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View article: A combined cell and growth factor delivery for the repair of a critical size tibia defect using biodegradable hydrogel implants
A combined cell and growth factor delivery for the repair of a critical size tibia defect using biodegradable hydrogel implants Open
The ability to repair critical-sized long-bone injuries using growth factor and cell delivery was investigated using hydrogel biomaterials. Physiological doses of the recombinant human bone morphogenic protein-2 (rhBMP2) were delivered in …
View article: Mutant <i>KRAS</i> Circulating Tumor DNA Is an Accurate Tool for Pancreatic Cancer Monitoring
Mutant <i>KRAS</i> Circulating Tumor DNA Is an Accurate Tool for Pancreatic Cancer Monitoring Open
Background Many new pancreatic cancer treatment combinations have been discovered in recent years, yet the prognosis of pancreatic ductal adenocarcinoma (PDAC) remains grim. The advent of new treatments highlights the need for better monit…
View article: Characterization of Factors Affecting the Detection Limit of EGFR p.T790M in Circulating Tumor DNA
Characterization of Factors Affecting the Detection Limit of EGFR p.T790M in Circulating Tumor DNA Open
Objective: Circulating tumor DNA is a promising noninvasive tool for cancer monitoring. One of the challenges in applying this tool is the detection of low-frequency mutations. The detection limit of these mutations varies between differen…
Clinically significant sub-clonality for common drivers can be detected in 26% of <i>KRAS/EGFR</i> mutated lung adenocarcinomas Open
Genetic sub-clonality has been described in multiple malignancies, however the presence of sub-clonality for major drivers in lung adenocarcinoma and its clinical significance is a subject under debate. Using molecular and morphometric app…
Variation in KRAS driver substitution distributions between tumor types is determined by both mutation and natural selection Open
Different tumor types vary greatly in their distribution of driver substitutions. Here, we analyzed how mutation and natural selection contribute to differences in the distribution of KRAS driver substitutions between lung, colon and pancr…
Subclonality for <i>BRAF</i> Mutation in Papillary Thyroid Carcinoma Is Associated With Earlier Disease Stage Open
In PTC, subclonality for BRAF mutation is associated with earlier stage. Molecular-morphometric analysis of PTC can provide clonality information with potential clinical significance.