Tai‐Tu Lin
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View article: Characterization of Cytokine Treatment on Human Pancreatic Islets by Top‐Down Proteomics
Characterization of Cytokine Treatment on Human Pancreatic Islets by Top‐Down Proteomics Open
Type 1 diabetes (T1D) results from autoimmune‐mediated destruction of insulin‐producing β cells in the pancreatic islet. This process is modulated by pro‐inflammatory cytokine signaling, which has been previously shown to alter protein exp…
View article: Characterization of cytokine treatment on human pancreatic islets by top-down proteomics
Characterization of cytokine treatment on human pancreatic islets by top-down proteomics Open
Type 1 diabetes (T1D) results from autoimmune-mediated destruction of insulin-producing β cells in the pancreatic islet. This process is modulated by pro-inflammatory cytokine signaling, which have been previously shown to alter protein ex…
View article: Biomarkers, Proteoforms, and Mass Spectrometry–Based Assays for Diabetes Clinical Research
Biomarkers, Proteoforms, and Mass Spectrometry–Based Assays for Diabetes Clinical Research Open
The prevalence of diabetes, particularly type 2 diabetes, has reached epidemic proportions globally. The number of patients with type 1 diabetes (T1D) is also increasing rapidly. Despite advancements in understanding the pathogenesis of di…
View article: Interlaboratory Comparison of Antibody-Free LC-MS/MS Measurements of C-peptide and Insulin
Interlaboratory Comparison of Antibody-Free LC-MS/MS Measurements of C-peptide and Insulin Open
Background The enhanced precision and selectivity of liquid chromatography–tandem mass spectrometry (LC-MS/MS) makes it an attractive alternative to certain clinical immunoassays. Easily transferrable work flows could help facilitate harmo…
View article: Transcriptome and secretome profiling of sensory neurons reveals sex differences in pathways relevant to insulin sensing and insulin secretion
Transcriptome and secretome profiling of sensory neurons reveals sex differences in pathways relevant to insulin sensing and insulin secretion Open
Sensory neurons in the dorsal root ganglia (DRG) convey somatosensory and metabolic cues to the central nervous system and release substances from stimulated terminal endings in peripheral organs. Sex‐biased variations driven by the sex ch…
View article: Targeted Mass Spectrometry Assays for Specific Quantification of Urinary proPSA Isoforms
Targeted Mass Spectrometry Assays for Specific Quantification of Urinary proPSA Isoforms Open
Prostate cancer (PCa) is the second leading cause of male cancer-related deaths in the United States. The pre-mature forms of prostate-specific antigen (PSA), proPSA, were shown to be associated with PCa. However, there is a technical chal…