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View article: Next-generation FVIIIa-mimetic bispecific antibody NXT007: evaluation in preclinical models of hemostasis and thrombosis
Next-generation FVIIIa-mimetic bispecific antibody NXT007: evaluation in preclinical models of hemostasis and thrombosis Open
NXT007 is a next-generation factor (F)VIIIa-mimetic bispecific antibody currently in Phase 1/2 trials. It was developed by optimizing the framework of emicizumab to achieve hemostatic normalization in people with hemophilia A (PwHA). Here,…
View article: Transcriptomic atlas reveals inflammation and complement as pathogenic factors in hemolysis-induced tissue damage
Transcriptomic atlas reveals inflammation and complement as pathogenic factors in hemolysis-induced tissue damage Open
Intravascular hemolysis contributes to sickle cell disease (SCD) by releasing danger signals like hemoglobin and heme, which trigger inflammation and oxidative stress. Yet, the exact mechanisms behind organ damage remain unclear. Using bul…
View article: Consistent clinical factor VIII equivalency is unlikely for non-factor therapies in hemophilic mice
Consistent clinical factor VIII equivalency is unlikely for non-factor therapies in hemophilic mice Open
Non-factor therapies are changing the treatment paradigm in hemophilia A, which was previously dominated by replacement-therapy using factor VIII (FVIII)-concentrates. However, the FVIIIequivalence of these new therapies has remained uncle…
View article: Structural Basis for Activity and Specificity of an Anticoagulant Anti-FXIa Monoclonal Antibody and a Reversal Agent
Structural Basis for Activity and Specificity of an Anticoagulant Anti-FXIa Monoclonal Antibody and a Reversal Agent Open
View article: Plasma treated with amotosalen and ultraviolet <scp>A</scp> light retains activity for hemostasis after 5 days post‐thaw storage at 1 to 6<sup>o</sup><scp>C</scp>
Plasma treated with amotosalen and ultraviolet <span>A</span> light retains activity for hemostasis after 5 days post‐thaw storage at 1 to 6<sup>o</sup><span>C</span> Open
BACKGROUND Plasma thawed and stored at 1 to 6 ° C for up to 5 days (thawed plasma [TP]) provides rapid availability in emergencies and reduces plasma waste, but it carries risks of coagulation factor loss or activation, bacterial outgrowth…
View article: Acyl-CoA:Diacylglycerol Acyltransferase 1 Expression Level in the Hematopoietic Compartment Impacts Inflammation in the Vascular Plaques of Atherosclerotic Mice
Acyl-CoA:Diacylglycerol Acyltransferase 1 Expression Level in the Hematopoietic Compartment Impacts Inflammation in the Vascular Plaques of Atherosclerotic Mice Open
The final step of triacylglycerol synthesis is catalyzed by acyl-CoA:diacylglycerol acyltransferases (DGATs). We have previously shown that ApoE-/-Dgat1-/- mice are protected from developing atherosclerosis in association with reduced foam…
View article: No increased inflammatory response in ACI-35 treated Tau.P301L mice.
No increased inflammatory response in ACI-35 treated Tau.P301L mice. Open
(A) IHC did not reveal marked differences in inflammation-related parameters in forebrain of ACI-35 vaccinated Tau.P301L mice, relative to PBS-injected Tau.P301L mice. IHC reaction with the different specific antibodies, specified in the c…
View article: ACI-35 elicits robust and specific antisera against Tau in wild-type and Tau.P301L mice.
ACI-35 elicits robust and specific antisera against Tau in wild-type and Tau.P301L mice. Open
(A) Vaccination schedule with ACI-35 in wild-type mice is shown schematically with s.c. injections represented by the syringes and the bleedings by the letter B with a number. Antisera titers were measured by ELISA on the phosphorylated an…
View article: Non-invasive imaging and cellular tracking of pulmonary emboli by near-infrared fluorescence and positron-emission tomography
Non-invasive imaging and cellular tracking of pulmonary emboli by near-infrared fluorescence and positron-emission tomography Open
View article: Mice expressing a mutant form of fibrinogen that cannot support fibrin formation exhibit compromised antimicrobial host defense
Mice expressing a mutant form of fibrinogen that cannot support fibrin formation exhibit compromised antimicrobial host defense Open
Key Points Mutation of the fibrinogen Aα chain in mice to selectively eliminate thrombin cleavage prevents fibrin polymer formation in vivo. Fibrin polymer formation drives antimicrobial function and supports host survival following S aure…