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View article: Hunters and Gatherers: Strategies for Curriculum Mapping and Data Collection for Assuring Learning (SP10 - 1862) - Final Report 2013
Hunters and Gatherers: Strategies for Curriculum Mapping and Data Collection for Assuring Learning (SP10 - 1862) - Final Report 2013 Open
Assurance of learning (AoL) is an important process in educational settings. It evaluates how well an institution accomplishes the educational aims at the core of its activities, while assisting the faculty members to manage and improve pr…
View article: Developing a multi-level framework for analyzing public sports-based programmes to integrate migrants and refugees into organized sports
Developing a multi-level framework for analyzing public sports-based programmes to integrate migrants and refugees into organized sports Open
Voluntary sports clubs (VSCs) are viewed by governments as an important catalyst for the integration of migrants/refugees. However, research has shown that only a small number of VSCs are directly involved in ‘integration through sport’ pr…
View article: The burden of incidental SARS-CoV-2 infections in hospitalized patients across pandemic waves in Canada
The burden of incidental SARS-CoV-2 infections in hospitalized patients across pandemic waves in Canada Open
Many health authorities differentiate hospitalizations in patients infected with SARS-CoV-2 as being “for COVID-19” (due to direct manifestations of SARS-CoV-2 infection) versus being an “incidental” finding in someone admitted for an unre…
View article: Exploring (Semi) Professionalization in Women’s Team Sport Through a Continuum of Care Lens
Exploring (Semi) Professionalization in Women’s Team Sport Through a Continuum of Care Lens Open
Professional team male-dominated sports have been built on masculine values; however, these values are challenged by the increasing number of women athletes entering this workplace. In this research, we explore the suitability and gender a…
View article: Women’s professional sport leagues: a systematic review and future directions for research
Women’s professional sport leagues: a systematic review and future directions for research Open
Women’s professional sport has grown over the last decade and so has academic scholarship investigating it. It is timely to review and consolidate extant scholarship to identify patterns and gaps in research and future directions for resea…
View article: Women leaders in sport: a community of practice programme to create social learning
Women leaders in sport: a community of practice programme to create social learning Open
Purpose A community of practice (CoP) social learning approach can purposefully support change and provide rich experiences to benefit participants and their sport organisations. We explore how a CoP intervention programme creates social l…
View article: Managing sport and leisure in the era of Covid-19
Managing sport and leisure in the era of Covid-19 Open
In December 2019 the world was first informed of a new virus, called SARS-CoV-2 (hereafter Covid-19) spreading fast originally in China and quickly in the rest of the world, resulting in the hospitalisation and death of millions of people …
View article: Workplace Experiences of Women With Disability in Sport Organizations
Workplace Experiences of Women With Disability in Sport Organizations Open
Women with disability often experience barriers to employment and career progression, most notably in hyper-masculinised industry sectors such as sport. Applying an intersectionality lens and insights from critical disability theory, this …
View article: Editorial: Women's Professional Sport: Understanding Distinctiveness
Editorial: Women's Professional Sport: Understanding Distinctiveness Open
EDITORIAL article Front. Sports Act. Living, 10 December 2021Sec. Sports Management, Marketing and Business https://doi.org/10.3389/fspor.2021.806247
View article: A balancing act: women players in a new semi-Professional team sport league
A balancing act: women players in a new semi-Professional team sport league Open
Research question: Women commencing semi-professional careers in traditionally male team sports face unique opportunities and challenges. This study aimed to understand player's personal, organisational and societal barriers and supportive…
View article: Discovery of Branebrutinib (BMS-986195): A Strategy for Identifying a Highly Potent and Selective Covalent Inhibitor Providing Rapid in Vivo Inactivation of Bruton’s Tyrosine Kinase (BTK)
Discovery of Branebrutinib (BMS-986195): A Strategy for Identifying a Highly Potent and Selective Covalent Inhibitor Providing Rapid in Vivo Inactivation of Bruton’s Tyrosine Kinase (BTK) Open
Bruton's tyrosine kinase (BTK), a non-receptor tyrosine kinase, is a member of the Tec family of kinases and is essential for B cell receptor (BCR) mediated signaling. BTK also plays a critical role in the downstream signaling pathways for…
View article: Bruton's tyrosine kinase inhibitor BMS-986142 in experimental models of rheumatoid arthritis enhances efficacy of agents representing clinical standard-of-care
Bruton's tyrosine kinase inhibitor BMS-986142 in experimental models of rheumatoid arthritis enhances efficacy of agents representing clinical standard-of-care Open
Bruton's tyrosine kinase (BTK) regulates critical signal transduction pathways involved in the pathobiology of rheumatoid arthritis (RA) and other autoimmune disorders. BMS-986142 is a potent and highly selective reversible small molecule …
View article: The Security Agencies’ Perspective
The Security Agencies’ Perspective Open
This chapter provides an overview of the context of sport event security and of the various types of security agencies, such as local, national, international, public, and private organisations, and other related stakeholders involved in t…
View article: Socially sustainable ethnic tourism: a comparative study of two Hakka communities in China
Socially sustainable ethnic tourism: a comparative study of two Hakka communities in China Open
© 2017 Informa UK Limited, trading as Taylor & Francis Group. Ethnic tourism is a catalyst for economic and sociocultural development in many countries. However, ethnic tourism development has given rise to many challenges associated with …
View article: Empowering Women for Economic Growth: A Measurement of Social and Demographic Impacts on Afghan Women in Business
Empowering Women for Economic Growth: A Measurement of Social and Demographic Impacts on Afghan Women in Business Open
Non-governmental organizations working in conflict-prone, resource-deprived developing countries face a very unique set of challenges. Like with other non-profits, program dollars and other resources must be allocated carefully and thought…
View article: Identification of potent tricyclic prodrug S1P<sub>1</sub> receptor modulators
Identification of potent tricyclic prodrug S1P<sub>1</sub> receptor modulators Open
Herein, S1P1 partial agonists with shorter half-life than our previous clinical candidate are reported. The pulmonary and cardiac safety are assessed, issues currently observed with commercial Gilenya.
View article: Discovery of 6-Fluoro-5-(<i>R</i>)-(3-(<i>S</i>)-(8-fluoro-1-methyl-2,4-dioxo-1,2-dihydroquinazolin-3(4<i>H</i>)-yl)-2-methylphenyl)-2-(<i>S</i>)-(2-hydroxypropan-2-yl)-2,3,4,9-tetrahydro-1<i>H</i>-carbazole-8-carboxamide (BMS-986142): A Reversible Inhibitor of Bruton’s Tyrosine Kinase (BTK) Conformationally Constrained by Two Locked Atropisomers
Discovery of 6-Fluoro-5-(<i>R</i>)-(3-(<i>S</i>)-(8-fluoro-1-methyl-2,4-dioxo-1,2-dihydroquinazolin-3(4<i>H</i>)-yl)-2-methylphenyl)-2-(<i>S</i>)-(2-hydroxypropan-2-yl)-2,3,4,9-tetrahydro-1<i>H</i>-carbazole-8-carboxamide (BMS-986142): A Reversible Inhibitor of Bruton’s Tyrosine Kinase (BTK) Conformationally Constrained by Two Locked Atropisomers Open
Bruton's tyrosine kinase (BTK), a nonreceptor tyrosine kinase, is a member of the Tec family of kinases. BTK plays an essential role in B cell receptor (BCR)-mediated signaling as well as Fcγ receptor signaling in monocytes and Fcε recepto…
View article: Small Molecule Reversible Inhibitors of Bruton’s Tyrosine Kinase (BTK): Structure–Activity Relationships Leading to the Identification of 7-(2-Hydroxypropan-2-yl)-4-[2-methyl-3-(4-oxo-3,4-dihydroquinazolin-3-yl)phenyl]-9<i>H</i>-carbazole-1-carboxamide (BMS-935177)
Small Molecule Reversible Inhibitors of Bruton’s Tyrosine Kinase (BTK): Structure–Activity Relationships Leading to the Identification of 7-(2-Hydroxypropan-2-yl)-4-[2-methyl-3-(4-oxo-3,4-dihydroquinazolin-3-yl)phenyl]-9<i>H</i>-carbazole-1-carboxamide (BMS-935177) Open
Bruton's tyrosine kinase (BTK) belongs to the TEC family of nonreceptor tyrosine kinases and plays a critical role in multiple cell types responsible for numerous autoimmune diseases. This article will detail the structure-activity relatio…
View article: A preliminary investigation into the neural basis of the production effect.
A preliminary investigation into the neural basis of the production effect. Open
Items that are produced (e.g., read aloud) during encoding typically are better remembered than items that are not produced (e.g., read silently). This "production effect" has been explained by distinctiveness: Produced items have more dis…
View article: Potent and Selective Agonists of Sphingosine 1-Phosphate 1 (S1P<sub>1</sub>): Discovery and SAR of a Novel Isoxazole Based Series
Potent and Selective Agonists of Sphingosine 1-Phosphate 1 (S1P<sub>1</sub>): Discovery and SAR of a Novel Isoxazole Based Series Open
Sphingosine 1-phosphate (S1P) is the endogenous ligand for the sphingosine 1-phosphate receptors (S1P1-5) and evokes a variety of cellular responses through their stimulation. The interaction of S1P with the S1P receptors plays a fundament…