Tsukasa Takemura
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View article: Correction: Pathologic tonsillar findings similar to IgA nephropathy and the role of tonsillectomy in a patient with nephrotic syndrome
Correction: Pathologic tonsillar findings similar to IgA nephropathy and the role of tonsillectomy in a patient with nephrotic syndrome Open
View article: Markedly Increased Small Dense Low-Density Lipoprotein During Acute Phase in Childhood and Adolescent Nephrotic Syndrome
Markedly Increased Small Dense Low-Density Lipoprotein During Acute Phase in Childhood and Adolescent Nephrotic Syndrome Open
Background : Hyperlipidemia is an important characteristic feature of idiopathic nephrotic syndrome (NS) in children. This study was conducted to examine the lipid profiles, including small dense low-density lipoprotein (sdLDL-C), in child…
View article: Generation of two human induced pluripotent stem cell lines derived from two juvenile nephronophthisis patients with NPHP1 deletion
Generation of two human induced pluripotent stem cell lines derived from two juvenile nephronophthisis patients with NPHP1 deletion Open
View article: Association of the clinicopathologic features and mitochondrial disorders in 8 cases with a low birth weight history
Association of the clinicopathologic features and mitochondrial disorders in 8 cases with a low birth weight history Open
早産・低出生体重児関連腎症の腎組織像は寡少糸球体，巣状分節性糸球体硬化(focal segmental glomerulosclerosis: FSGS) を主な特徴とする．病理像がミトコンドリア(Mt)腎症の組織像と類似することから，病態形成に Mt 障害が関与すると考えられている．今回，早産・低出生体重の出生歴を有した 8 例を対象に，Mt 障害の指標として COX4，TFAM を含む組織評価を行い，臨床像との関連性を検討した．腎組織では，平均糸球体数は 3.2 個/m…
View article: Pathologic tonsillar findings similar to IgA nephropathy and the role of tonsillectomy in a patient with nephrotic syndrome
Pathologic tonsillar findings similar to IgA nephropathy and the role of tonsillectomy in a patient with nephrotic syndrome Open
View article: A case of membranoproliferative glomerulonephritis in whom clinical remission could be achieved by tonsillectomy
A case of membranoproliferative glomerulonephritis in whom clinical remission could be achieved by tonsillectomy Open
扁桃腺炎を契機に尿所見の増悪を認めた膜性増殖性糸球体腎炎(membranoproliferative glomerulonephritis: MPGN)に対し扁桃摘出術を施行し，臨床的，および免疫組織学的に有効であった1 例を経験した．症例は21 歳の女性．11 歳時に溶連菌感染後糸球体腎炎を発病し，経過観察されていたが，5 か月を経過しても尿所見と低補体血症の改善がなく，腎生検によりMPGN Type I と診断した．その後，メチルプレドニゾロン・パルス療法を3 クール施…
View article: A case of treatment-resistant pleuropulmonary blastoma that led to end-of-life at home with home-based palliative care
A case of treatment-resistant pleuropulmonary blastoma that led to end-of-life at home with home-based palliative care Open
View article: 〈Original〉Preventing development of cow's milk allergies in infants with atopic dermatitis through intake of cow's milk formula before weaning: A cross-sectional study
〈Original〉Preventing development of cow's milk allergies in infants with atopic dermatitis through intake of cow's milk formula before weaning: A cross-sectional study Open
View article: Composition of Coronary Arterial Calcifications Following Kawasaki Disease as Determined by Single-Source Dual-Energy Computed Tomography
Composition of Coronary Arterial Calcifications Following Kawasaki Disease as Determined by Single-Source Dual-Energy Computed Tomography Open
View article: Clinical Features of Radiofrequency Catheter Ablation in Children with Atrioventricular Nodal Reentrant Tachycardia
Clinical Features of Radiofrequency Catheter Ablation in Children with Atrioventricular Nodal Reentrant Tachycardia Open
View article: Impact of sirolimus treatment for refractory kaposiform hemangioendothelioma with exacerbation of the disease 10 years after initial diagnosis
Impact of sirolimus treatment for refractory kaposiform hemangioendothelioma with exacerbation of the disease 10 years after initial diagnosis Open
We describe our experience with a 12 year-old girl with kaposiform hemangioendothelioma accompanied by Kasabach–Merritt phenomenon with exacerbation of the disease 10 years after the initial diagnosis. Kaposiform hemangioendothelioma infil…
View article: Atriofascicular Mahaim with Ebstein anomaly: A case report
Atriofascicular Mahaim with Ebstein anomaly: A case report Open
We report a case of a 7‐year‐old girl with atriofascicular Mahaim (AFM) pathway concomitant with Ebstein's anomaly. The QRS wave showed left bundle branch block pattern on electrocardiogram. Holter electrocardiogram showed prolongation of …
View article: 〈Originals〉Treatment of trisomy 18 at 2 Japanese hospitals during a 10-year period
〈Originals〉Treatment of trisomy 18 at 2 Japanese hospitals during a 10-year period Open
View article: Myasthenia gravis during the clinical course of chronic graft-versus-host disease after allogeneic bone marrow transplantation
Myasthenia gravis during the clinical course of chronic graft-versus-host disease after allogeneic bone marrow transplantation Open
12歳，男子。8歳時に再生不良性貧血（再不貧）最重症型の診断で，HLA一致の妹より骨髄移植を施行した。急性GVHD（皮膚，腸管，grade Ⅲ）を認め，特に消化管症状のコントロールに難渋し，種々の免疫抑制剤等で加療中の移植後268日に移植関連微小血管障害を発症した。その後，移植後1年11か月頃より苔癬様の皮疹が四肢中心に出現し，血清IgG値2,172mg/dL，リウマトイド因子や抗核抗体が陽性となり，皮膚慢性GVHDと考えられた。Prednisolone（PSL）で加療し漸…
View article: Heterozygous p.S811F RET gene mutation associated with renal agenesis, oligomeganephronia and total colonic aganglionosis: a case report
Heterozygous p.S811F RET gene mutation associated with renal agenesis, oligomeganephronia and total colonic aganglionosis: a case report Open
View article: 〈Originals〉Strategies for preventing and managing allergic reactions to food in Japanese educational facilities such as kindergartens and schools
〈Originals〉Strategies for preventing and managing allergic reactions to food in Japanese educational facilities such as kindergartens and schools Open
View article: A case of Henoch-Schönlein purpura nephritis with autosomal dominant polycystic kidney disease
A case of Henoch-Schönlein purpura nephritis with autosomal dominant polycystic kidney disease Open
今回，我々は紫斑病性腎炎を合併した常染色体優性多発性囊胞腎(autosomal dominant polycystic kidney disease: ADPKD)の1 症例を経験した。症例は7 歳の女児。溶連菌感染から3 週間後に，下腿の微小出血斑と関節痛が出現し，Henoch-Schönlein 紫斑病と診断された。安静のみで症状は改善したが，紫斑病の発症から8 週後の尿検査で尿蛋白，尿潜血がみられたことから，紫斑病性腎炎が疑われた。また，ADPKD の家族歴があり，腹…
View article: A Prospective Observational Survey on the Long-Term Effect of LDL Apheresis on Drug-Resistant Nephrotic Syndrome
A Prospective Observational Survey on the Long-Term Effect of LDL Apheresis on Drug-Resistant Nephrotic Syndrome Open
Background/Aims: LDL apheresis (LDL-A) is used for drug-resistant nephrotic syndrome (NS) as an alternative therapy to induce remission by improvement of hyperlipidemia. Several clinical studies have suggested the efficacy of…
View article: The clinicogenetic features of Japanese patients with nephronophthisis
The clinicogenetic features of Japanese patients with nephronophthisis Open
ネフロン癆は，小児期の末期腎不全（ESRD）の原因疾患の1 つである。本症の病態は，他の囊胞性腎疾患と同様，一次繊毛（primary cilia）の異常である。Primary ciliaは，非運動性の繊毛であり，腎を含め多くの組織や臓器に存在する。腎におけるprimary cilia は，尿細管のapical surface に存在する。その役割として，細胞内外のシグナル伝達や細胞周期，細胞骨格などに関与する。したがってprimary cilia の異常は，尿細管のみに留ま…