Vincent Quoc‐Huy Trinh
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View article: Mutant GNAS drives a pyloric metaplasia with tumor suppressive glycans in intraductal papillary mucinous neoplasia
Mutant GNAS drives a pyloric metaplasia with tumor suppressive glycans in intraductal papillary mucinous neoplasia Open
Intraductal papillary mucinous neoplasms (IPMNs) are cystic lesions and bona fide precursors of pancreatic ductal adenocarcinoma (PDAC), one of the deadliest solid tumors. Although ∼90% of IPMNs are detected before PDAC forms, markers dist…
View article: Nanofilament immunotherapy induces potent antitumor vaccine responses
Nanofilament immunotherapy induces potent antitumor vaccine responses Open
Background Checkpoint inhibitors revolutionized cancer treatment by potentiating antitumor immune responses. However, many patients do not respond to these therapies, often due to the lack of a pre-existing immune response against cancer c…
View article: ADPv2: A Hierarchical Histological Tissue Type-Annotated Dataset for Potential Biomarker Discovery of Colorectal Disease
ADPv2: A Hierarchical Histological Tissue Type-Annotated Dataset for Potential Biomarker Discovery of Colorectal Disease Open
Computational pathology (CoPath) leverages histopathology images to enhance diagnostic precision and reproducibility in clinical pathology. However, publicly available datasets for CoPath that are annotated with extensive histological tiss…
View article: Gender representation in professorship and research productivity across all surgical specialties in Canadian academic institutions
Gender representation in professorship and research productivity across all surgical specialties in Canadian academic institutions Open
Women surgeons were underrepresented across all academic ranks, were less likely to achieve senior professorship, and had lower research productivity metrics.
View article: UWB-Based Positioning System for Outdoor and Indoor Environments
UWB-Based Positioning System for Outdoor and Indoor Environments Open
View article: Mutant GNAS Drives a Pyloric Metaplasia with Tumor Suppressive Glycans in Intraductal Papillary Mucinous Neoplasia
Mutant GNAS Drives a Pyloric Metaplasia with Tumor Suppressive Glycans in Intraductal Papillary Mucinous Neoplasia Open
View article: Lipid-based nanoparticles deliver mRNA to reverse the pathogenesis of lysosomal acid lipase deficiency in a preclinical model
Lipid-based nanoparticles deliver mRNA to reverse the pathogenesis of lysosomal acid lipase deficiency in a preclinical model Open
Lysosomal acid lipase (LAL) is the only known enzyme that degrades cholesteryl esters (CEs) and triglycerides (TGs) in the lysosomes. LAL deficiency (LAL-D) results in hepatosplenomegaly with extensive accumulation of CEs and TGs, and can …
View article: 2DMamba: Efficient State Space Model for Image Representation with Applications on Giga-Pixel Whole Slide Image Classification
2DMamba: Efficient State Space Model for Image Representation with Applications on Giga-Pixel Whole Slide Image Classification Open
Efficiently modeling large 2D contexts is essential for various fields including Giga-Pixel Whole Slide Imaging (WSI) and remote sensing. Transformer-based models offer high parallelism but face challenges due to their quadratic complexity…
View article: Comparative Analysis of Diffusion Generative Models in Computational Pathology
Comparative Analysis of Diffusion Generative Models in Computational Pathology Open
Diffusion Generative Models (DGM) have rapidly surfaced as emerging topics in the field of computer vision, garnering significant interest across a wide array of deep learning applications. Despite their high computational demand, these mo…
View article: Efficient Self-Supervised Barlow Twins from Limited Tissue Slide Cohorts for Colonic Pathology Diagnostics
Efficient Self-Supervised Barlow Twins from Limited Tissue Slide Cohorts for Colonic Pathology Diagnostics Open
Colorectal cancer (CRC) is one of the few cancers that have an established dysplasia-carcinoma sequence that benefits from screening. Everyone over 50 years of age in Canada is eligible for CRC screening. About 20\% of those people will un…
View article: CRYOVATE: A Pilot Study of Lung Cancer Cryoactivation in Combination With Immunotherapy in Advanced NSCLC
CRYOVATE: A Pilot Study of Lung Cancer Cryoactivation in Combination With Immunotherapy in Advanced NSCLC Open
View article: Syngeneic mouse model of YES-driven metastatic and proliferative hepatocellular carcinoma
Syngeneic mouse model of YES-driven metastatic and proliferative hepatocellular carcinoma Open
Hepatocellular carcinoma (HCC) is a disease of high unmet medical need that has become a global health problem. The development of targeted therapies for HCC has been hindered by the incomplete understanding of HCC pathogenesis and the lim…
View article: Vim4Path: Self-Supervised Vision Mamba for Histopathology Images
Vim4Path: Self-Supervised Vision Mamba for Histopathology Images Open
Representation learning from Gigapixel Whole Slide Images (WSI) poses a significant challenge in computational pathology due to the complicated nature of tissue structures and the scarcity of labeled data. Multi-instance learning methods h…
View article: A senescence restriction point acting on chromatin integrates oncogenic signals
A senescence restriction point acting on chromatin integrates oncogenic signals Open
We identify a senescence restriction point (SeRP) as a critical event for cells to commit to senescence. The SeRP integrates the intensity and duration of oncogenic stress, keeps a memory of previous stresses, and combines oncogenic signal…
View article: Mutant GNAS drives a pyloric metaplasia with tumor suppressive glycans in intraductal papillary mucinous neoplasia
Mutant GNAS drives a pyloric metaplasia with tumor suppressive glycans in intraductal papillary mucinous neoplasia Open
BACKGROUND & AIMS Intraductal Papillary Mucinous Neoplasms (IPMNs) are cystic lesions and bona fide precursors for pancreatic ductal adenocarcinoma (PDAC). Recent studies have shown that pancreatic precancer is characterized by a transcrip…
View article: Undifferentiated carcinoma of the pancreas with osteoclast-like giant cells, a two cases report
Undifferentiated carcinoma of the pancreas with osteoclast-like giant cells, a two cases report Open
We presented two cases of UCOCGC a rare pancreatic cancer variant, exposing diagnostic particularities and clinical evolution.
View article: Oncogenic Fatty Acid Metabolism Rewires Energy Supply Chain in Gastric Carcinogenesis
Oncogenic Fatty Acid Metabolism Rewires Energy Supply Chain in Gastric Carcinogenesis Open
View article: Computational pathology: A survey review and the way forward
Computational pathology: A survey review and the way forward Open
View article: Differential spatial distribution of HNF4α isoforms during dysplastic progression of intraductal papillary mucinous neoplasms of the pancreas
Differential spatial distribution of HNF4α isoforms during dysplastic progression of intraductal papillary mucinous neoplasms of the pancreas Open
View article: Hepatic stellate cells maintain liver homeostasis through paracrine neurotrophin-3 signaling that induces hepatocyte proliferation
Hepatic stellate cells maintain liver homeostasis through paracrine neurotrophin-3 signaling that induces hepatocyte proliferation Open
Organ size is maintained by the controlled proliferation of distinct cell populations. In the mouse liver, hepatocytes in the midlobular zone that are positive for cyclin D1 (CCND1) repopulate the parenchyma at a constant rate to preserve …
View article: Klf4 protects thymus integrity during late pregnancy
Klf4 protects thymus integrity during late pregnancy Open
Pregnancy causes abrupt thymic atrophy. This atrophy is characterized by a severe decrease in the number of all thymocyte subsets and qualitative (but not quantitative) changes in thymic epithelial cells (TECs). Pregnancy-related thymic in…
View article: Computational Pathology: A Survey Review and The Way Forward
Computational Pathology: A Survey Review and The Way Forward Open
Computational Pathology CPath is an interdisciplinary science that augments developments of computational approaches to analyze and model medical histopathology images. The main objective for CPath is to develop infrastructure and workflow…
View article: Xenogeneic cross-circulation for physiological support and recovery of ex vivo human livers
Xenogeneic cross-circulation for physiological support and recovery of ex vivo human livers Open
Background and Aims: The scarcity of suitable donor livers highlights a continuing need for innovation to recover organs with reversible injuries in liver transplantation. Approach and Results: Explanted human donor livers (n = 5) declined…
View article: PCSK7: a Novel Regulator of Apolipoprotein B and a Potential Target Against Non-Alcoholic Fatty Liver Disease
PCSK7: a Novel Regulator of Apolipoprotein B and a Potential Target Against Non-Alcoholic Fatty Liver Disease Open
Epidemiological evidence links the proprotein convertase subtilisin/kexin 7 (PCSK7) to triglyceride (TG) metabolism. PCSK7-SNPs gain-of-function and loss-of-function variants were associated with higher and lower levels of plasma apoB and …
View article: Hepatic stellate cells maintain liver homeostasis through paracrine neurotrophin-3 signaling
Hepatic stellate cells maintain liver homeostasis through paracrine neurotrophin-3 signaling Open
Organ homeostasis is maintained by regulated proliferation of distinct cell populations. In mouse liver, cyclin D1-positive hepatocytes in the midlobular zone repopulate the parenchyma at a constant rate to preserve liver homeostasis. The …
View article: Pulmonary artery banding in sheep: a novel large animal model for congestive hepatopathy
Pulmonary artery banding in sheep: a novel large animal model for congestive hepatopathy Open
We present here a large animal platform for congestive hepatopathy, a disease growing in clinical prevalence due to the increasing number of Fontan-palliated patients. Further data are needed to develop a better clinical management strateg…
View article: Distinct spatial distribution and roles of Kupffer cells and monocyte-derived macrophages in mouse acute liver injury
Distinct spatial distribution and roles of Kupffer cells and monocyte-derived macrophages in mouse acute liver injury Open
Macrophages are key regulators of inflammation and repair, but their heterogeneity and multiple roles in the liver are not fully understood. We aimed herein to map the intrahepatic macrophage populations and their function(s) during acute …
View article: Peak density of immature nerve cells occurs with high‐grade dysplasia in intraductal papillary mucinous neoplasms of the pancreas
Peak density of immature nerve cells occurs with high‐grade dysplasia in intraductal papillary mucinous neoplasms of the pancreas Open
The development of neural structures within tumors is now considered vital for carcinogenesis. However, the time course of this development in human pre‐invasive neoplasia has been incompletely described. Therefore, we performed a detailed…
View article: Enteroendocrine Cell Formation Is an Early Event in Pancreatic Tumorigenesis
Enteroendocrine Cell Formation Is an Early Event in Pancreatic Tumorigenesis Open
Pancreatic ductal adenocarcinoma (PDAC) is a devastating disease with a 5-year survival rate of only 11%, due, in part, to late diagnosis, making the need to understand early events in tumorigenesis critical. Acinar-to-ductal metaplasia (A…
View article: Sex-Dependent Hepatoprotective Role of IL-22 Receptor Signaling in Non-Alcoholic Fatty Liver Disease-Related Fibrosis
Sex-Dependent Hepatoprotective Role of IL-22 Receptor Signaling in Non-Alcoholic Fatty Liver Disease-Related Fibrosis Open