Explanipedia

OR08-08 Evaluating the Clinical Use of Verapamil in Type 1 Diabetes: A Real-World Experience Open

Tugce Akcan, Ryan Kingman, Bailey Suh, Kailee Kingston, YING-TING LIU , et al. · 2025

Disclosure: T. Akcan: None. R.S. Kingman: None. B. Suh: None. K. Kingston: None. Y. Liu: None. M. Morgan: None. M. Lee: None. B. Buckingham: None. M.S. Hughes: None. R.A. Lal: None. Background: Verapamil, a calcium channel blocker, has eme…

HDL meets triglyceride Open

Tugce Akcan, Fredric B. Kraemer · 2025

The study by Liu et al in this issue of the Journal of Lipid Research leverages data from the UK Biobank to explore the impact of HDL-TG on atherosclerotic cardiovascular disease risk. The investigators observed that elevated serum triglyc…

6799 RZ358 Therapy. A Novel Approach To Hyperinsulinemia In Metastatic Neuroendocrine Tumor Patients Open

Jairo Noreña, Tugce Akcan, Shruti Patel, Welsh Madeleine, Shagufta Shaheen , et al. · 2024

Disclosure: J. Noreña: None. T. Akcan: None. S. Patel: None. W. Madeleine: None. S. Shaheen: None. M. Tan: None. RZ358, an intravenously administered monoclonal antibody, targets a unique allosteric site on the insulin receptor. It is unde…

6799 RZ358 Therapy. A Novel Approach to Hyperinsulinemia in Metastatic Neuroendocrine Tumor Patients Open

Jairo Noreña, Tugce Akcan, Shruti Patel, Welsh Madeleine, Shagufta Shaheen , et al. · 2024

Disclosure: J. Noreña: None. T. Akcan: None. S. Patel: None. W. Madeleine: None. S. Shaheen: None. M. Tan: None. RZ358, an intravenously administered monoclonal antibody, targets a unique allosteric site on the insulin receptor. It is unde…

9286 RZ358 Therapy. A Novel Approach To Hyperinsulinemia In Metastatic Neuroendocrine Tumor Patients Open

Jairo Noreña, Tugce Akcan, Shruti Patel, Madeleine Welsh, Shagufta Shaheen , et al. · 2024

Disclosure: J. Noreña: None. T. Akcan: None. S. Patel: None. M. Welsh: None. S. Shaheen: None. M. Tan: None. RZ358, an intravenously administered monoclonal antibody, targets a unique allosteric site on the insulin receptor. It is under in…

9286 RZ358 Therapy. A Novel Approach to Hyperinsulinemia in Metastatic Neuroendocrine Tumor Patients Open

Jairo Noreña, Tugce Akcan, Shruti Patel, Madeleine Welsh, Shagufta Shaheen , et al. · 2024

Disclosure: J. Noreña: None. T. Akcan: None. S. Patel: None. M. Welsh: None. S. Shaheen: None. M. Tan: None. RZ358, an intravenously administered monoclonal antibody, targets a unique allosteric site on the insulin receptor. It is under in…

FRI641 Assessing Insulin Prescription Adequacy At Hospital Discharge And Its Association With Characteristics Of Diabetic Patients Open

Tugce Akcan, Shivy Sharma, Junting Liu, Amog Jayarangaiah, Muhammad Gilani , et al. · 2023

Disclosure: T. Akcan: None. S. Sharma: None. J. Liu: None. A. Jayarangaiah: None. M. Gilani: None. A. Surendran: None. N. Imamudeen: None. R. Gabor: None. R.D. Pathak: None. Diabetes is becoming increasingly prevalent, and appropriate insu…

Recurrent Hypoglycemia Secondary to Insulinoma in an Adult With Beckwith-Wiedemann Syndrome Open

Tugce Akcan, Julia Rose R Shariff · 2023

Beckwith-Wiedemann syndrome (BWS) is a rare genetic disorder characterized by genetic and epigenetic changes on the chromosome 11p15.5 region, which includes genes that are important for fetal and postnatal growth. Children with BWS have a…

LBSUN178 Teniposide Improves Adeno-associated Virus-mediated Insulin Gene Therapy In Diabetic Mice. Open

Tugce Akcan, Sam Spyra, Hans W. Sollinger, Tausif Alam · 2022

Type 1 Diabetes Mellitus (T1DM) results from the autoimmune destruction of insulin-producing pancreatic β cells. Despite advances in our understanding of the pathogenesis and management of diabetes, as well as treatment options, which prim…

LBSAT367 Association Of Thyroid Functioning With Depression: A Population-based Historical Cohort Study Open

Junting Liu, Tugce Akcan, Rachel Gabor, Brooke Delgoffe, Shivy Sharma , et al. · 2022

Background Despite the abundance of literature, the relationship between hypothyroidism and depression is not clearly defined. We conducted this study to investigate the association of thyroid functioning [measured by serum Thyroid Stimula…

LBSUN255 Recurrent Hypoglycemia In A Patient With Beckwith-Wiedemann Syndrome Secondary To Insulinoma Open

Tugce Akcan, Julia Rose R Shariff · 2022

Background Beckwith-Wiedemann Syndrome (BWS) is a genetic condition characterized by macrosomia, childhood tumors, and neonatal hypoglycemia and hyperinsulinemia. The cause of this hyperinsulinemic hypoglycemia is unknown, but it is believ…

PMON84 A Unique Case of Diabetes Insipidus Revealing Hodgkin's lymphoma Open

Tugce Akcan, Hiral Patel, Ram Pathak · 2022

Introduction While diabetes insipidus rarely presents as a symptom of non-Hodgkin's lymphoma, it is very rarely a revealing symptom of Hodgkin's lymphoma. We present a case of this unique association. Case presentation We report a case of …

Acute Disseminated Encephalomyelitis Associated With Chronic Cannabis Abuse Open

Tugce Akcan, Milan Gajera, Javad Najjar Mojarrab, Abuzaid Medani · 2022

Acute disseminated encephalomyelitis (ADEM) is a rare monophasic immune-mediated inflammatory disorder characterized by multifocal demyelinating lesions of the central nervous system. Clinically, it is distinguished by a variety of acute n…

Retroperitoneal Fat Necrosis in Response to an Episode of Acute Pancreatitis Open

Muhammad Gilani, Tugce Akcan, Mark D. Peterson, Amina Zahid · 2021

Acute pancreatitis can result in fat necrosis, typically occurring in the peripancreatic region within weeks to months, and it generally appears as a low attenuation collection, with minimal heterogeneity. There are no specific imaging fea…

A Case of De Novo Antiglomerular Basement Membrane Disease Presenting during Pregnancy Open

Fahad Aftab Khan Lodhi, Tugce Akcan, Javad Najjar Mojarrab, Syed Sajjad, Rebecca Blonsky · 2021

Background. Acute kidney injury (AKI) requiring dialysis during pregnancy is uncommon. We present a case of a young female diagnosed with antiglomerular basement membrane (anti-GBM) disease during pregnancy. Case Presentation. A 23-year-ol…

Design of efficacious somatic cell genome editing strategies for recessive and polygenic diseases Open

Jared Carlson-Stevermer, Amritava Das, Amr A. Abdeen, David N. Fiflis, Benjamin Isaac Grindel , et al. · 2020

Compound heterozygous recessive or polygenic diseases could be addressed through gene correction of multiple alleles. However, targeting of multiple alleles using genome editors could lead to mixed genotypes and adverse events that amplify…

Design of efficacious somatic cell genome editing strategies for recessive and polygenic diseases Open

Jared Carlson-Stevemer, Amritava Das, Amr A. Abdeen, David N. Fiflis, Benjamin Isaac Grindel , et al. · 2020

Gene correction of multiple alleles for compound heterozygous recessive or polygenic diseases is a promising therapeutic strategy. However, the targeting of multiple alleles using genome editors in a single cell could lead to mixed genotyp…

Design of efficacious somatic cell genome editing strategies for recessive and polygenic diseases Open

Jared Carlson-Stevermer, Amritava Das, Amr A. Abdeen, David N. Fiflis, Benjamin Isaac Grindel , et al. · 2020

Gene correction of multiple alleles for compound heterozygous recessive or polygenic diseases is a promising therapeutic strategy. However, the targeting of multiple alleles using genome editors in a single cell could lead to mixed genotyp…

Differential Expression of Ormdl Genes in the Islets of Mice and Humans with Obesity Open

Hugo Lee, Rachel J. Fenske, Tugce Akcan, Elliot Domask, Dawn Belt Davis , et al. · 2020

Insulin Gene Therapy for Treating Type I Diabetes Mellitus: History, Progress and Future Challenges Open

Tugce Akcan, Tanweer Alam, Sollinger Hw · 2020

Type 1 Diabetes Mellitus (T1DM) results from the autoimmune destruction of insulin-producing pancreatic β cells.Despite advances in our understanding of both the pathogenesis and management of diabetes and treatment options, which mainly i…

Differential expression of Ormdl genes in the islets of mice and humans with obesity Open

Rachel J. Fenske, Hugo Lee, Tugce Akcan, Elliot Domask, Dawn Belt Davis , et al. · 2019

Summary The orosomucoid-like proteins (Ormdl1-3) are emerging as the critical regulators of sphingolipid homeostasis, inflammation and ER stress. However, their roles in β-cells and obesity remain unknown. Here, we showed that islets isola…

A Rare Case of Triple-Negative Essential Thrombocythemia in a Young Postsplenectomy Patient: A Diagnostic Challenge Open

Tugce Akcan, Paolo Strati, Melissa Yan, Modupe Idowu · 2018

The distinction between primary and reactive thrombocytosis by bone marrow histology is very important. Reactive thrombocytosis, the most common cause of thrombocytosis, can be expected in postsplenectomy states; however, close hematologic…

Cost-effectiveness analysis of type 2 diabetes in outpatient therapy in Turkey Open

Gülden Yürüyen, Eylem ÖZGÜN ÇİL, Yücel Arman, Pınar Demir Gündoğmuş, Ramazan Çakmak , et al. · 2017

Objective: The purpose of this study is toestimate the cost-effectiveness of screening, treatment, and examination ofpatients with type 2 diabetes during a yearly period and expose its importancein diabetes control.Materials and Methods: F…

Content Vol. 136, 2016 Open

Eytan M. Stein, Robert E. Gallagher, Frederick R. Appelbaum, Jeffrey E. Lancet, Martin S. Tallman , et al. · 2016

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