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View article: Distinct responses to non-autonomous UPRER mediated by glutamatergic and octopaminergic neurons
Distinct responses to non-autonomous UPRER mediated by glutamatergic and octopaminergic neurons Open
The capacity to deal with stress declines during the aging process, and preservation of cellular stress responses is critical to healthy aging. The unfolded protein response of the endoplasmic reticulum (UPRER) is one such conse…
View article: Form and function of actin impacts actin health and aging
Form and function of actin impacts actin health and aging Open
The actin cytoskeleton is a fundamental and highly conserved structure that functions in diverse cellular processes, yet its direct contribution to organismal aging remains unclear. Here, we systematically interrogated how genetic and phar…
View article: Methionine cycle in C. elegans serotonergic neurons regulates diet-dependent behaviour and longevity through neuron-gut signaling
Methionine cycle in C. elegans serotonergic neurons regulates diet-dependent behaviour and longevity through neuron-gut signaling Open
The folate and methionine cycles (Met-C) are regulated by vitamin B12 (B12), obtained exclusively from diet and microbiota. Met-C supports amino acid, nucleotide, and lipid biosynthesis and provides one-carbon moieties for methylation reac…
View article: SEROTONIN DEFICIENCY FROM CONSTITUTIVE SKN-1 ACTIVATION DRIVES PATHOGEN APATHY
SEROTONIN DEFICIENCY FROM CONSTITUTIVE SKN-1 ACTIVATION DRIVES PATHOGEN APATHY Open
When an organism encounters a pathogen, the host innate immune system activates to defend against pathogen colonization and toxic xenobiotics produced. In humans, nuclear factor erythroid 2-related factor (Nrf2) is a critical regulator in …
View article: THE CONNECTION BETWEEN SEROTONIN SIGNALING, AGING, AND IMMUNITY WHEN OBSERVED FROM C. ELEGANS AND HUMAN STUDIES
THE CONNECTION BETWEEN SEROTONIN SIGNALING, AGING, AND IMMUNITY WHEN OBSERVED FROM C. ELEGANS AND HUMAN STUDIES Open
As humans age, various environmental threats impact healthspan. Therefore maintaining an intact immune system is vital. Efficiency of human immune response can decline over time leading to complications with age-related diseases. Homeostat…
View article: SKN-1 ISOFORM-C IS ESSENTIAL FOR C. ELEGANS DEVELOPMENT
SKN-1 ISOFORM-C IS ESSENTIAL FOR C. ELEGANS DEVELOPMENT Open
The transcription factor SKN-1 in Caenorhabditis elegans is a critical regulator of various biological processes, impacting development, diet and immune responses, cellular detoxification, and lipid metabolism; thereby playing a pivotal ro…
View article: Serotonin deficiency from constitutive SKN-1 activation drives pathogen apathy
Serotonin deficiency from constitutive SKN-1 activation drives pathogen apathy Open
View article: Distinct mechanisms of non-autonomous UPR<sup>ER</sup>mediated by GABAergic, glutamatergic, and octopaminergic neurons
Distinct mechanisms of non-autonomous UPR<sup>ER</sup>mediated by GABAergic, glutamatergic, and octopaminergic neurons Open
The capacity to deal with stress declines during the aging process, and preservation of cellular stress responses is critical to healthy aging. The unfolded protein response of the endoplasmic reticulum (UPR ER ) is one such conserved mech…
View article: SKN-1 isoform-c is essential for C. elegans development
SKN-1 isoform-c is essential for C. elegans development Open
The transcription factor SKN-1 in Caenorhabditis elegans is a critical regulator of various biological processes, impacting development, diet and immune responses, cellular detoxification, and lipid metabolism; thereby playing a piv…
View article: Methionine cycle in a pair of serotonergic neurons regulates diet-dependent behavior and longevity through a neuron-gut signaling
Methionine cycle in a pair of serotonergic neurons regulates diet-dependent behavior and longevity through a neuron-gut signaling Open
The folate-methionine cycle (Met-C) is a central metabolic pathway that is regulated by vitamin B12 (B12), a micronutrient obtained exclusively from diet and microbiota. This metabolic hub supports amino acid, nucleotide and lipid biosynth…
View article: Serotonin deficiency from constitutive SKN-1 activation drives pathogen apathy
Serotonin deficiency from constitutive SKN-1 activation drives pathogen apathy Open
When an organism encounters a pathogen, the host innate immune system activates to defend against pathogen colonization and toxic xenobiotics produced. C. elegans employ multiple defense systems to ensure survival when exposed to Pseudomon…
View article: Metabolic Rewiring of Mycobacterium tuberculosis upon Drug Treatment and Antibiotics Resistance
Metabolic Rewiring of Mycobacterium tuberculosis upon Drug Treatment and Antibiotics Resistance Open
Tuberculosis (TB), caused by Mycobacterium tuberculosis (Mtb), remains a significant global health challenge, further compounded by the issue of antimicrobial resistance (AMR). AMR is a result of several system-level molecular rearrangemen…
View article: PATHOGEN APATHY RESULTING FROM SKN-1 ACTIVATION: A MARK OF RESILIENCE OR A RATTLED GUT FEELING?
PATHOGEN APATHY RESULTING FROM SKN-1 ACTIVATION: A MARK OF RESILIENCE OR A RATTLED GUT FEELING? Open
Innate immunity is a key driver in promoting survival against xenobiotic stressors and hostile environments and an appropriate immune response is essential to organismal health across lifespan. Caenorhabditis elegans encounter pathogens in…
View article: Gut microbiome associated dysbiosis: Limited regimens and expanding horizons of phage therapy
Gut microbiome associated dysbiosis: Limited regimens and expanding horizons of phage therapy Open
Human gut microbiota plays an important role in health, broadly influencing metabolism to the immune system and drug resistance to pathogenic colonization. Since antibiotic resistance is on the rise, and wide-spectrum antibiotics are known…
View article: Taurine deficiency as a driver of aging
Taurine deficiency as a driver of aging Open
Aging is associated with changes in circulating levels of various molecules, some of which remain undefined. We find that concentrations of circulating taurine decline with aging in mice, monkeys, and humans. A reversal of this decline thr…
View article: Adaptive capacity to dietary Vitamin B12 levels is maintained by a gene-diet interaction that ensures optimal life span
Adaptive capacity to dietary Vitamin B12 levels is maintained by a gene-diet interaction that ensures optimal life span Open
The file contains all primary data used to prepare figures and supplementary figures.
View article: Adaptive capacity to dietary Vitamin B12 levels is maintained by a gene‐diet interaction that ensures optimal life span
Adaptive capacity to dietary Vitamin B12 levels is maintained by a gene‐diet interaction that ensures optimal life span Open
Diet regulates complex life‐history traits such as longevity. For optimal lifespan, organisms employ intricate adaptive mechanisms whose molecular underpinnings are less known. We show that Caenorhabditis elegans FLR‐4 kinase prevents life…