Yi Lu
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View article: Harnessing Photoenzymatic Systems for Intermolecular C–H Fluorination
Harnessing Photoenzymatic Systems for Intermolecular C–H Fluorination Open
Organofluorine compounds are vital in pharmaceuticals, and enzymes, nature's most efficient catalysts, offer tremendous potential for precise fluorination. However, no enzymatic strategies for intermolecular C–H fluorination have been real…
View article: TLyp-1-modified exosome–mediated delivery of circRAPGEF5 ASO inhibits lung adenocarcinoma metastasis via regulating the miR-570-3p/SPP1 axis
TLyp-1-modified exosome–mediated delivery of circRAPGEF5 ASO inhibits lung adenocarcinoma metastasis via regulating the miR-570-3p/SPP1 axis Open
Exosome circRAPGEF5 promotes lung adenocarcinoma (LUAD) metastasis and may serve as an intervention target, but its mechanism of action is unclear. Consequently, using engineered exosomal preparations of circular RNAs for delivery into tum…
View article: Significance of circular RNAs in regulating protein ubiquitination for malignant tumor progression
Significance of circular RNAs in regulating protein ubiquitination for malignant tumor progression Open
CircRNAs are an important class of non-coding RNAs, which are produced via back-splicing of exons and/or intron sequences of precursor mRNAs and generally cannot be translated into proteins as they do not bind to ribosomes. There is varyin…
View article: Targeting SREBP-dependent lipogenesis potentiates the anti-tumor activity of docetaxel by increasing membrane permeability and intracellular drug accumulation
Targeting SREBP-dependent lipogenesis potentiates the anti-tumor activity of docetaxel by increasing membrane permeability and intracellular drug accumulation Open
Lipid metabolism is among the most frequently dysregulated metabolic processes in human cancer, yet how cellular lipids, the end products of lipogenesis, and their composition are altered to support various aspects of cancer remains poorly…
View article: Correction: Crosstalk between hypoxia-inducible factor (HIF) and lncRNAs in digestive tumors: from molecular mechanisms to clinical translation
Correction: Crosstalk between hypoxia-inducible factor (HIF) and lncRNAs in digestive tumors: from molecular mechanisms to clinical translation Open
[This corrects the article DOI: 10.3389/fcell.2025.1611889.].
View article: Unveiling an Ultrareduced State of Heme in Myoglobin
Unveiling an Ultrareduced State of Heme in Myoglobin Open
Heme proteins are essential metalloproteins with diverse biological roles, and these functions are facilitated by the heme's ability to adopt multiple oxidation states, with Fe(II), Fe(III), and Fe(IV) being the most commonly observed. Whi…
View article: Comparing Perioperative Outcomes of Robotic-Assisted Versus Laparoscopic Liver Resection in Patients with Hepatocellular Carcinoma
Comparing Perioperative Outcomes of Robotic-Assisted Versus Laparoscopic Liver Resection in Patients with Hepatocellular Carcinoma Open
Background: Despite the implementation of laparoscopic and robotic-assisted liver resection (LLR vs. RLR) in many centers, there remains controversy surrounding the differences in perioperative outcomes between the two approaches. This stu…
View article: PCR‐Free Site‐Directed Mutagenesis on Repetitive Sequences Using Single‐Stranded DNA‐Assisted Double‐Stranded DNA Nicking by DNAzymes
PCR‐Free Site‐Directed Mutagenesis on Repetitive Sequences Using Single‐Stranded DNA‐Assisted Double‐Stranded DNA Nicking by DNAzymes Open
Site‐directed mutagenesis (SDM) is a key driver for many biochemical investigations and biotechnological applications. Despite decades of development, it is still difficult to perform SDM on some sequences, including highly repetitive ones…
View article: MicroRNA-145 in urologic tumors: biological roles, regulatory networks, and clinical translation
MicroRNA-145 in urologic tumors: biological roles, regulatory networks, and clinical translation Open
Tumors of the urinary system primarily encompass prostate, bladder, and kidney cancers, which exhibit high morbidity and mortality rates worldwide and pose a particularly significant threat to men’s health. Given the associated high morbid…
View article: Tandem ssDNA in neutrophil extracellular traps binds thrombin and regulates immunothrombosis
Tandem ssDNA in neutrophil extracellular traps binds thrombin and regulates immunothrombosis Open
Neutrophils release neutrophil extracellular traps (NETs) to neutralize infections, a process that also contributes to immunothrombosis. While beneficial in localized infections, excessive NET formation can lead to widespread coagulopathy …
View article: [A study on the predictive model of porous hyperelastic properties of human alveolar bone based on computed tomography imaging].
[A study on the predictive model of porous hyperelastic properties of human alveolar bone based on computed tomography imaging]. Open
Alveolar bone reconstruction simulation is an effective means for quantifying orthodontics, but currently, it is not possible to directly obtain human alveolar bone material models for simulation. This study introduces a prediction method …
View article: A New Pallet-Positioning Method Based on a Lightweight Component Segmentation Network for AGV Toward Intelligent Warehousing
A New Pallet-Positioning Method Based on a Lightweight Component Segmentation Network for AGV Toward Intelligent Warehousing Open
In human–robot hybrid intelligent warehouses, pallets often come in various shapes and sizes, posing challenges for AGVs to automate pallet picking. This, in turn, reduces the overall operational efficiency of the warehouse. To address thi…
View article: Signal Transduction Strategies for DNAzyme-Based Sensing and Imaging of Metal Ions in Cells and <i>in Vivo</i>
Signal Transduction Strategies for DNAzyme-Based Sensing and Imaging of Metal Ions in Cells and <i>in Vivo</i> Open
Metal ions play crucial roles in biological processes, and their dysregulation can lead to various diseases. Understanding the distribution of these metal ions provides deeper insight into their roles in both health and disease. DNAzymes o…
View article: Synthetic transmembrane DNA receptors enable engineered sensing and actuation
Synthetic transmembrane DNA receptors enable engineered sensing and actuation Open
In living organisms, cells synergistically couple cascade reaction pathways to achieve inter- and intracellular signal transduction by transmembrane protein receptors. The construction and assembly of synthetic receptor analogs that can mi…
View article: Formulation of Hyperelastic Constitutive Model for Human Periodontal Ligament Based on Fiber Volume Fraction
Formulation of Hyperelastic Constitutive Model for Human Periodontal Ligament Based on Fiber Volume Fraction Open
Collagen fibers of the Periodontal ligament (PDL) play a crucial role in determining its mechanical properties. Based on this premise, we investigated the effect of the volume fraction of human PDL collagen fibers on the hyperelastic mecha…
View article: Protein phosphatase EYA1 regulates the dephosphorylation and turnover of BCL2L12 to promote glioma development
Protein phosphatase EYA1 regulates the dephosphorylation and turnover of BCL2L12 to promote glioma development Open
Glioma is the most prevalent and deadly type of intracranial tumor. Understanding the molecular drivers and their underlying mechanisms in glioma development is urgently needed. EYA1 is a unique protein phosphatase that drives gliomagenesi…
View article: Elucidating the synergistic action between sulfonated lignin and lytic polysaccharide monooxygenases (LPMOs) in enhancing cellulose hydrolysis
Elucidating the synergistic action between sulfonated lignin and lytic polysaccharide monooxygenases (LPMOs) in enhancing cellulose hydrolysis Open
Modern enzyme cocktails often include lytic polysaccharide monooxygenase (LPMO) as an accessory enzyme that enhances cellulose accessibility during hydrolysis. Although lignin is known to generally impede cellulose hydrolysis, previous res…
View article: Highly selective DNA aptamer sensor for intracellular detection of coenzyme A
Highly selective DNA aptamer sensor for intracellular detection of coenzyme A Open
DNA aptamers struggle to detect CoA due to the dominance of adenosine in SELEX. Using capture SELEX with rigorous counter selections, a CoA-specific aptamer is obtained and converted to a fluorescent sensor, allowing visualizing CoA in liv…
View article: Unexpected effect of an axial ligand mutation in the type 1 copper center in small laccase: structure-based analyses and engineering to increase reduction potential and activity
Unexpected effect of an axial ligand mutation in the type 1 copper center in small laccase: structure-based analyses and engineering to increase reduction potential and activity Open
A mutation of the axial methionine to leucine unexpectedly lowered the reduction potential of type 1 copper in small laccase, attributable to the presence of water. Two additional mutations removed the water, increasing the potential and a…
View article: Genetically Encoded Fluorogenic DNA Aptamers for Imaging Metabolite in Living Cells
Genetically Encoded Fluorogenic DNA Aptamers for Imaging Metabolite in Living Cells Open
Genetically encoded fluorescent protein and fluorogenic RNA sensors are indispensable tools for imaging biomolecules in cells. To expand the toolboxes and improve the generalizability and stability of this type of sensor, we report herein …
View article: Deciphering Iron Redox Changes in Alzheimer’s Disease using DNAzyme Sensors that can Simultaneously Monitor Fe<sup>2+</sup> and Fe<sup>3+</sup>
Deciphering Iron Redox Changes in Alzheimer’s Disease using DNAzyme Sensors that can Simultaneously Monitor Fe<sup>2+</sup> and Fe<sup>3+</sup> Open
Background Imbalanced Fe levels can lead to oxidative stress and initiate ferroptosis, an Fe‐dependent cell death that involves lipid peroxidation and can lead to neuron cell loss in neurodegenerative diseases including Alzheimer’s disease…
View article: Mixture of Experts Fusion for Fake Audio Detection Using Frozen wav2vec 2.0
Mixture of Experts Fusion for Fake Audio Detection Using Frozen wav2vec 2.0 Open
Speech synthesis technology has posed a serious threat to speaker verification systems. Currently, the most effective fake audio detection methods utilize pretrained models, and integrating features from various layers of pretrained model …
View article: A Noval Feature via Color Quantisation for Fake Audio Detection
A Noval Feature via Color Quantisation for Fake Audio Detection Open
In the field of deepfake detection, previous studies focus on using reconstruction or mask and prediction methods to train pre-trained models, which are then transferred to fake audio detection training where the encoder is used to extract…
View article: Delivering DNA Aptamers Across the Blood–Brain Barrier Reveals Heterogeneous Decreased ATP in Different Brain Regions of Alzheimer’s Disease Mouse Models
Delivering DNA Aptamers Across the Blood–Brain Barrier Reveals Heterogeneous Decreased ATP in Different Brain Regions of Alzheimer’s Disease Mouse Models Open
DNA aptamers have been developed as sensors to detect metabolites with high sensitivity, selectivity, and biocompatibility. While they are effective in sensing important targets in the brain, the lack of methods for their efficient deliver…
View article: Detecting mir-155-3p through a Molecular Beacon Bead-Based Assay
Detecting mir-155-3p through a Molecular Beacon Bead-Based Assay Open
Lung cancer (LC) is recognized as one of the most prevalent and lethal cancers worldwide, underscoring an urgent need for innovative diagnostic and therapeutic approaches. MicroRNAs (miRNAs) have emerged as promising biomarkers for several…
View article: Tumor-intrinsic P2RY6 drives immunosuppression by enhancing PGE2 production
Tumor-intrinsic P2RY6 drives immunosuppression by enhancing PGE2 production Open
Despite the success of anti-programmed cell death-1 (anti-PD-1) immunotherapy, many cancer patients remain unresponsive, and reliable predictive biomarkers are lacking. Here, we show that aberrant expression of the pyrimidinergic receptor …