Tsubasa Watanabe
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View article: Intravenous Methylprednisolone for Acute Right Middle Cerebral Artery Occlusion in Granulomatosis Polyangiitis
Intravenous Methylprednisolone for Acute Right Middle Cerebral Artery Occlusion in Granulomatosis Polyangiitis Open
A 17-year-old Japanese woman diagnosed with granulomatosis with polyangiitis (GPA) and was treated with immunotherapy suddenly developed an impaired consciousness, left hemiplegia, and conjugate eye deviation to the right. Magnetic resonan…
View article: Tmem132a Autoimmunity in Patients with Suspected Autoimmune Cerebellar Ataxia
Tmem132a Autoimmunity in Patients with Suspected Autoimmune Cerebellar Ataxia Open
View article: Association Between Disease Severity and Frailty in Patients with Aortic Stenosis
Association Between Disease Severity and Frailty in Patients with Aortic Stenosis Open
Frailty is highly prevalent among patients with aortic stenosis (AS). Nonetheless, the impact of AS severity on frailty remains unclear. This study aimed to clarify the association between AS severity and frailty in this population.This re…
View article: Case report: Atypical case of autoimmune glial fibrillary acidic protein astrocytopathy following COVID-19 vaccination refractory to immunosuppressive treatments
Case report: Atypical case of autoimmune glial fibrillary acidic protein astrocytopathy following COVID-19 vaccination refractory to immunosuppressive treatments Open
A 54-year-old Japanese man presented with headache and fever the day after SARS-CoV-2 vaccination. He became deeply unconscious within a week. Brain MRI showed periventricular linear enhancements and a few spotty lesions in the cerebral wh…
View article: Proposal of recommended experimental protocols for <i>in vitro</i> and <i>in vivo</i> evaluation methods of boron agents for neutron capture therapy
Proposal of recommended experimental protocols for <i>in vitro</i> and <i>in vivo</i> evaluation methods of boron agents for neutron capture therapy Open
Recently, boron neutron capture therapy (BNCT) has been attracting attention as a minimally invasive cancer treatment. In 2020, the accelerator-based BNCT with L-BPA (Borofalan) as its D-sorbitol complex (Steboronine®) for head and neck ca…
View article: Evaluation of the Effectiveness of Boron Neutron Capture Therapy with Iodophenyl-Conjugated closo-Dodecaborate on a Rat Brain Tumor Model
Evaluation of the Effectiveness of Boron Neutron Capture Therapy with Iodophenyl-Conjugated closo-Dodecaborate on a Rat Brain Tumor Model Open
High-grade gliomas present a significant challenge in neuro-oncology because of their aggressive nature and resistance to current therapies. Boron neutron capture therapy (BNCT) is a potential treatment method; however, the boron used by t…
View article: Factors associated with household transmission of SARS‐CoV‐2 omicron variant to health care workers: A retrospective cohort study
Factors associated with household transmission of SARS‐CoV‐2 omicron variant to health care workers: A retrospective cohort study Open
Aim The aim of this study was to determine the risk factors for household transmission of the omicron variant of SARS‐CoV‐2. Background The household infection rate has been reported to be higher for the omicron variant than for non‐omicro…
View article: Evaluation of the Effectiveness of Boron Neutron Capture Therapy with Iodophenyl-Conjugated Closo-Dodecaborate on a Rat Brain Tumor Model
Evaluation of the Effectiveness of Boron Neutron Capture Therapy with Iodophenyl-Conjugated Closo-Dodecaborate on a Rat Brain Tumor Model Open
High-grade gliomas present a significant challenge in neuro-oncology because of their aggressive nature and resistance to current therapies. Boron neutron capture therapy (BNCT) is a potential treatment method; however, the boron carrier c…
View article: Correlation between antibiotic use and resistance of gram-negative bacteria at a university hospital in Japan from 2013 to 2021: a study using the Japan Surveillance for Infection Prevention and Healthcare Epidemiology (J-SIPHE) system
Correlation between antibiotic use and resistance of gram-negative bacteria at a university hospital in Japan from 2013 to 2021: a study using the Japan Surveillance for Infection Prevention and Healthcare Epidemiology (J-SIPHE) system Open
This is the first study to investigate the correlation between antibiotic use and AMR at a single hospital in time series and inter-ward analyses using the J-SIPHE system and data prepared for this system, suggesting that this system may b…
View article: FigureS2 from Adding Indoximod to Hypofractionated Radiotherapy with Anti-PD-1 Checkpoint Blockade Enhances Early NK and CD8<sup>+</sup> T-Cell–Dependent Tumor Activity
FigureS2 from Adding Indoximod to Hypofractionated Radiotherapy with Anti-PD-1 Checkpoint Blockade Enhances Early NK and CD8<sup>+</sup> T-Cell–Dependent Tumor Activity Open
Supplementary Figure 2
View article: FigureS4 from Adding Indoximod to Hypofractionated Radiotherapy with Anti-PD-1 Checkpoint Blockade Enhances Early NK and CD8<sup>+</sup> T-Cell–Dependent Tumor Activity
FigureS4 from Adding Indoximod to Hypofractionated Radiotherapy with Anti-PD-1 Checkpoint Blockade Enhances Early NK and CD8<sup>+</sup> T-Cell–Dependent Tumor Activity Open
Supplementary Figure 4
View article: Data from Adding Indoximod to Hypofractionated Radiotherapy with Anti-PD-1 Checkpoint Blockade Enhances Early NK and CD8<sup>+</sup> T-Cell–Dependent Tumor Activity
Data from Adding Indoximod to Hypofractionated Radiotherapy with Anti-PD-1 Checkpoint Blockade Enhances Early NK and CD8<sup>+</sup> T-Cell–Dependent Tumor Activity Open
Purpose:There is growing interest in combinations of immunogenic radiotherapy (RT) and immune checkpoint blockade, but clinical responses are still limited. Therefore, we tested the triple therapy with an inhibitor of the indoleamine 2,3-d…
View article: Supplementary figure legends from Adding Indoximod to Hypofractionated Radiotherapy with Anti-PD-1 Checkpoint Blockade Enhances Early NK and CD8<sup>+</sup> T-Cell–Dependent Tumor Activity
Supplementary figure legends from Adding Indoximod to Hypofractionated Radiotherapy with Anti-PD-1 Checkpoint Blockade Enhances Early NK and CD8<sup>+</sup> T-Cell–Dependent Tumor Activity Open
Supplementary figure legends
View article: FigureS3 from Adding Indoximod to Hypofractionated Radiotherapy with Anti-PD-1 Checkpoint Blockade Enhances Early NK and CD8<sup>+</sup> T-Cell–Dependent Tumor Activity
FigureS3 from Adding Indoximod to Hypofractionated Radiotherapy with Anti-PD-1 Checkpoint Blockade Enhances Early NK and CD8<sup>+</sup> T-Cell–Dependent Tumor Activity Open
Supplementary Figure 3
View article: FigureS1 from Adding Indoximod to Hypofractionated Radiotherapy with Anti-PD-1 Checkpoint Blockade Enhances Early NK and CD8<sup>+</sup> T-Cell–Dependent Tumor Activity
FigureS1 from Adding Indoximod to Hypofractionated Radiotherapy with Anti-PD-1 Checkpoint Blockade Enhances Early NK and CD8<sup>+</sup> T-Cell–Dependent Tumor Activity Open
Supplementary Figure 1
View article: FigureS1 from Adding Indoximod to Hypofractionated Radiotherapy with Anti-PD-1 Checkpoint Blockade Enhances Early NK and CD8<sup>+</sup> T-Cell–Dependent Tumor Activity
FigureS1 from Adding Indoximod to Hypofractionated Radiotherapy with Anti-PD-1 Checkpoint Blockade Enhances Early NK and CD8<sup>+</sup> T-Cell–Dependent Tumor Activity Open
Supplementary Figure 1
View article: Supplementary figure legends from Adding Indoximod to Hypofractionated Radiotherapy with Anti-PD-1 Checkpoint Blockade Enhances Early NK and CD8<sup>+</sup> T-Cell–Dependent Tumor Activity
Supplementary figure legends from Adding Indoximod to Hypofractionated Radiotherapy with Anti-PD-1 Checkpoint Blockade Enhances Early NK and CD8<sup>+</sup> T-Cell–Dependent Tumor Activity Open
Supplementary figure legends
View article: Data from Adding Indoximod to Hypofractionated Radiotherapy with Anti-PD-1 Checkpoint Blockade Enhances Early NK and CD8<sup>+</sup> T-Cell–Dependent Tumor Activity
Data from Adding Indoximod to Hypofractionated Radiotherapy with Anti-PD-1 Checkpoint Blockade Enhances Early NK and CD8<sup>+</sup> T-Cell–Dependent Tumor Activity Open
Purpose:There is growing interest in combinations of immunogenic radiotherapy (RT) and immune checkpoint blockade, but clinical responses are still limited. Therefore, we tested the triple therapy with an inhibitor of the indoleamine 2,3-d…
View article: FigureS4 from Adding Indoximod to Hypofractionated Radiotherapy with Anti-PD-1 Checkpoint Blockade Enhances Early NK and CD8<sup>+</sup> T-Cell–Dependent Tumor Activity
FigureS4 from Adding Indoximod to Hypofractionated Radiotherapy with Anti-PD-1 Checkpoint Blockade Enhances Early NK and CD8<sup>+</sup> T-Cell–Dependent Tumor Activity Open
Supplementary Figure 4
View article: FigureS3 from Adding Indoximod to Hypofractionated Radiotherapy with Anti-PD-1 Checkpoint Blockade Enhances Early NK and CD8<sup>+</sup> T-Cell–Dependent Tumor Activity
FigureS3 from Adding Indoximod to Hypofractionated Radiotherapy with Anti-PD-1 Checkpoint Blockade Enhances Early NK and CD8<sup>+</sup> T-Cell–Dependent Tumor Activity Open
Supplementary Figure 3
View article: FigureS2 from Adding Indoximod to Hypofractionated Radiotherapy with Anti-PD-1 Checkpoint Blockade Enhances Early NK and CD8<sup>+</sup> T-Cell–Dependent Tumor Activity
FigureS2 from Adding Indoximod to Hypofractionated Radiotherapy with Anti-PD-1 Checkpoint Blockade Enhances Early NK and CD8<sup>+</sup> T-Cell–Dependent Tumor Activity Open
Supplementary Figure 2
View article: Multi-Targeted Neutron Capture Therapy Combined with an 18 kDa Translocator Protein-Targeted Boron Compound Is an Effective Strategy in a Rat Brain Tumor Model
Multi-Targeted Neutron Capture Therapy Combined with an 18 kDa Translocator Protein-Targeted Boron Compound Is an Effective Strategy in a Rat Brain Tumor Model Open
Background: Boron neutron capture therapy (BNCT) has been adapted to high-grade gliomas (HG); however, some gliomas are refractory to BNCT using boronophenylalanine (BPA). In this study, the feasibility of BNCT targeting the 18 kDa translo…
View article: Breaking away from an endemic state of multidrug-resistant <i>Pseudomonas aeruginosa</i> by daily sink disinfection
Breaking away from an endemic state of multidrug-resistant <i>Pseudomonas aeruginosa</i> by daily sink disinfection Open
The detection rate of multidrug-resistant Pseudomonas aeruginosa in patients admitted to 2 wards and the intensive care unit decreased from 20.3% (129 of 636 isolates) to 4.2% (37 of 889 isolates) after the start of disinfection of hand wa…
View article: Correlation between the expression of LAT1 in cancer cells and the potential efficacy of boron neutron capture therapy
Correlation between the expression of LAT1 in cancer cells and the potential efficacy of boron neutron capture therapy Open
Boron neutron capture therapy (BNCT) is a binary cancer therapy that involves boron administration and neutron irradiation. The nuclear reaction caused by the interaction of boron atom and neutron produces heavy particles with highly cytoc…
View article: Anti-tumor effect of boron neutron capture therapy in pelvic human colorectal cancer in a mouse model
Anti-tumor effect of boron neutron capture therapy in pelvic human colorectal cancer in a mouse model Open
Local recurrence of colorectal cancer (CRC) can occur in patients after curative resection, and additional surgical resection may therefore be required; however, this is a significant burden for patients, because additional surgical resect…
View article: Repeated Brain Magnetic Resonance Imaging Provides Clues for the Diagnosis of Autoimmune Glial Fibrillary Acid Protein Astrocytopathy
Repeated Brain Magnetic Resonance Imaging Provides Clues for the Diagnosis of Autoimmune Glial Fibrillary Acid Protein Astrocytopathy Open
We herein report a 47-year-old man with autoimmune glial fibrillary acidic protein astrocytopathy (GFAP-A) revealed by periventricular radial linear enhancement on repeated brain magnetic resonance imaging (MRI). He presented with a histor…
View article: A preclinical boron neutron capture therapy (BNCT) evaluation using a maleimide-functionalized closo-dodecaborate albumin conjugate induced an efficient neutron capture reaction to an experimental F98 rat glioma bearing brain tumor model
A preclinical boron neutron capture therapy (BNCT) evaluation using a maleimide-functionalized closo-dodecaborate albumin conjugate induced an efficient neutron capture reaction to an experimental F98 rat glioma bearing brain tumor model Open
View article: Efficacy of Boron Neutron Capture Therapy in Primary Central Nervous System Lymphoma: In Vitro and In Vivo Evaluation
Efficacy of Boron Neutron Capture Therapy in Primary Central Nervous System Lymphoma: In Vitro and In Vivo Evaluation Open
Background: Boron neutron capture therapy (BNCT) is a nuclear reaction-based tumor cell-selective particle irradiation method. High-dose methotrexate and whole-brain radiation therapy (WBRT) are the recommended treatments for primary centr…
View article: Development of an irradiation method for superficial tumours using a hydrogel bolus in an accelerator-based BNCT
Development of an irradiation method for superficial tumours using a hydrogel bolus in an accelerator-based BNCT Open
The aim of this study is the development of an irradiation method for the treatment of superficial tumours using a hydrogel bolus to produce thermal neutrons in accelerator-based Boron Neutron Capture Therapy (BNCT). To evaluate the neutro…
View article: Translational Evaluation of a Dodecaborated Albumin Conjugate With Maleimide as a Boron Delivery System for a Neutron Capture Reaction to an F98 Rat Glioma Model
Translational Evaluation of a Dodecaborated Albumin Conjugate With Maleimide as a Boron Delivery System for a Neutron Capture Reaction to an F98 Rat Glioma Model Open
Boron neutron capture therapy (BNCT) is a biologically targeted, cell-selective particle irradiation therapy that utilizes the nuclear capture reaction of boron and neutron. Recently, accelerator neutron generators have been used in clinic…