Tripti Verma
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View article: CD138-Negative Extra-oral Plasmablastic Lymphoma in an Immuno-competent Patient—Diagnostic Challenge: A Case Report and Review of Literature
CD138-Negative Extra-oral Plasmablastic Lymphoma in an Immuno-competent Patient—Diagnostic Challenge: A Case Report and Review of Literature Open
Plasmablastic lymphoma (PBL) is an aggressive lymphoid neoplasm, classified as a distinct entity in 2017 World Health Organization classification. These are generally associated with immunodeficiency states especially in human immunodefici…
View article: The deubiquitinase inhibitor <scp>WP1130</scp> drives nuclear aggregation and reactivation of mutant p53 for selective cancer cell targeting
The deubiquitinase inhibitor <span>WP1130</span> drives nuclear aggregation and reactivation of mutant p53 for selective cancer cell targeting Open
Mutations in the TP53 gene may lead to the loss of its tumor suppressor function and the acquisition of oncogenic properties. The enhanced stability of mutant p53 (mutp53) is one of the pivotal factors for its oncogenic functions, renderin…
View article: Amyloidogenic occipital mass obscuring plasmacytoma: a rare presentation and review of literature
Amyloidogenic occipital mass obscuring plasmacytoma: a rare presentation and review of literature Open
Solitary plasmacytoma of bone are a spectrum of plasma cell disorder which are defined by presence of clonal plasma cell in the bone including skull. The occurrence of true plasmacytoma of skull with large amyloid deposits in young patient…
View article: Primary Malignant Solitary Fibrous Tumor of Mediastinum
Primary Malignant Solitary Fibrous Tumor of Mediastinum Open
Solitary fibrous tumor (SFT) of the pleura is a rare mesenchymal tumor with <800 cases reported in literature when compared to mesotheliomas – 3000 cases yearly. These arise from the noncommitted mesenchymal cells adjacent to the mesotheli…
View article: Long-standing Renal Amyloidosis Leading to Massive Amyloid Goiter
Long-standing Renal Amyloidosis Leading to Massive Amyloid Goiter Open
Figs 1A to D: (A) Clinical picture; (B) Gross specimen; (C) Pale eosinophilic deposit (amyloid
View article: Histone acetylation: a key determinant of acquired cisplatin resistance in cancer
Histone acetylation: a key determinant of acquired cisplatin resistance in cancer Open
Cisplatin is an alkylating class of chemotherapeutic drugs used to treat cancer patients. However, cisplatin fails in long-term treatment, and drug resistance is the primary reason for tumor recurrence. Hence, understanding the mechanism o…
View article: Monstrous Adrenal Myelolipoma
Monstrous Adrenal Myelolipoma Open
PHOTO ASSAYcomponent within it in the right upper quadrant suggestive of adrenal myelolipoma (Fig. 2 ). Patient underwent openA 79-year-old presented with pain and swelling over the abdomen for 1 month (Fig. 1).On evaluation; the patient w…
View article: An increase in polyadenylation of histone isoforms, Hist1h2ah and Hist2h3c2, is governed by 3′-UTR in de-differentiated and undifferentiated hepatocyte
An increase in polyadenylation of histone isoforms, Hist1h2ah and Hist2h3c2, is governed by 3′-UTR in de-differentiated and undifferentiated hepatocyte Open
Replication-dependent histones have a stem-loop structure at the 3′ end of messenger RNA (mRNA) and are stabilized by stem-loop binding protein (SLBP). Moreover, loss of SLBP and imbalance in the level of ARE (adenylate-uridylate-rich elem…
View article: Effect of Educational Video on Maternal Nutrition, Hygiene and Sanitation Among Maternal Age Group Women: A Prospective Interventional Study from Prayagraj, Uttar Pradesh, India
Effect of Educational Video on Maternal Nutrition, Hygiene and Sanitation Among Maternal Age Group Women: A Prospective Interventional Study from Prayagraj, Uttar Pradesh, India Open
Introduction: Interventions that try to alter behaviour in order to promote health and disease management are typically time and resource-consuming. At the moment, boosting maternal and child nutrition is the main focus of nutrition progra…
View article: Comparison of circulating DNA in malignant neoplasia from diverse locations
Comparison of circulating DNA in malignant neoplasia from diverse locations Open
Context: Circulating free DNA (cfDNA) analysis has emerged as novel noninvasive diagnostic biomarker in several solid tumors. Raised levels have been reported in several malignancies and may correlate with clinicopathological and treatment…
View article: Dynamic Alterations of Histone H3 Phospho-acetylation Correlate With Radio Sensitivity of Mitotic Cells During DNA&nbsp;Damage
Dynamic Alterations of Histone H3 Phospho-acetylation Correlate With Radio Sensitivity of Mitotic Cells During DNA Damage Open
Background - Histone Post Translational Modifications (PTMs) change in a cell cycle dependent manner and also orchestrate the DNA repair process for radiation induced DNA damage. Mitosis is the most radiosensitive phase of the cell cycle b…
View article: Plant Based Anti-cancerous Superfoods, Boosting Immunity: A Coherent Critique
Plant Based Anti-cancerous Superfoods, Boosting Immunity: A Coherent Critique Open
Introduction-Superfood is a nutritional term and a marketing tool for selling specific foods, dietary supplements, foods with selected food additives, promising an enhancement to health with supposed health benefits as a result of some par…
View article: Circulating free DNA as a marker of response to chemoradiation in locally advanced head and neck squamous cell carcinoma
Circulating free DNA as a marker of response to chemoradiation in locally advanced head and neck squamous cell carcinoma Open
Our study adds to the evidence that cfDNA levels are significantly higher in HNSCC cases and provides some evidence that levels increase with tumor progression. CfDNA may be a promising prospective non-invasive marker to predict response i…