Tracer Yong
YOU?
Author Swipe
View article: AID facilitates TET2 demethylation of <i>Irf4</i> for plasma cell fate in germinal center B cells
AID facilitates TET2 demethylation of <i>Irf4</i> for plasma cell fate in germinal center B cells Open
Activation-induced cytidine deaminase (AID) is essential for B cell affinity maturation. We investigated why AID deficiency gives rise to giant germinal centers (GC) using the AID R112H mouse model that is devoid of AID activity. The incre…
View article: Increased cross-presentation by dendritic cells and enhanced anti-tumour therapy using the Arp2/3 inhibitor CK666
Increased cross-presentation by dendritic cells and enhanced anti-tumour therapy using the Arp2/3 inhibitor CK666 Open
Background Dendritic cell (DC) vaccines for cancer therapy offer the possibility to let the patient’s own immune system kill cancer cells. However, DC vaccines have shown less efficacy than expected due to failure to induce cancer cell kil…
View article: A novel and robust method for counting components within bio-molecular complexes using fluorescence microscopy and statistical modelling
A novel and robust method for counting components within bio-molecular complexes using fluorescence microscopy and statistical modelling Open
Cellular biology occurs through myriad interactions between diverse molecular components, many of which assemble in to specific complexes. Various techniques can provide a qualitative survey of which components are found in a given complex…
View article: Active Humoral Response Reverts Tumorigenicity through Disruption of Key Signaling Pathway
Active Humoral Response Reverts Tumorigenicity through Disruption of Key Signaling Pathway Open
Immune checkpoint inhibitors such as monoclonal antibodies (mAbs) are amongst the most important breakthroughs in cancer therapeutics. However, high cost and short acting time limits its affordability and clinical application. Therefore, a…
View article: Learning to count: determining the stoichiometry of bio-molecular complexes using fluorescence microscopy and statistical modelling
Learning to count: determining the stoichiometry of bio-molecular complexes using fluorescence microscopy and statistical modelling Open
Cellular biology occurs through myriad interactions between diverse molecular components, many of which assemble in to specific complexes. Various techniques can provide a qualitative survey of which components are found in a given complex…