Explanipedia

Quantitative Susceptibility Mapping of Deep Grey Matter in MS: Association With Clinical Scores and Brain Volume Measures Open

Cui Ci Voon, Jakob Meineke, Tun Wiltgen, Julian McGinnis, Ronja Berg , et al. · 2025

Background Changes in quantitative susceptibility mapping (QSM) of the deep grey matter (DGM) in multiple sclerosis (MS) are thought to reflect tissue damage invisible in conventional magnetic resonance imaging (MRI) sequences, such as iro…

Differentiating central fever from infectious fever in intracerebral haemorrhage Open

F Hess, Enayatullah Baki, Julian McGinnis, Tun Wiltgen, Hanne Scholz , et al. · 2025

Background In addition to infectious fever, stroke-related disturbances in thermoregulation, referred to as central fever, are frequently observed in patients with stroke, particularly in those with intracerebral haemorrhage (ICH). Rapid i…

Towards quantitative intensity analysis of conventional T1-weighted images in multiple sclerosis Open

Tun Wiltgen, Julian McGinnis, Ronja Berg, Cui Ci Voon, Oula Puonti , et al. · 2025

Conventional T1-weighted (T1w) magnetic resonance imaging (MRI) is commonly used in multiple sclerosis (MS) morphometry and volumetry research. However, arbitrary intensity scales preclude interpretation of signal values across patients, s…

Predictors and Implications of Myocardial Injury in Intracerebral Hemorrhage Open

F Hess, Julian McGinnis, Enayatullah Baki, Tun Wiltgen, Arne Müller , et al. · 2025

Purpose Myocardial injury, indicated by an elevation of high-sensitive cardiac Troponin (hs-cTnT), is a frequent stroke-related complication. Most studies investigated patients with ischemic stroke, but only little is known about its occur…

Corrigendum to “Quantitative susceptibility mapping in multiple sclerosis: A systematic review and meta-analysis” [Neuroimage: Clin. 42 (2024) 103598] Open

Cui Ci Voon, Tun Wiltgen, Benedikt Wiestler, Sarah Schlaeger, Mark Mühlau · 2024

Intensity scaling of conventional brain magnetic resonance images avoiding cerebral reference regions: A systematic review Open

Tun Wiltgen, Cui Ci Voon, Koen Van Leemput, Benedikt Wiestler, Mark Mühlau · 2024

Background Conventional brain magnetic resonance imaging (MRI) produces image intensities that have an arbitrary scale, hampering quantification. Intensity scaling aims to overcome this shortfall. As neurodegenerative and inflammatory diso…

Quantitative susceptibility mapping in multiple sclerosis: A systematic review and meta-analysis Open

Cui Ci Voon, Tun Wiltgen, Benedikt Wiestler, Sarah Schlaeger, Mark Mühlau · 2024

LST-AI: A deep learning ensemble for accurate MS lesion segmentation Open

Tun Wiltgen, Julian McGinnis, Sarah Schlaeger, Florian Kofler, Cui Ci Voon , et al. · 2024

Cortical Thin Patch Fraction Reflects Disease Burden in MS: The Mosaic Approach Open

Marlene Tahedl, Tun Wiltgen, Cui Ci Voon, Achim Berthele, Jan S. Kirschke , et al. · 2023

This study demonstrates the validity of the mosaic approach as a neuroradiologic biomarker in MS. The output of the mosaic approach, namely the thin patch fraction, is a candidate biomarker for assessing and localizing cortical GM patholog…

Association of retinal vessel pathology and brain atrophy in relapsing-remitting multiple sclerosis Open

Eva Feodora Romahn, Tun Wiltgen, Matthias Bussas, Lilian Aly, Rebecca Wicklein , et al. · 2023

Background Optical coherence tomography angiography (OCTA) allows non-invasive assessment of retinal vessel structures. Thinning and loss of retinal vessels is evident in eyes of patients with multiple sclerosis (MS) and might be associate…

LST-AI: a Deep Learning Ensemble for Accurate MS Lesion Segmentation Open

Tun Wiltgen, Julian McGinnis, Sarah Schlaeger, Florian Kofler, Cui Ci Voon , et al. · 2023

Automated segmentation of brain white matter lesions is crucial for both clinical assessment and scientific research in multiple sclerosis (MS). Over a decade ago, we introduced an engineered lesion segmentation tool, LST. While recent les…

Issue Information Open

Damilola D. Adingupu, Taelor Evans, Ateyeh Soroush, Ayden Hansen, Scott Jarvis , et al. · 2023

Wiley is a founding member of the UN-backed HINARI, AGORA, and OARE initiatives.They are now collectively known as Research4Life, making online scientific content available free or at nominal cost to researchers in developing countries.

Benefits of a mosaic approach for assessing cortical atrophy in individual multiple sclerosis patients Open

Marlene Tahedl, Tun Wiltgen, Cui Ci Voon, Achim Berthele, Jan S. Kirschke , et al. · 2023

Objective Cortical gray matter (GM) atrophy plays a central role in multiple sclerosis (MS) pathology. However, it is not commonly assessed in clinical routine partly because a number of methodological problems hamper the development of a …

A Genetic Risk Variant for Multiple Sclerosis Severity is Associated with Brain Atrophy Open

Christiane Gasperi, Tun Wiltgen, Julian McGinnis, Stefano Cerri, Thomas Moridi , et al. · 2023

The minor allele of the genetic variant rs10191329 in the DYSF‐ZNF638 locus is associated with unfavorable long‐term clinical outcomes in multiple sclerosis patients. We investigated if rs10191329 is associated with brain atrophy measured …

18F-FET PET radiomics-based survival prediction in glioblastoma patients receiving radio(chemo)therapy Open

Tun Wiltgen, Daniel F. Fleischmann, Lena Kaiser, Adrien Holzgreve, Stefanie Corradini , et al. · 2022

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