Travis Larsh
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View article: Divergent aperiodic slope and alpha dynamics expose cortical excitability gradients in fragile X syndrome
Divergent aperiodic slope and alpha dynamics expose cortical excitability gradients in fragile X syndrome Open
Compared to traditional band-limited power measures, aperiodic slope provides a more direct and validated index of excitation-inhibition balance. Our findings of reduced aperiodic slope in male subjects with FXS align with preclinical circ…
View article: Stimulation-related increases in power spectral density covary with clinical evidence of overstimulation during deep brain stimulation for pediatric dystonia
Stimulation-related increases in power spectral density covary with clinical evidence of overstimulation during deep brain stimulation for pediatric dystonia Open
BACKGROUND Dystonia patients undergoing deep brain stimulation (DBS) often require individualized stimulation settings. While effective settings reduce dystonia, excessive stimulation can worsen symptoms. Assessing DBS effects during offic…
View article: Accelerated Theta Burst Transcranial Magnetic Stimulation for Refractory Depression in Autism Spectrum Disorder
Accelerated Theta Burst Transcranial Magnetic Stimulation for Refractory Depression in Autism Spectrum Disorder Open
Purpose Major depressive disorder (MDD) disproportionately affects those living with autism spectrum disorder (ASD) and is associated with significant impairment and treatment recidivism. Methods We studied the use of accelerated theta bur…
View article: Spectrum of Pediatric to Early Adulthood <scp><i>POLR3A</i>‐Associated</scp> Movement Disorders
Spectrum of Pediatric to Early Adulthood <span><i>POLR3A</i>‐Associated</span> Movement Disorders Open
Background POLR3A pathogenic variants are associated with hypomyelination, hypodontia, hypogonadism, and movement disorders. Cases We describe the range of movement disorders seen in six patients (four female, two male) with POLR3A variant…
View article: Deep Brain Stimulation for Pediatric Dystonia: A Review of the Literature and Suggested Programming Algorithm
Deep Brain Stimulation for Pediatric Dystonia: A Review of the Literature and Suggested Programming Algorithm Open
Deep brain stimulation (DBS) is an established intervention for use in pediatric movement disorders, especially dystonia. Although multiple publications have provided guidelines for deep brain stimulation patient selection and programming …
View article: From urges to tics in children with Tourette syndrome: associations with supplementary motor area GABA and right motor cortex physiology
From urges to tics in children with Tourette syndrome: associations with supplementary motor area GABA and right motor cortex physiology Open
Tourette syndrome (TS) is a childhood-onset disorder in which tics are often preceded by premonitory sensory urges. More severe urges correlate with worse tics and can render behavioral therapies less effective. The supplementary motor are…
View article: EEG Correlates of Active Stopping and Preparation for Stopping in Chronic Tic Disorder
EEG Correlates of Active Stopping and Preparation for Stopping in Chronic Tic Disorder Open
Motor inhibition is an important cognitive process involved in tic suppression. As the right frontal lobe contains important inhibitory network nodes, we characterized right superior, middle, and inferior frontal gyral (RSFG, RMFG, RIFG) e…
View article: Characteristic neuroimaging findings in β-propeller protein-associated neurodegeneration
Characteristic neuroimaging findings in β-propeller protein-associated neurodegeneration Open
β-propeller protein-associated neurodegeneration (BPAN) is a subtype of neurodegeneration with brain iron accumulation. Characteristic neuroimaging features can help distinguish BPAN from other disorders and prompt confirmatory genetic tes…
View article: Child Neurology: Genetically determined dystonias with childhood onset
Child Neurology: Genetically determined dystonias with childhood onset Open
A previously healthy 10-year-old girl of Croatian descent presented to the pediatric neurology clinic with an abnormal gait. She first noted symptoms 1.5 years prior to presentation, which included flexion–inversion posturing of her left f…