Sophia Tsong Huey Chew
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View article: Effect of preoperative rapamycin supplementation on perioperative clinical frailty and cognitive performance in a murine model undergoing anesthesia and surgery
Effect of preoperative rapamycin supplementation on perioperative clinical frailty and cognitive performance in a murine model undergoing anesthesia and surgery Open
View article: Difficult Lung Isolation in a Heavy Smoker With a History of Left Lower Lobectomy: A Case Report
Difficult Lung Isolation in a Heavy Smoker With a History of Left Lower Lobectomy: A Case Report Open
Anatomical changes in the bronchial tree following a left lower lung lobectomy are not well documented in the current literature. Understanding these changes is crucial for selecting the appropriate lung isolation device and achieving opti…
View article: Feasibility of continuous non-invasive delivery of oxygen monitoring in cardiac surgical patients: a proof-of-concept preliminary study
Feasibility of continuous non-invasive delivery of oxygen monitoring in cardiac surgical patients: a proof-of-concept preliminary study Open
View article: Predictors of unplanned hospital readmission after non-cardiac surgery in Singapore: a 2-year retrospective review
Predictors of unplanned hospital readmission after non-cardiac surgery in Singapore: a 2-year retrospective review Open
Introduction Unplanned hospital readmissions after surgery contribute significantly to healthcare costs and potential complications. Identifying predictors of readmission is inherently complex and involves an intricate interplay between me…
View article: Point-of-care platelet function testing for guided transfusion in neurosurgical management of intracranial hemorrhage: a systematic review
Point-of-care platelet function testing for guided transfusion in neurosurgical management of intracranial hemorrhage: a systematic review Open
View article: Point of Care Platelet Function Testing for Guided Transfusion in Neurosurgical Management of Intracranial Hemorrhage: A Systematic Review
Point of Care Platelet Function Testing for Guided Transfusion in Neurosurgical Management of Intracranial Hemorrhage: A Systematic Review Open
Given the rising prevalence of antiplatelet therapy, rapid preoperative identification of patients with bleeding diathesis is necessary for the guidance of blood product administration. This is especially relevant in neurosurgery for intra…
View article: Variant landscape of the RYR1 gene based on whole genome sequencing of the Singaporean population
Variant landscape of the RYR1 gene based on whole genome sequencing of the Singaporean population Open
The RYR1 gene codes for a ryanodine receptor which is a calcium release channel in the skeletal muscle sarcoplasmic reticulum. It is associated with Malignant Hyperthermia (MH) and congenital myopathies including Central Core Disease (CCD)…
View article: Incidence and risk factors of delirium in post-anaesthesia care unit
Incidence and risk factors of delirium in post-anaesthesia care unit Open
Introduction: Post-anaesthesia care unit (PACU) delirium is a potentially preventable condition that results in a significant long-term effect. In a multicentre prospective cohort study, we investigate the incidence and risk factors of pos…
View article: Obstructive fibrinous pseudomembrane tracheitis after double-lumen tube intubation -a case report-
Obstructive fibrinous pseudomembrane tracheitis after double-lumen tube intubation -a case report- Open
Background: Obstructive fibrinous pseudomembrane tracheitis (OFPT) is a rare complication of endotracheal intubation. Case: We describe the case of a 73-year-old woman who underwent short-term intubation for video-assisted thoracoscopic su…
View article: Awareness and Perspectives among Asian Anesthesiologists on Postoperative Delirium: A Multinational Survey
Awareness and Perspectives among Asian Anesthesiologists on Postoperative Delirium: A Multinational Survey Open
Postoperative delirium (POD) is a common perioperative complication. Although POD is preventable in up to 40% of patients, it is frequently overlooked. The objective of the survey is to determine the level of knowledge and clinical practic…
View article: Risk factors of post-anaesthesia care unit delirium in patients undergoing non-cardiac surgery in Singapore
Risk factors of post-anaesthesia care unit delirium in patients undergoing non-cardiac surgery in Singapore Open
Introduction: Post-anaesthesia care unit (PACU) delirium affects 5%–45% of patients after surgery and is associated with postoperative delirium and increased mortality. Up to 40% of PACU delirium is preventable, but it remains under-recogn…
View article: Perioperative temperature management: a survey of 6 Asia–Pacific countries
Perioperative temperature management: a survey of 6 Asia–Pacific countries Open
Background Anesthesia leads to impairments in central and peripheral thermoregulatory responses. Inadvertent perioperative hypothermia is hence a common perioperative complication, and is associated with coagulopathy, increased surgical si…
View article: Variant landscape of the<i>RYR1 gene</i>based on whole genome sequencing of the Singaporean population
Variant landscape of the<i>RYR1 gene</i>based on whole genome sequencing of the Singaporean population Open
Background The RYR1 gene codes for a ryanodine receptor which is a calcium release channel in the skeletal muscle sarcoplasmic reticulum. It is associated with Malignant Hyperthermia (MH) and several congenital myopathies including Central…
View article: A survey of Singapore anaesthesiologists for practice and prevention ofperi-operative hypothermia in adult surgical patients
A survey of Singapore anaesthesiologists for practice and prevention ofperi-operative hypothermia in adult surgical patients Open
Core temperature is the temperature of blood and internal organs; influenced by biorhythm, metabolism, activity and hormones.It is regulated within a narrow range, 1 but this is impaired during general and/or neuraxial anaesthesia.][5] The…
View article: Risk factors and impact of postoperative hyperglycemia in nondiabetic patients after cardiac surgery
Risk factors and impact of postoperative hyperglycemia in nondiabetic patients after cardiac surgery Open
Cardiac surgery induces a significant inflammatory hypermetabolic stress response, resulting in postoperative hyperglycemia in both preoperatively diabetic and nondiabetic patients. Such postoperative hyperglycemia has been associated with…
View article: Research in Anaesthesia – The PEGASUS Journey
Research in Anaesthesia – The PEGASUS Journey Open
I. INTRODUCTION
\nWe never quite know how a scientific journey pans out, or any journey for that matter. What started for us as a scientific quest to better understand local clinical data and practice in cardiac surgery is yielding answers…
View article: Ethnicity and postoperative hyperglycaemia in a South-East Asian population undergoing cardiac surgery
Ethnicity and postoperative hyperglycaemia in a South-East Asian population undergoing cardiac surgery Open
Postoperative hyperglycaemia is a known risk factor of adverse outcomes following cardiac surgery.[1][1] Although South Asian ethnicity is a known risk factor of postoperative hyperglycaemia,[2][2] variances in risk profile between the dif…
View article: Successful use of extracorporeal cardiopulmonary membrane oxygenation in acute severe aortic regurgitation with cardiovascular collapse
Successful use of extracorporeal cardiopulmonary membrane oxygenation in acute severe aortic regurgitation with cardiovascular collapse Open
We report the case of a 55-year-old man who was transferred from an overseas institution with an initial impression of non-ST-elevation myocardial infarction (NSTEMI). Subsequent investigation found a severe aortic regurgitation (AR) compl…
View article: Wider perioperative glycemic fluctuations increase risk of postoperative atrial fibrillation and ICU length of stay
Wider perioperative glycemic fluctuations increase risk of postoperative atrial fibrillation and ICU length of stay Open
Increased magnitudes of acute perioperative glycemic fluctuations are associated with a significantly increased risk of POAF and length of ICU stay; and should therefore be minimised but balanced against the risks of hypoglycemia so as to …
View article: Unanticipated Difficult Laryngoscopy in a Diabetic Patient Undergoing Coronary Artery Bypass Graft Surgery
Unanticipated Difficult Laryngoscopy in a Diabetic Patient Undergoing Coronary Artery Bypass Graft Surgery Open
View article: Acute kidney injury increases the risk of end-stage renal disease after cardiac surgery in an Asian population: a prospective cohort study
Acute kidney injury increases the risk of end-stage renal disease after cardiac surgery in an Asian population: a prospective cohort study Open
AKI is associated with ESRD and mortality after cardiac surgery in our Asian population. The trajectory from AKI to ESRD is rapid within 5 years of cardiac surgery. A concerted periodic follow-up assessment is advocated for AKI patients po…
View article: A proposal for a new scoring system to predict difficult ventilation through a supraglottic airway
A proposal for a new scoring system to predict difficult ventilation through a supraglottic airway Open
View article: The Association of Acute Kidney Injury and Atrial Fibrillation after Cardiac Surgery in an Asian Prospective Cohort Study
The Association of Acute Kidney Injury and Atrial Fibrillation after Cardiac Surgery in an Asian Prospective Cohort Study Open
Acute kidney injury (AKI) and atrial fibrillation (AF) after cardiac surgery are common occurrences and increase patient morbidity and mortality. Inflammation plays a role in increased incidence of AF in patients with chronic kidney diseas…
View article: Wider Perioperative Glycemic Fluctuations Increase Risk of Postoperative Acute Kidney Injury
Wider Perioperative Glycemic Fluctuations Increase Risk of Postoperative Acute Kidney Injury Open
Acute kidney injury (AKI) is a common complication after cardiac surgery. Recent studies have revealed emerging associations between the magnitude of acute glycemic fluctuations and intensive care unit (ICU) mortality rates. However, the e…
View article: Incidence of and risk factors for difficult ventilation via a supraglottic airway device in a population of 14 480 patients from South‐East Asia
Incidence of and risk factors for difficult ventilation via a supraglottic airway device in a population of 14 480 patients from South‐East Asia Open
Summary Difficult airway practice guidelines include the use of a supraglottic airway device as part of the armamentarium to provide and maintain ventilation and oxygenation. We retrospectively reviewed 14 480 patients aged ≥ 18 years who …