Travis McMurphy
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View article: AAV-mediated co-expression of an immunogenic transgene plus PD-L1 enables sustained expression through immunological evasion
AAV-mediated co-expression of an immunogenic transgene plus PD-L1 enables sustained expression through immunological evasion Open
Adeno-associated virus (AAV) vectors can mediate long-term expression of immunogenic transgenes in vivo through transduction of tolerogenic cells in the liver. Tissue-targeted AAV vectors allow transduction of non-hepatic cells, but this n…
View article: A Novel Role for the Adenovirus L4 Region 22K and 33K Proteins in Adeno-Associated Virus Production
A Novel Role for the Adenovirus L4 Region 22K and 33K Proteins in Adeno-Associated Virus Production Open
Despite decades of research in adeno-associated virus (AAV) and the role of adenovirus in production, the interplay of AAV and adenovirus is not fully understood. Specific regions of the adenoviral genome containing E1, E2a, E4 open readin…
View article: Adipose PTEN acts as a downstream mediator of a brain-fat axis in environmental enrichment
Adipose PTEN acts as a downstream mediator of a brain-fat axis in environmental enrichment Open
View article: Adipose PTEN regulates adult adipose tissue homeostasis and redistribution via a PTEN-leptin-sympathetic loop
Adipose PTEN regulates adult adipose tissue homeostasis and redistribution via a PTEN-leptin-sympathetic loop Open
View article: Hypothalamic gene transfer of BDNF promotes healthy aging in mice
Hypothalamic gene transfer of BDNF promotes healthy aging in mice Open
The aging process and age‐related diseases all involve perturbed energy adaption and impaired ability to cope with adversity. Brain‐derived neurotrophic factor (BDNF) in the hypothalamus plays important role in regulation of energy balance…
View article: Implementation of environmental enrichment after middle age promotes healthy aging
Implementation of environmental enrichment after middle age promotes healthy aging Open
With increases in life expectancy, it is vital to understand the dynamics of aging, their interaction with lifestyle factors, and the connections to age-related disease processes. Our work on environmental enrichment (EE), a housing enviro…
View article: Environmental and gene therapy approaches to improve glycemic control and promote healthy aging
Environmental and gene therapy approaches to improve glycemic control and promote healthy aging Open
View article: Molecular Therapy of Melanocortin-4-Receptor Obesity by an Autoregulatory BDNF Vector
Molecular Therapy of Melanocortin-4-Receptor Obesity by an Autoregulatory BDNF Vector Open
View article: Hepatic Expression of Adenovirus 36 E4ORF1 Improves Glycemic Control and Promotes Glucose Metabolism Through AKT Activation
Hepatic Expression of Adenovirus 36 E4ORF1 Improves Glycemic Control and Promotes Glucose Metabolism Through AKT Activation Open
Considering that impaired proximal insulin signaling is linked with diabetes, approaches that enhance glucose disposal independent of insulin signaling are attractive. In vitro data indicate that the E4ORF1 peptide derived from human adeno…
View article: Genetic Manipulation of Brown Fat Via Oral Administration of an Engineered Recombinant Adeno-associated Viral Serotype Vector
Genetic Manipulation of Brown Fat Via Oral Administration of an Engineered Recombinant Adeno-associated Viral Serotype Vector Open