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View article: Cyanidin‐3‐Glucoside Supplementation Modulates Bone Resorption in Experimental Apical Periodontitis
Cyanidin‐3‐Glucoside Supplementation Modulates Bone Resorption in Experimental Apical Periodontitis Open
Apical periodontitis (AP) is an inflammatory/infectious disease that leads to alveolar bone resorption. Cyanidin‐3‐glucoside (C3G) is an anthocyanin known for its anti‐inflammatory, antioxidant, and bone metabolism‐regulating properties, s…
View article: Enhancing the Quality of Single Cone Obturation Using Hydroxyapatite Precursor Grafted Nanocomplex for Dentine Conditioning: An In Vitro Study
Enhancing the Quality of Single Cone Obturation Using Hydroxyapatite Precursor Grafted Nanocomplex for Dentine Conditioning: An In Vitro Study Open
Aim This study aimed to quantify the effect of chitosan‐hydroxyapatite precursor nanocomplexes (C‐HA) on void reduction in the root canal system and isthmus regions, characterise void distribution patterns and assess sealer‐dentin interfac…
View article: Investigation of the effect of addition/replacement of bioactive glass to hydraulic calcium silicate cement
Investigation of the effect of addition/replacement of bioactive glass to hydraulic calcium silicate cement Open
The BG-incorporation whether added or replacing the cement decreased the solubility in clinically relevant media and did not deteriorate the antimicrobial and biological properties of the materials.
View article: Antibacterial and Antibiofilm Efficacy of Green Synthesised <i>Haloxylon</i> Capped Silver Nanoparticles Against <scp> <i>Enterococcus faecalis</i> </scp>
Antibacterial and Antibiofilm Efficacy of Green Synthesised <i>Haloxylon</i> Capped Silver Nanoparticles Against <span> <i>Enterococcus faecalis</i> </span> Open
This study synthesised and characterised Haloxylon ‐capped silver nanoparticles ( Haloxylon ‐AgNPs) and assessed their antibacterial and antibiofilm activity against Enterococcus faecalis . The study also examined Haloxylon‐AgNPs' ability …
View article: Dysfunctional crosstalk between macrophages and fibroblasts under LPS-infected and hyperglycemic environment in diabetic wounds
Dysfunctional crosstalk between macrophages and fibroblasts under LPS-infected and hyperglycemic environment in diabetic wounds Open
Diabetic wounds, especially diabetic foot ulcers, present a major clinical challenge due to delayed healing and prolonged inflammation. Macrophage-fibroblast interactions are essential for wound repair, yet this crosstalk is disrupted in d…
View article: Clinical Oral Investigations Biological and Physicochemical Characterization of Nanoemulsions Containing Morin and its Derivatives for Endodontic Purposes
Clinical Oral Investigations Biological and Physicochemical Characterization of Nanoemulsions Containing Morin and its Derivatives for Endodontic Purposes Open
Objectives Considering the lack of medications with a wide range of therapeutic effects for the endodontic treatment of immature teeth, this study aimed at synthesizing two morin (Mo) derivatives and testing their cytotoxicity and effect o…
View article: Comparative Analysis of Autologous Scaffold Formation Protocols in Regenerative Endodontic Therapy: A Systematic Review and Meta-analysis
Comparative Analysis of Autologous Scaffold Formation Protocols in Regenerative Endodontic Therapy: A Systematic Review and Meta-analysis Open
Aims: To evaluate the protocols of autogenous scaffold formation in regenerative endodontic therapy, with a focus on their efficacy in functional recovery, continued root development, and periapical healing in necrotic permanent teeth with…
View article: EDITORIAL Beyond the Hype: What Is the True Value of Advanced Disinfection Technologies in Endodontics?
EDITORIAL Beyond the Hype: What Is the True Value of Advanced Disinfection Technologies in Endodontics? Open
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View article: Guidance for evaluating biomaterials’ properties and biological potential for dental pulp tissue engineering and regeneration research
Guidance for evaluating biomaterials’ properties and biological potential for dental pulp tissue engineering and regeneration research Open
This article aims to present the biological foundations of dental pulp tissue engineering alongside potential testing methodologies and their advantages and limitations. It provides guidance for developing research protocols to evaluate th…
View article: Photomechanical Investigation on the Impact of Endodontic Cavity Design on the Biomechanical Response in Mandibular Posterior Teeth
Photomechanical Investigation on the Impact of Endodontic Cavity Design on the Biomechanical Response in Mandibular Posterior Teeth Open
The roof of the pulp chamber contributes to a distinct biomechanical response in posterior teeth. The microstrain at the coronal and cervical level increased significantly following de-roofing of the pulp chamber in both CEC and TEC groups…
View article: Dysfunctional crosstalk between macrophages and fibroblasts under LPS-infected and hyperglycemic environment in diabetic wounds
Dysfunctional crosstalk between macrophages and fibroblasts under LPS-infected and hyperglycemic environment in diabetic wounds Open
Diabetic wounds, especially diabetic foot ulcers, present a major clinical challenge due to delayed healing and prolonged inflammation. Macrophage-fibroblast interactions are essential for wound repair, yet this crosstalk is disrupted in d…
View article: Deciphering 3D periodontal fibroblast-macrophage crosstalk in bioactive nanoparticle-guided immunomodulation for treating traumatic dental avulsion
Deciphering 3D periodontal fibroblast-macrophage crosstalk in bioactive nanoparticle-guided immunomodulation for treating traumatic dental avulsion Open
Prolonged extra-oral period in dental avulsion is often associated with loss of viability of Periodontal fibroblasts (PDLF) and increased risk of ankylosis. Root surface treatment with bioactive agents to reduce the risk of ankylosis can b…
View article: Bioarchitectural Design of Bioactive Biopolymers: Structure–Function Paradigm for Diabetic Wound Healing
Bioarchitectural Design of Bioactive Biopolymers: Structure–Function Paradigm for Diabetic Wound Healing Open
Chronic wounds such as diabetic ulcers are a major complication in diabetes caused by hyperglycemia, prolonged inflammation, high oxidative stress, and bacterial bioburden. Bioactive biopolymers have been found to have a biological respons…
View article: Irrigants and irrigation activation systems in Endodontics
Irrigants and irrigation activation systems in Endodontics Open
Root canal infections are typically polymicrobial and involve strong bacterial interactions. The goal of endodontic treatment is to remove infected content from the root canal system to allow the healing of a pre-existing periapical lesion…
View article: Nociceptor–Macrophage Interactions in Apical Periodontitis: How Biomolecules Link Inflammation with Pain
Nociceptor–Macrophage Interactions in Apical Periodontitis: How Biomolecules Link Inflammation with Pain Open
Periradicular tissues have a rich supply of peripheral afferent neurons, also known as nociceptive neurons, originating from the trigeminal nerve. While their primary function is to relay pain signals to the brain, these are known to be in…
View article: 3D Organoids for Regenerative Endodontics
3D Organoids for Regenerative Endodontics Open
Apical periodontitis is the inflammation and destruction of periradicular tissues, mediated by microbial factors originating from the infected pulp space. This bacteria-mediated inflammatory disease is known to interfere with root developm…
View article: Endocytic internalization mechanism of bioactive antibacterial nanoparticles by fibroblasts
Endocytic internalization mechanism of bioactive antibacterial nanoparticles by fibroblasts Open
Studying the uptake mechanism of photosensitizers is an important step in developing an ideal photosensitizer for use in photodynamic therapy (PDT). Understanding the uptake mechanism can help design novel photosensitizers that are selecti…
View article: Silver Nanoparticles and Their Therapeutic Applications in Endodontics: A Narrative Review
Silver Nanoparticles and Their Therapeutic Applications in Endodontics: A Narrative Review Open
The efficient elimination of microorganisms and their byproducts from infected root canals is compromised by the limitations in conventional root canal disinfection strategies and antimicrobials. Silver nanoparticles (AgNPs) are advantageo…
View article: Application of Proteomics in Apical Periodontitis
Application of Proteomics in Apical Periodontitis Open
Apical periodontitis is an inflammatory reaction of the periradicular tissues as a consequence of multispecies microbial communities organized as biofilms within the root canal system. Periradicular tissue changes at the molecular level in…