Tsitsi Apollo
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View article: Cost-effectiveness of Zvandiri, a community-based support intervention to reduce virological failure in adolescents living with HIV in Zimbabwe: Results of a decision analytical model
Cost-effectiveness of Zvandiri, a community-based support intervention to reduce virological failure in adolescents living with HIV in Zimbabwe: Results of a decision analytical model Open
Improving antiretroviral therapy (ART) adherence among adolescents living with HIV (ALHIV) improves outcomes, but with resource implications. We conducted a cost-effectiveness analysis extrapolating the costs and benefits of a community-ba…
View article: Uptake of community-based integrated HIV and sexual and reproductive health services for young people in Zimbabwe: the CHIEDZA study
Uptake of community-based integrated HIV and sexual and reproductive health services for young people in Zimbabwe: the CHIEDZA study Open
Introduction Limited engagement with health services contributes to the poorer HIV care outcomes observed in young people. We conducted a cluster-randomised trial to investigate the impact of community-based integrated HIV and sexual and r…
View article: HIV Testing Uptake in a Sexual and Reproductive Health Service for Youth and Impact on Population-Level Prevalence of Undiagnosed HIV in Zimbabwe
HIV Testing Uptake in a Sexual and Reproductive Health Service for Youth and Impact on Population-Level Prevalence of Undiagnosed HIV in Zimbabwe Open
Although community-based integrated HIV/SRH achieved high HIV testing uptake, there was no impact on population-level prevalence of undiagnosed HIV. Concerted efforts are needed to identify and reach those at highest risk, and to address s…
View article: Trends in the incidence of cancers related to HIV-AIDS in Harare, Zimbabwe 1990-2019
Trends in the incidence of cancers related to HIV-AIDS in Harare, Zimbabwe 1990-2019 Open
Background HIV prevalence in Harare reached a maximum of around 33% of adults in 1995, before falling to 12% in 2019. We examine trends in the incidence of Kaposi sarcoma (KS), non-Hodgkin lymphoma (NHL), Hodgkin lymphoma, and squamous cel…
View article: Evaluation of antiretroviral regimen switching options in adults with HIV with sustained viral load non-suppression on dolutegravir, lamivudine, and tenofovir in eastern, central, southern, and western Africa: a modelling study
Evaluation of antiretroviral regimen switching options in adults with HIV with sustained viral load non-suppression on dolutegravir, lamivudine, and tenofovir in eastern, central, southern, and western Africa: a modelling study Open
Gates Foundation as part of the HIV Modelling Consortium.
View article: Integrated community-based HIV and sexual and reproductive health services for youth: a cluster-randomized trial
Integrated community-based HIV and sexual and reproductive health services for youth: a cluster-randomized trial Open
Human immunodeficiency virus (HIV) viral suppression rates are disproportionately worse in youth compared to other age groups, and improving this will require addressing the whole HIV cascade, including HIV testing, linkage to care and sup…
View article: Use of biometrics to evaluate intervention coverage and contamination in a cluster randomised trial in Zimbabwe
Use of biometrics to evaluate intervention coverage and contamination in a cluster randomised trial in Zimbabwe Open
Introduction Low intervention uptake and contamination can dilute effects of cluster randomised trials (CRTs) but can be difficult to assess. We investigated the feasibility of digital fingerprints to assess intervention coverage and conta…
View article: Awareness, access to and uptake of HIV prevention interventions among youth in Zimbabwe: a population-based survey
Awareness, access to and uptake of HIV prevention interventions among youth in Zimbabwe: a population-based survey Open
View article: An evaluation of a choice architecture-based intervention on prescribing of TB preventive treatment to people living with HIV in southern Africa (the CAT study): a cluster-randomised trial
An evaluation of a choice architecture-based intervention on prescribing of TB preventive treatment to people living with HIV in southern Africa (the CAT study): a cluster-randomised trial Open
Introduction While highly effective for reducing the risk of tuberculosis (TB) disease, TB preventive treatment (TPT) is underused among people living with HIV (PWH). We evaluated the effectiveness of a behavioural economics-based choice a…
View article: HIV Testing During Systematic Screening for Tuberculosis Among Household Contacts Inhigh-Tuberculosis Burden Settings: A Systematic Review and Meta-Analysis
HIV Testing During Systematic Screening for Tuberculosis Among Household Contacts Inhigh-Tuberculosis Burden Settings: A Systematic Review and Meta-Analysis Open
View article: Uptake of community-based integrated HIV and sexual and reproductive health services for youth in Zimbabwe
Uptake of community-based integrated HIV and sexual and reproductive health services for youth in Zimbabwe Open
Introduction: Limited engagement with health services contributes to the poorer HIV care outcomes observed in youth. We conducted a cluster-randomised trial to investigate the impact of community-based integrated HIV and sexual and reprodu…
View article: Tuberculosis preventive treatment uptake among adults living with human immunodeficiency virus: Analysis of Zimbabwe population-based human immunodeficiency virus impact assessment 2020
Tuberculosis preventive treatment uptake among adults living with human immunodeficiency virus: Analysis of Zimbabwe population-based human immunodeficiency virus impact assessment 2020 Open
Background Tuberculosis remains the leading cause of death by an infectious disease among people living with HIV (PLHIV). TB Preventive Treatment (TPT) is a cost-effective intervention known to reduce morbidity and mortality. We used data …
View article: HIV Incidence and Prevalence Projections for Zimbabwe: Findings from Five Mathematical Models
HIV Incidence and Prevalence Projections for Zimbabwe: Findings from Five Mathematical Models Open
View article: Adolescents and young adults are the most undiagnosed of HIV and virally unsuppressed in Eastern and Southern Africa: Pooled analyses from five population-based surveys
Adolescents and young adults are the most undiagnosed of HIV and virally unsuppressed in Eastern and Southern Africa: Pooled analyses from five population-based surveys Open
Age and gender disparities within the HIV cascade of care are critical to focus interventions efficiently. We assessed gender-age groups at the highest probability of unfavorable outcomes in the HIV cascade in five HIV prevalent settings. …
View article: The impact of community-based integrated HIV and sexual and reproductive health services for youth on population-level HIV viral load and sexually transmitted infections in Zimbabwe: protocol for the CHIEDZA cluster-randomised trial
The impact of community-based integrated HIV and sexual and reproductive health services for youth on population-level HIV viral load and sexually transmitted infections in Zimbabwe: protocol for the CHIEDZA cluster-randomised trial Open
Background Youth have poorer HIV-related outcomes when compared to other age-groups. We describe the protocol for a cluster randomised trial (CRT) to evaluate the effectiveness of community-based, integrated HIV and sexual and reproductive…
View article: Neuropsychiatric manifestations and sleep disturbances with dolutegravir-based antiretroviral therapy versus standard of care in children and adolescents: a secondary analysis of the ODYSSEY trial
Neuropsychiatric manifestations and sleep disturbances with dolutegravir-based antiretroviral therapy versus standard of care in children and adolescents: a secondary analysis of the ODYSSEY trial Open
View article: Integrating 3HP‐based tuberculosis preventive treatment into Zimbabwe's Fast Track HIV treatment model: experiences from a pilot study
Integrating 3HP‐based tuberculosis preventive treatment into Zimbabwe's Fast Track HIV treatment model: experiences from a pilot study Open
Introduction Tuberculosis (TB) causes one‐third of HIV‐related deaths worldwide, making TB preventive treatment (TPT) a critical element of HIV programmes. Approximately 16% of people living with HIV (PLHIV) on antiretrovirals in Zimbabwe …
View article: Fidelity, Feasibility and Adaptation of a Family Planning Intervention for Young Women in Zimbabwe: Provider Perspectives and Experiences
Fidelity, Feasibility and Adaptation of a Family Planning Intervention for Young Women in Zimbabwe: Provider Perspectives and Experiences Open
View article: Cost-effectiveness of voluntary medical male circumcision for HIV prevention across sub-Saharan Africa: results from five independent models
Cost-effectiveness of voluntary medical male circumcision for HIV prevention across sub-Saharan Africa: results from five independent models Open
View article: Economic implications of COVID-19 for the HIV epidemic and the response in Zimbabwe
Economic implications of COVID-19 for the HIV epidemic and the response in Zimbabwe Open
Understanding the economic implications of COVID-19 for the HIV epidemic and response is critical for designing policies and strategies to effectively sustain past gains and accelerate progress to end these colliding pandemics. While consi…
View article: Putting youth at the centre: co-design of a community-based intervention to improve HIV outcomes among youth in Zimbabwe
Putting youth at the centre: co-design of a community-based intervention to improve HIV outcomes among youth in Zimbabwe Open
Background Youth have disproportionately poor HIV outcomes. We aimed to co-design a community-based intervention with youth to improve HIV outcomes among 16-24 year-olds, to be trialled in Zimbabwe. Methods We conducted 90 in-depth inter…
View article: Process evaluation of an intervention to improve HIV treatment outcomes among children and adolescents
Process evaluation of an intervention to improve HIV treatment outcomes among children and adolescents Open
SETTING: Children and adolescents with HIV encounter challenges in initiation and adherence to antiretroviral therapy (ART). A community-based support intervention of structured home visits, aimed at improving initiation, adherence and tre…
View article: Once-daily dolutegravir-based antiretroviral therapy in infants and children living with HIV from age 4 weeks: results from the below 14 kg cohort in the randomised ODYSSEY trial
Once-daily dolutegravir-based antiretroviral therapy in infants and children living with HIV from age 4 weeks: results from the below 14 kg cohort in the randomised ODYSSEY trial Open
View article: Dolutegravir twice-daily dosing in children with HIV-associated tuberculosis: a pharmacokinetic and safety study within the open-label, multicentre, randomised, non-inferiority ODYSSEY trial
Dolutegravir twice-daily dosing in children with HIV-associated tuberculosis: a pharmacokinetic and safety study within the open-label, multicentre, randomised, non-inferiority ODYSSEY trial Open
Penta Foundation, ViiV Healthcare, UK Medical Research Council.
View article: Virological outcomes and risk factors for non-suppression for routine and repeat viral load testing after enhanced adherence counselling during viral load testing scale-up in Zimbabwe: analytic cross-sectional study using laboratory data from 2014 to 2018
Virological outcomes and risk factors for non-suppression for routine and repeat viral load testing after enhanced adherence counselling during viral load testing scale-up in Zimbabwe: analytic cross-sectional study using laboratory data from 2014 to 2018 Open
View article: Interrupted Access to and Use of Family Planning Among Youth in a Community‐Based Service in Zimbabwe During the First Year of the COVID‐19 Pandemic
Interrupted Access to and Use of Family Planning Among Youth in a Community‐Based Service in Zimbabwe During the First Year of the COVID‐19 Pandemic Open
The COVID‐19 pandemic has had serious impacts on economic, social, and health systems, and fragile public health systems have become overburdened in many countries, exacerbating existing service delivery challenges. This study describes th…
View article: Family Planning Experiences and Needs of Young Women Living With and Without HIV Accessing an Integrated HIV and SRH Intervention in Zimbabwe-An Exploratory Qualitative Study
Family Planning Experiences and Needs of Young Women Living With and Without HIV Accessing an Integrated HIV and SRH Intervention in Zimbabwe-An Exploratory Qualitative Study Open
Background People living with HIV have higher unmet family planning needs compared to those without HIV. This is heightened for young people. However, the provision of family planning for young people within HIV programmes is uncommon. We …
View article: “Other risks don't stop”: adapting a youth sexual and reproductive health intervention in Zimbabwe during COVID-19
“Other risks don't stop”: adapting a youth sexual and reproductive health intervention in Zimbabwe during COVID-19 Open
COVID-19 threatens hard-won gains in sexual and reproductive health (SRH) through compromising the ability of services to meet needs. Youth are particularly threatened due to existing barriers to their access to services. CHIEDZA is a comm…
View article: The impact of community-based integrated HIV and sexual and reproductive health services for youth on population-level HIV viral load and sexually transmitted infections in Zimbabwe: protocol for the CHIEDZA cluster-randomised trial
The impact of community-based integrated HIV and sexual and reproductive health services for youth on population-level HIV viral load and sexually transmitted infections in Zimbabwe: protocol for the CHIEDZA cluster-randomised trial Open
Background: Youth have poorer HIV-related outcomes when compared to other age-groups. We describe the protocol for a cluster randomised trial (CRT) to evaluate the effectiveness of community-based, integrated HIV and sexual and reproductiv…
View article: Putting youth at the centre: co-design of a community-based intervention to improve HIV outcomes among youth in Zimbabwe
Putting youth at the centre: co-design of a community-based intervention to improve HIV outcomes among youth in Zimbabwe Open
Background Youth have disproportionately poor HIV outcomes. We aimed to co-design a community-based intervention with youth to improve HIV outcomes among 16-24 year-olds, to be trialled in Zimbabwe. Methods We conducted 90 in-depth inter…