Lisa Tran
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View article: Prevalence and Clinical Predictors of Stroke Mimics in the Extended Thrombectomy Window: A Cross-Sectional Study in Vietnam
Prevalence and Clinical Predictors of Stroke Mimics in the Extended Thrombectomy Window: A Cross-Sectional Study in Vietnam Open
Background Stroke mimics pose diagnostic challenges in the emergency department, particularly in patients presenting within the 4.5-24 hour thrombectomy window. Misdiagnosis may result in unnecessary interventions or delayed stroke treatme…
View article: Wage Rates and Job Requirements Prediction: An Application to Logistics Online Job Postings Using Search Tools and Web Scraping
Wage Rates and Job Requirements Prediction: An Application to Logistics Online Job Postings Using Search Tools and Web Scraping Open
View article: Isolation and selection of indigenous chicken-derived <i>Bacillus subtilis</i> strains as potential probiotic alternatives to antibiotics against Gram-negative enteropathogens.
Isolation and selection of indigenous chicken-derived <i>Bacillus subtilis</i> strains as potential probiotic alternatives to antibiotics against Gram-negative enteropathogens. Open
Objective: The increasing antibiotic resistance in poultry pathogens presents a significant public health risk, leading to the exploration of effective alternatives in broiler feed, particularly probiotics such as Bacillus subtilis.…
View article: Increased serum interleukin-31 levels correlate with pruritus in psoriatic patients: a cross-sectional study in Vietnam
Increased serum interleukin-31 levels correlate with pruritus in psoriatic patients: a cross-sectional study in Vietnam Open
Psoriasis is recognized not only as a skin disease but also as a systemic disorder. Interleukin-31 (IL-31) may be associated with psoriasis and systemic inflammation. We aimed to quantify serum IL-31 levels in patients with psoriasis and e…
View article: Povidone iodine-infused pars plana vitrectomy for severe Arthrographis kalrae fungal endophthalmitis
Povidone iodine-infused pars plana vitrectomy for severe Arthrographis kalrae fungal endophthalmitis Open
Povidone iodine-infused pars plana vitrectomy offers promise as a treatment for infectious endophthalmitis that fails medical management. This is the first report demonstrating eradication of fungal endophthalmitis using povidone iodine-in…
View article: The Impact of Biosimilar Use on Total Cost of Care and Provider Financial Performance in the Medicare Oncology Care Model: A Population-Based Simulation Study
The Impact of Biosimilar Use on Total Cost of Care and Provider Financial Performance in the Medicare Oncology Care Model: A Population-Based Simulation Study Open
On the basis of our simulation study using observed Medicare claims and OCM criteria, we found that biosimilar substitution for reference products can significantly lower episode TCOC and improve provider financial performance under the te…
View article: Collaborating single-cell and bulk RNA sequencing for comprehensive characterization of the intratumor heterogeneity and prognostic model development for bladder cancer
Collaborating single-cell and bulk RNA sequencing for comprehensive characterization of the intratumor heterogeneity and prognostic model development for bladder cancer Open
We have developed a prognostic model that has demonstrated significant efficacy in stratifying patients with BLCA.
View article: Connecting Young Minds (CYM) 2023 Undergraduate Research Conference: 5-Minute Scientific Research Presentations
Connecting Young Minds (CYM) 2023 Undergraduate Research Conference: 5-Minute Scientific Research Presentations Open
Connecting Young Minds (CYM) is a bilingual research conference created and run by students at the University of Ottawa. Our mission is to enrich the undergraduate experiences of STEM students by providing a vessel to inspire interest in r…
View article: CD8 + T-cell marker genes reveal different immune subtypes of oral lichen planus by integrating single-cell RNA-seq and bulk RNA-sequencing
CD8 + T-cell marker genes reveal different immune subtypes of oral lichen planus by integrating single-cell RNA-seq and bulk RNA-sequencing Open
Background Oral lichen planus (OLP) is a local autoimmune disease induced by T-cell dysfunction that frequently affects middle-aged or elderly people, with a higher prevalence in women. CD8 + T cells, also known as killer T cells, play an …
View article: FAM family gene prediction model reveals heterogeneity, stemness and immune microenvironment of UCEC
FAM family gene prediction model reveals heterogeneity, stemness and immune microenvironment of UCEC Open
Background: Endometrial cancer (UCEC) is a highly heterogeneous gynecologic malignancy that exhibits variable prognostic outcomes and responses to immunotherapy. The Familial sequence similarity (FAM) gene family is known to contribute to …
View article: 257TiP VERITAC-2: A global, randomized phase III study of ARV-471, a PROteolysis TArgeting Chimera (PROTAC) estrogen receptor (ER) degrader, vs fulvestrant in ER+/human epidermal growth factor receptor 2 (HER2)- advanced breast cancer
257TiP VERITAC-2: A global, randomized phase III study of ARV-471, a PROteolysis TArgeting Chimera (PROTAC) estrogen receptor (ER) degrader, vs fulvestrant in ER+/human epidermal growth factor receptor 2 (HER2)- advanced breast cancer Open
ARV-471 is an oral PROTAC ER degrader that binds to and degrades wild-type ER and clinically relevant mutants. ARV-471 directly recruits the ubiquitin-proteasome system to degrade ER, whereas selective ER degraders (SERDs) indirectly cause…
View article: Pharmacist-delivered HIV point-of-care testing in Ontario: Lessons learned from the GetaTest pilot
Pharmacist-delivered HIV point-of-care testing in Ontario: Lessons learned from the GetaTest pilot Open
View article: Multiple BCG vaccinations for the prevention of COVID-19 and other infectious diseases in type 1 diabetes
Multiple BCG vaccinations for the prevention of COVID-19 and other infectious diseases in type 1 diabetes Open
There is a need for safe and effective platform vaccines to protect against coronavirus disease 2019 (COVID-19) and other infectious diseases. In this randomized, double-blinded, placebo-controlled phase 2/3 trial, we evaluate the safety a…
View article: Improved assay for detecting SARS-CoV-2 from nonporous hospital surfaces using surrogate human coronavirus OC43
Improved assay for detecting SARS-CoV-2 from nonporous hospital surfaces using surrogate human coronavirus OC43 Open
Background: Understanding SARS-CoV-2 persistence on surfaces can help inform transmission risk from surfaces in healthcare and community settings. A sensitive viral infectivity assay is crucial for the detection of infective virus in envir…
View article: Clinicopathologic and molecular characteristics of EGFR-mutant lung adenocarcinomas that transform to small cell lung cancer after TKI therapy
Clinicopathologic and molecular characteristics of EGFR-mutant lung adenocarcinomas that transform to small cell lung cancer after TKI therapy Open
In our series, most patients with small cell transformation had poorly differentiated adenocarcinomas at baseline. RB1 loss was not universal in transformed patients in this series, though TP53 mutation was present in all tum…
View article: BCG therapy is associated with long-term, durable induction of Treg signature genes by epigenetic modulation
BCG therapy is associated with long-term, durable induction of Treg signature genes by epigenetic modulation Open
View article: Invasive <i>Mycobacterium abscessus</i> Outbreak at a Pediatric Dental Clinic
Invasive <i>Mycobacterium abscessus</i> Outbreak at a Pediatric Dental Clinic Open
Background Mycobacterium species, specifically M. abscessus and M. chelonae (MABs), are known to contaminate water systems and are uncommon causes of health care–associated infection, but morbidity can be significant and treatment complex.…
View article: BCG Vaccinations Upregulate Myc, a Central Switch for Improved Glucose Metabolism in Diabetes
BCG Vaccinations Upregulate Myc, a Central Switch for Improved Glucose Metabolism in Diabetes Open
Myc has emerged as a pivotal transcription factor for four metabolic pathways: aerobic glycolysis, glutaminolysis, polyamine synthesis, and HIF-1α/mTOR. Each of these pathways accelerates the utilization of sugar. The BCG vaccine, a deriva…
View article: Inpatient Management of Uncomplicated Skin and Soft Tissue Infections in 34 Veterans Affairs Medical Centers: A Medication Use Evaluation
Inpatient Management of Uncomplicated Skin and Soft Tissue Infections in 34 Veterans Affairs Medical Centers: A Medication Use Evaluation Open
Background Skin and soft tissue infections (SSTIs) are a key antimicrobial stewardship target because they are a common infection in hospitalized patients, and non-guideline-concordant antibiotic use is frequent. To inform antimicrobial st…
View article: Landscape of Immune-Related Pneumonitis in Cancer Patients with Asthma Being Treated with Immune Checkpoint Blockade
Landscape of Immune-Related Pneumonitis in Cancer Patients with Asthma Being Treated with Immune Checkpoint Blockade Open
Introduction: Predicting the factors that increase the risk of immune-related pneumonitis, a potentially life-threatening complication of treatment with immune checkpoint inhibitors for cancer, is a clinical challenge. Baseli…
View article: MON-179 Repeat BCG Vaccination Creates Lasting HbA1c Reductions in Adult Subjects with Longstanding Type 1 Diabetes by Correcting Immune-Metabolic Defects
MON-179 Repeat BCG Vaccination Creates Lasting HbA1c Reductions in Adult Subjects with Longstanding Type 1 Diabetes by Correcting Immune-Metabolic Defects Open
The move to cleaner and more urban environments is speculated to be involved in not just how type 1 diabetes develops, but also in the increased incidence of many immune diseases. The bacillus Calmette-Guérin (BCG) vaccine, originally deve…
View article: 926. Outbreak of Invasive Nontuberculous Mycobacterium (NTM) Infections Associated With a Pediatric Dental Practice
926. Outbreak of Invasive Nontuberculous Mycobacterium (NTM) Infections Associated With a Pediatric Dental Practice Open
Background In 2016, an Orange County, California, pediatric dental clinic’s contaminated water system led to the largest outbreak of odontogenic NTM infections yet described. Methods Mandatory reporting and active case finding directed by …
View article: Targeted killing of TNFR2-expressing tumor cells and Tregs by TNFR2 antagonistic antibodies in advanced Sézary syndrome
Targeted killing of TNFR2-expressing tumor cells and Tregs by TNFR2 antagonistic antibodies in advanced Sézary syndrome Open
View article: The Effects of Age and Dose on Gene Expression and Segmental Bone Defect Repair After BMP‐2 Delivery
The Effects of Age and Dose on Gene Expression and Segmental Bone Defect Repair After BMP‐2 Delivery Open
Age is a well‐known influential factor in bone healing, with younger patients generally healing bone fractures more rapidly and suffering fewer complications compared with older patients. Yet the impact age has on the response to current b…
View article: Preoperative Circulating Tumor DNA in Patients with Peritoneal Carcinomatosis is an Independent Predictor of Progression-Free Survival
Preoperative Circulating Tumor DNA in Patients with Peritoneal Carcinomatosis is an Independent Predictor of Progression-Free Survival Open
View article: Long-term reduction in hyperglycemia in advanced type 1 diabetes: the value of induced aerobic glycolysis with BCG vaccinations
Long-term reduction in hyperglycemia in advanced type 1 diabetes: the value of induced aerobic glycolysis with BCG vaccinations Open
Mycobacterium are among the oldest co-evolutionary partners of humans. The attenuated Mycobacterium bovis Bacillus Calmette Guérin (BCG) strain has been administered globally for 100 years as a vaccine against tuberculosis. BCG also shows …