Troy C. Lund
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View article: Expanding the Phenotype Spectrum of β-Mannosidosis
Expanding the Phenotype Spectrum of β-Mannosidosis Open
Genotype-phenotype correlation in β-mannosidosis remains elusive, likely due to phenotypic variability, disease rarity, and lack of association between the enzyme activity and the clinical severity. Modifier genes in the N-glycan degradati…
View article: Neurofilament light chain as a prognostic marker in cerebral adrenoleukodystrophy
Neurofilament light chain as a prognostic marker in cerebral adrenoleukodystrophy Open
Cerebral adrenoleukodystrophy (C-ALD) is a rapidly progressing inflammatory neurodegenerative disease with unpredictable onset in males with ALD. It must be treated at an early stage of demyelination, determined by MRI, to preserve neuroco…
View article: Remodeling the sarcoma microenvironment by simultaneous targeting of urokinase-type plasminogen activator receptors and epidermal growth factor receptors to promote antitumor activity
Remodeling the sarcoma microenvironment by simultaneous targeting of urokinase-type plasminogen activator receptors and epidermal growth factor receptors to promote antitumor activity Open
View article: Inflammation and Immunomodulation in Cerebral X-linked Adrenoleukodystrophy: Review of Pathology and Interventions
Inflammation and Immunomodulation in Cerebral X-linked Adrenoleukodystrophy: Review of Pathology and Interventions Open
Objectives More than half of males with X-linked adrenoleukodystrophy (ALD) develop progressive, inflammatory cerebral demyelination (cerebral adrenoleukodystrophy). Treatment for cerebral adrenoleukodystrophy is limited with no standard t…
View article: Neurofilament light chain as a biomarker to indicate early activation of cerebral disease in boys with adrenoleukodystrophy
Neurofilament light chain as a biomarker to indicate early activation of cerebral disease in boys with adrenoleukodystrophy Open
As far as we are aware, this is the first report highlighting that a bloodborne biomarker, plasma NfL, could potentially be used as a concomitant indicator of cerebral disease initiation, thus simplifying surveillance for cerebral ALD.
View article: Mosaic X-linked adrenoleukodystrophy in males identified by newborn screening and next-generation sequencing
Mosaic X-linked adrenoleukodystrophy in males identified by newborn screening and next-generation sequencing Open
View article: Bodyweight and Absolute Lymphocyte Count-Based Dosing of Rabbit Anti-thymocyte Globulin Results in Early CD4+ Immune Reconstitution in Patients with Inborn Errors of Metabolism Undergoing Umbilical Cord Blood Transplantation
Bodyweight and Absolute Lymphocyte Count-Based Dosing of Rabbit Anti-thymocyte Globulin Results in Early CD4+ Immune Reconstitution in Patients with Inborn Errors of Metabolism Undergoing Umbilical Cord Blood Transplantation Open
In patients with IEM, individualized dosing of rATG was associated with a robust and early CD4+ immune reconstitution, with no graft failures and low GVHD incidence.
View article: Insights From Minnesota on Newborn Screening for Adrenoleukodystrophy: A 5‐Year Update
Insights From Minnesota on Newborn Screening for Adrenoleukodystrophy: A 5‐Year Update Open
Our objectives are to report on the outcomes of adrenal insufficiency (AI) and cerebral ALD (cALD) in children diagnosed with X‐linked adrenoleukodystrophy (ALD) identified by newborn screening (NBS) in Minnesota in the first 5 years follo…
View article: Bone marrow transplantation reverses metabolic alterations in multiple sulfatase deficiency: a case series
Bone marrow transplantation reverses metabolic alterations in multiple sulfatase deficiency: a case series Open
View article: Metabolomic Profiling in Treated Mucopolysaccharidosis Ih Reveals Candidate Biomarkers and Adjunctive Therapeutic Pathways
Metabolomic Profiling in Treated Mucopolysaccharidosis Ih Reveals Candidate Biomarkers and Adjunctive Therapeutic Pathways Open
View article: Intrathecal or intravenous AAV9-IDUA/RGX-111 at minimal effective dose prevents cardiac, skeletal and neurologic manifestations of murine MPS I
Intrathecal or intravenous AAV9-IDUA/RGX-111 at minimal effective dose prevents cardiac, skeletal and neurologic manifestations of murine MPS I Open
Mucopolysaccharidosis type I (MPS I) is a rare metabolic disorder caused by deficiency of α-L-iduronidase (IDUA), resulting in glycosaminoglycan (GAG) accumulation and multisystemic disease. Current treatments include hematopoietic stem ce…
View article: Bone marrow transplantation increases sulfatase activity in somatic tissues in a multiple sulfatase deficiency mouse model
Bone marrow transplantation increases sulfatase activity in somatic tissues in a multiple sulfatase deficiency mouse model Open
Our results indicate that HSCT could be a suitable approach to treat MSD-pathology affecting peripheral organs, however that benefit to CNS pathology might be limited.
View article: Lipidomic biomarkers in plasma correlate with disease severity in adrenoleukodystrophy
Lipidomic biomarkers in plasma correlate with disease severity in adrenoleukodystrophy Open
Background X-linked adrenoleukodystrophy (ALD) is a neurometabolic disorder caused by pathogenic variants in ABCD1 resulting very long-chain fatty acids (VLCFA) accumulation in plasma and tissues. Males can present with various clinical ma…
View article: Diffusion Tensor Imaging in Boys With Adrenoleukodystrophy
Diffusion Tensor Imaging in Boys With Adrenoleukodystrophy Open
DTI was sensitive to lesion presence and severity as well as clinical neurocognitive effects of C-ALD. DTI metrics quantify C-ALD even at an early stage.
View article: Retraction Note: Pluripotency of mesenchymal stem cells derived from adult marrow
Retraction Note: Pluripotency of mesenchymal stem cells derived from adult marrow Open
View article: FIGURE 2 from Hemangiosarcoma Cells Promote Conserved Host-derived Hematopoietic Expansion
FIGURE 2 from Hemangiosarcoma Cells Promote Conserved Host-derived Hematopoietic Expansion Open
Hematopoietic expansion derived from adoptive transplantation of canine hemangiosarcoma in immunodeficient mice. A and B, Xenotransplantation of canine hemangiosarcoma cell lines created exuberant myeloid hyperplasia in mouse…
View article: Supplementary Figure S2 from Hemangiosarcoma Cells Promote Conserved Host-derived Hematopoietic Expansion
Supplementary Figure S2 from Hemangiosarcoma Cells Promote Conserved Host-derived Hematopoietic Expansion Open
Supplementary Figure S2
View article: FIGURE 4 from Hemangiosarcoma Cells Promote Conserved Host-derived Hematopoietic Expansion
FIGURE 4 from Hemangiosarcoma Cells Promote Conserved Host-derived Hematopoietic Expansion Open
Hematopoietic support and stromal regulation of canine hemangiosarcoma cells. A, Flow cytometric data depict populations of cells expressing CD43 and CD45 differentiated from CD34+ hUCB cells. CD34+ hUCB cells …
View article: Supplementary Figure S10 from Hemangiosarcoma Cells Promote Conserved Host-derived Hematopoietic Expansion
Supplementary Figure S10 from Hemangiosarcoma Cells Promote Conserved Host-derived Hematopoietic Expansion Open
Supplementary Figure S10
View article: Supplementary Figure S5 from Hemangiosarcoma Cells Promote Conserved Host-derived Hematopoietic Expansion
Supplementary Figure S5 from Hemangiosarcoma Cells Promote Conserved Host-derived Hematopoietic Expansion Open
Supplementary Figure S5
View article: Supplementary Figure S2 from Hemangiosarcoma Cells Promote Conserved Host-derived Hematopoietic Expansion
Supplementary Figure S2 from Hemangiosarcoma Cells Promote Conserved Host-derived Hematopoietic Expansion Open
Supplementary Figure S2
View article: Supplementary Figure S9 from Hemangiosarcoma Cells Promote Conserved Host-derived Hematopoietic Expansion
Supplementary Figure S9 from Hemangiosarcoma Cells Promote Conserved Host-derived Hematopoietic Expansion Open
Supplementary Figure S9
View article: Supplementary Table S4 from Hemangiosarcoma Cells Promote Conserved Host-derived Hematopoietic Expansion
Supplementary Table S4 from Hemangiosarcoma Cells Promote Conserved Host-derived Hematopoietic Expansion Open
Supplementary Table S4
View article: FIGURE 1 from Hemangiosarcoma Cells Promote Conserved Host-derived Hematopoietic Expansion
FIGURE 1 from Hemangiosarcoma Cells Promote Conserved Host-derived Hematopoietic Expansion Open
Establishment of xenografts derived from canine hemangiosarcoma in immunodeficient mice. A, Schematic illustration depicts process of tumor xenografts in BNX mice. B, DHSA-1426 tumor cell line was established from a canine pa…
View article: Supplementary Figure S3 from Hemangiosarcoma Cells Promote Conserved Host-derived Hematopoietic Expansion
Supplementary Figure S3 from Hemangiosarcoma Cells Promote Conserved Host-derived Hematopoietic Expansion Open
Supplementary Figure S3
View article: Supplementary Figure S1 from Hemangiosarcoma Cells Promote Conserved Host-derived Hematopoietic Expansion
Supplementary Figure S1 from Hemangiosarcoma Cells Promote Conserved Host-derived Hematopoietic Expansion Open
Supplementary Figure S1
View article: Supplementary Figure S8 from Hemangiosarcoma Cells Promote Conserved Host-derived Hematopoietic Expansion
Supplementary Figure S8 from Hemangiosarcoma Cells Promote Conserved Host-derived Hematopoietic Expansion Open
Supplementary Figure S8
View article: Supplementary Figure S4 from Hemangiosarcoma Cells Promote Conserved Host-derived Hematopoietic Expansion
Supplementary Figure S4 from Hemangiosarcoma Cells Promote Conserved Host-derived Hematopoietic Expansion Open
Supplementary Figure S4
View article: Supplementary Figure S1 from Hemangiosarcoma Cells Promote Conserved Host-derived Hematopoietic Expansion
Supplementary Figure S1 from Hemangiosarcoma Cells Promote Conserved Host-derived Hematopoietic Expansion Open
Supplementary Figure S1
View article: Data from Hemangiosarcoma Cells Promote Conserved Host-derived Hematopoietic Expansion
Data from Hemangiosarcoma Cells Promote Conserved Host-derived Hematopoietic Expansion Open
Hemangiosarcoma and angiosarcoma are soft-tissue sarcomas of blood vessel–forming cells in dogs and humans, respectively. These vasoformative sarcomas are aggressive and highly metastatic, with disorganized, irregular blood-filled vascular…