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View article: Autophagic regulation of CD8+ T cell metabolic reprogramming defines acute and latent phases of cytomegalovirus infection in vivo
Autophagic regulation of CD8+ T cell metabolic reprogramming defines acute and latent phases of cytomegalovirus infection in vivo Open
Understanding the immunoregulatory mechanism during cytomegalovirus (CMV) infection may help to combat CMV reactivation in immunocompromised or immunosuppressed individuals. Here we developed a CMV infection model in immunocompetent Spragu…
View article: Tumor arachidonic acid synthesis impairs metabolic fitness of CXCR6+ resident memory CD8+ T cells and drives immunotherapy resistance in hepatocellular carcinoma
Tumor arachidonic acid synthesis impairs metabolic fitness of CXCR6+ resident memory CD8+ T cells and drives immunotherapy resistance in hepatocellular carcinoma Open
Lipid metabolic reprogramming in the hepatocellular carcinoma (HCC) tumor microenvironment (TME) drives immunosuppression, yet the critical mediators orchestrating tumor-immune crosstalk remain elusive. Here, we identify arachidonic acid (…
View article: Computer Assisted Verbal Autopsy: Comparing Large Language Models to Physicians for Assigning Causes to 6939 Deaths in Sierra Leone from 2019-2022
Computer Assisted Verbal Autopsy: Comparing Large Language Models to Physicians for Assigning Causes to 6939 Deaths in Sierra Leone from 2019-2022 Open
Background Verbal autopsies (VAs) collect information on deaths in low and middle-income countries occurring outside healthcare facilities to estimate causes of death (CODs) for use in epidemiological or planning studies. Physician coding …
View article: Erector Spinae Plane versus Pectoralis Nerve Block for Mastectomy in Cancer Patients: A Retrospective, Multicenter Cohort Study
Erector Spinae Plane versus Pectoralis Nerve Block for Mastectomy in Cancer Patients: A Retrospective, Multicenter Cohort Study Open
Compared to the PECS block, the ESP block demonstrated no significant difference in acute pain outcomes and recovery in patients undergoing mastectomy for breast cancer, with similar hospital discharge times and long-term outcomes.
View article: The Singapore Consensus on Global AI Safety Research Priorities
The Singapore Consensus on Global AI Safety Research Priorities Open
Rapidly improving AI capabilities and autonomy hold significant promise of transformation, but are also driving vigorous debate on how to ensure that AI is safe, i.e., trustworthy, reliable, and secure. Building a trusted ecosystem is ther…
View article: Emerging Roles of C-C Motif Ligand 11 (CCL11) in Cancers and Liver Diseases: Mechanisms and Therapeutic Implications
Emerging Roles of C-C Motif Ligand 11 (CCL11) in Cancers and Liver Diseases: Mechanisms and Therapeutic Implications Open
C-C motif ligand 11 (CCL11) is a multifunctional chemokine that regulates immunity, angiogenesis, and tissue remodeling. In addition to its allergic inflammation role, CCL11 exhibits context-dependent dual functions in relation to cancer p…
View article: International AI Safety Report
International AI Safety Report Open
The first International AI Safety Report comprehensively synthesizes the current evidence on the capabilities, risks, and safety of advanced AI systems. The report was mandated by the nations attending the AI Safety Summit in Bletchley, UK…
View article: International Scientific Report on the Safety of Advanced AI (Interim Report)
International Scientific Report on the Safety of Advanced AI (Interim Report) Open
This is the interim publication of the first International Scientific Report on the Safety of Advanced AI. The report synthesises the scientific understanding of general-purpose AI -- AI that can perform a wide variety of tasks -- with a f…
View article: Arachidonic acid activates NLRP3 inflammasome in MDSCs via FATP2 to promote post-transplant tumour recurrence in steatotic liver grafts
Arachidonic acid activates NLRP3 inflammasome in MDSCs via FATP2 to promote post-transplant tumour recurrence in steatotic liver grafts Open
The high incidence of non-alcoholic fatty liver disease resulted in the frequent application of steatotic donors in liver transplantation. Our data showed that the patients who underwent liver transplantation using fatty grafts experienced…
View article: IDDF2023-ABS-0258 Decipher the mitochondrial reprogramming in dysregulated immunometabolism during steatotic liver graft injury
IDDF2023-ABS-0258 Decipher the mitochondrial reprogramming in dysregulated immunometabolism during steatotic liver graft injury Open
Background The polarization of M1 macrophage facilitates steatotic liver graft injury and is regulated by metabolic reprogramming. We previously demonstrated that compromised PGC1α signaling mediated steatotic graft injury by dysregulating…
View article: The Landscape of Aberrant Alternative Splicing Events in Steatotic Liver Graft Post Transplantation via Transcriptome-Wide Analysis
The Landscape of Aberrant Alternative Splicing Events in Steatotic Liver Graft Post Transplantation via Transcriptome-Wide Analysis Open
The application of steatotic liver graft has been increased significantly due to the severe donor shortage and prevalence of non-alcoholic fatty liver disease. However, steatotic donor livers are vulnerable to acute phase inflammatory inju…
View article: Supplementary Tables 1 through 6 from Identification of Transmembrane Protein 98 as a Novel Chemoresistance-Conferring Gene in Hepatocellular Carcinoma
Supplementary Tables 1 through 6 from Identification of Transmembrane Protein 98 as a Novel Chemoresistance-Conferring Gene in Hepatocellular Carcinoma Open
PDF - 150K, Supplementary Table 1: List of primers. Supplementary Table 2: List of commonly up-regulated genes in drug resistant sublines. Supplementary Table 3: List of commonly down-regulated genes in drug resistant sublines. Supplementa…
View article: Data from Identification of Transmembrane Protein 98 as a Novel Chemoresistance-Conferring Gene in Hepatocellular Carcinoma
Data from Identification of Transmembrane Protein 98 as a Novel Chemoresistance-Conferring Gene in Hepatocellular Carcinoma Open
Chemoresistance is one of the major obstacles in systemic chemotherapy and targeted therapy for patients with advanced hepatocellular carcinoma. To identify novel chemoresistance-associated targets in hepatocellular carcinoma, chemoresista…
View article: Supplementary Figures 1 through 8 from Identification of Transmembrane Protein 98 as a Novel Chemoresistance-Conferring Gene in Hepatocellular Carcinoma
Supplementary Figures 1 through 8 from Identification of Transmembrane Protein 98 as a Novel Chemoresistance-Conferring Gene in Hepatocellular Carcinoma Open
PDF - 924K, Supplementary Figure 1: Morphology and growth curves of MHCC97L, MHCC97L/CisR and MHCC97L/DoxR cells. Supplementary Figure 2: In vivo growth rate of MHCC97L, MHCC97L/CisR and MHCC97L/DoxR cells in nude mice. Supplementary Figur…
View article: Data from Identification of Transmembrane Protein 98 as a Novel Chemoresistance-Conferring Gene in Hepatocellular Carcinoma
Data from Identification of Transmembrane Protein 98 as a Novel Chemoresistance-Conferring Gene in Hepatocellular Carcinoma Open
Chemoresistance is one of the major obstacles in systemic chemotherapy and targeted therapy for patients with advanced hepatocellular carcinoma. To identify novel chemoresistance-associated targets in hepatocellular carcinoma, chemoresista…
View article: Supplementary Figures 1 through 8 from Identification of Transmembrane Protein 98 as a Novel Chemoresistance-Conferring Gene in Hepatocellular Carcinoma
Supplementary Figures 1 through 8 from Identification of Transmembrane Protein 98 as a Novel Chemoresistance-Conferring Gene in Hepatocellular Carcinoma Open
PDF - 924K, Supplementary Figure 1: Morphology and growth curves of MHCC97L, MHCC97L/CisR and MHCC97L/DoxR cells. Supplementary Figure 2: In vivo growth rate of MHCC97L, MHCC97L/CisR and MHCC97L/DoxR cells in nude mice. Supplementary Figur…
View article: Supplementary Tables 1 through 6 from Identification of Transmembrane Protein 98 as a Novel Chemoresistance-Conferring Gene in Hepatocellular Carcinoma
Supplementary Tables 1 through 6 from Identification of Transmembrane Protein 98 as a Novel Chemoresistance-Conferring Gene in Hepatocellular Carcinoma Open
PDF - 150K, Supplementary Table 1: List of primers. Supplementary Table 2: List of commonly up-regulated genes in drug resistant sublines. Supplementary Table 3: List of commonly down-regulated genes in drug resistant sublines. Supplementa…
View article: Data from Postoperative Plasmacytoid Dendritic Cells Secrete IFNα to Promote Recruitment of Myeloid-Derived Suppressor Cells and Drive Hepatocellular Carcinoma Recurrence
Data from Postoperative Plasmacytoid Dendritic Cells Secrete IFNα to Promote Recruitment of Myeloid-Derived Suppressor Cells and Drive Hepatocellular Carcinoma Recurrence Open
Patients with hepatocellular carcinoma (HCC) confront a high incidence of tumor recurrence after curative surgical resection. Hepatic ischemia-reperfusion injury (IRI) is the major consequence of surgical stress during hepatectomy. Althoug…
View article: Data from Postoperative Plasmacytoid Dendritic Cells Secrete IFNα to Promote Recruitment of Myeloid-Derived Suppressor Cells and Drive Hepatocellular Carcinoma Recurrence
Data from Postoperative Plasmacytoid Dendritic Cells Secrete IFNα to Promote Recruitment of Myeloid-Derived Suppressor Cells and Drive Hepatocellular Carcinoma Recurrence Open
Patients with hepatocellular carcinoma (HCC) confront a high incidence of tumor recurrence after curative surgical resection. Hepatic ischemia-reperfusion injury (IRI) is the major consequence of surgical stress during hepatectomy. Althoug…
View article: Supplementary Data from Postoperative Plasmacytoid Dendritic Cells Secrete IFNα to Promote Recruitment of Myeloid-Derived Suppressor Cells and Drive Hepatocellular Carcinoma Recurrence
Supplementary Data from Postoperative Plasmacytoid Dendritic Cells Secrete IFNα to Promote Recruitment of Myeloid-Derived Suppressor Cells and Drive Hepatocellular Carcinoma Recurrence Open
Supplementary Data from Postoperative Plasmacytoid Dendritic Cells Secrete IFNα to Promote Recruitment of Myeloid-Derived Suppressor Cells and Drive Hepatocellular Carcinoma Recurrence
View article: Supplementary Figure from Postoperative Plasmacytoid Dendritic Cells Secrete IFNα to Promote Recruitment of Myeloid-Derived Suppressor Cells and Drive Hepatocellular Carcinoma Recurrence
Supplementary Figure from Postoperative Plasmacytoid Dendritic Cells Secrete IFNα to Promote Recruitment of Myeloid-Derived Suppressor Cells and Drive Hepatocellular Carcinoma Recurrence Open
Supplementary Figure from Postoperative Plasmacytoid Dendritic Cells Secrete IFNα to Promote Recruitment of Myeloid-Derived Suppressor Cells and Drive Hepatocellular Carcinoma Recurrence
View article: Supplementary Data from Postoperative Plasmacytoid Dendritic Cells Secrete IFNα to Promote Recruitment of Myeloid-Derived Suppressor Cells and Drive Hepatocellular Carcinoma Recurrence
Supplementary Data from Postoperative Plasmacytoid Dendritic Cells Secrete IFNα to Promote Recruitment of Myeloid-Derived Suppressor Cells and Drive Hepatocellular Carcinoma Recurrence Open
Supplementary Data from Postoperative Plasmacytoid Dendritic Cells Secrete IFNα to Promote Recruitment of Myeloid-Derived Suppressor Cells and Drive Hepatocellular Carcinoma Recurrence
View article: Supplementary Data from Postoperative Plasmacytoid Dendritic Cells Secrete IFNα to Promote Recruitment of Myeloid-Derived Suppressor Cells and Drive Hepatocellular Carcinoma Recurrence
Supplementary Data from Postoperative Plasmacytoid Dendritic Cells Secrete IFNα to Promote Recruitment of Myeloid-Derived Suppressor Cells and Drive Hepatocellular Carcinoma Recurrence Open
Supplementary Data from Postoperative Plasmacytoid Dendritic Cells Secrete IFNα to Promote Recruitment of Myeloid-Derived Suppressor Cells and Drive Hepatocellular Carcinoma Recurrence
View article: Trends in Outpatient Visits and Hospital and Intensive Care Unit Admissions of Adults With COVID-19 in an Integrated US Health Care System, March 2020 to January 2022
Trends in Outpatient Visits and Hospital and Intensive Care Unit Admissions of Adults With COVID-19 in an Integrated US Health Care System, March 2020 to January 2022 Open
This cohort study of patients at a single integrated health system examines trends in COVID-19–related treatment location and mortality.
View article: Prognostic MicroRNA Fingerprints Predict Recurrence of Early-Stage Hepatocellular Carcinoma Following Hepatectomy
Prognostic MicroRNA Fingerprints Predict Recurrence of Early-Stage Hepatocellular Carcinoma Following Hepatectomy Open
Purpose: This study aims to develop liquid biopsy assays for early HCC diagnosis and prognosis. Methods: Twenty-three microRNAs were first consolidated as a panel (HCCseek-23 panel) based on their reported functions in HCC development. Ser…
View article: 509 Immune checkpoint blockade boosts anti-tumour B cell responses in lung adenocarcinoma
509 Immune checkpoint blockade boosts anti-tumour B cell responses in lung adenocarcinoma Open
Background B cells are frequently found in the margins of solid tumours, where they are organized in tertiary lymphoid structures (TLS) that resemble antibody-producing germinal centres. The presence of TLS has been associated with improve…
View article: Postoperative Plasmacytoid Dendritic Cells Secrete IFNα to Promote Recruitment of Myeloid-Derived Suppressor Cells and Drive Hepatocellular Carcinoma Recurrence
Postoperative Plasmacytoid Dendritic Cells Secrete IFNα to Promote Recruitment of Myeloid-Derived Suppressor Cells and Drive Hepatocellular Carcinoma Recurrence Open
Patients with hepatocellular carcinoma (HCC) confront a high incidence of tumor recurrence after curative surgical resection. Hepatic ischemia-reperfusion injury (IRI) is the major consequence of surgical stress during hepatectomy. Althoug…
View article: Novel approach to analysis of the immune system using an ungated model of immune surface marker abundance to predict health outcomes
Novel approach to analysis of the immune system using an ungated model of immune surface marker abundance to predict health outcomes Open
Traditionally, the immune system is understood to be divided into discrete cell types that are identified via surface markers. While some cell type distinctions are no doubt discrete, others may in fact vary on a continum, and even within …
View article: Novel approach to analysis of the immune system using an ungated model of immune surface marker abundance to predict health outcomes
Novel approach to analysis of the immune system using an ungated model of immune surface marker abundance to predict health outcomes Open
Traditionally, the immune system is understood to be divided into discrete cell types that are identified via surface markers. While some cell type distinctions are no doubt discrete, others may in fact vary on a continuum, and even within…