T. H. Bacon
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View article: Analgesic efficacy of sustained release paracetamol in patients with osteoarthritis of the knee
Analgesic efficacy of sustained release paracetamol in patients with osteoarthritis of the knee Open
Aims Paracetamol is widely recommended as the initial treatment for pain associated with osteoarthritis (OA). A sustained release (SR) paracetamol formulation (Panadol Extend ™ ) was compared with standard immediate release (IR) paracetamo…
View article: Inhibition of Varicella-Zoster Virus by Penciclovir in Cell Culture and Mechanism of Action
Inhibition of Varicella-Zoster Virus by Penciclovir in Cell Culture and Mechanism of Action Open
The effect of penciclovir (BRL 39123) on the replication of varicella-zoster virus (VZV) in human embryonic lung fibroblasts (MRC-5 cells) was similar to aciclovir when the compounds were present continuously. However, when the compounds w…
View article: Activity of penciclovir against Epstein-Barr virus
Activity of penciclovir against Epstein-Barr virus Open
Penciclovir inhibited the productive replication cycle of Epstein-Barr virus (EBV) in assays measuring infectious virus production, viral antigen expression, and viral DNA synthesis. In the test measuring inhibition of EBV DNA synthesis, 5…
View article: An Overview of the Further Evaluation of Penciclovir against Herpes Simplex Virus and Varicella-Zoster Virus in Cell Culture Highlighting Contrasts with Acyclovir
An Overview of the Further Evaluation of Penciclovir against Herpes Simplex Virus and Varicella-Zoster Virus in Cell Culture Highlighting Contrasts with Acyclovir Open
The antiviral action of penciclovir against herpes simplex virus (HSV) and varicella-zoster virus (VZV) in cell culture is reviewed. Acyclovir was included for comparison in most of the experiments described. Whilst these two acyclic nucle…
View article: Mode of antiviral action of penciclovir in MRC-5 cells infected with herpes simplex virus type 1 (HSV-1), HSV-2, and varicella-zoster virus
Mode of antiviral action of penciclovir in MRC-5 cells infected with herpes simplex virus type 1 (HSV-1), HSV-2, and varicella-zoster virus Open
The metabolism and mode of action of penciclovir [9-(4-hydroxy-3-hydroxymethylbut-1-yl)guanine; BRL 39123] were studied and compared with those of acyclovir. In uninfected MRC-5 cells, low concentrations of the triphosphates of penciclovir…
View article: Interferon-gamma production by peripheral blood mononuclear cells from patients with Behçet's syndrome.
Interferon-gamma production by peripheral blood mononuclear cells from patients with Behçet's syndrome. Open
Interferon-gamma (IFN-gamma) production by peripheral blood mononuclear cells (MNC) from patients with Behçet's syndrome was compared with production by MNC from control donors. There was no evidence of significant spontaneous production o…
View article: Interferon system in patients with systemic juvenile chronic arthritis: in vivo and in vitro studies.
Interferon system in patients with systemic juvenile chronic arthritis: in vivo and in vitro studies. Open
Eighteen patients with active systemic juvenile chronic arthritis (JCA) were studied for periods of up to 1 year to see whether any relationships existed between the interferon (IFN) response, the course of the underlying disease and inter…