Tracey Jooste
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View article: PA-511 Utility of host transcriptomic biomarkers in the diagnosis of spinal tuberculosis
PA-511 Utility of host transcriptomic biomarkers in the diagnosis of spinal tuberculosis Open
Background Spinal tuberculosis (TB) is a potentially severe form of TB that accounts for 50% of all musculoskeletal TB cases. The condition presents with non-specific symptoms often resulting in delayed diagnosis. Therefore, there is an ur…
View article: PA-347 Diagnostic accuracy of published host blood transcriptomic tuberculosis signatures in a low burden hospital setting
PA-347 Diagnostic accuracy of published host blood transcriptomic tuberculosis signatures in a low burden hospital setting Open
Background Several host blood transcriptomic signatures have shown promise as tuberculosis (TB) diagnostic candidates, supporting the use of such biomarkers in prototype RNA-based point-of-care tests. Further validation of these signatures…
View article: PA-320 Optimisation of RNA extraction methods for small blood volumes for future use in TB host transcriptomic biosignature applications
PA-320 Optimisation of RNA extraction methods for small blood volumes for future use in TB host transcriptomic biosignature applications Open
Background Whole-blood-based transcriptomic methods have limitations, including in the amount of blood required for standard RNA blood collection tubes. This is particularly relevant to individuals with difficulty in providing large volume…
View article: Challenges of Diagnosing Mendelian Susceptibility to Mycobacterial Diseases in South Africa
Challenges of Diagnosing Mendelian Susceptibility to Mycobacterial Diseases in South Africa Open
Inborn errors of immunity (IEI) are genetic disorders with extensive clinical presentations. They can range from increased susceptibility to infections to significant immune dysregulation that results in immune impairment. While IEI cases …
View article: Utility of a three-gene transcriptomic signature in the diagnosis of tuberculosis in a low-endemic hospital setting
Utility of a three-gene transcriptomic signature in the diagnosis of tuberculosis in a low-endemic hospital setting Open
The three-genes signature may have potential to improve diagnosis of TB in a hospitalised low-burden setting. However, the influence of confounding variables or covariates such as age requires further evaluation in larger studies.
View article: Utility of a three-gene transcriptomic signature in the diagnosis of tuberculosis in a low-endemic hospital setting
Utility of a three-gene transcriptomic signature in the diagnosis of tuberculosis in a low-endemic hospital setting Open
Host transcriptomic blood signatures have demonstrated diagnostic potential for tuberculosis (TB), requiring further validation across different geographical settings. Discriminating TB from other diseases with similar clinical manifestati…
View article: Human whole genome sequencing in South Africa
Human whole genome sequencing in South Africa Open
The advent and evolution of next generation sequencing has considerably impacted genomic research. Until recently, South African researchers were unable to access affordable platforms capable of human whole genome sequencing locally and DN…
View article: Identification of potential biomarkers for predicting the early onset of diabetic cardiomyopathy in a mouse model
Identification of potential biomarkers for predicting the early onset of diabetic cardiomyopathy in a mouse model Open
View article: Human Whole Genome Sequencing in South Africa
Human Whole Genome Sequencing in South Africa Open
The advent and evolution of next generation sequencing has considerably impacted genomic research. Until recently, South African researchers were unable to access affordable platforms capable of human whole genome sequencing locally and DN…
View article: In Silico Probe-Based Detection of Citrus Viruses in NGS Data
In Silico Probe-Based Detection of Citrus Viruses in NGS Data Open
The conservation of plant biosecurity relies on the rapid identification of pathogenic organisms, including viruses. With next-generation sequencing (NGS), it is possible to identify multiple viruses within a metagenomic sample. In this st…
View article: The detection of Citrus tristeza virus genetic variants using pathogen specific electronic probes
The detection of Citrus tristeza virus genetic variants using pathogen specific electronic probes Open