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View article: PSV-4 Clodronate re-release in response to controlled exercise and bone stressors in juvenile horses
PSV-4 Clodronate re-release in response to controlled exercise and bone stressors in juvenile horses Open
Concerns over the extra-label use of bisphosphonates in skeletally immature horses has extended to include its likely re-release from bone into circulation in response to stressors. Therefore, the objective of this study was to be first to…
View article: PSVI-8 Bisphosphonate Pharmacokinetics in Juvenile Horses
PSVI-8 Bisphosphonate Pharmacokinetics in Juvenile Horses Open
Bisphosphonates alter bone metabolism via inhibition of osteoclastic bone resorption. Although bisphosphonates are beneficial to treat bone disease, extra-label use in healthy juvenile horses may interfere with normal bone metabolism. The …
View article: Evaluation of an Oral Supplemental Cannabidiol Product for Acceptability and Performance in Mature Horses
Evaluation of an Oral Supplemental Cannabidiol Product for Acceptability and Performance in Mature Horses Open
Thirty stock type geldings (15 ± 3 years; 556 ± 63 kg BW) were used in a randomized complete design over 28 days to determine the influence of cannabidiol (CBD) oil supplementation levels on body weight, body condition, and blood chemistry…
View article: Peer Review #1 of "Effects of delivery via pressure-adjustable pneumatic gas-powered dart gun of three antimicrobial drugs (ceftiofur crystalline free acid, tildopirosin, and tulathromycin) on drug disposition and meat quality in cattle (v0.2)"
Peer Review #1 of "Effects of delivery via pressure-adjustable pneumatic gas-powered dart gun of three antimicrobial drugs (ceftiofur crystalline free acid, tildopirosin, and tulathromycin) on drug disposition and meat quality in cattle (v0.2)" Open
Background.Although Beef Quality Assurance guidelines do not recommend use of darting methods to deliver drugs, cattle in the US may be raised on farms and ranches without restraint facilities, and reports from the field suggest that dart …
View article: Effects of delivery <i>via</i> pressure-adjustable pneumatic gas-powered dart gun of three antimicrobial drugs (ceftiofur crystalline free acid, tildopirosin, and tulathromycin) on drug disposition and meat quality in cattle
Effects of delivery <i>via</i> pressure-adjustable pneumatic gas-powered dart gun of three antimicrobial drugs (ceftiofur crystalline free acid, tildopirosin, and tulathromycin) on drug disposition and meat quality in cattle Open
Background Although Beef Quality Assurance guidelines do not recommend use of darting methods to deliver drugs, cattle in the US may be raised on farms and ranches without restraint facilities, and reports from the field suggest that dart …
View article: Plasma, Urine and Tissue Concentrations of Flunixin and Meloxicam in Pigs
Plasma, Urine and Tissue Concentrations of Flunixin and Meloxicam in Pigs Open
Background : The objective of this study was to determine the renal clearance of flunixin and meloxicam in pigs and compare plasma and urine concentrations and tissue residues of these drugs. Urine clearance is important for livestock show…
View article: Tissue Residue Levels of the Tranquilizer Combination of Butorphanol, Azaperone, and Medetomidine, and the Antagonists, Naltrexone, Atipamezole, and Tolazoline, in Black Bears (Ursus americanus) Postimmobilization
Tissue Residue Levels of the Tranquilizer Combination of Butorphanol, Azaperone, and Medetomidine, and the Antagonists, Naltrexone, Atipamezole, and Tolazoline, in Black Bears (Ursus americanus) Postimmobilization Open
The tranquilizer combination of butorphanol, azaperone, and medetomidine (BAM) has shown good efficacy for immobilization of wildlife, including black bears (Ursus americanus). BAM is antagonized with a combination of naltrexone and atipam…
View article: Plasma, Urine and Tissue Concentrations of Flunixin and Meloxicam in Pigs
Plasma, Urine and Tissue Concentrations of Flunixin and Meloxicam in Pigs Open
Background: The objective of this study was to compare plasma and urine concentrations of flunixin and meloxicam in pigs, in order to determine urine withdrawal intervals for animals at livestock shows where urine is routinely tested for t…
View article: Detection of flunixin in the urine of untreated pigs housed with pigs treated with flunixin meglumine at labeled doses1
Detection of flunixin in the urine of untreated pigs housed with pigs treated with flunixin meglumine at labeled doses1 Open
The objective of this study was to determine the likelihood that swine treated with flunixin meglumine could contaminate their environment, which could cause untreated swine housed in the same pen to ingest or absorb enough drug to be dete…
View article: Establishing Decision Limits for Therapeutic Drugs Detected in Animals Exhibited at Livestock Shows
Establishing Decision Limits for Therapeutic Drugs Detected in Animals Exhibited at Livestock Shows Open
Food animal species, such as cattle, sheep, goats, and pigs, are widely exhibited at stock shows and fairs across the United States. Animals are judged on phenotypical traits such as muscling, structural correctness, and frame-size. The le…
View article: Comparative plasma and urine concentrations of flunixin and meloxicam in show goats
Comparative plasma and urine concentrations of flunixin and meloxicam in show goats Open
The allowable tolerance for a drug is based on edible tissue, yet a majority of livestock shows use urine samples to test for the presence of performance enhancing drugs. Currently, there is limited data on the relationship between urine a…
View article: Pharmacokinetics and safety of oral glyburide in dogs with acute spinal cord injury
Pharmacokinetics and safety of oral glyburide in dogs with acute spinal cord injury Open
Background Glyburide (also known as glibenclamide) is effective in reducing the severity of tissue destruction and improving functional outcome after experimental spinal cord injury in rodents and so has promise as a therapy in humans. The…
View article: Tissue Residue Levels after Immobilization of Rocky Mountain Elk (<i>Cervus elaphus nelsoni</i>) using a Combination of Nalbuphine, Medetomidine, and Azaperone Antagonized with Naltrexone, Atipamezole, and Tolazoline
Tissue Residue Levels after Immobilization of Rocky Mountain Elk (<i>Cervus elaphus nelsoni</i>) using a Combination of Nalbuphine, Medetomidine, and Azaperone Antagonized with Naltrexone, Atipamezole, and Tolazoline Open
Previous studies demonstrated that nalbuphine, medetomidine, and azaperone (NalMed-A) can effectively immobilize adult elk ( Cervus elaphus nelsoni), and be antagonized using naltrexone and atipamezole, with or without tolazoline. To asses…
View article: Elevated storage temperatures and concentration of large animal pharmaceuticals
Elevated storage temperatures and concentration of large animal pharmaceuticals Open
Most veterinary pharmaceuticals are labelled to be stored at or below 77°F or 86°F. Previous work showed that temperatures in ambulatory veterinary practice vehicles exceeded those temperatures for 67-100% of days in the summer of 2013. Th…
View article: Does dart gun delivery of antibiotics cause changes in drug disposition or meat quality?
Does dart gun delivery of antibiotics cause changes in drug disposition or meat quality? Open
Use of remote delivery devices in non-restrained cattle has increased in the last few years, and it is unknown whether this route will result in subcutaneous delivery, appropriate drug levels, or tissue damage. The objectives were to asses…