Explanipedia

ELF5 modulates casein synthesis in goat mammary epithelial cells via JAK2/STAT5 signaling pathway Open

Yuzhu Guo, Cunxia Ma, Tao Meng, Tao Tu, Shuangshuang Cui , et al. · 2025

ELF5 upregulates casein synthesis by activating JAK2/STAT5 signaling pathway, which provides the strategy for manipulating ELF5 to increase casein content and improve goat milk protein quality.

Associations between parental psychological control and negative emotions in early adolescents: a moderated mediation model Open

Min Zhu, Tao Tu · 2025

Introduction Previous research on negative emotions has primarily focused on middle and high school students. Based on the cumulative risk model framework, this study targeting early adolescents integrates parental psychological control, p…

miR-34c regulates the proliferation, apoptosis, and testosterone synthesis of bovine leydig cells by targeted ATG5 gene Open

Tao Tu, Xin Wang, Shuangshuang Cui, Xiang Meng, Ibrar Muhammad Khan , et al. · 2025

The reproductive potential of bull represents a key economic trait in modern cattle husbandry. The primary determinant of bull reproductive capacity is the proper development of the testes, which is essential for the production of spermato…

Integrated machine learning and population attributable fraction analysis of systemic inflammatory indices for mortality risk prediction in diabetes and prediabetes Open

Zixi Zhang, Chenyang Li, Yichao Xiao, Chan Liu, Xiao-Qin Luo , et al. · 2025

Systemic inflammatory indices are independent predictors of mortality in individuals with DM or PreDM. Their integration into machine learning models enhances risk prediction and may inform population-level strategies for cardiometabolic r…

Agricultural biotechnology in China: product development, commercialization, and perspectives Open

Jingang Liang, Yu-Hua Sun, Yanchao Yang, Zeyu Wang, Han Wu , et al. · 2025

Behavioral Drivers of Solar Energy Adoption: Implications for Business Analysis and Sustainable Management Open

Do Viet Phuong, Tao Tu · 2025

The need to switch to renewable energy sources is growing due to environmental issues in developing countries, where green technologies can achieve sustainable development. Thus, this research focuses on the psychological and social antece…

Time course of the rubber hand illusion–induced analgesia Open

Benjamin Mosch, Xaver Fuchs, Tao Tu, Martin Diers · 2025

Introduction: Previous investigations on pain modulatory effects of the rubber hand illusion (RHI) yielded mixed results. However, these studies used separate stimuli to induce pain and the RHI. Using a visual-thermal stimulation approach,…

ELF5 gene promotes milk lipid synthesis in goat mammary epithelial cells by transcriptomic analysis Open

Cunxia Ma, Yuzhu Guo, Tao Tu, Shuangshuang Cui, Jintao Zhong , et al. · 2025

E74-like factor 5 (ELF5) is an Ets transcription factor of epithelial development, while the function of ELF5 gene in goat milk fat synthesis remains to be elucidated. In goat mammary epithelial cells, we performed RNA sequencing and analy…

Casual associations between frailty and nine mental disorders: bidirectional Mendelian randomisation study Open

Yong Zhou, Jubao Duan, Jiayi Zhu, Yunying Huang, Tao Tu , et al. · 2025

Background An increasing number of observational studies have reported associations between frailty and mental disorders, but the causality remains ambiguous. Aims To assess the bidirectional causal relationship between frailty and nine me…

The triglyceride–glucose index and its obesity-related derivatives as predictors of all-cause and cardiovascular mortality in hypertensive patients: insights from NHANES data with machine learning analysis Open

Chenyang Li, Zixi Zhang, Xiao-Qin Luo, Yichao Xiao, Tao Tu , et al. · 2025

EfficientISP: A Deep Learning-based Field Programmable Gate Array-enabled High-speed and Energy-efficient Image Signal Processor Open

Tao Tu, Tianle Liu, Haoxuan Wang, Wenjun Wei, Jinjin Zheng , et al. · 2025

Lipoprotein(a) and Atrial Fibrillation: Mechanistic Insights and Therapeutic Approaches Open

Zixi Zhang, Bo Peng, Akedanmu Nuranmubieke, Yangfan Xu, Yan Liu , et al. · 2024

Elevated lipoprotein(a) [Lp(a)] levels are increasingly recognized as a significant risk factor for cardiovascular diseases and may also contribute to atrial fibrillation (AF). This review investigated the indirect mechanisms through which…

Kehuang capsule inhibits MAPK and AKT signaling pathways to mitigate CCl4-induced acute liver injury Open

Qinyu Ni, Jiacheng Lin, Weifan Huang, Yang Liu, Ran Li , et al. · 2024

These findings suggest that KH capsule could exert protective effects against CCl₄-induced ALI, with the inhibition of MAPK and PI3K-AKT signaling pathways playing a crucial role in its mechanism of action.

Advancing Guideline-Directed Medical Therapy in Heart Failure: Overcoming Challenges and Maximizing Benefits Open

Zixi Zhang, Cancan Wang, Tao Tu, Qiuzhen Lin, Jiabao Zhou , et al. · 2024

The delayed titration of guideline-directed drug therapy (GDMT) is a complex event influenced by multiple factors that often result in poor prognosis for patients with heart failure (HF). Individualized adjustments in GDMT titration may be…

Pulsed field ablation: A promising approach for ventricular tachycardia ablation Open

Zixi Zhang, Yichao Xiao, Cancan Wang, Jiabao Zhou, Qiuzhen Lin , et al. · 2024

Radiofrequency ablation (RFA) has been a central therapeutic strategy for ventricular tachycardia (VT). However, concerns about its long-term effectiveness and complications have arisen. Pulsed field ablation (PFA), characterized by its no…

Amino acid profile alteration in age-related atrial fibrillation Open

Yunying Huang, Qiuzhen Lin, Yong Zhou, Jiayi Zhu, Yingxu Ma , et al. · 2024

Background Amino acids (AAs) are one of the primary metabolic substrates for cardiac work. The correlation between AAs and both atrial fibrillation (AF) and aging has been documented. However, the relationship between AAs and age-related A…

Causal relationship between particulate matter and COVID-19 risk: A mendelian randomization study Open

Jiayi Zhu, Yong Zhou, Qiuzhen Lin, Keke Wu, Yingxu Ma , et al. · 2024

Contents Open

Tao Tu, Benno Zehnder, Baolin Qu, Stephan Urban, Mette Vesterhus , et al. · 2023

Identification and validation of aging-related genes in atrial fibrillation Open

Yong Zhou, Chao Sun, Yingxu Ma, Yunyin Huang, Keke Wu , et al. · 2023

Atrial fibrillation (AF) is the most common sustained cardiac arrhythmia in the clinic. Aging plays an essential role in the occurrence and development of AF. Herein, we aimed to identify the aging-related genes associated with AF using bi…

Exploring immune related gene signatures and mechanisms linking non alcoholic fatty liver disease to atrial fibrillation through transcriptome data analysis Open

Keke Wu, Jiayi Zhu, Yingxu Ma, Yong Zhou, Qiuzhen Lin , et al. · 2023

Intensive Lipid‐Lowering Therapy as per the Latest Dyslipidemia Management Guideline in Predicting Favorable Long‐Term Clinical Outcomes in Patients Undergoing Coronary Artery Bypass Grafting: A Retrospective Cohort Study Open

Liang Tang, Hao Chen, Xinqun Hu, Zhenfei Fang, Xiao‐Bo Liao , et al. · 2023

Background There are limited data on low‐density lipoprotein cholesterol (LDL‐C) goal achievement per the 2019 European Society of Cardiology/European Atherosclerosis Society dyslipidemia management guidelines and its impact on long‐term o…

Novel Drug Targets for Atrial Fibrillation Identified Through Mendelian Randomization Analysis Open

Zuodong Ning, Yunying Huang, Haocheng Lu, Yong Zhou, Tao Tu , et al. · 2023

Purpose : Novel, effective, and safe preventive therapy targets for AF are still warranted. Circulating proteins with causal genetic evidence represents promising candidates. We aimed to systematically screen circulating proteins for AF dr…

Students’ difficulties with the Dirac delta function in quantum mechanics Open

Tao Tu, Chuan‐Feng Li, Jin‐Shi Xu, Guang‐Can Guo · 2023

In the context of quantum mechanics, students are often asked to use delta functions to solve problems. Here, we investigate three typical problem-solving processes using delta functions: a delta function potential well problem, a position…

Nicotinamide mononucleotide attenuates HIF-1α activation and fibrosis in hypoxic adipose tissue via NAD+/SIRT1 axis Open

Keke Wu, Biao Li, Yingxu Ma, Tao Tu, Qiuzhen Lin , et al. · 2023

Background Fibrosis is increasingly considered as a major contributor in adipose tissue dysfunction. Hypoxic activation of hypoxia-inducible factor 1α (HIF-1α) induces a profibrotic transcription, leading to adipose fibrosis. Nicotinamide …

Quantitative acetylated proteomics on left atrial appendage tissues revealed atrial energy metabolism and contraction status in patients with valvular heart disease with atrial fibrillation Open

Tao Tu, Fen Qin, Fan Bai, Yichao Xiao, Yingxu Ma , et al. · 2022

Background Numerous basic studies have demonstrated critical roles of metabolic and contractile remodeling in pathophysiological changes of atrial fibrillation (AF), but acetylation changes underlying atrial remodeling have not been fully …

Towards entanglement distillation between atomic ensembles using high-fidelity spin operations Open

Chao Liu, Tao Tu, Pei-Yun Li, Xiao Liu, Xingyu Zhu , et al. · 2022

Entanglement distillation is an essential ingredient for long-distance quantum communication. However, owing to their demanding requirements, integrating such entanglement distillation processing in scalable quantum devices remains an outs…

Associations of Visceral Adipose Tissue, Circulating Protein Biomarkers, and Risk of Cardiovascular Diseases: A Mendelian Randomization Analysis Open

Yunying Huang, Yaozhong Liu, Yingxu Ma, Tao Tu, Na Liu , et al. · 2022

Aim: To evaluate the genetic associations of visceral adipose tissue (VAT) mass with metabolic risk factors and cardiovascular disease (CVD) endpoints and to construct a network analysis about the underlying mechanism using Mendelian rando…

Metformin suppresses vascular smooth muscle cell senescence by promoting autophagic flux Open

Shi Tai, Jiaxing Sun, Yuying Zhou, Zhaowei Zhu, Yuhu He , et al. · 2021

Students’ difficulties with solving bound and scattering state problems in quantum mechanics Open

Tao Tu, Chuan‐Feng Li, Jin‐Shi Xu, Guang‐Can Guo · 2021

In quantum mechanics courses, students are often asked to solve bound and scattering state problems. The use of an ordinary differential equation is a standard technique to solve these questions. Here, we investigated students’ problem-sol…

In-Hospital Cardiac Arrest after Emotional Stress in a Patient Hospitalized with Gastrointestinal Symptoms and Chronic Anxiety Disorder Open

Tao Tu, Jiang Li, Zhenfei Fang, Xinqun Hu, Jianjun Tang , et al. · 2021

Background: We report an acute emotional stress–induced in-hospital cardiac arrest in a patient admitted with gastrointestinal symptoms after experiencing chronic anxiety disorder. Case Presentation: The patient was admitted to the Second …

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