Tue Fryland
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View article: Porcine model of <i>BRD1</i> haploinsufficiency reveals neurodevelopmental, behavioral, and molecular alterations relevant to psychiatric disorders
Porcine model of <i>BRD1</i> haploinsufficiency reveals neurodevelopmental, behavioral, and molecular alterations relevant to psychiatric disorders Open
Psychiatric disorders are heritable and biologically complex, with overlapping genetic architectures and shared molecular pathways. Among implicated genes, BRD1 has emerged as an epigenetic regulator of neurodevelopment with broad relevanc…
View article: Synergistic effect of serotonin 1A and serotonin 1B/D receptor agonists in the treatment of L-DOPA-induced dyskinesia in 6-hydroxydopamine-lesioned rats
Synergistic effect of serotonin 1A and serotonin 1B/D receptor agonists in the treatment of L-DOPA-induced dyskinesia in 6-hydroxydopamine-lesioned rats Open
The strong anti-dyskinetic effect found with combined 5-HT1A and 5-HT1B/D agonism renders buspirone and zolmitriptan together a meaningful treatment for LID in PD.
View article: The psychiatric risk gene BRD1 modulates mitochondrial bioenergetics by transcriptional regulation
The psychiatric risk gene BRD1 modulates mitochondrial bioenergetics by transcriptional regulation Open
View article: Reduced Brd1 expression leads to reversible depression-like behaviors and gene-expression changes in female mice
Reduced Brd1 expression leads to reversible depression-like behaviors and gene-expression changes in female mice Open
View article: Brain proteome changes in female Brd1 mice unmask dendritic spine pathology and show enrichment for schizophrenia risk
Brain proteome changes in female Brd1 mice unmask dendritic spine pathology and show enrichment for schizophrenia risk Open
View article: Dominant-negative SERPING1 variants cause intracellular retention of C1 inhibitor in hereditary angioedema
Dominant-negative SERPING1 variants cause intracellular retention of C1 inhibitor in hereditary angioedema Open
Hereditary angioedema (HAE) is an autosomal dominant disease characterized by recurrent edema attacks associated with morbidity and mortality. HAE results from variations in the SERPING1 gene that encodes the C1 inhibitor (C1INH), a serine…
View article: The neurobiology of BRD1 implicates sex-biased dysregulation of nuclear receptor signaling in mental disorders
The neurobiology of BRD1 implicates sex-biased dysregulation of nuclear receptor signaling in mental disorders Open
The schizophrenia and bipolar disorder associated gene, BRD1 , encodes a scaffold protein that in complex with epigenetic modifiers regulate gene sets enriched for psychiatric disorder risk. Preclinical evidence from male Brd1 +/− mice has…
View article: The Schizophrenia-Associated BRD1 Gene Regulates Behavior, Neurotransmission, and Expression of Schizophrenia Risk Enriched Gene Sets in Mice
The Schizophrenia-Associated BRD1 Gene Regulates Behavior, Neurotransmission, and Expression of Schizophrenia Risk Enriched Gene Sets in Mice Open
View article: Identification of the BRD1 interaction network and its impact on mental disorder risk
Identification of the BRD1 interaction network and its impact on mental disorder risk Open
Our results show that BRD1 interacts with chromatin remodeling proteins, e.g. PBRM1, as well as histone modifiers, e.g. MYST2 and SUV420H1. We find that BRD1 primarily binds in close proximity to transcription start sites and regulates exp…
View article: Additional file 12: of Identification of the BRD1 interaction network and its impact on mental disorder risk
Additional file 12: of Identification of the BRD1 interaction network and its impact on mental disorder risk Open
Metadata and statistics of integrative ChIP-seq and expression analysis. This file contains three Excel spreadsheets. Spreadsheet 1 contains information on the number of genes common to both the exon expression array and ChIPseq analyses. …
View article: Additional file 14: of Identification of the BRD1 interaction network and its impact on mental disorder risk
Additional file 14: of Identification of the BRD1 interaction network and its impact on mental disorder risk Open
Ingenuity pathway analysis of DEGs after overexpressing either BRD1-S or BRD1-L. This Excel spreadsheet contains a list of enriched canonical pathways identified by Ingenuity pathway analysis using the identified DEGs after upregulating ei…
View article: Additional file 16: of Identification of the BRD1 interaction network and its impact on mental disorder risk
Additional file 16: of Identification of the BRD1 interaction network and its impact on mental disorder risk Open
Supporting information for the gene-set enrichment analyses using MAGMA. This file contains two Excel spreadsheets. Spreadsheet 1 contains gene-wide and experiment-wide significant genes from the gene-set enrichment analysis of the BRD1 in…
View article: Additional file 9: of Identification of the BRD1 interaction network and its impact on mental disorder risk
Additional file 9: of Identification of the BRD1 interaction network and its impact on mental disorder risk Open
Ingenuity pathway analysis of BRD1 interaction networks. This Excel file includes three spreadsheets containing enriched categories, sub-categories, and canonical pathways identified by Ingenuity pathway analysis on the BRD1 interaction ne…
View article: EWS and FUS bind a subset of transcribed genes encoding proteins enriched in RNA regulatory functions
EWS and FUS bind a subset of transcribed genes encoding proteins enriched in RNA regulatory functions Open
The presented results yield new insights into gene interactions of EWS and FUS and have identified a set of FUS and EWS target genes involved in pathways at the RNA regulatory level with potential to mediate normal and disease-associated f…
View article: Additional file 1: of EWS and FUS bind a subset of transcribed genes encoding proteins enriched in RNA regulatory functions
Additional file 1: of EWS and FUS bind a subset of transcribed genes encoding proteins enriched in RNA regulatory functions Open
List of significant FUS binding peaks within or close (within 10Â kb distance) to annotated genes. (XLSX 11 kb)
View article: Additional file 7: of EWS and FUS bind a subset of transcribed genes encoding proteins enriched in RNA regulatory functions
Additional file 7: of EWS and FUS bind a subset of transcribed genes encoding proteins enriched in RNA regulatory functions Open
Expression analyses based on microarray data of genes presented with FUS, EWS, FUS and EWS, and Ac-H3K9 ChIP-seq peaks. (XLS 70 kb)
View article: Additional file 8: of EWS and FUS bind a subset of transcribed genes encoding proteins enriched in RNA regulatory functions
Additional file 8: of EWS and FUS bind a subset of transcribed genes encoding proteins enriched in RNA regulatory functions Open
Microarray data gene probe sets for actively transcribed genes also presented with FUS and Ac-H3K9 (n = 35), EWS and Ac-H3K9 (n = 135), or FUS and EWS and Ac-H3K9 (n = 58) ChIP-seq peaks. The probe sets were used in GO analysis. (XLSX 41 k…
View article: Additional file 2: of EWS and FUS bind a subset of transcribed genes encoding proteins enriched in RNA regulatory functions
Additional file 2: of EWS and FUS bind a subset of transcribed genes encoding proteins enriched in RNA regulatory functions Open
List of significant EWS binding peaks within or close (within 10Â kb distance) to annotated genes. (XLSX 15 kb)
View article: Additional file 9: of EWS and FUS bind a subset of transcribed genes encoding proteins enriched in RNA regulatory functions
Additional file 9: of EWS and FUS bind a subset of transcribed genes encoding proteins enriched in RNA regulatory functions Open
List of FUS and EWS ChIP-seq peaks assigned with a position downstream the poly(A)-signal of a target gene. (XLSX 14 kb)