Trinh Thi Bich Tram YOU? Author Swipe

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Pre-treatment untargeted cerebrospinal fluid metabolomic profiling in tuberculous meningitis uncovers pathways associated with mortality Open

Thanh Hoang Nhat Le, Kirsten C J van Abeelen, Edwin Ardiansyah, Julián Ávila-Pacheco, Sofiati Dian , et al. · 2025

National Institute of Health; Wellcome Trust, UK.

Single-cell profiling of blood and cerebrospinal fluid in tuberculous meningitis Open

Trinh Thi Bich Tram, Lucy C. Garner, L. Thai, Le Thanh Hoang Nhat, Do Dang Anh Thu , et al. · 2025

Tuberculous meningitis (TBM) is the most severe form of tuberculosis, with a fatality rate of 20-50% in treated individuals. Although corticosteroid therapy can increase survival in HIV-negative people with TBM, better antimicrobial and ho…

Trend of Representation of Women in Gastroenterology, Hepatology, and Endoscopy Conferences in Asia Open

Jalpa Devi, Tanyaporn Chantarojanasiri, Hang Viet Dao, Rashid N. Lui, Raja Affendi Raja Ali , et al. · 2025

Objectives Despite progress in promoting gender equality, gender bias remains a significant obstacle for women and hinders their academic advancement. We aim to survey and critically analyze women's representation in conferences and change…

Author response: Whole blood transcriptional profiles and the pathogenesis of tuberculous meningitis Open

Hoang Thanh Hai, Le Thanh Hoang Nhat, Trinh Thi Bich Tram, Do Dinh Vinh, Artika P. Nath , et al. · 2024

Author response: Whole blood transcriptional profiles and the pathogenesis of tuberculous meningitis Open

Hoang Thanh Hai, Le Thanh Hoang Nhat, Trinh Thi Bich Tram, Do Dinh Vinh, Artika P. Nath , et al. · 2024

Mortality and morbidity from tuberculous meningitis (TBM) are frequent and strongly associated with the inflammatory response to Mycobacterium tuberculosis infection. However, the mechanisms driving the associations are uncertain. We sough…

Reviewer #2 (Public Review): Whole blood transcriptional profiles and the pathogenesis of tuberculous meningitis Open

Hoang Thanh Hai, Le Thanh Hoang Nhat, Trinh Thi Bich Tram, Do Dinh Vinh, Artika P. Nath , et al. · 2024

Mortality and morbidity from tuberculous meningitis (TBM) are frequent and strongly associated with the inflammatory response to Mycobacterium tuberculosis infection. However, the mechanisms driving the associations are uncertain. We sough…

Whole blood transcriptional profiles and the pathogenesis of tuberculous meningitis Open

Hoang Thanh Hai, Le Thanh Hoang Nhat, Trinh Thi Bich Tram, Do Dinh Vinh, Artika P. Nath , et al. · 2024

Background Mortality and morbidity from tuberculous meningitis (TBM) are frequent and strongly associated with the inflammatory response to Mycobacterium tuberculosis infection. However, the mechanisms driving the associations are uncertai…

Reviewer #1 (Public Review): Whole blood transcriptional profiles and the pathogenesis of tuberculous meningitis Open

Hoang Thanh Hai, Le Thanh Hoang Nhat, Trinh Thi Bich Tram, Do Dinh Vinh, Artika P. Nath , et al. · 2024

Mortality and morbidity from tuberculous meningitis (TBM) are frequent and strongly associated with the inflammatory response to Mycobacterium tuberculosis infection. However, the mechanisms driving the associations are uncertain. We sough…

Whole blood transcriptional profiles and the pathogenesis of tuberculous meningitis Open

Hoang Thanh Hai, Le Thanh Hoang Nhat, Trinh Thi Bich Tram, Artika P. Nath, Joseph Donovan , et al. · 2024

Background Mortality and morbidity from tuberculous meningitis (TBM) are frequent and strongly associated with the inflammatory response to Mycobacterium tuberculosis infection. However, the mechanisms driving the associations are uncertai…

Author Response: Whole blood transcriptional profiles and the pathogenesis of tuberculous meningitis Open

Hoang Thanh Hai, Le Thanh Hoang Nhat, Trinh Thi Bich Tram, Artika P. Nath, Joseph Donovan , et al. · 2024

Mortality and morbidity from tuberculous meningitis (TBM) are frequent and strongly associated with the inflammatory response to Mycobacterium tuberculosis infection. However, the mechanisms driving the associations are uncertain. We sough…

Whole blood transcriptional profiles and the pathogenesis of tuberculous meningitis Open

Hoang Thanh Hai, Le Thanh Hoang Nhat, Trinh Thi Bich Tram, Do Dinh Vinh, Artika P. Nath , et al. · 2023

Background Mortality and morbidity from tuberculous meningitis (TBM) are frequent and strongly associated with the inflammatory response to Mycobacterium tuberculosis infection. However, the mechanisms driving the associations are uncertai…

Author response: Tryptophan metabolism determines outcome in tuberculous meningitis: a targeted metabolomic analysis Open

Edwin Ardiansyah, Julián Ávila-Pacheco, Le Thanh Hoang Nhat, Sofiati Dian, Dao Nguyen Vinh , et al. · 2023

Tryptophan metabolism determines outcome in tuberculous meningitis: a targeted metabolomic analysis Open

Edwin Ardiansyah, Julián Avila Pacheco, Le Thanh Hoang Nhat, Sofiati Dian, Dao Nguyen Vinh , et al. · 2023

Background Cellular metabolism is critical for the host immune function against pathogens, and metabolomic analysis may help understand the characteristic immunopathology of tuberculosis. We performed targeted metabolomic analyses in a lar…

<i>MUC5AC</i> genetic variation is associated with tuberculosis meningitis CSF cytokine responses and mortality Open

Michelle C. Sabo, Nguyễn Thụy Thương Thương, Xuling Chang, Edwin Ardiansyah, Trinh Thi Bich Tram , et al. · 2022

Rationale Lung mucins are an understudied component of the mucosal immune response and may influence tuberculosis pathogenesis and outcomes. Objectives To assess if variants in lung mucins MUC5B and MUC5AC are associated with Mycobacterium…

Variations in Antimicrobial Activities of Human Monocyte-Derived Macrophage and Their Associations With Tuberculosis Clinical Manifestations Open

Trinh Thi Bich Tram, Vu Thi Ngoc Ha, Do D. A. Thu, Tran D. Dinh, Hoang Ngoc Nhung , et al. · 2020

Macrophages play a significant role in preventing infection through antimicrobial activities, particularly acidification, and proteolysis. Mycobacterium tuberculosis (Mtb) infection can lead to diverse outcomes, from latent asymptom…

Variations in human monocyte-derived macrophage antimicrobial activities and their associations with tuberculosis clinical manifestations Open

Trinh Thi Bich Tram, Vu Thi Ngoc Ha, Do D. A. Thu, Tran D. Dinh, Hoang Ngoc Nhung , et al. · 2020

Macrophages play a significant role in preventing infection through antimicrobial activities, particularly acidification and proteolysis. Mycobacterium tuberculosis infection can lead to diverse outcomes, from latent asymptomatic infection…

Virulence of Mycobacterium tuberculosis Clinical Isolates Is Associated With Sputum Pre-treatment Bacterial Load, Lineage, Survival in Macrophages, and Cytokine Response Open

Trinh Thi Bich Tram, Hoang Ngoc Nhung, Srinivasan Vijay, Hoang Thanh Hai, Do D. A. Thu , et al. · 2018

It is uncertain whether differences in Mycobacterium tuberculosis (Mtb) virulence defined in vitro influence clinical tuberculosis pathogenesis, transmission, and mortality. We primarily used a macrophage lysis model t…

Leukotriene A4 Hydrolase Genotype and HIV Infection Influence Intracerebral Inflammation and Survival From Tuberculous Meningitis Open

Nguyễn Thụy Thương Thương, Dorothee Heemskerk, Trinh Thi Bich Tram, Lê Thị Phương Thảo, Lalita Ramakrishnan , et al. · 2017

BACKGROUND: Tuberculous meningitis (TBM) is the most devastating form of tuberculosis, yet very little is known about the pathophysiology. We hypothesized that the genotype of leukotriene A4 hydrolase (encoded by LTA4H), which determines i…

MARCO variants are associated with phagocytosis, pulmonary tuberculosis susceptibility and Beijing lineage Open

Nguyễn Thụy Thương Thương, Trinh Thi Bich Tram, Tran D. Dinh, Phan Vuong Khac Thai, Dorothee Heemskerk , et al. · 2016

LTA4H Genotype Is Associated with Susceptibility to Bacterial Meningitis but Is Not a Critical Determinant of Outcome Open

Sarah J. Dunstan, Trinh Thi Bich Tram, Guy Thwaites, Tran Thi Hong Chau, Nguyen Hoan Phu , et al. · 2015

Adjunctive dexamethasone saves lives in the treatment of tuberculous meningitis but this response is influenced by the patient's LTA4H genotype. Despite less certain benefit, adjunctive dexamethasone is also frequently used in the treatmen…

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