Tobias Bopp
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Single‐Cell Hyperthermia: Diamond Quantum Thermometry Reveals Thermal Control of Macrophage Polarization Open
Fever elevates body temperature to enhance immune response; however, intracellular temperature can fluctuate by up to 15 °C, suggesting a previously unrecognized layer of thermal regulation. While hyperthermia has long been exploited in me…
Role of CD5 signalling for pro-inflammatory Th17 response in multiple sclerosis Open
Pro-inflammatory T-helper 17 (Th17) cells are of vital importance in human autoimmune diseases such as multiple sclerosis (MS). Due to differentiation and functional plasticity, Th17 cells are able to produce a variety of pro-inflammatory …
Polyamines regulate adaptive antitumor immunity by functional specialization of regulatory T cells Open
In cancer, metabolic changes and uncontrolled tumor growth alter nutrient availability, impacting antitumor immune responses. Regulatory T (Treg) cells are a subset of T cells with immunosuppressive properties that can also influence tissu…
View article: CREB regulates Foxp3+ST-2+ TREGS with enhanced IL-10 production
CREB regulates Foxp3+ST-2+ TREGS with enhanced IL-10 production Open
Introduction Regulatory T-cells (T regs ) are characterized by the expression of Foxp3, a master regulator involved in the development and function of T regs . Foxp3 expression is dependent on activity of the Treg specific demethylated sit…
Autonomous Activation of a Gated Chemiluminescent Photosensitizer Enables Targeted Photodynamic Therapy in Tumor Cells Open
Chemiluminescence-based photodynamic therapy (CLPDT) offers a promising solution to the light penetration limits of traditional PDT. However, it lacks spatiotemporal control. Intracellularly activated, self-luminescent PDT agents via a mol…
View article: Supplementary Data from IL18 Receptor Signaling Regulates Tumor-Reactive CD8<sup>+</sup> T-cell Exhaustion via Activation of the IL2/STAT5/mTOR Pathway in a Pancreatic Cancer Model
Supplementary Data from IL18 Receptor Signaling Regulates Tumor-Reactive CD8<sup>+</sup> T-cell Exhaustion via Activation of the IL2/STAT5/mTOR Pathway in a Pancreatic Cancer Model Open
Supplementary Table S1-3 and Figures S1-6
View article: Single-cell chromatin landscape and DNA methylation patterns reveal shared molecular programs in human tumor and non-tumor tissue CCR8 <sup>+</sup> Treg cells
Single-cell chromatin landscape and DNA methylation patterns reveal shared molecular programs in human tumor and non-tumor tissue CCR8 <sup>+</sup> Treg cells Open
Regulatory T (Treg) cells, a subset of CD4 + T cells, play a crucial role in immunoregulation. Notably, CCR8-expressing Treg cells in tissues also contribute to organ homeostasis and repair. To determine whether these tissue-regenerative p…
Innate Lymphoid Cell 1– and NK Cell–Derived, Early IFNg Release Depends on ICER and Promotes Protection against Leishmania major Infection Open
Innate lymphoid cells (ILCs) participate in different skin diseases. Cutaneous leishmaniasis evokes T helper 1/cytotoxic T cell 1-dominated immunity, whereas in immune-compromised individuals, a T helper 2/regulatory T cell/T helper 17 imm…
View article: B cells maintain the homeostasis of splenic marginal zone antigen-presenting cells to promote the anti-viral CD8 <sup>+</sup> T cell response
B cells maintain the homeostasis of splenic marginal zone antigen-presenting cells to promote the anti-viral CD8 <sup>+</sup> T cell response Open
Natural killer and CD8 + T cells are critical in the elimination of blood-borne viruses such as cytomegalovirus (CMV); however, the role of B cells in this process is less clear. Here, using the murine CMV (MCMV) infection model, we demons…
View article: Proteomic Atlas of Post-COVID Sequelae
Proteomic Atlas of Post-COVID Sequelae Open
The emergence of post-COVID sequelae (PCS) represents a global challenge. However, understanding of biological mechanisms and the definition of quantifiable risk factors remains limited. This study harnessed the power of predictive machine…
View article: Unveiling IRF4-steered regulation of context-dependent effector programs in CD4+ T cells under Th17- and Treg-skewing conditions
Unveiling IRF4-steered regulation of context-dependent effector programs in CD4+ T cells under Th17- and Treg-skewing conditions Open
The transcription factor interferon regulatory factor 4 (IRF4) is crucial for the fate determination of pro-inflammatory T helper (Th) 17 and the functionally opposing group of immunomodulatory regulatory T (Treg) cells. However, the molec…
Cortical Single-Cell Primers of Abnormal Brain Activity in Parkinson’s Disease Open
Abnormal brain oscillatory activity is a well-established hallmark of bradykinesia and motor impairment in Parkinson’s disease (PD), yet its molecular underpinnings remain unclear. To address this gap, we analyzed over 100,000 single-cell …
Different Treatment Outcomes of Multiple Sclerosis Patients Receiving Ocrelizumab or Ofatumumab Open
Objective B‐cell–depletion via CD20 antibodies is a safe and effective treatment for active relapsing multiple sclerosis (RMS). Both ocrelizumab (OCR) and ofatumumab (OFA) have demonstrated efficacy in randomized controlled trials and are …
View article: Non-invasive visualization of pH changes within the tumor-micro-environment by positron emission tomography
Non-invasive visualization of pH changes within the tumor-micro-environment by positron emission tomography Open
Slight changes in the pH value of the tumor microenvironment (TME) have crucial effects on host defense, metastatic behavior, immune regulation and cellular metabolism. Due to the high metabolic activity and insufficient perfusion of tumor…
Correction: Ziemssen et al. Immune Response to Initial and Booster SARS-CoV-2 mRNA Vaccination in Patients Treated with Siponimod—Final Analysis of a Nonrandomized Controlled Clinical Trial (AMA-VACC). Vaccines 2023, 11, 1374 Open
The authors would like to make the following corrections to this published paper [...]
The MYB-related transcription factor MYPOP acts as a selective regulator of cancer cell growth Open
The MYB-related transcription factor and partner of profilin (MYPOP or p42POP) is a ubiquitously expressed and understudied protein, recently discovered in restricting oncogenic human papillomaviruses (HPV) and suggested as a tumor suppres…
Neutralizing antibody titers over 12 months after SARS-CoV-2 mRNA vaccine booster in patients with relapsing multiple sclerosis continuously treated with ofatumumab Open
Booster vaccinations against SARS-CoV-2 are recommended 6-12 months after the last dose or infection in elderly and high-risk groups. The present analysis aims to evaluate whether an interval shorter than 12 months is required in multiple …
View article: 497 PTT-4256 is a first-in-class small molecule inhibitor of GPR65 that counteracts the low pH-dependent immunosuppressive effects on immune cells and displays pronounced anti-tumor activity in mice
497 PTT-4256 is a first-in-class small molecule inhibitor of GPR65 that counteracts the low pH-dependent immunosuppressive effects on immune cells and displays pronounced anti-tumor activity in mice Open
Background An important facet of the hostile tumor microenvironment (TME) and a recognized driver of cancer immunosuppression is extracellular acidification which results from the glycolytic nature of rapidly proliferating cancer cells. Pa…
A20 regulates lymphocyte adhesion in murine neuroinflammation by restricting endothelial ICOSL expression in the CNS Open
A20 is a ubiquitin-modifying protein that negatively regulates NF-κB signaling. Mutations in A20/TNFAIP3 are associated with a variety of autoimmune diseases, including multiple sclerosis (MS). We found that deletion of A20 in central nerv…
View article: Externalized histones fuel pulmonary fibrosis via a platelet-macrophage circuit of TGFβ1 and IL-27
Externalized histones fuel pulmonary fibrosis via a platelet-macrophage circuit of TGFβ1 and IL-27 Open
Externalized histones erupt from the nucleus as extracellular traps, are associated with several acute and chronic lung disorders, but their implications in the molecular pathogenesis of interstitial lung disease are incompletely defined. …
Unveiling IRF4-steered regulation of context-dependent effector programs in Th17 and Treg cells Open
The transcription factor interferon regulatory factor 4 (IRF4) is crucial for the differentiation and fate determination of pro-inflammatory T helper (Th)17 and the functionally opposing group of immunomodulatory regulatory T (Treg) cells.…
Immune Response to Initial and Booster SARS-CoV-2 mRNA Vaccination in Patients Treated with Siponimod—Final Analysis of a Nonrandomized Controlled Clinical Trial (AMA-VACC) Open
Background: Evidence on SARS-CoV-2 mRNA vaccination under siponimod treatment is rare. Methods: AMA-VACC is a prospective, open-label clinical study on SARS-CoV-2 mRNA vaccination during ongoing siponimod treatment (cohort 1), during sipon…
View article: Solid tumors exploit proton-sensing GPR65 for orchestration of an immunosuppressive tumor microenvironment
Solid tumors exploit proton-sensing GPR65 for orchestration of an immunosuppressive tumor microenvironment Open
Extracellular acidification profoundly influences anti-tumor immunity but the molecular details of this immune evasion mechanism are not well understood. Here we demonstrate that tumor-associated macrophages (TAM) are capable of sensing H+…
Results on SARS-CoV-2 mRNA Vaccine Booster from an Open-Label Multicenter Study in Ofatumumab-Treated Participants with Relapsing Multiple Sclerosis Open
Background: Few data exist on how ofatumumab treatment impacts SARS-CoV-2 booster vaccination response. Methods: KYRIOS is an ongoing prospective open-label multicenter study on the response to initial and booster SARS-CoV-2 mRNA vaccinati…