Trisha Peel
YOU?
Author Swipe
View article: Fluconazole exposure during mechanical circulatory support (MCS) device insertion
Fluconazole exposure during mechanical circulatory support (MCS) device insertion Open
In 10 patients undergoing MCS device insertion, fluconazole 200 to 400 mg IV achieved median plasma levels of between 3 and 4 mg/L throughout the surgical procedure but may not adequately cover for C. glabrata.
View article: Association between daptomycin dosing and in-hospital mortality in patients with vancomycin-resistant <i>Enterococcus faecium</i> bloodstream infection
Association between daptomycin dosing and in-hospital mortality in patients with vancomycin-resistant <i>Enterococcus faecium</i> bloodstream infection Open
Background Vancomycin-resistant Enterococcus faecium (VREfm) bloodstream infections (BSIs) pose significant management challenges with uncertainties relating to the optimal daptomycin dose for treatment. Methods A retrospective cohort stud…
View article: Global collaboration between platform trials in surgery and anaesthesia
Global collaboration between platform trials in surgery and anaesthesia Open
Summary Large, randomized trials are the bedrock of evidence-based medicine, but the resources required to complete such trials greatly limit the number of important clinical questions that can be addressed within a reasonable period of ti…
View article: Healthcare-associated infections and antimicrobial use at a major referral hospital in Papua New Guinea: a point prevalence survey
Healthcare-associated infections and antimicrobial use at a major referral hospital in Papua New Guinea: a point prevalence survey Open
View article: Oral challenge vs routine care to assess low-risk penicillin allergy in critically ill hospital patients (ORACLE): a pilot safety and feasibility randomised controlled trial
Oral challenge vs routine care to assess low-risk penicillin allergy in critically ill hospital patients (ORACLE): a pilot safety and feasibility randomised controlled trial Open
These findings support the safety, validity, and feasibility of direct enteral challenge for critically ill patients with PEN-FAST assessed low-risk penicillin allergy. The absence of false negative results was confirmed by subsequent nega…
View article: PREPARE: A Pilot RCT in Perioperative Penicillin and Cephalosporin Antibiotic Allergy Assessment and Testing
PREPARE: A Pilot RCT in Perioperative Penicillin and Cephalosporin Antibiotic Allergy Assessment and Testing Open
View article: A Pilot RCT of Direct Oral Challenge (DOC) vs Routine Care for Low-Risk Penicillin Allergy in Critical Illness: The ORACLE Study
A Pilot RCT of Direct Oral Challenge (DOC) vs Routine Care for Low-Risk Penicillin Allergy in Critical Illness: The ORACLE Study Open
View article: Referee report. For: Understanding hospital antimicrobial prescribing decisions and determinants of uptake of new local antimicrobial prescribing guidelines in Laos [version 2; peer review: 3 approved]
Referee report. For: Understanding hospital antimicrobial prescribing decisions and determinants of uptake of new local antimicrobial prescribing guidelines in Laos [version 2; peer review: 3 approved] Open
View article: Development of a cross-sectoral antimicrobial resistance capability assessment framework
Development of a cross-sectoral antimicrobial resistance capability assessment framework Open
Antimicrobial resistance (AMR) is an urgent and growing global health concern, and a clear understanding of existing capacities to address AMR, particularly in low-income and middle-income countries (LMICs), is needed to inform national pr…
View article: Pilot study to evaluate the need and implementation of a multifaceted nurse-led antimicrobial stewardship intervention in residential aged care
Pilot study to evaluate the need and implementation of a multifaceted nurse-led antimicrobial stewardship intervention in residential aged care Open
Objectives To evaluate the need and feasibility of a nurse-led antimicrobial stewardship (AMS) programme in two Australian residential aged care homes (RACHs) to inform a stepped-wedged, cluster randomized controlled trial (SW-cRCT). Metho…
View article: Pilot study of a multifaceted nurse-led antimicrobial stewardship intervention in residential aged care
Pilot study of a multifaceted nurse-led antimicrobial stewardship intervention in residential aged care Open
Objective To evaluate the feasibility of a nurse-led antimicrobial stewardship (AMS) program in two Australian residential aged care homes (RACHs) to inform a stepped-wedged, cluster randomised controlled trial (SW-cRCT). Methods A mixed-m…
View article: Impact of antibiotic allergy labels on timely and appropriate antibiotics for sepsis in the emergency department
Impact of antibiotic allergy labels on timely and appropriate antibiotics for sepsis in the emergency department Open
Objectives Time to initiation of effective antibiotic therapy is a strong predictor of survival for patients with sepsis presenting to the Emergency Department (ED). Antibiotic allergy labels (AALs) are a known barrier to timely sepsis man…
View article: Oral challenge vs routine care to assess low-risk penicillin allergy in critically ill hospital patients (ORACLE): a pilot randomised controlled trial
Oral challenge vs routine care to assess low-risk penicillin allergy in critically ill hospital patients (ORACLE): a pilot randomised controlled trial Open
Background Self-reported penicillin allergies are highly prevalent in hospitalised patients and are associated with poor health and health service outcomes. Critically ill patients have historically been underrepresented in prospective del…
View article: The clinical application of beta-lactam antibiotic therapeutic drug monitoring in the critical care setting
The clinical application of beta-lactam antibiotic therapeutic drug monitoring in the critical care setting Open
Critically ill patients have increased variability in beta-lactam antibiotic (beta-lactam) exposure due to alterations in their volume of distribution and elimination. Therapeutic drug monitoring (TDM) of beta-lactams, as a dose optimizati…
View article: Understanding patient and healthcare worker experiences and perspectives of multidrug-resistant organisms
Understanding patient and healthcare worker experiences and perspectives of multidrug-resistant organisms Open
Objectives Transmission of MDR organisms (MROs) such as carbapenemase-producing Enterobacteriaceae (CPE) and VRE in healthcare facilities is a major issue globally. Knowledge gaps exist, including the impact of these microorganisms on pati…
View article: Therapeutics for Vancomycin-Resistant Enterococcal Bloodstream Infections
Therapeutics for Vancomycin-Resistant Enterococcal Bloodstream Infections Open
Vancomycin-resistant enterococci (VRE) are common causes of bloodstream infections (BSIs) with high morbidity and mortality rates. They are pathogens of global concern with a limited treatment pipeline.
View article: Oral challenge vs routine care to assess low-risk penicillin allergy in critically ill hospital patients (ORACLE): a pilot safety and feasibility randomised controlled trial
Oral challenge vs routine care to assess low-risk penicillin allergy in critically ill hospital patients (ORACLE): a pilot safety and feasibility randomised controlled trial Open
Background: Self-reported penicillin allergies are highly prevalent in hospitalised patients and are associated with poor health and health service outcomes. Critically ill patients have historically been underrepresented in prospective de…
View article: Accuracy of antibacterial indication documentation in an electronic medicines management system
Accuracy of antibacterial indication documentation in an electronic medicines management system Open
Introduction Electronic medicines management (EMM) systems are relatively new in the Australian healthcare system. This tertiary hospital network implemented an EMM in 2018, with mandatory documentation of antimicrobial indication when pre…
View article: Study protocol for PREPARE: a phase II feasibility/safety randomised controlled trial on PeRiopErative Penicillin AlleRgy TEsting
Study protocol for PREPARE: a phase II feasibility/safety randomised controlled trial on PeRiopErative Penicillin AlleRgy TEsting Open
Introduction Patient-reported antibiotic allergy labels (AALs) are common. These labels have been demonstrated to have a negative impact on use of appropriate antibiotics and patient-related health outcomes. These patients are more likely …
View article: Impact of Antimicrobial Allergy Labels on Timely and Appropriate Antimicrobials for Sepsis in the Emergency Department
Impact of Antimicrobial Allergy Labels on Timely and Appropriate Antimicrobials for Sepsis in the Emergency Department Open
View article: Implementation of an antimicrobial stewardship program in the Australian private hospital system: qualitative study of attitudes to antimicrobial resistance and antimicrobial stewardship
Implementation of an antimicrobial stewardship program in the Australian private hospital system: qualitative study of attitudes to antimicrobial resistance and antimicrobial stewardship Open
View article: A desirability of outcome ranking (DOOR) for periprosthetic joint infection – a Delphi analysis
A desirability of outcome ranking (DOOR) for periprosthetic joint infection – a Delphi analysis Open
Background: Treatment outcomes in studies on prosthetic joint infection are generally assessed using a dichotomous outcome relating to treatment success or failure. These outcome measures neither include patient-centred outcome measures in…
View article: Beta-Lactam Antibiotic Therapeutic Drug Monitoring in Critically Ill Patients: A Systematic Review and Meta-Analysis
Beta-Lactam Antibiotic Therapeutic Drug Monitoring in Critically Ill Patients: A Systematic Review and Meta-Analysis Open
Therapeutic drug monitoring (TDM) of beta-lactam antibiotics is recommended to address the variability in exposure observed in critical illness. However, the impact of TDM-guided dosing on clinical outcomes remains unknown. We conducted a …
View article: Antibiotic management of urinary tract infections in the post-antibiotic era: a narrative review highlighting diagnostic and antimicrobial stewardship
Antibiotic management of urinary tract infections in the post-antibiotic era: a narrative review highlighting diagnostic and antimicrobial stewardship Open
View article: 165. Decreased Antimicrobial Consumption and Decreased Rates of Multi-drug Resistant Organisms Following Onset of the COVID-19 Pandemic: Experience from an Australian Tertiary Hospital
165. Decreased Antimicrobial Consumption and Decreased Rates of Multi-drug Resistant Organisms Following Onset of the COVID-19 Pandemic: Experience from an Australian Tertiary Hospital Open
Background Current guidelines recommend empiric antibiotics be used only for severe cases of coronavirus disease 2019 (COVID-19) or in cases where there is high clinical suspicion for bacterial co-infection. Level of adherence to guideline…
View article: Antimicrobial stewardship in Australia: the role of qualitative research in programme development
Antimicrobial stewardship in Australia: the role of qualitative research in programme development Open
Antimicrobial stewardship (AMS) in Australia is supported by a number of factors, including enabling national policies, sectoral clinical governance frameworks and surveillance programmes, clinician-led educational initiatives and health s…
View article: Early antimicrobial stewardship team intervention on appropriateness of antimicrobial therapy in suspected sepsis: a randomized controlled trial
Early antimicrobial stewardship team intervention on appropriateness of antimicrobial therapy in suspected sepsis: a randomized controlled trial Open
Objectives There has been concern that the imperative to administer rapid antimicrobials in septic patients may result in inappropriate antimicrobial use. We aimed to determine the impact of early antimicrobial stewardship (AMS) team inter…
View article: Preface
Preface Open
View article: Multicentre stepped-wedge cluster randomised controlled trial of an antimicrobial stewardship programme in residential aged care: protocol for the START trial
Multicentre stepped-wedge cluster randomised controlled trial of an antimicrobial stewardship programme in residential aged care: protocol for the START trial Open
Introduction Antimicrobial resistance is a growing global health threat, driven by increasing inappropriate use of antimicrobials. High prevalence of unnecessary use of antimicrobials in residential aged care facilities (RACFs) has driven …
View article: Randomised Controlled Trials of Alcohol-Based Surgical Site Skin Preparation for the Prevention of Surgical Site Infections: Systematic Review and Meta-Analysis
Randomised Controlled Trials of Alcohol-Based Surgical Site Skin Preparation for the Prevention of Surgical Site Infections: Systematic Review and Meta-Analysis Open
(1) Background: Surgical site skin preparation is an important approach to prevent postoperative wound infections. International guidelines recommend that alcohol-based combinations be used, however, the optimal combination remains uncerta…