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View article: Motor resonance and inhibitory mechanisms in action observation as revealed by corticospinal excitability
Motor resonance and inhibitory mechanisms in action observation as revealed by corticospinal excitability Open
Motor resonance (MoR) refers to the automatic activation of motor circuits during action observation, reflecting an internal simulation of the observed movement. This phenomenon is thought to arise from the activity of mirror neuron region…
View article: Improving cerebellar TMS targeting: MRI-neuronavigation and landmark-based approaches assessed by E-field modeling
Improving cerebellar TMS targeting: MRI-neuronavigation and landmark-based approaches assessed by E-field modeling Open
View article: Multimodal neuroimaging of fatigability development
Multimodal neuroimaging of fatigability development Open
Fatigability refers to the inability of the neuromuscular system to generate enough force to produce movements to meet task challenges. Fatigability has a central and a peripheral component linked via the neuromuscular system, but how thes…
View article: Native learning ability and not age determines the effects of brain stimulation
Native learning ability and not age determines the effects of brain stimulation Open
Healthy aging often entails a decline in cognitive and motor functions, affecting independence and quality of life in older adults. Brain stimulation shows potential to enhance these functions, but studies show variable effects. Previous s…
View article: Differential induction of Parieto-motor plasticity in writer's cramp and cervical dystonia
Differential induction of Parieto-motor plasticity in writer's cramp and cervical dystonia Open
This study suggests that PAR-MOT cc-PAS abnormally increases M1 excitability in patients with WC but not in those with CD. Additionally, this increased plastic response in patients with WC does not appear to be directly linked to PPC to M1…
View article: Noninvasive modulation of the hippocampal-entorhinal complex during spatial navigation in humans
Noninvasive modulation of the hippocampal-entorhinal complex during spatial navigation in humans Open
Because of the depth of the hippocampal-entorhinal complex (HC-EC) in the brain, understanding of its role in spatial navigation via neuromodulation was limited in humans. Here, we aimed to better elucidate this relationship in healthy vol…
View article: Physiology-inspired bifocal fronto-parietal tACS for working memory enhancement
Physiology-inspired bifocal fronto-parietal tACS for working memory enhancement Open
View article: Non-invasive stimulation of the human striatum disrupts reinforcement learning of motor skills
Non-invasive stimulation of the human striatum disrupts reinforcement learning of motor skills Open
View article: Deep phenotyping of post-infectious myalgic encephalomyelitis/chronic fatigue syndrome
Deep phenotyping of post-infectious myalgic encephalomyelitis/chronic fatigue syndrome Open
View article: Non-invasive stimulation of the human striatum disrupts reinforcement learning of motor skills - UPHUMMEL - EPFL
Non-invasive stimulation of the human striatum disrupts reinforcement learning of motor skills - UPHUMMEL - EPFL Open
Dataset and code to reproduce the main results of the paper "Non-invasive stimulation of the human striatum disrupts reinforcement learning of motor skills" see Vassiliadis et al., Nature Human Behaviour (2024) Different Readme are provide…
View article: Non-invasive stimulation of the human striatum disrupts reinforcement learning of motor skills - UPHUMMEL - EPFL
Non-invasive stimulation of the human striatum disrupts reinforcement learning of motor skills - UPHUMMEL - EPFL Open
Dataset and code to reproduce the main results of the paper "Non-invasive stimulation of the human striatum disrupts reinforcement learning of motor skills" see Vassiliadis et al., Nature Human Behaviour (2024) Different Readme are provide…
View article: Adaptive video games for the assessment and rehabilitation of dementia
Adaptive video games for the assessment and rehabilitation of dementia Open
Background Neurorehabilitation in dementia becomes an increasingly relevant topic and requires early detection of signs of domain‐specific cognitive decline. To this end, neuropsychological testing is usually performed in specialized cente…
View article: Noninvasive theta-burst stimulation of the human striatum enhances striatal activity and motor skill learning
Noninvasive theta-burst stimulation of the human striatum enhances striatal activity and motor skill learning Open
View article: Effects of hippocampal noninvasive theta-burst stimulation on consolidation of associative memory in healthy older adults
Effects of hippocampal noninvasive theta-burst stimulation on consolidation of associative memory in healthy older adults Open
Stimulation of deep brain areas can offer benefits against cognitive impairments associated with aging. So far, this was only possible via invasive methods accompanied by risks. Grossman et al. proposed a new noninvasive stimulation techni…
View article: Bradykinesia and dystonia
Bradykinesia and dystonia Open
Background: Bradykinesia has been reported in patients with dystonia. Despite this, the pathophysiological mechanisms of bradykinesia in dystonia remain largely unknown. Methods: We here performed a comprehensive literature search and revi…
View article: Not only a matter of age: Machine learning-based characterization of the differential effect of brain stimulation on skill acquisition
Not only a matter of age: Machine learning-based characterization of the differential effect of brain stimulation on skill acquisition Open
Brain stimulation shows potential at enhancing cognitive and motor functions in humans. However, multiple studies assessing its effects on behavior show heterogeneous results, especially in healthy older subjects. We propose a new method t…
View article: Impact of cerebellar beta entrainment using non-invasive brain stimulation: Insights from an ongoing rhythmic TMS—EEG study in healthy human participants
Impact of cerebellar beta entrainment using non-invasive brain stimulation: Insights from an ongoing rhythmic TMS—EEG study in healthy human participants Open
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View article: Non-invasive stimulation of the human striatum disrupts reinforcement learning of motor skills
Non-invasive stimulation of the human striatum disrupts reinforcement learning of motor skills Open
Reinforcement feedback can improve motor learning, but the underlying brain mechanisms remain underexplored. Especially, the causal contribution of specific patterns of oscillatory activity within the human striatum is unknown. To address …
View article: LTP-like noninvasive striatal brain stimulation enhances striatal activity and motor skill learning in humans
LTP-like noninvasive striatal brain stimulation enhances striatal activity and motor skill learning in humans Open
The stimulation of deep brain structures has thus far been possible only with invasive methods. Transcranial electrical temporal interference stimulation (tTIS) is a novel, noninvasive technology that might overcome this limitation. The in…
View article: Inter-Individual Variability in Motor Output Is Driven by Recruitment Gain in the Corticospinal Tract Rather Than Motor Threshold
Inter-Individual Variability in Motor Output Is Driven by Recruitment Gain in the Corticospinal Tract Rather Than Motor Threshold Open
Variability in the response of individuals to various non-invasive brain stimulation protocols is a major problem that limits their potential for clinical applications. Baseline motor-evoked potential (MEP) amplitude is the key predictor o…
View article: Toward individualized medicine in stroke—The TiMeS project: Protocol of longitudinal, multi-modal, multi-domain study in stroke
Toward individualized medicine in stroke—The TiMeS project: Protocol of longitudinal, multi-modal, multi-domain study in stroke Open
Despite recent improvements, complete motor recovery occurs in <15% of stroke patients. To improve the therapeutic outcomes, there is a strong need to tailor treatments to each individual patient. However, there is a lack of knowledge c…
View article: Evaluating interhemispheric connectivity during midline object recognition using EEG
Evaluating interhemispheric connectivity during midline object recognition using EEG Open
Functional integration between two hemispheres is crucial for perceptual binding to occur when visual stimuli are presented in the midline of the visual field. Mima and colleagues (2001) showed using EEG that midline object recognition was…
View article: Dissecting motor skill acquisition: Spatial coordinates take precedence
Dissecting motor skill acquisition: Spatial coordinates take precedence Open
Practicing a previously unknown motor sequence often leads to the consolidation of motor chunks, which enable its accurate execution at increasing speeds. Recent imaging studies suggest the function of these structures to be more related t…
View article: Boosting mitochondrial health to counteract neurodegeneration
Boosting mitochondrial health to counteract neurodegeneration Open
Mitochondrial health is based on a delicate balance of specific mitochondrial functions (e.g. metabolism, signaling, dynamics) that are impaired in neurodegenerative diseases. Rescuing mitochondrial function by selectively targeting mitoch…
View article: Towards individualized Medicine in Stroke – the TiMeS project: protocol of longitudinal, multi-modal, multi-domain study in stroke
Towards individualized Medicine in Stroke – the TiMeS project: protocol of longitudinal, multi-modal, multi-domain study in stroke Open
Despite recent improvements, complete motor recovery occurs in less than 15% of stroke patients. To improve the therapeutic outcomes, there is a strong need to tailor treatments to each individual patient. However, there is a lack of knowl…
View article: Transcranial magnetic stimulation of the brain: What is stimulated? – A consensus and critical position paper
Transcranial magnetic stimulation of the brain: What is stimulated? – A consensus and critical position paper Open
View article: Depotentiation of associative plasticity is intact in Parkinson's disease with mild dyskinesia
Depotentiation of associative plasticity is intact in Parkinson's disease with mild dyskinesia Open
View article: Dissecting motor skill acquisition: Spatial coordinates take precedence
Dissecting motor skill acquisition: Spatial coordinates take precedence Open
The data contained in this repository can be used to replicate the results detailed in (Maceira-Elvira et al., 2022, AAAS) using the code in (10.5281/zenodo.6490843). Please note the estimated chunking patterns may differ slightly to those…
View article: Dissecting motor skill acquisition: Spatial coordinates take precedence
Dissecting motor skill acquisition: Spatial coordinates take precedence Open
The data contained in this repository can be used to replicate the results detailed in (Maceira-Elvira et al., 2022, AAAS) using the code in (10.5281/zenodo.6490843). Please note the estimated chunking patterns may differ slightly to those…
View article: Black-box testing in motor sequence learning
Black-box testing in motor sequence learning Open
During learning of novel motor sequences, practice leads to the consolidation of hierarchical structures, namely motor chunks, facilitating the accurate execution of sequences at increasing speeds. Recent studies show that such hierarchica…