Trevor Sharp
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View article: 5-Hydroxytryptamine receptors in GtoPdb v.2025.3
5-Hydroxytryptamine receptors in GtoPdb v.2025.3 Open
5-HT receptors (nomenclature as agreed by the NC-IUPHAR Subcommittee on 5-HT receptors [201] and subsequently revised [183]) are, with the exception of the ionotropic 5-HT3 class, GPCRs where the endogenous agonist is 5-hydroxytryptamine. …
View article: Evidence that 5‐HT<sub>2A</sub> receptor signalling efficacy and not biased agonism differentiates serotonergic psychedelic from non‐psychedelic drugs
Evidence that 5‐HT<sub>2A</sub> receptor signalling efficacy and not biased agonism differentiates serotonergic psychedelic from non‐psychedelic drugs Open
Background and Purpose Serotonergic psychedelic drugs are under investigation as therapies for various psychiatric disorders, including major depression. Although serotonergic psychedelic drugs are 5‐HT 2A receptor agonists, some such agon…
View article: Perinatal serotonin signalling dynamically influences the development of cortical GABAergic circuits with consequences for lifelong sensory encoding
Perinatal serotonin signalling dynamically influences the development of cortical GABAergic circuits with consequences for lifelong sensory encoding Open
View article: Increased c-Fos immunoreactivity in anxiety-related brain regions following paroxetine discontinuation
Increased c-Fos immunoreactivity in anxiety-related brain regions following paroxetine discontinuation Open
Selective serotonin reuptake inhibitor (SSRI) therapy cessation often induces a disabling discontinuation syndrome, including increased anxiety. We recently reported that SSRI discontinuation induced behavioural changes in mice, which we h…
View article: Neuropsychopharmacology of hallucinogenic and non‐hallucinogenic 5‐HT<sub>2A</sub> receptor agonists
Neuropsychopharmacology of hallucinogenic and non‐hallucinogenic 5‐HT<sub>2A</sub> receptor agonists Open
Psychedelic drugs such as LSD and psilocin were once relegated to the fringes of medical research because of their association with counterculture movements and a perceived concern about harm through recreational use, and their consequent …
View article: Vigilance state dissociation induced by 5-MeO DMT in mice
Vigilance state dissociation induced by 5-MeO DMT in mice Open
Psychedelics lead to profound changes in subjective experience and behaviour, which are typically conceptualised in psychological terms rather than corresponding to an altered brain state or a distinct state of arousal. Here, we performed …
View article: 5-Hydroxytryptamine receptors in GtoPdb v.2025.1
5-Hydroxytryptamine receptors in GtoPdb v.2025.1 Open
5-HT receptors (nomenclature as agreed by the NC-IUPHAR Subcommittee on 5-HT receptors [200] and subsequently revised [182]) are, with the exception of the ionotropic 5-HT3 class, GPCRs where the endogenous agonist is 5-hydroxytryptamine. …
View article: More and Less Fear in Serotonin Transporter Knockout Mice
More and Less Fear in Serotonin Transporter Knockout Mice Open
Recent theories suggest that reduced serotonin transporter (5‐HTT) function, which increases serotonin (5‐HT) levels at the synapse, enhances neural plasticity and affects sensitivity to environmental cues. This may promote learning about …
View article: Perinatal serotonin signalling dynamically influences the development of cortical GABAergic circuits with consequences for lifelong sensory encoding
Perinatal serotonin signalling dynamically influences the development of cortical GABAergic circuits with consequences for lifelong sensory encoding Open
Serotonin plays a prominent role in neurodevelopment, regulating processes from cell division to synaptic connectivity. Clinical studies suggest that alterations in serotonin signalling such as genetic polymorphisms or antidepressant expos…
View article: Increased 5-HT<sub>2A</sub>receptor signalling efficacy differentiates serotonergic psychedelics from non-psychedelics
Increased 5-HT<sub>2A</sub>receptor signalling efficacy differentiates serotonergic psychedelics from non-psychedelics Open
Background and Purpose Serotonergic psychedelic drugs are under renewed investigation for the potential treatment of several psychiatric disorders. While all serotonergic psychedelics have 5-HT 2A receptor activity, the explanation for why…
View article: International union of basic and clinical pharmacology. Cx. Classification of receptors for 5-hydroxytryptamine; pharmacology and function
International union of basic and clinical pharmacology. Cx. Classification of receptors for 5-hydroxytryptamine; pharmacology and function Open
5-HT receptors expressed throughout the human body are targets for established therapeutics and various drugs in development. Their diversity of structure and function reflects the important role 5-HT receptors play in physiologic and path…
View article: Rebound activation of 5-HT neurons following SSRI discontinuation
Rebound activation of 5-HT neurons following SSRI discontinuation Open
View article: Evidence for a Role of 5-HT-glutamate Co-releasing Neurons in Acute Stress Mechanisms
Evidence for a Role of 5-HT-glutamate Co-releasing Neurons in Acute Stress Mechanisms Open
A major subpopulation of midbrain 5-hydroxytryptamine (5-HT) neurons expresses the vesicular glutamate transporter 3 (VGLUT3) and co-releases 5-HT and glutamate, but the function of this co-release is unclear. Given the strong links betwee…
View article: <i>In Vivo</i> Two-Photon Microscopy Reveals Sensory-Evoked Serotonin (5-HT) Release in Adult Mammalian Neocortex
<i>In Vivo</i> Two-Photon Microscopy Reveals Sensory-Evoked Serotonin (5-HT) Release in Adult Mammalian Neocortex Open
The recent development of genetically encoded fluorescent neurotransmitter biosensors has opened the door to recording serotonin (5-hydroxytryptamine, 5-HT) signaling dynamics with high temporal and spatial resolution in vivo. While…
View article: Evidence for a role of 5-HT-glutamate co-releasing neurons in acute stress mechanisms
Evidence for a role of 5-HT-glutamate co-releasing neurons in acute stress mechanisms Open
The majority of midbrain 5-hydroxytryptamine (5-HT) neurons express the vesicular glutamate transporter 3 (VGLUT3) and co-release 5-HT and glutamate, but the function of this co-release is unclear. Given the strong links between 5-HT and u…
View article: Rebound activation of 5-HT neurons following SSRI discontinuation
Rebound activation of 5-HT neurons following SSRI discontinuation Open
Cessation of therapy with a selective serotonin (5-HT) reuptake inhibitor (SSRI) is often associated with an early onset, disabling discontinuation syndrome the mechanism of which is surprisingly little investigated. Here we determined the…
View article: Continuous home cage monitoring of activity and sleep in mice during repeated paroxetine treatment and discontinuation
Continuous home cage monitoring of activity and sleep in mice during repeated paroxetine treatment and discontinuation Open
View article: Prelimbic Cortical Stimulation Induces Antidepressant-like Responses through Dopaminergic-Dependent and -Independent Mechanisms
Prelimbic Cortical Stimulation Induces Antidepressant-like Responses through Dopaminergic-Dependent and -Independent Mechanisms Open
High-frequency stimulation (HFS) is a promising therapy for patients with depression. However, the mechanisms underlying the HFS-induced antidepressant-like effects on susceptibility and resilience to depressive-like behaviors remain obscu…
View article: 5-Hydroxytryptamine receptors in GtoPdb v.2023.1
5-Hydroxytryptamine receptors in GtoPdb v.2023.1 Open
5-HT receptors (nomenclature as agreed by the NC-IUPHAR Subcommittee on 5-HT receptors [198] and subsequently revised [180]) are, with the exception of the ionotropic 5-HT3 class, GPCRs where the endogenous agonist is 5-hydroxytryptamine. …
View article: Degeneracy and stability in neural circuits of dopamine and serotonin neuromodulators: A theoretical consideration
Degeneracy and stability in neural circuits of dopamine and serotonin neuromodulators: A theoretical consideration Open
Degenerate neural circuits perform the same function despite being structurally different. However, it is unclear whether neural circuits with interacting neuromodulator sources can themselves degenerate while maintaining the same neuromod…
View article: Mice with a genetic loss of vesicular glutamate transporter 3 targeted to 5-hydroxytryptamine neurons show impairments in reward-based learning
Mice with a genetic loss of vesicular glutamate transporter 3 targeted to 5-hydroxytryptamine neurons show impairments in reward-based learning Open
View article: Sleep-like state during wakefulness induced by psychedelic 5-MeO-DMT in mice
Sleep-like state during wakefulness induced by psychedelic 5-MeO-DMT in mice Open
Psychedelics lead to profound changes in subjective experience and behaviour, which are typically conceptualised in psychological terms rather than corresponding to an altered brain state or a distinct state of arousal. Here, we performed …
View article: Effect of selective serotonin reuptake inhibitor discontinuation on anxiety-like behaviours in mice
Effect of selective serotonin reuptake inhibitor discontinuation on anxiety-like behaviours in mice Open
Background: Abrupt cessation of therapy with a selective serotonin reuptake inhibitor (SSRI) is associated with a discontinuation syndrome, typified by numerous disabling symptoms, including anxiety. Surprisingly, little is known of the be…
View article: Psilocin acutely alters sleep-wake architecture and cortical brain activity in laboratory mice
Psilocin acutely alters sleep-wake architecture and cortical brain activity in laboratory mice Open
Serotonergic psychedelic drugs, such as psilocin (4-hydroxy-N,N-dimethyltryptamine), profoundly alter the quality of consciousness through mechanisms which are incompletely understood. Growing evidence suggests that a single psychedelic ex…
View article: <i>In vivo</i> electrophysiological study of the targeting of 5‐HT<sub>3</sub> receptor‐expressing cortical interneurons by the multimodal antidepressant, vortioxetine
<i>In vivo</i> electrophysiological study of the targeting of 5‐HT<sub>3</sub> receptor‐expressing cortical interneurons by the multimodal antidepressant, vortioxetine Open
The antidepressant vortioxetine has high affinity for the ionotropic 5‐HT 3 receptor (5‐HT 3 R) as well as other targets including the 5‐HT transporter. The procognitive effects of vortioxetine have been linked to altered excitatory:inhibi…
View article: Immunohistochemical evidence that paroxetine discontinuation in mice is associated with increased activation of 5-HT neurons
Immunohistochemical evidence that paroxetine discontinuation in mice is associated with increased activation of 5-HT neurons Open
View article: Effect of SSRI discontinuation on anxiety-like behaviours in mice
Effect of SSRI discontinuation on anxiety-like behaviours in mice Open
Background Abrupt cessation of therapy with a selective serotonin reuptake inhibitor (SSRI) is associated with a discontinuation syndrome, typified by numerous disabling symptoms including anxiety. Surprisingly little is known of the behav…
View article: Striatal Dopamine Transporter Function Is Facilitated by Converging Biology of α-Synuclein and Cholesterol
Striatal Dopamine Transporter Function Is Facilitated by Converging Biology of α-Synuclein and Cholesterol Open
Striatal dopamine transporters (DAT) powerfully regulate dopamine signaling, and can contribute risk to degeneration in Parkinson’s disease (PD). DATs can interact with the neuronal protein α-synuclein, which is associated with the etiolog…
View article: Psilocin acutely disrupts sleep and affects local but not global sleep homeostasis in laboratory mice
Psilocin acutely disrupts sleep and affects local but not global sleep homeostasis in laboratory mice Open
Serotonergic psychedelic drugs, such as psilocin (4-hydroxy-N,N-dimethyltryptamine), profoundly alter the quality of consciousness through mechanisms which are incompletely understood. Growing evidence suggests that a single psychedelic ex…
View article: An Early Stage Researcher's Primer on Systems Medicine Terminology
An Early Stage Researcher's Primer on Systems Medicine Terminology Open
Background: Systems Medicine is a novel approach to medicine, that is, an interdisciplinary field that considers the human body as a system, composed of multiple parts and of complex relationships at multiple levels, and further int…