Trista E. North
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View article: Apelin signaling acts as a molecular switch between endothelial and hematopoietic stem cell fates
Apelin signaling acts as a molecular switch between endothelial and hematopoietic stem cell fates Open
Hematopoietic stem and progenitor cells (HSPCs) emerge from arterial endothelial cells (ECs) through a process termed endothelial-to-hematopoietic-transition (EHT), a process induced by paracrine signals and driven by a transcriptional cas…
Dynamic activity of Erg promotes maturation of the hematopoietic system Open
Hematopoiesis changes over the lifetime to adapt to the physiology of development, maturation, and aging. Temporal changes in hematopoiesis parallel age-dependent incidences of certain blood diseases. Several heterochronic regulators of he…
RNA Editors Sculpt the Transcriptome During Terminal Erythropoiesis Open
Selective RNA degradation during terminal erythropoiesis results in a globin-rich transcriptome in mature erythrocytes, but the specific RNA decay pathways remain unknown. We found that deficiency of the terminal uridylyl transferase enzym…
Heterochromatin fidelity is a therapeutic vulnerability in lymphoma and other human cancers Open
Genes involved in the regulation of chromatin structure are frequently disrupted in cancer, contributing to an aberrant transcriptome and phenotypic plasticity. Yet, therapeutics targeting mutant forms of chromatin-modifying enzymes have y…
Dynamic activity of <i>Erg</i> promotes aging of the hematopoietic system Open
Hematopoiesis changes to adapt to the physiology of development and aging. Temporal changes in hematopoiesis parallel age-dependent incidences of blood diseases. Several heterochronic regulators of hematopoiesis have been identified, but h…
Bnip3lb-driven mitophagy sustains expansion of the embryonic hematopoietic stem cell pool Open
SUMMARY Embryonic hematopoietic stem and progenitor cells (HSPCs) have the unique ability to undergo rapid proliferation while maintaining multipotency, a clinically-valuable quality which currently cannot be replicated in vitro. Here, we …
Design of a Soluble Multivalent Notch Agonist Open
Designed protein agonists can enhance the efficiency of endogenous signaling pathways, and provide a powerful means to control cellular functions and develop disease therapeutics. Designing a soluble cytokine-like agonist for Notch signali…
A multistep computational approach reveals a neuro-mesenchymal cell population in the embryonic hematopoietic stem cell niche Open
The first hematopoietic stem and progenitor cells (HSPCs) emerge in the Aorta-Gonad-Mesonephros (AGM) region of the mid-gestation mouse embryo. However, the precise nature of their supportive mesenchymal microenvironment remains largely un…
950 Epigenetic reprogramming of iPSC-derived T cells for CAR T cell therapy Open
Background Cancer immunotherapy using T cells engineered with chimeric antigen receptors (CAR) has proven remarkably effective against lymphoid malignancies. However, broader application has been impeded by the cumbersome, labor-intensive …
View article: SARS-CoV-2 viral liver aggregates and scarce parenchymal infection implicate systemic disease as a driver of abnormal liver function
SARS-CoV-2 viral liver aggregates and scarce parenchymal infection implicate systemic disease as a driver of abnormal liver function Open
Background: Liver function tests (LFTs) are elevated in >50% of hospitalized individuals infected with severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2), with increased enzyme levels correlating with a more severe COVID-19 cours…
View article: Structural basis for inactivation of PRC2 by G-quadruplex RNA
Structural basis for inactivation of PRC2 by G-quadruplex RNA Open
Polycomb repressive complex 2 (PRC2) silences genes through trimethylation of histone H3K27. PRC2 associates with numerous precursor messenger RNAs (pre-mRNAs) and long noncoding RNAs (lncRNAs) with a binding preference for G-quadruplex RN…
Embryonic alcohol exposure disrupts the ubiquitin-proteasome system Open
Ethanol (EtOH) is a commonly encountered teratogen that can disrupt organ development and lead to fetal alcohol spectrum disorders (FASDs); many mechanisms of developmental toxicity are unknown. Here, we used transcriptomic analysis in an …
Prediction of intercellular communication networks using CellComm Open
Intercellular communication is important for tissue development and homeostasis, and when dysregulated contributes to a multitude of pathobiological processes. Cells communicate with each other by several mechanisms, including direct cell-…
Developmental maturation of the hematopoietic system controlled by a Lin28b-<i>let</i>-<i>7</i>-PRC1 axis Open
SUMMARY Hematopoiesis changes over life to meet the demands of maturation and aging. Here, we find that the definitive hematopoietic stem and progenitor cell (HSPC) compartment is remodeled from gestation into adulthood, a process regulate…
Making Blood from the Vessel: Extrinsic and Environmental Cues Guiding the Endothelial-to-Hematopoietic Transition Open
It is increasingly recognized that specialized subsets of endothelial cells carry out unique functions in specific organs and regions of the vascular tree. Perhaps the most striking example of this specialization is the ability to contribu…