Trina Ekawati Tallei
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View article: SH003 as a Redox-Immune Modulating Phytomedicine: A Ferroptosis Induction, Exosomal Crosstalk, and Translational Oncology Perspective
SH003 as a Redox-Immune Modulating Phytomedicine: A Ferroptosis Induction, Exosomal Crosstalk, and Translational Oncology Perspective Open
Redox dysregulation, ferroptosis evasion, and immune suppression are major barriers in cancer therapy. SH003, a multi-herbal formulation standardized under GMP conditions and evaluated in early-phase clinical studies (NCT03081819; KCT00047…
View article: Network Pharmacology Identifies AKT1, SRC, and STAT3 as Therapeutic Targets of Tempeh-Derived Peptides in Breast Cancer
Network Pharmacology Identifies AKT1, SRC, and STAT3 as Therapeutic Targets of Tempeh-Derived Peptides in Breast Cancer Open
Breast cancer remains a major cause of mortality among women, particularly the aggressive subtypes HER2-positive and triple-negative breast cancer (TNBC). Fermented foods such as tempeh contain bioactive peptides with potential therapeutic…
View article: Employing multi-omics, pharmacoinformatics, and in vitro approaches to discover functional biomolecules in oyster mushroom flour
Employing multi-omics, pharmacoinformatics, and in vitro approaches to discover functional biomolecules in oyster mushroom flour Open
Oyster mushroom ( Pleurotus ostreatus ) is recognized as a functional food due to its bioactive compounds content which have therapeutic potential, particularly in metabolic disorder management. This study aims to explore the bioactive pro…
View article: Comparative Study of DNA Barcoding and Mini-Barcoding based on COI Gene for Species Identification and Phylogeny of Formicidae Family (Insecta: Hymenoptera)
Comparative Study of DNA Barcoding and Mini-Barcoding based on COI Gene for Species Identification and Phylogeny of Formicidae Family (Insecta: Hymenoptera) Open
DNA barcoding and mini-barcoding are widely used to study insect biodiversity, including ants (Hymenoptera: Formicidae). This study evaluated the effectiveness of both approaches for species identification and phylogenetic inference in ant…
View article: In Silico Analysis of the Antigastritis Activity of Gedi (Abelmoschus manihot) Flower Flavonoids on H2 Receptor
In Silico Analysis of the Antigastritis Activity of Gedi (Abelmoschus manihot) Flower Flavonoids on H2 Receptor Open
Gastritis remains a highly prevalent health concern in Indonesia, underscoring a continuous demand for innovative therapeutic interventions. The flower of Abelmoschus manihot, commonly known as Gedi, has garnered interest for its potential…
View article: Investigation on low-performance tuned-regressor of inhibitory concentration targeting the SARS-CoV-2 polyprotein 1ab
Investigation on low-performance tuned-regressor of inhibitory concentration targeting the SARS-CoV-2 polyprotein 1ab Open
Hyperparameter tuning is a key optimization strategy in machine learning (ML), often used with GridSearchCV to find optimal hyperparameter combinations. This study aimed to predict the half-maximal inhibitory concentration (IC50…
View article: Bibliometric Trend Analysis: Turner Syndrome in Childhood
Bibliometric Trend Analysis: Turner Syndrome in Childhood Open
Turner Syndrome is a genetic disorder in females caused by the partial or complete absence of one X chromosome, significantly impacting neuropsychological development during childhood. Using a bibliometric approach, this study aims to map …
View article: Fraction Understanding in Children: Bibliometric Analysis
Fraction Understanding in Children: Bibliometric Analysis Open
This study used a bibliometric analysis approach to investigate the literature on children’s development of fraction understanding. Fraction understanding is crucial in early mathematics education because it is the foundation for more adva…
View article: Metabolomic profiling and anti-inflammatory activity of Blumea balsamifera: Insights from in silico and in vitro studies
Metabolomic profiling and anti-inflammatory activity of Blumea balsamifera: Insights from in silico and in vitro studies Open
Blumea balsamifera is a medicinal plant with recognized anti-inflammatory properties. This study employed both LC-HRMS and GC-MS to comprehensively profile its ethanolic extract. Distinct analytical objectives were pursued: LC-HRMS was use…
View article: Integrated DNA Barcoding and Morphometric Characterization of Palm Weevils (Rhynchophorus spp.) in North Sulawesi
Integrated DNA Barcoding and Morphometric Characterization of Palm Weevils (Rhynchophorus spp.) in North Sulawesi Open
Palm weevils (Rhynchophorus spp.) are significant pests of sago palms worldwide. Yet, the taxonomy and evolutionary lineage of these species in North Sulawesi remain unclear, likely due to geographic isolation driving genetic variation and…
View article: Mechanistic insights into the anti-aging and anti-cancer potential of rosemary via P53, SRC, and AKT1 through a network pharmacology perspective
Mechanistic insights into the anti-aging and anti-cancer potential of rosemary via P53, SRC, and AKT1 through a network pharmacology perspective Open
This study investigates the anti-aging and anticancer properties of rosemary extract, focusing on its bioactive compounds and their interactions with key proteins through network pharmacology and molecular docking. Bioactive compounds were…
View article: Integrative in silico and in vivo Drosophila model studies reveal the anti-inflammatory, antioxidant, and anticancer properties of red radish microgreen extract
Integrative in silico and in vivo Drosophila model studies reveal the anti-inflammatory, antioxidant, and anticancer properties of red radish microgreen extract Open
View article: Network Pharmacology-Based Identification of Key Metabolites from Immunized Rhynchophorus Larvae as Therapeutic Agents Against Antibiotic-Resistant Neisseria gonorrhoea
Network Pharmacology-Based Identification of Key Metabolites from Immunized Rhynchophorus Larvae as Therapeutic Agents Against Antibiotic-Resistant Neisseria gonorrhoea Open
Background and Objective: Gonorrhoea, caused by Neisseria gonorrhoeae, continues to pose a major global health threat due to the rising incidence of antibiotic resistance. This study aimed to explore the potential of metaboli…
View article: The gut-skin axis in psoriasis: Evidence-based insights from a meta-analysis on probiotics-synbiotics-mediated microbiota interventions
The gut-skin axis in psoriasis: Evidence-based insights from a meta-analysis on probiotics-synbiotics-mediated microbiota interventions Open
View article: Mapping Cognitive Impairment in Adolescents a Bibliometric Exploration of Trends and Insights
Mapping Cognitive Impairment in Adolescents a Bibliometric Exploration of Trends and Insights Open
This study explores cognitive impairment in adolescents through a bibliometric analysis, aiming to identify trends, influential researchers, and key concepts in the field. Adolescence is a critical developmental stage where cognitive abili…
View article: Probiotic Lactobacillus sp. as a strategy for modulation of non-comorbid obesity: A systematic meta-analysis and GRADE assessment of randomized controlled trials
Probiotic Lactobacillus sp. as a strategy for modulation of non-comorbid obesity: A systematic meta-analysis and GRADE assessment of randomized controlled trials Open
Given the high prevalence of obesity worldwide, effective therapeutic strategies are crucial to prevent and manage obesity-related health conditions. Existing studies indicate that Lactobacillus sp. showed beneficial effects on body weight…
View article: Targeting Redox Signaling Through Exosomal MicroRNA: Insights into Tumor Microenvironment and Precision Oncology
Targeting Redox Signaling Through Exosomal MicroRNA: Insights into Tumor Microenvironment and Precision Oncology Open
Reactive oxygen species (ROS) play a dual role in cancer progression, acting as both signaling molecules and drivers of oxidative damage. Emerging evidence highlights the intricate interplay between ROS, microRNAs (miRNAs), and exosomes wi…
View article: Delites™ supplementation prevents metabolic syndrome onset and modulates gut microbiome in male Sprague Dawley rats fed on cholesterol- and fat-enriched diet: a randomized preclinical trial study
Delites™ supplementation prevents metabolic syndrome onset and modulates gut microbiome in male Sprague Dawley rats fed on cholesterol- and fat-enriched diet: a randomized preclinical trial study Open
Background Metabolic syndrome (MetS) is a global health concern, characterized by a combination of dyslipidemia, insulin resistance, obesity, and hypertension, significantly increasing the risk of type 2 diabetes mellitus (T2DM) and cardio…
View article: Dual anti-inflammatory and antimicrobial effects of stingless bee propolis on second-degree burns
Dual anti-inflammatory and antimicrobial effects of stingless bee propolis on second-degree burns Open
Propolis, a natural resinous product from stingless bees, is widely recognized for its anti-inflammatory and antimicrobial properties. However, its combined effects in addressing both inflammation and infection in second-degree burns have …
View article: Mechanistic insights into the anticancer, anti-inflammatory, and antioxidant effects of yellowfin tuna collagen peptides using network pharmacology.
Mechanistic insights into the anticancer, anti-inflammatory, and antioxidant effects of yellowfin tuna collagen peptides using network pharmacology. Open
Marine-derived collagen peptides have been acknowledged for their therapeutic potential, especially in cancer therapy and inflammation management. The aim of this study was to investigate the molecular mechanisms that contribute to the ant…
View article: Cytotoxicity assessment of medicinal plants from three geothermal areas using the brine shrimp lethality assay
Cytotoxicity assessment of medicinal plants from three geothermal areas using the brine shrimp lethality assay Open
The exploration of natural products for therapeutic applications is a critical area of research, particularly in regions with unique environmental conditions, such as geothermal areas. The cytotoxicity profile of 15 medicinal plants collec…
View article: Phytochemical analysis and antioxidant activity of two Phyllanthaceae family plants from Ie-Brôuk geothermal area
Phytochemical analysis and antioxidant activity of two Phyllanthaceae family plants from Ie-Brôuk geothermal area Open
The Phyllanthaceae family encompasses a diverse range of flowering plants with significant ecological and cultural relevance. In the geothermal area of Ie-Brôuk in Aceh Province, Indonesia, two species from this family, Baccaurea pyriformi…
View article: Comparative study of drying techniques on the anti-inflammatory content of bitter leaf simplicia (Vernonia amygdalina Del.)
Comparative study of drying techniques on the anti-inflammatory content of bitter leaf simplicia (Vernonia amygdalina Del.) Open
Bitter leaf (Vernonia amygdalina Del.) hold significant potential for development in the pharmaceutical industry due to its high content of bioactive compounds, particularly flavonoids, which serve as a source of anti-inflammatory agents. …
View article: In Silico Study of Quercetin and Its Derivatives as Potential Antituberculosis
In Silico Study of Quercetin and Its Derivatives as Potential Antituberculosis Open
Tuberculosis (TB) remains the second leading cause of death in the world, with the resistance of Mycobacterium tuberculosis to first-line drugs, such as isoniazid (INH), contributing to the emergence of multi-drug resistant TB (MDR-TB). Th…
View article: In Silico Study Of Natural Bioactive Compounds As Potential Anti-Mpox Through Molecular Docking On D13 Protein
In Silico Study Of Natural Bioactive Compounds As Potential Anti-Mpox Through Molecular Docking On D13 Protein Open
Mpox is a zoonotic disease caused by Monkeypox virus (MPXV), with a surge in cases posing a major challenge due to the unavailability of specific antivirals. Indonesia's biodiversity offers great opportunities for the exploration of bioact…
View article: Targeting Prostate Cancer with Rambutan Peel-Derived Compounds via Network Pharmacology
Targeting Prostate Cancer with Rambutan Peel-Derived Compounds via Network Pharmacology Open
Prostate cancer is a prevalent malignancy in men, originating in the prostate gland and often driven by genetic alterations and hormonal dysregulation. Rambutan (Nephelium lappaceum L.) peel, a byproduct of fruit consumption, has demonstra…
View article: Prostate Cancer Vaccines: Progress, Challenges, and Future Directions
Prostate Cancer Vaccines: Progress, Challenges, and Future Directions Open
Prostate cancer remains a major contributor to cancer-related deaths in men, with its incidence rising significantly with age. Conventional treatment modalities, including surgery, radiation therapy, hormonal therapy, and chemotherapy, oft…
View article: Isolation and evaluation of the antimicrobial activity of endophytic fungi from Orthosiphon aristatus
Isolation and evaluation of the antimicrobial activity of endophytic fungi from Orthosiphon aristatus Open
Satriawan H, Zaimi NA, Eriadi A, Efdi M, Tallei TE, Andayani R, Handayani D. 2025. Isolation and evaluation of the antimicrobial activity of endophytic fungi from Orthosiphon aristatus. Biodiversitas 26: 963-970. Orthosiphon aristatus, kno…
View article: Algal peptides for future food: Key players and multifaceted agents in the fight against cardiometabolic syndrome
Algal peptides for future food: Key players and multifaceted agents in the fight against cardiometabolic syndrome Open
Cardiometabolic syndrome (CMS) is a cluster of metabolic disorders, including obesity, hypertension, oxidative stress, and atherosclerosis, that significantly increase the risk of cardiovascular diseases. Recent studies highlight the thera…
View article: Network Pharmacology Insights into Broccoli Microgreens for Prostate Cancer
Network Pharmacology Insights into Broccoli Microgreens for Prostate Cancer Open
Prostate cancer is a leading malignancy in men, ranking fourth globally and fifth in Indonesia (GLOBOCAN 2020). Conventional therapies, though available, are limited by high costs, side effects, and resistance, highlighting the need for ac…