Tristan T. Timbrook
YOU?
Author Swipe
View article: Performance evaluation of a commercial multiplex pathogen panel for detection of bacteria in sputum specimens from non-ICU patients with suspected lower respiratory tract infection
Performance evaluation of a commercial multiplex pathogen panel for detection of bacteria in sputum specimens from non-ICU patients with suspected lower respiratory tract infection Open
Rapid diagnostic testing can improve pathogen detection and lead to targeted antibiotics. The BioFire FilmArray Pneumonia Panel (BFPP) is a multiplex PCR that has displayed strong concordance with traditional microbiologic techniques. Howe…
View article: Multiplex PCR panel dynamics: implications for therapy duration and methodological considerations
Multiplex PCR panel dynamics: implications for therapy duration and methodological considerations Open
View article: Beyond Accuracy: Methodological Advances for Assessing the Clinical Impact of Infectious Disease Diagnostics
Beyond Accuracy: Methodological Advances for Assessing the Clinical Impact of Infectious Disease Diagnostics Open
Evaluating the clinical impact of in vitro diagnostic tests (IVDs) for infectious diseases is complex given their effectiveness depends on context, implementation, and provider behavior. Traditional methodologies for therapy interventions …
View article: Prevalence and healthcare burden of inappropriate antimicrobial treatment in patients at high risk of complications from acute respiratory infections: a scoping review
Prevalence and healthcare burden of inappropriate antimicrobial treatment in patients at high risk of complications from acute respiratory infections: a scoping review Open
Background Evidence of inappropriate antimicrobial treatment for acute respiratory infections (ARIs) is well-established in literature. However, comprehensive evaluations of inappropriate antimicrobial use and associated clinical and econo…
View article: P-2248. Modeling the Economic Impact of Different Testing Strategies for Meningitis/Encephalitis in Adult Patients from a US Hospital Perspective
P-2248. Modeling the Economic Impact of Different Testing Strategies for Meningitis/Encephalitis in Adult Patients from a US Hospital Perspective Open
Background Meningitis/encephalitis (ME) is a life-threatening disease whose severity and trajectory vary by etiology. Many times, patients with suspected ME are unnecessarily hospitalized and treated with empiric therapy as a precaution wh…
View article: P-816. Diagnostic Performance of Molecular Sample-to-Answer Tests for Bloodstream Infections in the Clinical Setting: a Systematic Literature Review and Meta-Analysis
P-816. Diagnostic Performance of Molecular Sample-to-Answer Tests for Bloodstream Infections in the Clinical Setting: a Systematic Literature Review and Meta-Analysis Open
Background Rapid identification of bloodstream pathogens and antimicrobial resistance (AMR) genes by molecular tests from positive blood cultures (PBCs) have the potential to improve patient management. A systematic review and meta-analysi…
View article: Modeling the Economic Impact of Different Testing Strategies for Meningitis/Encephalitis in Adult Patients from a Us Hospital Perspective
Modeling the Economic Impact of Different Testing Strategies for Meningitis/Encephalitis in Adult Patients from a Us Hospital Perspective Open
View article: Evolving strategies in microbe identification—a comprehensive review of biochemical, MALDI-TOF MS and molecular testing methods
Evolving strategies in microbe identification—a comprehensive review of biochemical, MALDI-TOF MS and molecular testing methods Open
Detection and identification of microorganisms are the first steps to guide susceptibility testing and enable clinicians to confirm diseases and guide therapy. The faster the pathogen identification is determined, the quicker the appropria…
View article: Learning from the impact of misinformation and past infodemics: advancing public health through transparency, trust, and community engagement
Learning from the impact of misinformation and past infodemics: advancing public health through transparency, trust, and community engagement Open
View article: Disease burden and high-risk populations for complications in patients with acute respiratory infections: a scoping review
Disease burden and high-risk populations for complications in patients with acute respiratory infections: a scoping review Open
Background Acute respiratory infections (ARIs) represent a significant public health concern in the U.S. This study aimed to describe the disease burden of ARIs and identify U.S. populations at high risk of developing complications. Method…
View article: Reemergence of <i>Bordetella parapertussis</i>, United States, 2019–2023
Reemergence of <i>Bordetella parapertussis</i>, United States, 2019–2023 Open
To determine changes in Bordetella pertussis and B. parapertussis detection rates, we analyzed 1.43 million respiratory multiplex PCR test results from US facilities from 2019 through mid-2023. From mid-2022 through mid-2023, Bordetella sp…
View article: Breaking Boundaries in Pneumonia Diagnostics: Transitioning from Tradition to Molecular Frontiers with Multiplex PCR
Breaking Boundaries in Pneumonia Diagnostics: Transitioning from Tradition to Molecular Frontiers with Multiplex PCR Open
The advent of rapid molecular microbiology testing has revolutionized infectious disease diagnostics and is now impacting pneumonia diagnosis and management. Molecular platforms offer highly multiplexed assays for diverse viral and bacteri…
View article: The epidemiology of pediatric outpatient acute respiratory tract infections in the US: a multi-facility analysis of multiplex PCR testing from 2018 to 2023
The epidemiology of pediatric outpatient acute respiratory tract infections in the US: a multi-facility analysis of multiplex PCR testing from 2018 to 2023 Open
Acute respiratory tract infections in children increase the healthcare burden. Gaps exist in our understanding of the outpatient epidemiology of pediatric respiratory illnesses, especially following the emergence of SARS-CoV-2. The utiliza…
View article: Comparative analysis of a rapid diagnostic test and scoring tools for ESBL detection in <i>Enterobacterales</i> bloodstream infections for optimizing antimicrobial therapy
Comparative analysis of a rapid diagnostic test and scoring tools for ESBL detection in <i>Enterobacterales</i> bloodstream infections for optimizing antimicrobial therapy Open
Extended-spectrum beta-lactamase (ESBL)-producing Enterobacterales bloodstream infections (BSI) are associated with increased cost, morbidity, and mortality compared with BSI by non-ESBL-producing bacteria. Phenotypic susceptibility data f…
View article: 128. Validation of a rapid diagnostics platform for detecting extended-spectrum beta-lactamase resistance in gram negative bacteremia
128. Validation of a rapid diagnostics platform for detecting extended-spectrum beta-lactamase resistance in gram negative bacteremia Open
Background Extended-spectrum beta-lactamase-producing Enterobacterales (ESBL-E) bloodstream infections (BSI) are associated with increased cost, morbidity, and mortality compared with BSI by non-ESBL-producing bacteria. Phenotypic suscepti…
View article: Procalcitonin and Risk Prediction for Diagnosing Bacteremia in Hospitalized Patients: A Retrospective, National Observational Study
Procalcitonin and Risk Prediction for Diagnosing Bacteremia in Hospitalized Patients: A Retrospective, National Observational Study Open
Bacteremia is associated with significant morbidity and mortality. Timely, appropriate therapy may improve clinical outcomes, and therefore, determining which patients benefit from more comprehensive diagnostic strategies (i.e., direct spe…
View article: Predicting Extended-Spectrum Beta-Lactamase and Carbapenem Resistance in Enterobacteriaceae Bacteremia: A Diagnostic Model Systematic Review and Meta-Analysis
Predicting Extended-Spectrum Beta-Lactamase and Carbapenem Resistance in Enterobacteriaceae Bacteremia: A Diagnostic Model Systematic Review and Meta-Analysis Open
Enterobacteriaceae bacteremia, particularly when associated with antimicrobial resistance, can result in increased mortality, emphasizing the need for timely effective therapy. Clinical risk prediction models are promising tools, stratifyi…
View article: <i>Candida auris</i> rates in blood culture on the rise: results of US surveillance
<i>Candida auris</i> rates in blood culture on the rise: results of US surveillance Open
Candida auris is an emerging pathogen that poses a significant public health risk. Its multidrug resistance has led to high mortality, making rapid detection crucial for effective treatment and prevention of transmission. Recent data from …
View article: Rapid multiplex PCR for respiratory viruses reduces time to result and improves clinical care: Results of a systematic review and meta-analysis
Rapid multiplex PCR for respiratory viruses reduces time to result and improves clinical care: Results of a systematic review and meta-analysis Open
Our systematic review and meta-analysis demonstrates a reduction in time to results and length of stay for patients overall along with improvements in appropriate antiviral and infection control management among influenza-positive patients…
View article: Relationship between Diagnostic Method and Pathogen Detection, Healthcare Resource Use, and Cost in U.S. Adult Outpatients Treated for Acute Infectious Gastroenteritis
Relationship between Diagnostic Method and Pathogen Detection, Healthcare Resource Use, and Cost in U.S. Adult Outpatients Treated for Acute Infectious Gastroenteritis Open
A retrospective observational study was performed to assess the relationship between diagnostic method (traditional work-up [TW], multiplex PCR panel with < 12 target pathogens [PCR < 12], or multiplex PCR panel with ≥ 12 target pathogens …
View article: Epidemiology and Economic Burden of Acute Infectious Gastroenteritis Among Adults Treated in Outpatient Settings in US Health Systems
Epidemiology and Economic Burden of Acute Infectious Gastroenteritis Among Adults Treated in Outpatient Settings in US Health Systems Open
INTRODUCTION: Acute infectious gastroenteritis (AGE) is a common reason for outpatient visits and hospitalizations in the United States. This study aimed to understand the demographic and clinical characteristics, common pathogens detected…
View article: Diagnostic and antimicrobial stewardship workforce challenges: A crisis in combating antimicrobial resistance
Diagnostic and antimicrobial stewardship workforce challenges: A crisis in combating antimicrobial resistance Open
An abstract is not available for this content. As you have access to this content, full HTML content is provided on this page. A PDF of this content is also available in through the ‘Save PDF’ action button.
View article: Measuring clinical outcomes of highly multiplex molecular diagnostics for respiratory infections: A systematic review and conceptual framework
Measuring clinical outcomes of highly multiplex molecular diagnostics for respiratory infections: A systematic review and conceptual framework Open
Objectives: To review methodologies and outcomes reporting among these studies and to develop a conceptual framework of outcomes to assist in guiding studies and production of clinical metrics. Data sources: PubMed and Embase from January …
View article: 167. Clinical Impact of Rapid Multiplex Polymerase Chain Reaction-Based Diagnostic Testing for Hospitalized Patients with Bloodstream Infections (BSIs) in a National Cohort of Veterans Affairs Patients
167. Clinical Impact of Rapid Multiplex Polymerase Chain Reaction-Based Diagnostic Testing for Hospitalized Patients with Bloodstream Infections (BSIs) in a National Cohort of Veterans Affairs Patients Open
Background Polymerase chain reaction (PCR)-based diagnostic testing for BSIs, such as the BioFire FilmArray® Blood Culture Identification (BCID) Panel, has the potential to shorten time to appropriate therapy and duration of overly broad-s…
View article: 1997. Epidemiology and Burden of Acute Infectious Gastroenteritis Among Adult Outpatient Treated in United States Hospitals
1997. Epidemiology and Burden of Acute Infectious Gastroenteritis Among Adult Outpatient Treated in United States Hospitals Open
Background Little is known about the epidemiology and burden of acute infectious gastroenteritis (AIG) among adult outpatients treated in United States (US) hospitals. We assessed the demographic and clinical characteristics, common pathog…
View article: Epidemiology and Economic Outcomes Associated with Timely versus Delayed Receipt of Appropriate Antibiotic Therapy among US Patients Hospitalized for Native Septic Arthritis: A Retrospective Cohort Study
Epidemiology and Economic Outcomes Associated with Timely versus Delayed Receipt of Appropriate Antibiotic Therapy among US Patients Hospitalized for Native Septic Arthritis: A Retrospective Cohort Study Open
Timely administration of appropriate antibiotic therapy is associated with better patient outcomes and lower costs of care compared to delayed appropriate therapy, yet initial treatment is often empiric since causal pathogens are typically…
View article: 1996. Association between Multiplex Polymerase Chain Reaction Stool Diagnostic Testing and Pathogen Detection, Healthcare Resource Use, and Cost Among Adult Outpatients Treated in United States Hospitals for Acute Infectious Gastroenteritis
1996. Association between Multiplex Polymerase Chain Reaction Stool Diagnostic Testing and Pathogen Detection, Healthcare Resource Use, and Cost Among Adult Outpatients Treated in United States Hospitals for Acute Infectious Gastroenteritis Open
Background Multiplex polymerase chain reaction (PCR) gastroenteritis testing panels simultaneously detect multiple pathogens with rapid turnaround, allowing more accurate and timely diagnosis and treatment. This retrospective observational…
View article: Improving antimicrobial stewardship with penicillin allergy testing: a review of current practices and unmet needs
Improving antimicrobial stewardship with penicillin allergy testing: a review of current practices and unmet needs Open
Penicillin allergy, the most frequently reported drug allergy, has been associated with suboptimal antibiotic therapy, increased antimicrobial resistance, increased rates of Clostridioides difficile colonization and infection, as well as e…
View article: Assessment of the Impact of a Meningitis/Encephalitis Panel on Hospital Length of Stay: A Systematic Review and Meta-Analysis
Assessment of the Impact of a Meningitis/Encephalitis Panel on Hospital Length of Stay: A Systematic Review and Meta-Analysis Open
Meningitis and encephalitis are central nervous system infections with considerable morbidity and mortality. The BioFire® FilmArray® Meningitis/Encephalitis Panel (multiplex ME panel) can identify pathogens rapidly potentially aiding in ta…
View article: Epidemiology of Antimicrobial Resistance Among Blood and Respiratory Specimens in the United States Using Genotypic Analysis From a Cloud-Based Population Surveillance Network
Epidemiology of Antimicrobial Resistance Among Blood and Respiratory Specimens in the United States Using Genotypic Analysis From a Cloud-Based Population Surveillance Network Open
Background Antimicrobial resistance (AMR) surveillance is critical in informing strategies for infection control in slowing the spread of resistant organisms and for antimicrobial stewardship in the care of patients. However, significant c…