Toyofumi F. Chen‐Yoshikawa
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View article: Uniportal fully robotic-assisted lobectomy via the fifth intercostal space with a cross-arm technique
Uniportal fully robotic-assisted lobectomy via the fifth intercostal space with a cross-arm technique Open
View article: The Impact of Post-Operative Phrenic Nerve Dysfunction on Lung Function Parameters and Long-Term Outcomes After Lung Transplantation
The Impact of Post-Operative Phrenic Nerve Dysfunction on Lung Function Parameters and Long-Term Outcomes After Lung Transplantation Open
A rare but important complication after lung transplantation (LTx) is postoperative phrenic nerve dysfunction (PND). Diaphragmatic plication (DP) is a well-established treatment option for PND, however, the long-term effect of PND and DP o…
View article: Impact of excessive body fat mass on mortality after lung transplantation
Impact of excessive body fat mass on mortality after lung transplantation Open
After lung transplantation, the patients had increased BMI, FFMI, and FMI. The FMI increased above the reference values in an increasing number of patients, and a high FMI at 1 year post-transplantation was associated with a poor prognosis.
View article: Innovative triple-directional robotic extended thymectomy using the rotatable patient cart of a robot-assisted thoracic surgical system
Innovative triple-directional robotic extended thymectomy using the rotatable patient cart of a robot-assisted thoracic surgical system Open
View article: Prophylactic azithromycin for chronic lung allograft dysfunction following lung transplantation: a systematic review and meta-analysis
Prophylactic azithromycin for chronic lung allograft dysfunction following lung transplantation: a systematic review and meta-analysis Open
Prophylactic AZI may reduce the risk of CLAD onset and improve 3- and 5-year CLAD-free survival, providing supporting evidence for its application in LTx community. More high-quality and well-designed studies are warranted to determine the…
View article: <scp>PBK</scp> Expression Promotes the Aggressive Phenotypes of Mesothelioma
<span>PBK</span> Expression Promotes the Aggressive Phenotypes of Mesothelioma Open
Mesothelioma is one of the most aggressive neoplasms worldwide that has a particularly poor prognosis. We have previously discovered that oxytocin receptors (OXTR) are highly expressed in mesothelioma and that OXTR knockdown significantly …
View article: An intratumorally discovered extracellular vesicle-derived biomarker enables ultrasensitive digital quantification in plasma for early detection of non-small cell lung cancer
An intratumorally discovered extracellular vesicle-derived biomarker enables ultrasensitive digital quantification in plasma for early detection of non-small cell lung cancer Open
Background Extracellular vesicle (EV)-based liquid biopsy remains challenging due to the limited specificity and low abundance of EV cargoes. This study aimed to identify cancer-specific molecules from tissue-derived EVs and evaluate their…
View article: Postoperative Pain Reduction and Clinical Value of Uniportal Video-Assisted Thoracic Surgery: A Secondary Analysis of the J-RATSIG 01 Study
Postoperative Pain Reduction and Clinical Value of Uniportal Video-Assisted Thoracic Surgery: A Secondary Analysis of the J-RATSIG 01 Study Open
View article: Can intraoperative improvement of radial endobronchial ultrasound imaging enhance the diagnostic yield in peripheral pulmonary lesions?
Can intraoperative improvement of radial endobronchial ultrasound imaging enhance the diagnostic yield in peripheral pulmonary lesions? Open
Improved R-EBUS findings during TBNA/TBB or TBB with EBUS-GS were associated with a high diagnostic yield without an increase in complications, even when the initial R-EBUS findings were inadequate. This suggests that repeated intraoperati…
View article: A novel program of cadaver surgical training for young surgeons at the Clinical Anatomy Laboratory Nagoya (CALNA)
A novel program of cadaver surgical training for young surgeons at the Clinical Anatomy Laboratory Nagoya (CALNA) Open
Purpose This study aimed to evaluate the effectiveness of a cadaver surgical training program at the Clinical Anatomy Laboratory Nagoya (CALNA), focusing on its impact on procedural skills, confidence, and anatomical understanding among yo…
View article: Postoperative Pain Reduction and Clinical Value of Uniportal Video-Assisted Thoracic Surgery: A Secondary Analysis of the J-RATSIG 01 Study
Postoperative Pain Reduction and Clinical Value of Uniportal Video-Assisted Thoracic Surgery: A Secondary Analysis of the J-RATSIG 01 Study Open
U-VATS significantly reduced postoperative pain and was associated with shorter operation times, chest tube duration, and hospitalization than M-VATS.
View article: Molecular Mechanisms of Tumor Progression and Novel Therapeutic and Diagnostic Strategies in Mesothelioma
Molecular Mechanisms of Tumor Progression and Novel Therapeutic and Diagnostic Strategies in Mesothelioma Open
Mesothelioma is characterized by the inactivation of tumor suppressor genes, with frequent mutations in neurofibromin 2 (NF2), BRCA1-associated protein 1 (BAP1), and cyclin-dependent kinase inhibitor 2A (CDKN2A). These mutations lead to di…
View article: Importance of anesthesiologists' non-technical skills in the management of a case of life-threatening cardiac tamponade during robot-assisted thoracic surgery.
Importance of anesthesiologists' non-technical skills in the management of a case of life-threatening cardiac tamponade during robot-assisted thoracic surgery. Open
Deficiency of non-technical skills may increase the number of adverse events in the operating room. Sustained life-threatening hypotension due to intraoperative cardiac tamponade during robot-assisted thoracic surgery is rare, requiring pr…
View article: Postoperative Outcome of Procedure for Middle Lobe Torsion Involving Right Upper and Lower Bilobectomy in Multiple Primary Lung Cancers
Postoperative Outcome of Procedure for Middle Lobe Torsion Involving Right Upper and Lower Bilobectomy in Multiple Primary Lung Cancers Open
View article: The novel compound PICCS improves cell viability during cold storage and reduces pulmonary ischemia-reperfusion injury in a rat model
The novel compound PICCS improves cell viability during cold storage and reduces pulmonary ischemia-reperfusion injury in a rat model Open
View article: Analysis of the changes in health-related quality of life and employment status after surgery in patients with lung cancer: a single-center longitudinal study
Analysis of the changes in health-related quality of life and employment status after surgery in patients with lung cancer: a single-center longitudinal study Open
Objective This study analyzed the changes in health-related quality of life (HRQOL) and employment status of patients undergoing lung cancer surgery in Japan. Methods This was a single-center, prospective study on patients who underwent lu…
View article: Molecular Mechanism of Tumor Progression and Novel Therapeutic and Diagnostic Strategies in Mesothelioma
Molecular Mechanism of Tumor Progression and Novel Therapeutic and Diagnostic Strategies in Mesothelioma Open
Mesothelioma is characterized by the inactivation of tumor suppressor genes, with frequent mutations in neurofibromin 2 (NF2), BRCA1-associated protein 1 (BAP1), and cyclin-dependent kinase inhibitor 2A (CDKN2A). These mutations lead to di…
View article: A Case of Myasthenia Gravis and Stiff‐Person Syndrome That Improved After Extended Thymectomy
A Case of Myasthenia Gravis and Stiff‐Person Syndrome That Improved After Extended Thymectomy Open
In cases of thymoma with autoimmune disease, extended thymectomy may improve disease symptoms and medication effects. Myasthenia gravis (MG) is the most common complication, but thymoma with Stiff‐Person syndrome (SPS) is rare, and there a…
View article: Increased sputum peripheral helper T cells are associated with the severity of rheumatoid arthritis but not with the severity of airway disease
Increased sputum peripheral helper T cells are associated with the severity of rheumatoid arthritis but not with the severity of airway disease Open
Objective Peripheral helper T (Tph) cells, together with plasma cells, are the major pathogenic lymphocytes in the synovium in rheumatoid arthritis (RA). However, whether these cells are involved in RA-associated lung and/or airway disease…
View article: Activation of anti-donor CD8 alloimmune response in clinically diagnosed acute rejection early after living-donor lobar lung transplantation and its impact on outcome
Activation of anti-donor CD8 alloimmune response in clinically diagnosed acute rejection early after living-donor lobar lung transplantation and its impact on outcome Open
Early lung graft infiltration after LDLLT increases the risk of the early development of CALD. Augmented anti-donor CD8 + response was also associated with graft infiltration, which could not be predicted from HLA mismatches but could be m…
View article: Avoiding extracorporeal membrane oxygenation using dual-lung ventilation: Carinal resection and left pneumonectomy for adenoid cystic carcinoma
Avoiding extracorporeal membrane oxygenation using dual-lung ventilation: Carinal resection and left pneumonectomy for adenoid cystic carcinoma Open
View article: Lobectomy for primary lung cancer: a comparison of perioperative and postoperative outcomes between robot-assisted thoracic surgery and video-assisted thoracic surgery
Lobectomy for primary lung cancer: a comparison of perioperative and postoperative outcomes between robot-assisted thoracic surgery and video-assisted thoracic surgery Open
View article: Accuracy of lung structure constructed by three-dimensional image analysis with non-enhanced computed tomography
Accuracy of lung structure constructed by three-dimensional image analysis with non-enhanced computed tomography Open
The 3D images of the lungs based on non-enhanced CT showed that the right middle lobe and both lower lobes were correctly depicted. The right and left upper lobes were poorly visualized using non-enhanced CT, while the right upper lobe was…
View article: Diagnostic utility of chest wall vessel involvement sign on ultra-high-resolution CT for primary lung cancer infiltrating the chest wall
Diagnostic utility of chest wall vessel involvement sign on ultra-high-resolution CT for primary lung cancer infiltrating the chest wall Open
Objectives Chest wall infiltration in primary lung cancer affects the surgical and therapeutic strategies. This study evaluates the efficacy of the chest wall vessel involvement in subpleural lung cancer (CWVI) on ultra-high-resolution CT …
View article: Difficult preoperative diagnosis of multiple mediastinal cholesterol granulomas: a case report
Difficult preoperative diagnosis of multiple mediastinal cholesterol granulomas: a case report Open
View article: Bilateral Video‐Assisted Thoracoscopic Resection for a Patient With Horseshoe Intralobar Pulmonary Sequestration: A Novel Minimally Invasive Approach
Bilateral Video‐Assisted Thoracoscopic Resection for a Patient With Horseshoe Intralobar Pulmonary Sequestration: A Novel Minimally Invasive Approach Open
We encountered a rare case of bilateral intralobar pulmonary sequestration presenting as horseshoe lung. A 44‐year‐old asymptomatic woman was referred to our hospital because of increased serum cancer antigen 125 and carbohydrate antigen 1…
View article: Delayed Diagnosis of Primary Pulmonary Sarcoma Arising from a Pulmonary Cyst in an Adult: A Case Report
Delayed Diagnosis of Primary Pulmonary Sarcoma Arising from a Pulmonary Cyst in an Adult: A Case Report Open
Primary pulmonary sarcoma is a rare disease and is much less common than lung cancer among tumors arising from pulmonary cysts. We report the case of a female patient who showed multifocal cysts in the left S9-10. Follow-up computed tomogr…
View article: Effects of the COVID-19 pandemic on surgical treatment for thoracic malignant tumor cases in Japan: a national clinical database analysis
Effects of the COVID-19 pandemic on surgical treatment for thoracic malignant tumor cases in Japan: a national clinical database analysis Open
Objective Surgical care has been significantly affected by the COVID-19 pandemic. This study was conducted to evaluate the effects of the pandemic on lung cancer and mediastinal tumor surgery. Methods Changes in the number of surgical proc…
View article: Managing recurrent thymic epithelial tumors after resection: outcomes and role of re-resection
Managing recurrent thymic epithelial tumors after resection: outcomes and role of re-resection Open
Thymic epithelial tumors (TETs) are rare neoplasms that include thymomas, thymic carcinomas (TCs), and thymic neuroendocrine neoplasms (TNENs). These three tumor categories differ in aggressiveness, the incidence of recurrence after resect…
View article: AB009. Impact of neoadjuvant therapy followed by surgical intervention for thymic carcinoma patients
AB009. Impact of neoadjuvant therapy followed by surgical intervention for thymic carcinoma patients Open
BACKGROUND: Thymic carcinoma has the potential to invade neighboring structures such as the cardiovascular system and lungs, making complete resection difficult with surgical treatment alone. This study aims to evaluate the outcomes of neo…