer treated with adjuvant cisplatin and paclitaxel chemotherapy post‑radical hysterectomy: The role of TBX2 expression Open
Cervical cancer remains a significant global health concern despite advances in prevention and treatment. Current management for intermediate- to high-risk stage IB-IIB cervical cancer post-radical hysterectomy involves irradiation or conc…
View article: Eyelid Edema in Eosinophilic Granulomatosis with Polyangiitis
Eyelid Edema in Eosinophilic Granulomatosis with Polyangiitis Open
View article: Corded and Hyalinized Endometrioid Endometrial Carcinoma: A Rare Case Treated With Robot-Assisted Surgery
Corded and Hyalinized Endometrioid Endometrial Carcinoma: A Rare Case Treated With Robot-Assisted Surgery Open
View article: Risk factors for severe immune‐related pneumonitis after nivolumab plus ipilimumab therapy for non‐small cell lung cancer
Risk factors for severe immune‐related pneumonitis after nivolumab plus ipilimumab therapy for non‐small cell lung cancer Open
Background The efficacy of anti‐CTLA‐4 antibody (ipilimumab) plus anti‐programmed cell death 1 antibody (nivolumab) in treating advanced non‐small cell lung cancer (NSCLC) is impeded by an elevated risk of severe immune‐related adverse eve…
View article: Lanthanide-Containing Polyoxometalate Crystallized with Bolaamphiphile Surfactants as Inorganic–Organic Hybrid Phosphors
Lanthanide-Containing Polyoxometalate Crystallized with Bolaamphiphile Surfactants as Inorganic–Organic Hybrid Phosphors Open
Lanthanide elements such as europium exhibit distinctive emissions due to the transitions of inner-shell 4f electrons. Inorganic materials containing lanthanide elements have been widely used as phosphors in conventional displays. The hybr…
View article: Prognostic significance of immunohistochemical classification utilizing biopsy specimens in patients with extensive-disease small-cell lung cancer treated with first-line chemotherapy and immune checkpoint inhibitors
Prognostic significance of immunohistochemical classification utilizing biopsy specimens in patients with extensive-disease small-cell lung cancer treated with first-line chemotherapy and immune checkpoint inhibitors Open
Purpose Although immune checkpoint inhibitors (ICIs), together with cytotoxic chemotherapy (chemoimmunotherapy), have been adapted for the initial treatment of extensive-disease small-cell lung cancer (ED-SCLC), they have achieved limited …
View article: Successful Treatment of Mucus Plug Due to Allergic Bronchopulmonary Aspergillosis Using Dupilumab
Successful Treatment of Mucus Plug Due to Allergic Bronchopulmonary Aspergillosis Using Dupilumab Open
View article: Immunotherapy or Chemoimmunotherapy in Older Adults With Advanced Non–Small Cell Lung Cancer
Immunotherapy or Chemoimmunotherapy in Older Adults With Advanced Non–Small Cell Lung Cancer Open
Importance Immune checkpoint inhibitor (ICI) plus chemotherapy combination treatment (ICI-chemotherapy) is now a standard treatment for non–small cell lung cancer (NSCLC) without targetable oncogene alterations, but there are few data on I…
View article: Sputum colour: An indicator of <i>Legionella pneumophila</i> pneumonia
Sputum colour: An indicator of <i>Legionella pneumophila</i> pneumonia Open
Key message The sputum colour in patients with severe pneumonia needs to be considered during diagnosis.