Ying‐Huang Tsai
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View article: Benefit of dual bronchodilator therapy on exacerbations in former and current smokers with chronic obstructive pulmonary disease in real-world clinical practice: a multicenter validation study (TOReTO)
Benefit of dual bronchodilator therapy on exacerbations in former and current smokers with chronic obstructive pulmonary disease in real-world clinical practice: a multicenter validation study (TOReTO) Open
View article: Invasive pulmonary aspergillosis among patients with severe community-acquired pneumonia and influenza in ICUs: a retrospective cohort study
Invasive pulmonary aspergillosis among patients with severe community-acquired pneumonia and influenza in ICUs: a retrospective cohort study Open
Rationale The prevalence, clinical characteristics, and outcomes of invasive pulmonary aspergillosis in patients with severe community-acquired pneumonia (CAP) in intensive care units remain underestimated because of the lack of a disease-…
View article: Associations between severe influenza-complicated thromboembolism events, intensive care unit stays and mortality, and associated risk factors: a retrospective cohort study
Associations between severe influenza-complicated thromboembolism events, intensive care unit stays and mortality, and associated risk factors: a retrospective cohort study Open
Background: Compelling evidence suggests associations between influenza infection and thromboembolism (TE) events. Risk factors related to the outcomes of severe influenza-complicated TE in intensive care unit (ICU) patients remain unknown…
View article: Serum vascular endothelial growth factor affects tissue fluid accumulation and is associated with deteriorating tissue perfusion and oxygenation in severe sepsis: a prospective observational study
Serum vascular endothelial growth factor affects tissue fluid accumulation and is associated with deteriorating tissue perfusion and oxygenation in severe sepsis: a prospective observational study Open
View article: Data from <i>EGFR</i> L858R Mutation and Polymorphisms of Genes Related to Estrogen Biosynthesis and Metabolism in Never-Smoking Female Lung Adenocarcinoma Patients
Data from <i>EGFR</i> L858R Mutation and Polymorphisms of Genes Related to Estrogen Biosynthesis and Metabolism in Never-Smoking Female Lung Adenocarcinoma Patients Open
Purpose: To assess whether polymorphisms of genes related to estrogen biosynthesis and metabolism are associated with EGFR mutations.Experimental Design: We studied 617 patients with lung adenocarcinoma, including 302 …
View article: Data from <i>EGFR</i> L858R Mutation and Polymorphisms of Genes Related to Estrogen Biosynthesis and Metabolism in Never-Smoking Female Lung Adenocarcinoma Patients
Data from <i>EGFR</i> L858R Mutation and Polymorphisms of Genes Related to Estrogen Biosynthesis and Metabolism in Never-Smoking Female Lung Adenocarcinoma Patients Open
Purpose: To assess whether polymorphisms of genes related to estrogen biosynthesis and metabolism are associated with EGFR mutations.Experimental Design: We studied 617 patients with lung adenocarcinoma, including 302 …
View article: Supplementary Data from <i>EGFR</i> L858R Mutation and Polymorphisms of Genes Related to Estrogen Biosynthesis and Metabolism in Never-Smoking Female Lung Adenocarcinoma Patients
Supplementary Data from <i>EGFR</i> L858R Mutation and Polymorphisms of Genes Related to Estrogen Biosynthesis and Metabolism in Never-Smoking Female Lung Adenocarcinoma Patients Open
Supplementary Methods; Supplementary Table S1.
View article: Supplementary Data from <i>EGFR</i> L858R Mutation and Polymorphisms of Genes Related to Estrogen Biosynthesis and Metabolism in Never-Smoking Female Lung Adenocarcinoma Patients
Supplementary Data from <i>EGFR</i> L858R Mutation and Polymorphisms of Genes Related to Estrogen Biosynthesis and Metabolism in Never-Smoking Female Lung Adenocarcinoma Patients Open
Supplementary Methods; Supplementary Table S1.
View article: Serum vascular endothelial growth factor independently affects tissue fluid accumulation and is related to deteriorating tissue perfusion and oxygenation in severe sepsis: a prospective observational study
Serum vascular endothelial growth factor independently affects tissue fluid accumulation and is related to deteriorating tissue perfusion and oxygenation in severe sepsis: a prospective observational study Open
Background: Positive fluid balance and tissue fluid accumulation are associated with adverse outcomes in sepsis. Vascular endothelial growth factor (VEGF) increases in sepsis, promotes vascular permeability, and may affect tissue fluid acc…
View article: The impacts of bacterial co-infections and secondary bacterial infections on patients with severe influenza pneumonitis admitted to the intensive care units
The impacts of bacterial co-infections and secondary bacterial infections on patients with severe influenza pneumonitis admitted to the intensive care units Open
High rates of drug-resistant bacterial co-infections and secondary bacterial infections were identified in patients with severe influenza pneumonitis requiring ICU care and were associated with more morbidity in these patients.
View article: Increased tissue water in patients with severe sepsis affects tissue oxygenation measured by near-infrared spectroscopy: a prospective, observational case-control study
Increased tissue water in patients with severe sepsis affects tissue oxygenation measured by near-infrared spectroscopy: a prospective, observational case-control study Open
NIRS can be used to quantify tissue H2O. Severe sepsis patients have increased tissue H2O, which responds to changes in arterial blood pressure and affects tissue oxygenation.
View article: Comparing Clinical Outcomes of Tiotropium/Olodaterol, Umeclidinium/Vilanterol, and Indacaterol/Glycopyrronium Fixed-Dose Combination Therapy in Patients with Chronic Obstructive Pulmonary Disease in Taiwan: A Multicenter Cohort Study
Comparing Clinical Outcomes of Tiotropium/Olodaterol, Umeclidinium/Vilanterol, and Indacaterol/Glycopyrronium Fixed-Dose Combination Therapy in Patients with Chronic Obstructive Pulmonary Disease in Taiwan: A Multicenter Cohort Study Open
This study presented valuable real-world outcome in terms of exacerbation and treatment response of COPD patients treated with fixed-dose LABA/LAMA regimens in Taiwan. The annualized rates of moderate-to-severe exacerbation in patients rec…
View article: The potential and limitation of targeted chromosomal breakpoint sequencing for the <i>ROS1</i> fusion gene identification in lung cancer.
The potential and limitation of targeted chromosomal breakpoint sequencing for the <i>ROS1</i> fusion gene identification in lung cancer. Open
ROS1 fusion genes are rare but important driver genes in lung cancer. Owing to their rarity, many clinicopathological features and treatment responses for each ROS1 fusion variant are still largely unknown and require further…
View article: Programmed Death Ligand 2 Gene Polymorphisms Are Associated With Lung Adenocarcinoma Risk in Female Never-Smokers
Programmed Death Ligand 2 Gene Polymorphisms Are Associated With Lung Adenocarcinoma Risk in Female Never-Smokers Open
Objectives Lung cancer in never-smokers is a distinct disease associated with a different genomic landscape, pathogenesis, risk factors, and immune checkpoint inhibitor responses compared to those observed in smokers. This study aimed to i…
View article: Total Sleep Time in the Taiwan Obstructive Lung Disease Cohort
Total Sleep Time in the Taiwan Obstructive Lung Disease Cohort Open
Patients with chronic obstructive pulmonary disease (COPD) have been reported to have poor sleep quality. However, total sleep time has not been evaluated in detail among patients with COPD. This retrospective, observational, multicenter r…
View article: Epigenome-wide association study on asthma and chronic obstructive pulmonary disease overlap reveals aberrant DNA methylations related to clinical phenotypes
Epigenome-wide association study on asthma and chronic obstructive pulmonary disease overlap reveals aberrant DNA methylations related to clinical phenotypes Open
View article: Incidence of nontuberculous mycobacterial disease and coinfection with tuberculosis in a tuberculosis-endemic region
Incidence of nontuberculous mycobacterial disease and coinfection with tuberculosis in a tuberculosis-endemic region Open
Nontuberculous mycobacteria (NTM) infection may interfere in the diagnosis and treatment of tuberculosis (TB) in TB-endemic regions. However, the population-based incidence of NTM disease and NTM–TB coinfection remains unclear. We used Tai…
View article: Effect of high flow nasal cannula on peripheral muscle oxygenation and hemodynamic during paddling exercise in patients with chronic obstructive pulmonary disease: a randomized controlled trial
Effect of high flow nasal cannula on peripheral muscle oxygenation and hemodynamic during paddling exercise in patients with chronic obstructive pulmonary disease: a randomized controlled trial Open
HFNC, with a lower oxygen concentration than that used with a traditional NC, yielded lower deoxygenated hemoglobin levels after 12 suboptimal exercise training sessions. In contrast, the higher oxygen concentration delivered by NC reduced…
View article: Improved appropriateness of anti-tuberculosis prescription by the expert prescription review program in Taiwan
Improved appropriateness of anti-tuberculosis prescription by the expert prescription review program in Taiwan Open
View article: Comparative Analysis of Two Methods for the Detection of EGFR Mutations in Plasma Circulating Tumor DNA from Lung Adenocarcinoma Patients
Comparative Analysis of Two Methods for the Detection of EGFR Mutations in Plasma Circulating Tumor DNA from Lung Adenocarcinoma Patients Open
Mutations in the epidermal growth factor receptor (EGFR) are associated with various solid tumors. This study aimed to compare two methods for the detection of EGFR mutations in circulating tumor DNA (ctDNA) from lung adenocarcinoma (LUAD)…
View article: Metformin Prolongs Survival in Type 2 Diabetes Lung Cancer Patients With EGFR-TKIs
Metformin Prolongs Survival in Type 2 Diabetes Lung Cancer Patients With EGFR-TKIs Open
Background: Metformin use reportedly reduces cancer risk and improves survival in lung cancer patients. This study aimed to investigate the effect of metformin use in patients with diabetes mellitus (DM) and lung cancer receiving epidermal…
View article: The Risk of Latent Tuberculosis Infection in Respiratory Therapists in a Country with Intermediate Incidence
The Risk of Latent Tuberculosis Infection in Respiratory Therapists in a Country with Intermediate Incidence Open
RTs had no higher risk for latent TB infection than other HCWs in a country with intermediate TB incidence.
View article: The impact of 2011 and 2017 Global Initiative for Chronic Obstructive Pulmonary Disease (GOLD) guidelines on allocation and pharmacological management of patients with COPD in Taiwan: Taiwan Obstructive Lung Disease (TOLD) study
The impact of 2011 and 2017 Global Initiative for Chronic Obstructive Pulmonary Disease (GOLD) guidelines on allocation and pharmacological management of patients with COPD in Taiwan: Taiwan Obstructive Lung Disease (TOLD) study Open
The distribution of COPD patients in Taiwan was more uneven with the GOLD 2017 than with the GOLD 2011. A pharmacological discordance to the guidelines was identified. Updated guidelines with reclassification of COPD patients resulted in m…
View article: Recovery of pulmonary functions, exercise capacity, and quality of life after pulmonary rehabilitation in survivors of <scp>ARDS</scp> due to severe influenza A (H1N1) pneumonitis
Recovery of pulmonary functions, exercise capacity, and quality of life after pulmonary rehabilitation in survivors of <span>ARDS</span> due to severe influenza A (H1N1) pneumonitis Open
Background Acute respiratory distress syndrome ( ARDS ) due to severe influenza A H1N1 pneumonitis would result in impaired pulmonary functions and health‐related quality of life ( HRQ oL) after hospital discharge. Objectives The recovery …
View article: Survival benefit associated with metformin use in inoperable non-small cell lung cancer patients with diabetes: A population-based retrospective cohort study
Survival benefit associated with metformin use in inoperable non-small cell lung cancer patients with diabetes: A population-based retrospective cohort study Open
Metformin use is associated with longer OS in inoperable NSCLC patients with diabetes, suggesting a potential anti-tumorigenic effect for metformin. Further research is needed to investigate the actual role of metformin in the treatment of…
View article: Chang Gung Research Database: A multi-institutional database consisting of original medical records
Chang Gung Research Database: A multi-institutional database consisting of original medical records Open
The CGRD is a multi-institutional, original medical record-based research database with high overall and disease-specific coverage of Taiwan. The population of the CGRD has significantly higher severity of comorbidities, and prevalence of …
View article: Impact of hypertrophic pulmonary osteoarthropathy on patients with lung cancer
Impact of hypertrophic pulmonary osteoarthropathy on patients with lung cancer Open
Male, smoking, and adenocarcinoma were the most common clinical characteristics of lung cancer patients with HPOA in our cohort. However, the proportion of EGFR-TKI-sensitive mutation cases was extremely low.
View article: Trends in health care resource utilization and pharmacological management of COPD in Taiwan from 2004 to 2010
Trends in health care resource utilization and pharmacological management of COPD in Taiwan from 2004 to 2010 Open
From 2004 to 2010, the average total medical cost per patient of COPD was slightly decreased because of the decreased average number of hospital admissions and ICU admissions. The costs of both LAMA and LABA/ICS increased, while the cost f…
View article: Impact of overweight and obesity on acute exacerbations of COPD &ndash; subgroup analysis of the Taiwan Obstructive Lung Disease cohort
Impact of overweight and obesity on acute exacerbations of COPD – subgroup analysis of the Taiwan Obstructive Lung Disease cohort Open
Our results suggest that overweight and obesity are associated with a lower frequency of COPD exacerbations in Taiwan.
View article: Incidence and risk factors of depression after diagnosis of lung cancer
Incidence and risk factors of depression after diagnosis of lung cancer Open
This study aimed to explore the incidence and risk factors of depression after lung cancer diagnosis. Using the Taiwan National Health Insurance Research Database (NHIRD), incidences and risk factors of depression in lung cancer and nonlun…