Travis Eisemann
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View article: Tankyrase interacts with the allosteric site of glucokinase and inhibits its glucose-sensing function in the beta cell
Tankyrase interacts with the allosteric site of glucokinase and inhibits its glucose-sensing function in the beta cell Open
Insulin secretion in the pancreatic beta cell is rate-limited by glucokinase (GCK), the glucose sensor that catalyzes the first step of glucose metabolism. GCK consists of two lobes connected by a flexible hinge that allows the kinase to e…
View article: The Sec1/Munc18 protein Vps45 holds the Qa-SNARE Tlg2 in an open conformation
The Sec1/Munc18 protein Vps45 holds the Qa-SNARE Tlg2 in an open conformation Open
Fusion of intracellular trafficking vesicles is mediated by the assembly of SNARE proteins into membrane-bridging complexes. SNARE-mediated membrane fusion requires Sec1/Munc18-family (SM) proteins, SNARE chaperones that can function as te…
View article: The Sec1/Munc18 protein Vps45 holds the Qa-SNARE Tlg2 in an open conformation
The Sec1/Munc18 protein Vps45 holds the Qa-SNARE Tlg2 in an open conformation Open
Fusion of intracellular trafficking vesicles is mediated by the assembly of soluble N -ethylmaleimide-sensitive fusion protein receptors (SNAREs) to form membrane-bridging complexes. Also required for SNARE-mediated membrane fusion are Sec…
View article: Tissue-Specific Regulation of the Wnt/β-Catenin Pathway by PAGE4 Inhibition of Tankyrase
Tissue-Specific Regulation of the Wnt/β-Catenin Pathway by PAGE4 Inhibition of Tankyrase Open
Spatiotemporal control of Wnt/β-catenin signaling is critical for organism development and homeostasis. The poly-(ADP)-ribose polymerase Tankyrase (TNKS1) promotes Wnt/β-catenin signaling through PARylation-mediated degradation of AXIN1, a…
View article: Munc18-1 catalyzes neuronal SNARE assembly by templating SNARE association
Munc18-1 catalyzes neuronal SNARE assembly by templating SNARE association Open
Sec1/Munc18-family (SM) proteins are required for SNARE-mediated membrane fusion, but their mechanism(s) of action remain controversial. Using single-molecule force spectroscopy, we found that the SM protein Munc18-1 catalyzes step-wise zi…
View article: Munc18-1 catalyzes neuronal SNARE assembly by templating SNARE association
Munc18-1 catalyzes neuronal SNARE assembly by templating SNARE association Open
Sec1/Munc18-family (SM) proteins are required for SNARE-mediated membrane fusion, but their mechanism(s) of action remain controversial. Using single-molecule force spectroscopy, we found that the SM protein Munc18-1 catalyzes step-wise zi…