Explanipedia

Deriving reference limits from historical data – A comparison of four novel methods Open

Tomasz Szymon Szczepanski, Petter Moe Omland, Øystein Dunker, Trond Sand, Robert Reijntjes , et al. · 2025

When combining the different novel methods, it is possible to create clinically useful reference limits using historical data.

Sensory Nerve Conduction Amplitudes and Z‐Compounds Depend on Body Mass Index in Overweight and Obese Individuals Open

Trond Sand, Martin Uglem, Gjermund Johnsen, Arnstein Grøtting, Øystein Dunker , et al. · 2025

Introduction/Aims The association between body mass index (BMI) and nerve conduction study (NCS) amplitudes has not been adequately studied in overweight and obese subjects. Our aim was to estimate the impact of high BMI on NCS amplitudes …

A meta-ethnography exploring parents’ experiences of fetal death and the care they received between diagnosis and birth induction Open

Cecilia Pettersson, Trond Sand, Bente Dahl · 2025

Optimal care performance, where communication is central, is a useful strategy for healthcare professionals in their encounters with parents who experience fetal death. Training is vital in order to provide good care and support for parent…

Using cross-recurrence quantification analysis to compute similarity measures for time series of unequal length with applications to sleep stage analysis Open

Henning Johannes Drews, Flavia Felletti, Håvard Kallestad, Annika Drews, Jan Scott , et al. · 2024

Comparing time series of unequal length requires data processing procedures that may introduce biases. This article describes, validates, and applies Cross-Recurrence Quantification Analysis (CRQA) to detect and quantify correlation and co…

Endogenous pain modulation after sleep restriction in migraine: a blinded crossover study Open

Jan Petter Neverdahl, Martin Uglem, Dagfinn Matre, Kristian Bernhard Nilsen, Knut Hagen , et al. · 2024

Utility and limitations of EEG in the diagnosis and management of ALDH7A1-related pyridoxine-dependent epilepsy. A retrospective observational study Open

Vibeke Arntsen, Ahmed Jamali, Alma Sikiric, Erle Kristensen, Trine Tangeraas , et al. · 2024

Purpose Pyridoxine-dependent epilepsy due to ALDH7A1 variants (PDE-ALDH7A1) is a rare disorder, presenting typically with severe neonatal, epileptic encephalopathy. Early diagnosis is imperative to prevent uncontrolled seizures. We have ex…

Visual outcomes and their association with grey and white matter microstructure in adults born preterm with very low birth weight Open

Sigrid Hegna Ingvaldsen, Anna P. M. Jørgensen, Arnstein Grøtting, Trond Sand, Live Eikenes , et al. · 2024

Individuals born with very low birth weight (VLBW; < 1500 g) have a higher risk of reduced visual function and brain alterations. In a longitudinal cohort study, we assessed differences in visual outcomes and diffusion metrics from diffusi…

Validation of Trøndelag Apnoea Score Proxy for Obstructive Sleep Apnoea in the General Population of Norway: The HUNT Study Open

James Filosa, Petter Moe Omland, Knut Hagen, Knut Langsrud, Morten Engstrøm , et al. · 2024

The aim was to validate a new seven‐item “TASC” (Trøndelag Apnoea Score) proxy for obstructive sleep apnoea (OSA) against polysomnography in the general population. Objectives included validation against different polysomnographic criteria…

Neuropathy 10–15 years after Roux-en-Y gastric bypass for severe obesity: A community-controlled nerve conduction study Open

Trond Sand, Arnstein Grøtting, Martin Uglem, Nils Augestad, Gjermund Johnsen , et al. · 2024

Effects of insufficient sleep on sensorimotor processing in migraine: A randomised, blinded crossover study of event related beta oscillations Open

Martin Syvertsen Mykland, Martin Uglem, Marte‐Helene Bjørk, Dagfinn Matre, Trond Sand , et al. · 2023

Background Migraine has a largely unexplained connection with sleep and is possibly related to a dysfunction of thalamocortical systems and cortical inhibition. In this study we investigate the effect of insufficient sleep on cortical sens…

Insufficient sleep may alter cortical excitability near the migraine attack: A blinded TMS crossover study Open

Martin Syvertsen Mykland, Martin Uglem, Lars Jacob Stovner, Eiliv Brenner, Mari Storli Snoen , et al. · 2023

Background Migraine is a brain disorder with a multifaceted and unexplained association to sleep. Brain excitability likely changes periodically throughout the migraine cycle. In this study we examine the effect of insufficient sleep on ne…

Obituary for Ottar Sjaastad, founding editor of Cephalalgia Open

Lars Jacob Stovner, T. A. Fredriksen, Trond Sand · 2022

Poorer Sleep Health is Associated With Altered Brain Activation During Cognitive Control Processing in Healthy Adults Open

Hanne Smevik, Sarah Habli, Simen Berg Saksvik, Elisabeth Kliem, Hallvard Røe Evensmoen , et al. · 2022

This study investigated how proactive and reactive cognitive control processing in the brain was associated with habitual sleep health. BOLD fMRI data was acquired from 81 healthy adults with normal sleep (41 females, age 20.96 - 39.58 yea…

Accuracy of neuropathic pain measurements in patients with symptoms of polyneuropathy: validation of painDETECT, Self-Completed Leeds Assessment of Neuropathic Symptoms and Signs, and Douleur Neuropathique 4 Open

Øystein Dunker, Margreth Grotle, Marie Bu Kvaløy, Martin Uglem, Sissel Løseth , et al. · 2022

Pain is a common symptom in patients referred to polyneuropathy assessment. Diagnostic evaluation and choice of treatment may depend on whether the pain is likely to be neuropathic or not. This study aimed to investigate the diagnostic acc…

Contact‐free radar recordings of body movement can reflect ultradian dynamics of sleep Open

Hanne Siri Amdahl Heglum, Henning Johannes Drews, Håvard Kallestad, Daniel Vethe, Knut Langsrud , et al. · 2022

Summary This work aimed to evaluate if a contact‐free radar sensor can be used to observe ultradian patterns in sleep physiology, by way of a data processing tool known as Locomotor Inactivity During Sleep (LIDS). LIDS was designed as a si…

Sleep restriction alters cortical inhibition in migraine: A transcranial magnetic stimulation study Open

Martin Syvertsen Mykland, Martin Uglem, Jan Petter Neverdahl, Lise Rystad Øie, Tore Wergeland Meisingset , et al. · 2022

Sleep related mechanisms appear to affect the pathophysiology of migraine and may differentiate between migraine subgroups.

Pain thresholds and suprathreshold pain after sleep restriction in migraine – A blinded crossover study Open

Jan Petter Neverdahl, Martin Uglem, Dagfinn Matre, Johannes Orvin Hansen, Morten Engstrøm , et al. · 2021

Objective There is an unexplained association between disturbed sleep and migraine. In this blinded crossover study, we investigate if experimental sleep restriction has a different effect on pain thresholds and suprathreshold pain in inte…

Which combined nerve conduction study scores are best suited for polyneuropathy in diabetic patients? Open

Øystein Dunker, Kristian Bernhard Nilsen, Sandra Elise Olsen, Bjørn Olav Åsvold, Marit Bjørgaas , et al. · 2021

Introduction/Aims Nerve conduction studies (NCS) are widely used in diagnosing diabetic polyneuropathy. Combining the Z scores of several measures (Z‐compounds) may improve diagnostics by grading abnormality. We aimed to determine which co…

Shift work, inflammation and musculoskeletal pain—The HUNT Study Open

Dagfinn Matre, Jan Olav Christensen, Paul Jarle Mork, Paulo H. Ferreira, Trond Sand , et al. · 2021

Background Studies have indicated that shift work, in particular night work, is associated with chronic musculoskeletal pain but the mechanisms are unclear. It has been suggested that sleep disturbance, a common complaint among shift and n…

A characteristic occipital epileptiform EEG pattern in ADCK3‐related mitochondrial disease Open

Vibeke Arntsen, Trond Sand, Omar Hikmat, Christian Samsonsen, Laurence A. Bindoff , et al. · 2021

Objective . ADCK3‐related disease is a mitochondrial disorder associated with an abnormality of coenzyme Q 10 metabolism. Ataxia and epilepsy are common, and the phenotype overlaps with other mitochondrial encephalopathies, particularly PO…

Daily associations between sleep and pain in patients with chronic musculoskeletal pain Open

Karin Abeler, Svein Bergvik, Trond Sand, Oddgeir Friborg · 2021

Patients with chronic pain commonly report sleep problems, and the evidence for a relationship between sleep disturbance and pain seems robust. The day‐to‐day associations between these constructs are less well studied, particularly with o…

Experimental sleep restriction increases latency jitter in pain elicited cortical responses Open

Johannes Orvin Hansen, Petter Moe Omland, Kristian Bernhard Nilsen, Trond Sand, Dagfinn Matre · 2021

Distinguishing sleep from wake with a radar sensor: a contact-free real-time sleep monitor Open

Hanne Siri Amdahl Heglum, Håvard Kallestad, Daniel Vethe, Knut Langsrud, Trond Sand , et al. · 2021

This work aimed to evaluate whether a radar sensor can distinguish sleep from wakefulness in real time. The sensor detects body movements without direct physical contact with the subject and can be embedded in the roof of a hospital room f…

Hjerneovervåking i sykehusene må styrkes Open

Anne Hege Aamodt, Erik Taubøll, Tom Eichele, Luis Romundstad, Angelika Sorteberg , et al. · 2021

Careful brain monitoring saves lives and is beneficial to patients' health. Nevertheless, Norway lacks guidelines for brain monitoring in hospitals.

Pain sensitivity in young adults with juvenile idiopathic arthritis: a quantitative sensory testing study Open

Ellen Dalen Arnstad, Johanne Marie Iversen, Martin Uglem, Mia Glerup, Pål Romundstad , et al. · 2020

Background To study for the first-time, pain perception, pain sensitivity, and self-reported pain in young adults with long disease duration of juvenile idiopathic arthritis (JIA) compared with controls. Methods Children from Central Norwa…

Sleep Characteristics in Adults With and Without Chronic Musculoskeletal Pain Open

Karin Abeler, Oddgeir Friborg, Morten Engstrøm, Trond Sand, Svein Bergvik · 2020

Objectives: Sleep disturbance is associated with persistence and exacerbation of chronic pain. As this relationship seems to be bidirectional, factors underpinning sleep disturbance may prove important in multimodal rehabilitation approach…

Seasonality in pain, sleep and mental distress in patients with chronic musculoskeletal pain at latitude 69° N Open

Karin Abeler, Trond Sand, Oddgeir Friborg, Svein Bergvik · 2020

Seasonality is evident in several aspects of human health and behavior, whereas seasonality in chronic pain is less well studied. We examined seasonal variation in pain severity and pain dissemination, as well as in pain-associated conditi…

A prospective three-year follow-up study on the clinical significance of anti-neuronal antibodies in acute psychiatric disorders Open

M Schou, Sverre Georg Sæther, Ole Kristian Drange, Erich Brenner, Joan Crespi , et al. · 2019

The clinical significance of anti-neuronal antibodies for psychiatric disorders is controversial. We investigated if a positive anti-neuronal antibody status at admission to acute psychiatric inpatient care was associated with a more sever…

The crossover design for migraine preventives: an analyses of four randomized placebo-controlled trials Open

Astrid Bjørke Jenssen, Lars Jacob Stovner, Erling Tronvik, Trond Sand, Grethe Helde , et al. · 2019

The joint effect of insomnia symptoms and lifestyle factors on risk of self-reported fibromyalgia in women: longitudinal data from the HUNT Study Open

Eivind Schjelderup Skarpsno, Tom Ivar Lund Nilsen, Trond Sand, Knut Hagen, Paul Jarle Mork · 2019

Objectives To investigate the association between insomnia symptoms and risk of self-reported fibromyalgia in women, and to explore whether leisure time physical activity and body mass index (BMI) modify this association. Design Prospectiv…

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