Tsuyoshi Saito
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View article: Potential Involvement of Myostatin in Smooth Muscle Differentiation in Pleomorphic Leiomyosarcoma
Potential Involvement of Myostatin in Smooth Muscle Differentiation in Pleomorphic Leiomyosarcoma Open
High-grade sarcomas often lack typical morphological features and exhibit no clear differentiation, often leading to a diagnosis of undifferentiated sarcoma (US). Pleomorphic leiomyosarcoma (PLMS) is a high-grade sarcoma consisting of a ty…
View article: Fatty Acid Metabolism Regulators Have Pivotal Roles in the Pathogenesis of Ovarian Carcinoma
Fatty Acid Metabolism Regulators Have Pivotal Roles in the Pathogenesis of Ovarian Carcinoma Open
To study the pathological contribution of fatty acid (FA) metabolism regulators including fatty acid binding protein 4 (FABP4), FABP5, peroxisome proliferator-activated receptor alpha (PPARα), and PPARγ in ovarian carcinoma, non-cancerous …
View article: Case Report: Gastric submucosal neoplasm with CTNNB1 mutation showing GLI1 overexpression and epithelial differentiation
Case Report: Gastric submucosal neoplasm with CTNNB1 mutation showing GLI1 overexpression and epithelial differentiation Open
New disease entities have been emerging based on molecular pathological findings, such as pseudoendocrine sarcoma and mesenchymal neoplasm with GLI1 gene alterations, which resemble well-differentiated neuroendocrine tumors. We report a un…
View article: Prognostic potential of fusion gene analysis using plasma cell-free RNA in malignant bone and soft tissue tumours
Prognostic potential of fusion gene analysis using plasma cell-free RNA in malignant bone and soft tissue tumours Open
The detection of specific fusion genes from cfRNAs shows potential for monitoring the progression of fusion-related sarcomas in the context of chemotherapy.
View article: A STUDY ON ACCELERATED CARBONATION BEHAVIOR OF SYNTHESES STRATLINGITE
A STUDY ON ACCELERATED CARBONATION BEHAVIOR OF SYNTHESES STRATLINGITE Open
View article: STUDY ON VARIOUS PRORERTIES OF CONCRETE USING BIOMASS ASH
STUDY ON VARIOUS PRORERTIES OF CONCRETE USING BIOMASS ASH Open
View article: EFFECT OF SODIUM ALUMINOSILICATE HYDRATE FORMATION ON C-（A）-S-H FORMATION
EFFECT OF SODIUM ALUMINOSILICATE HYDRATE FORMATION ON C-（A）-S-H FORMATION Open
View article: Endoscopic and Clinicopathological Features of a Colorectal Mucin-Rich Variant of Traditional Serrated Adenoma
Endoscopic and Clinicopathological Features of a Colorectal Mucin-Rich Variant of Traditional Serrated Adenoma Open
Introduction: The mucin-rich variant of traditional serrated adenoma (MR-TSA), pathologically defined by the presence of goblet cells comprising over 50% of the lesion compared to the absorptive epithelial eosinophilic cytoplasm, was recen…
View article: Maternal age and the rising incidence of hypertensive disorders of pregnancy: A comprehensive analysis of national claims data from Japan
Maternal age and the rising incidence of hypertensive disorders of pregnancy: A comprehensive analysis of national claims data from Japan Open
Background Hypertensive disorders of pregnancy (HDP) significantly increase the risk of developing hypertension and cardiovascular disease (CVD) later in life and are a major cause of maternal mortality. However, little is known about the …
View article: Effect of NBO/T of Biomass Ash on Compressive Strength of Hardened Cement: New Insights from Evaluation of Pore Structure and Hydration Products
Effect of NBO/T of Biomass Ash on Compressive Strength of Hardened Cement: New Insights from Evaluation of Pore Structure and Hydration Products Open
View article: Long-Term Outcomes after Shunt Surgery in Older Patients with Idiopathic Normal Pressure Hydrocephalus
Long-Term Outcomes after Shunt Surgery in Older Patients with Idiopathic Normal Pressure Hydrocephalus Open
View article: Analysis of Hydration Products in Novel Cementitious Materials Containing Activated Allophane
Analysis of Hydration Products in Novel Cementitious Materials Containing Activated Allophane Open
View article: Differential Expression of MicroRNAs in the Colorectal Serrated Neoplasia Pathway and Adenoma–Carcinoma Sequence
Differential Expression of MicroRNAs in the Colorectal Serrated Neoplasia Pathway and Adenoma–Carcinoma Sequence Open
Background and Aim: Colorectal carcinogenesis involves two distinct pathways, the serrated neoplasia pathway and adenoma (AD)–carcinoma sequence, whose precursors are sessile serrated lesion (SSL) and traditional AD, respectively. MicroRNA…
View article: Characterization of breast cancer tumors in older patients who show de novo resistance to endocrine therapy
Characterization of breast cancer tumors in older patients who show de novo resistance to endocrine therapy Open
View article: 10171- MPC-16 SCREENING OF NTRK FUSION IN JAPANESE CENTRAL NERVOUS SYSTEM TUMORS
10171- MPC-16 SCREENING OF NTRK FUSION IN JAPANESE CENTRAL NERVOUS SYSTEM TUMORS Open
NTRK fusions have been reported to be rare in cancers across various organs, except for certain types of tumors. NTRK fusion positive tumors are reported to be highly sensitive to TRK inhibitors such as Larotrectinib and Entrectinib. It is…
View article: Successful Outcome of Stage IB3 Cervical Cancer Treated With Neoadjuvant Chemotherapy Followed by Vaginal Radical Trachelectomy: A Case Report
Successful Outcome of Stage IB3 Cervical Cancer Treated With Neoadjuvant Chemotherapy Followed by Vaginal Radical Trachelectomy: A Case Report Open
Vaginal trachelectomy, which involves resecting the cervix and its parametrium, is a fertility-sparing option for the treatment of early-stage cervical cancer. Although no consensus has been reached on whether simple or radical trachelecto…
View article: Surgical Outcomes of da Vinci Xi™ and da Vinci SP™ for Early-Stage Endometrial Cancer in Patients Undergoing Hysterectomy
Surgical Outcomes of da Vinci Xi™ and da Vinci SP™ for Early-Stage Endometrial Cancer in Patients Undergoing Hysterectomy Open
Objectives: This study aimed to evaluate and compare the feasibility and outcomes of two robotic hysterectomy (da Vinci Xi™ vs. da Vinci SP™) systems without lymph node dissection in patients with early-stage endometrial cancer, and assess…
View article: CORROSION RATE OF REBAR IN MORTAR WITH COMBINED DETERIORATION DUE TO CHLORIDE ATTACK AND ASR
CORROSION RATE OF REBAR IN MORTAR WITH COMBINED DETERIORATION DUE TO CHLORIDE ATTACK AND ASR Open
塩害では鉄筋の不働態皮膜が破壊し、腐食が進行する。またアルカリシリカ反応(ASR)では骨材が膨張し、ひび割れが生じる。またそれらの予防策としてフライアッシュ(FA)の混和が挙げられる。本研究では、両者の複合劣化を対象に、コンクリート内部に埋設された鉄筋の腐食速度、およびFA混和の防食効果を評価した。すなわち、塩害の単独劣化および塩害とASRの複合劣化が生じ、加えてFA混和した供試体を湿潤気中に暴露し、膨張率や鉄筋腐食速度を測定した。また、ひび割れ観察、ゲルフルオレッセンス法…
View article: EFFECT OF NBO/T OF BIOMASS ASH ON COMPRESSIVE STRENGTH OF HARDENED CEMENT
EFFECT OF NBO/T OF BIOMASS ASH ON COMPRESSIVE STRENGTH OF HARDENED CEMENT Open
本研究では、バイオマス灰を大量に用いたセメント硬化体の諸物性について、ガラス中の非架橋酸素および四面体イオンの比であるNBO/Tが硬化体に及ぼすに影響に着目した検討を実施した。その結果、バイオマス灰を用いた場合、材齢の経過とともに硬化体中の数~数10nm程度の空隙量が大きくなっていた。FT-IRや27Al-NMRの分析結果から、エトリンガイト、C-A-S-H、モノサルフェートが多く生成されていたことが確認でき、圧縮強度が高くなった一要因であると考えられた。バイオマス灰のNB…
View article: APPLICATION OF CALCINED CLAY CONTAINING ALLOPHANE AND HALLOYSITE AS A SUPPLYMENTARY CEMENTIOUS MATERIALS
APPLICATION OF CALCINED CLAY CONTAINING ALLOPHANE AND HALLOYSITE AS A SUPPLYMENTARY CEMENTIOUS MATERIALS Open
本研究では、火山ガラス微粉末、アロフェンならびにハロイサイトを煆焼し、それらのSCMsとしての性能を評価した。煆焼前と比べて、煆焼火山ガラス微粉末をSCMsとして使用した場合、強度変化はなく、煆焼アロフェンならびに煆焼ハロイサイトをSCMsとして使用した場合、強度は大きく向上した。また、煆焼アロフェンや煆焼ハロイサイトの場合、石灰石を置換することで材齢7日強度が向上し、材齢28日強度は石灰石無置換のものと同程度であった。煆焼アロフェンならびに煆焼ハロイサイトをSCMsとして…
View article: NTRK2 expression in gastrointestinal stromal tumors with a special emphasis on the clinicopathological and prognostic impacts
NTRK2 expression in gastrointestinal stromal tumors with a special emphasis on the clinicopathological and prognostic impacts Open
View article: Breast Awareness Promotion Triggered by Notification of Breast Density (Breast Composition)
Breast Awareness Promotion Triggered by Notification of Breast Density (Breast Composition) Open
View article: Material Design of Geopolymers Using Calcined Allophane
Material Design of Geopolymers Using Calcined Allophane Open
View article: Hydration Analysis of Coal Gasification Slag by XRD/Rietveld Analysis
Hydration Analysis of Coal Gasification Slag by XRD/Rietveld Analysis Open
For the purpose of evaluating the reactivity of coal gasification slag sand (CGS), a cement paste was prepared by partially replacing alite (C3S) with CGS, and the reaction rate of C3S and CGS was evaluated by XRD/Rietveld analysis. As a r…
View article: Detection of Novel Tyrosine Kinase Fusion Genes as Potential Therapeutic Targets in Bone and Soft Tissue Sarcomas Using DNA/RNA-based Clinical Sequencing
Detection of Novel Tyrosine Kinase Fusion Genes as Potential Therapeutic Targets in Bone and Soft Tissue Sarcomas Using DNA/RNA-based Clinical Sequencing Open
Background Approximately 1% of clinically treatable tyrosine kinase fusions, including anaplastic lymphoma kinase, neurotrophic tyrosine receptor kinase, RET proto-oncogene, and ROS proto-oncogene 1, have been identified in soft tissue sar…
View article: Copy number loss of <i>KDM5D</i> may be a predictive biomarker for <scp>ATR</scp> inhibitor treatment in male patients with pulmonary squamous cell carcinoma
Copy number loss of <i>KDM5D</i> may be a predictive biomarker for <span>ATR</span> inhibitor treatment in male patients with pulmonary squamous cell carcinoma Open
A limited number of patients with lung squamous cell carcinoma (SCC) benefit clinically from molecular targeted drugs because of a lack of targetable driver alterations. We aimed to understand the prevalence and clinical significance of ly…
View article: Clinicopathological and molecular pathological characteristics in tamoxifen‑related endometrial cancer
Clinicopathological and molecular pathological characteristics in tamoxifen‑related endometrial cancer Open
Tamoxifen (TAM), a selective estrogen receptor modulator, is often used for long-term adjuvant endocrine therapy in patients with hormone receptor-positive breast cancer. TAM is known to increase the risk of endometrial cancer (EC); howeve…
View article: Effectiveness evaluation of Hazard Identification Support Method for Machine designers
Effectiveness evaluation of Hazard Identification Support Method for Machine designers Open
筆者らは,機械の設計段階で実施するリスクアセスメントにおいて最も重要なステップとされる「危険源同定」について,機械安全の知識が限られた設計者でも最低限同定すべき危険源を認識できるように支援する方法を提案した1).そして,支援された危険源同定を実行する手段の例として,デスクトップPC上で動作するアプリケーションツールを試作した1).本報では,試作したツールを用いて,提案した支援方法の有効性を評価した結果について述べる.中小規模の機械製造業者で設計業務に関わる技術者12名を対象…
View article: Proposal of Support Application Software to Implement Hazard Identification of Machinery for Small and Medium-Sized Business Sites
Proposal of Support Application Software to Implement Hazard Identification of Machinery for Small and Medium-Sized Business Sites Open
現在，リスクアセスメントによる労働災害防止対策の推進が図られているが，中小規模の事業場での取り組みは十分とは言えない．そこで，本研究では，機械災害を対象に，中小規模の事業場でのRAを支援する方策の一つとして，RAの中でも最も重要なステップとされる「危険源の同定」に焦点を当て，その簡易化と具体的な支援手段の例を提案する．具体的には，これまで危険源の同定で一般的に利用されてきた危険源リストを，機械の使用中に発生する労働災害をよりイメージしやすいよう，機械災害事例の分析結果から作…
View article: Eosinophils exert direct and indirect anti-tumorigenic effects in the development of esophageal squamous cell carcinoma
Eosinophils exert direct and indirect anti-tumorigenic effects in the development of esophageal squamous cell carcinoma Open
Background/Aims Eosinophils are present in several solid tumors and have context-dependent function. Our aim is to define the contribution of eosinophils in esophageal squamous cell carcinoma (ESCC), since their role in ESCC is unknown. Me…