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View article: LOOKING BACK ON THE AUSTRALIA - VIETNAM RELATIONSHIP IN THE CONTEXT OF ASIAN CENTURY
LOOKING BACK ON THE AUSTRALIA - VIETNAM RELATIONSHIP IN THE CONTEXT OF ASIAN CENTURY Open
Vietnam and Australia are both middle powers actively contributing to the strategy of adapting to China's rise in Southeast Asia. In particular, Australia has continuously taken advantage of and created opportunities, including the first a…
View article: Development of ethyl cellulose and lecithin nanoparticles: Permeability enhancement for berberine topical application
Development of ethyl cellulose and lecithin nanoparticles: Permeability enhancement for berberine topical application Open
Introduction: Berberine chloride (BER), a well-known medicine for treating gastroenteritis, was renovated into topical application by using nanoparticle platform with ethyl cellulose (EC) and lecithin (LEC). Method: BER was prepared into n…
View article: Preliminary study on simultaneous adsorption of nitrate and phosphate using CaFe2O4-modified biochar originated from lychee peels
Preliminary study on simultaneous adsorption of nitrate and phosphate using CaFe2O4-modified biochar originated from lychee peels Open
In this study, lychee peels derived-biochar modified with CaFe2O4NPs (MLPB) were successfully fabricated to adsorb simultaneously both nitrate (NO3-) and phosphate (PO43-) from aqueous solution. The preliminary investigation on the effect …
View article: Anti-inflammatory effect of Piper longum L. fruit methanolic extract on lipopolysaccharide-treated RAW 264.7 murine macrophages
Anti-inflammatory effect of Piper longum L. fruit methanolic extract on lipopolysaccharide-treated RAW 264.7 murine macrophages Open
View article: Solidifying Fenofibrate Nanocrystal Suspension: A Scalable Approach via Granulation Method
Solidifying Fenofibrate Nanocrystal Suspension: A Scalable Approach via Granulation Method Open
The pharmaceutical industry has highlighted particle-size reduction via preparing aqueous suspensions containing nano- or submicron drug particles. Owing to the risk of agglomeration and complications during the manufacturing of solid dosa…
View article: A Novel Combination Approach for the Vaginitis Management: Mucoadhesive Chitosan Based Vaginal Films Containing Metronidazole and Nystatin
A Novel Combination Approach for the Vaginitis Management: Mucoadhesive Chitosan Based Vaginal Films Containing Metronidazole and Nystatin Open
Vaginitis is a troublesome by its prevalence and repetition in women.In this study, we developed a novel approach to manage this annoying situation using mucoadhesive chitosan based vaginal films containing metronidazole plus nystatin.Vagi…
View article: Lactoferrin and Nanotechnology: The Potential for Cancer Treatment
Lactoferrin and Nanotechnology: The Potential for Cancer Treatment Open
Lactoferrin (Lf)—a glycoprotein of the transferrin family—has been investigated as a promising molecule with diverse applications, including infection inhibition, anti-inflammation, antioxidant properties and immune modulation. Along with …
View article: Anti-neuroinflammatory effects of alkaloid-enriched extract from <i>Huperzia serrata</i> on lipopolysaccharide-stimulated BV-2 microglial cells
Anti-neuroinflammatory effects of alkaloid-enriched extract from <i>Huperzia serrata</i> on lipopolysaccharide-stimulated BV-2 microglial cells Open
HsAE exerts anti-neuroinflammatory effects on LPS-stimulated BV-2 cells, suggesting that it may be a potential candidate for the treatment of neuroinflammation in neurodegenerative diseases.
View article: Solidification of Nanocrystal Suspension for a Conventional Dosage Form: A Scalable Approach Using Adsorption Technique
Solidification of Nanocrystal Suspension for a Conventional Dosage Form: A Scalable Approach Using Adsorption Technique Open
View article: Lychee Peels-Derived Biochar-Supported Cafe2o4 Magnetic Nanocomposite as an Excellent Adsorbent for Simultaneous and Effective Removal of Nitrate and Phosphate from Wastewater
Lychee Peels-Derived Biochar-Supported Cafe2o4 Magnetic Nanocomposite as an Excellent Adsorbent for Simultaneous and Effective Removal of Nitrate and Phosphate from Wastewater Open
View article: Development of Panax notoginseng saponins-loaded orodispersible films: A potential approach to enhance delivery efficacy in older adults
Development of Panax notoginseng saponins-loaded orodispersible films: A potential approach to enhance delivery efficacy in older adults Open
Panax notoginseng saponins (PNS), a fraction of Chinese herbal medicine P. notoginseng, have shown clinical potential in the management of diabetic and cardiovascular diseases.The oral administration of these saponins was impaired due to t…
View article: Targeting the PD-1/PD-L1 axis for cancer treatment: a review on nanotechnology
Targeting the PD-1/PD-L1 axis for cancer treatment: a review on nanotechnology Open
Although nanomedicines have been in the oncology field for almost three decades with the introduction of doxil, only a few nanomedicine products have reached approval. Can nanotechnology be a realistic tool to reduce the number of hospital…
View article: Checkpoint Inhibitors and the Gut
Checkpoint Inhibitors and the Gut Open
Checkpoint inhibitors have revolutionized treatments in modern oncology, including many conditions previously relegated to palliative therapies only. However, emerging recognition of checkpoint inhibitor-related adverse events has complica…
View article: Adenovirus-α-Defensin Complexes Induce NLRP3-Associated Maturation of Human Phagocytes via Toll-Like Receptor 4 Engagement
Adenovirus-α-Defensin Complexes Induce NLRP3-Associated Maturation of Human Phagocytes via Toll-Like Receptor 4 Engagement Open
This study examines the interactions between danger-associated molecular patterns and human adenoviruses, and their impact on vaccines. HAdVs and HNP-1 can interact, and these interactions will modify the response of antigen-presenting cel…
View article: Adenovirus-α-defensin complexes induce NLRP3-associated maturation of human phagocytes via TLR4 engagement
Adenovirus-α-defensin complexes induce NLRP3-associated maturation of human phagocytes via TLR4 engagement Open
Intramuscular delivery of human adenovirus (HAdV)-based vaccines leads to rapid recruitment of neutrophils, which then release antimicrobial peptides/proteins (AMPs). How these AMPs influence vaccine efficacy over the subsequent 24 hr is p…
View article: IgG-Complexed Adenoviruses Induce Human Plasmacytoid Dendritic Cell Activation and Apoptosis
IgG-Complexed Adenoviruses Induce Human Plasmacytoid Dendritic Cell Activation and Apoptosis Open
Following repeat exposure to many human adenoviruses (HAdVs), most adults harbour long-lived B- and T-cell responses. Combined, this response typically protects us for years from re-infection by the same HAdV type. In spite of these immune…
View article: Lactoferrin Retargets Human Adenoviruses to TLR4 to Induce an Abortive NLRP3-Associated Pyroptotic Response in Human Phagocytes
Lactoferrin Retargets Human Adenoviruses to TLR4 to Induce an Abortive NLRP3-Associated Pyroptotic Response in Human Phagocytes Open
Despite decades of clinical and preclinical investigations, we still poorly grasp our innate immune response to human adenoviruses (HAdVs) and their vectors. In this study, we explored the impact of lactoferrin on three HAdV types that are…
View article: Antimicrobial peptides – Advances in development of therapeutic applications
Antimicrobial peptides – Advances in development of therapeutic applications Open
View article: Tocilizumab for severe COVID‐19 pneumonia: Case series of 5 Australian patients
Tocilizumab for severe COVID‐19 pneumonia: Case series of 5 Australian patients Open
Aim To describe the first Australian cases of severe acute respiratory syndrome‐coronavirus 2 (SARS‐CoV2) disease (COVID‐19) pneumonia treated with the interleukin‐6 receptor antagonist tocilizumab. Methods Retrospective, open‐label, real‐…
View article: Lactoferrin retargets adenoviruses to TLR4 to induce an abortive NLRP3-associated pyroptotic response in human dendritic cells
Lactoferrin retargets adenoviruses to TLR4 to induce an abortive NLRP3-associated pyroptotic response in human dendritic cells Open
Despite decades of investigations, we still poorly grasp the immunogenicity of human adenovirus (HAdV)-based vaccines in humans. In this study, we explored the role of lactoferrin, which belong to the alarmin subset of antimicrobial peptid…
View article: Coronaviruses pandemics: Can neutralizing antibodies help?
Coronaviruses pandemics: Can neutralizing antibodies help? Open
View article: Bladder cancer therapy without toxicity—A dose‐escalation study of alpha1‐oleate
Bladder cancer therapy without toxicity—A dose‐escalation study of alpha1‐oleate Open
Potent chemotherapeutic agents are required to counteract the aggressive behavior of cancer cells and patients often experience severe side effects, due to tissue toxicity. Our study addresses if a better balance between efficacy and toxic…
View article: Synergistic Therapeutic Strategy of Dual Drug-loaded Lipid Polymer Hybrid Nanoparticles for Breast Cancer Treatment
Synergistic Therapeutic Strategy of Dual Drug-loaded Lipid Polymer Hybrid Nanoparticles for Breast Cancer Treatment Open
In this investigation, a smart nanocarrier-loaded docetaxel, a microtubules disrupting agent and vorinostat, a histone deacetylase inhibitor was developed to achieve a synergistic anticancer effect. Dual drug-loaded lipid polymer hybrid na…
View article: Modulating T-cell-based cancer immunotherapy via particulate systems
Modulating T-cell-based cancer immunotherapy via particulate systems Open
Immunotherapy holds tremendous promise for improving cancer treatment in which an appropriate stimulator may naturally trigger the immune system to control cancer. Up-to-date, adoptive T-cell therapy has received two new FDA approvals that…
View article: Nanoparticles for dendritic cell-based immunotherapy
Nanoparticles for dendritic cell-based immunotherapy Open
Crosstalk among immune cells has attracted considerable attention with the advent of immunotherapy as a novel therapeutic approach for challenging diseases, especially cancer, which is the leading cause of mortality worldwide. Dendritic ce…
View article: Preparation of High-Payload, Prolonged-Release Biodegradable Poly(lactic-<i>co</i>-glycolic acid)-Based Tacrolimus Microspheres Using the Single-Jet Electrospray Method
Preparation of High-Payload, Prolonged-Release Biodegradable Poly(lactic-<i>co</i>-glycolic acid)-Based Tacrolimus Microspheres Using the Single-Jet Electrospray Method Open
Tacrolimus-loaded poly(lactic-co-glycolic acid) microspheres (TAC-PLGA-M) can be administered for the long-term survival of transplanted organs due to their immunosuppressive activity. The purpose of our study was to optimize the parameter…
View article: WITHDRAWN: Preparation of surface-modified poly (d,l-lactide-co-glycolide) nano-particles for bone targeting
WITHDRAWN: Preparation of surface-modified poly (d,l-lactide-co-glycolide) nano-particles for bone targeting Open
This article has been withdrawn at the request of the author(s) and/or editor. The Publisher apologizes for any inconvenience this may cause. The full Elsevier Policy on Article Withdrawal can be found at http://www.elsevier.com/locate/wit…
View article: Development of Solid Self-Emulsifying Formulation for Improving the Oral Bioavailability of Erlotinib
Development of Solid Self-Emulsifying Formulation for Improving the Oral Bioavailability of Erlotinib Open
View article: Tumor-targeting, pH-sensitive nanoparticles for docetaxel delivery to drug-resistant cancer cells
Tumor-targeting, pH-sensitive nanoparticles for docetaxel delivery to drug-resistant cancer cells Open
The attachment of polyethylene glycol (PEG) increases the circulation time of drug-containing nanoparticles; however, this also negatively affects cellular uptake. To overcome this problem, unique lipid polymer hybrid (LPH) nanoparticles w…
View article: Preparation and characterization of solid dispersion using a novel amphiphilic copolymer to enhance dissolution and oral bioavailability of sorafenib
Preparation and characterization of solid dispersion using a novel amphiphilic copolymer to enhance dissolution and oral bioavailability of sorafenib Open
The objective of the current study was to enhance dissolution and oral bioavailability of the poorly water-soluble drug, sorafenib (SFN), by solid dispersion (SD) technique using a novel amphiphilic copolymer, polyvinyl caprolactam–polyvin…