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View article: Context dependent isoform specific PI3K inhibition confers drug resistance in hepatocellular carcinoma cells
Context dependent isoform specific PI3K inhibition confers drug resistance in hepatocellular carcinoma cells Open
Background Targeted therapies for Primary liver cancer (HCC) is limited to the multi-kinase inhibitors, and not fully effective due to the resistance to these agents because of the heterogeneous molecular nature of HCC developed during chr…
View article: Context dependent isoform specific PI3K inhibition confers drug resistance in Hepatocellular carcinoma cells
Context dependent isoform specific PI3K inhibition confers drug resistance in Hepatocellular carcinoma cells Open
Background Targeted therapies for Primary liver cancer (HCC) is limited to the multi-kinase inhibitors, and not fully effective due to the resistance to these agents because of the heterogeneous molecular nature of HCC developed during chr…
View article: Large‐scale automated function prediction of protein sequences and an experimental case study validation on PTEN transcript variants
Large‐scale automated function prediction of protein sequences and an experimental case study validation on PTEN transcript variants Open
Recent advances in computing power and machine learning empower functional annotation of protein sequences and their transcript variations. Here, we present an automated prediction system UniGOPred, for GO annotations and a database of GO …
View article: Iterative h‐minima‐based marker‐controlled watershed for cell nucleus segmentation
Iterative h‐minima‐based marker‐controlled watershed for cell nucleus segmentation Open
Automated microscopy imaging systems facilitate high‐throughput screening in molecular cellular biology research. The first step of these systems is cell nucleus segmentation, which has a great impact on the success of the overall system. …
View article: Liver cancer cells are sensitive to Lanatoside C induced cell death independent of their PTEN status
Liver cancer cells are sensitive to Lanatoside C induced cell death independent of their PTEN status Open
View article: PATZ1 Is a DNA Damage-Responsive Transcription Factor That Inhibits p53 Function
PATZ1 Is a DNA Damage-Responsive Transcription Factor That Inhibits p53 Function Open
Insults to cellular health cause p53 protein accumulation, and loss of p53 function leads to tumorigenesis. Thus, p53 has to be tightly controlled. Here we report that the BTB/POZ domain transcription factor PATZ1 (MAZR), previously known …
View article: The PI3K/AKT/mTOR interactive pathway
The PI3K/AKT/mTOR interactive pathway Open
The phosphatidylinositol 3-kinase (PI3K)/AKT/mammalian target of the rapamycin (mTOR) signalling pathway is hyperactivated or altered in many cancer types and regulates a broad range of cellular processes including survival, proliferation,…