Tunan Chen
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View article: Terahertz attenuated total reflection imaging of fresh brain glioma based on a solid immersion lens
Terahertz attenuated total reflection imaging of fresh brain glioma based on a solid immersion lens Open
The diagnosis and treatment of gliomas depend greatly on the precise delineation of tumor boundaries and the rapid extraction of molecular pathological features. The development of high-resolution and high-sensitivity terahertz (THz) atten…
View article: Clinical characteristics and outcomes of patients with traumatic brain injury transferred from ultra-high-altitude areas: patient series
Clinical characteristics and outcomes of patients with traumatic brain injury transferred from ultra-high-altitude areas: patient series Open
BACKGROUND Traumatic brain injury (TBI) patients transferred from high-altitude areas present with unique challenges that complicate the treatment of these patients. This study aims to summarize the clinical characteristics and treatment e…
View article: A Multiple Market Trading Mechanism for Virtual Power Plants Participating in Electricity Energy‐Renewable Energy Certificate‐Carbon Emission Right Markets
A Multiple Market Trading Mechanism for Virtual Power Plants Participating in Electricity Energy‐Renewable Energy Certificate‐Carbon Emission Right Markets Open
This paper introduces a novel trading mechanism that enables virtual power plants (VPPs) to simultaneously engage in electricity, renewable energy certificate (REC), and carbon emission right (CER) markets, taking into account the differen…
View article: Terahertz meta-biosensor for subtype detection and chemotherapy monitoring of glioma cells
Terahertz meta-biosensor for subtype detection and chemotherapy monitoring of glioma cells Open
Rapid and precise identification of glioma subtypes can assist surgeons in quickly determining patients’ conditions and developing treatment plans. However, current methods face challenges such as high cost and limited sensitivity, thereby…
View article: High-sensitivity THz-ATR imaging of cerebral ischemia in a rat model
High-sensitivity THz-ATR imaging of cerebral ischemia in a rat model Open
The fast label-free detection of the extent and degree of cerebral ischemia has been the difficulty and hotspot for precise and accurate neurosurgery. We experimentally demonstrated that the fresh cerebral tissues at different ischemic sta…
View article: Probing Phosphorylation-Induced Vibrational Couplings in CFTR by 2D IR Spectra Simulations
Probing Phosphorylation-Induced Vibrational Couplings in CFTR by 2D IR Spectra Simulations Open
Phosphorylation of the regulator (R) domain underlies the basis for gating in the human cystic fibrosis transmembrane conductance regulator (CFTR), malfunction or down regulation of CFTR leads to defective apical chloride transport. The bi…
View article: [Effects of enhancing the expression of aryl hydrocarbon receptor in post-traumatic mice macrophages on the inflammatory cytokine level and bactericidal ability].
[Effects of enhancing the expression of aryl hydrocarbon receptor in post-traumatic mice macrophages on the inflammatory cytokine level and bactericidal ability]. Open
Objective: To explore the expression pattern of aryl hydrocarbon receptor (AhR) in mice peritoneal macrophages (PMs) after major trauma and analyze the effects of enhanced AhR expression on the inflammatory cytokine level and bactericidal …
View article: Serum-based Raman spectroscopic diagnosis of blast-induced brain injury in a rat model
Serum-based Raman spectroscopic diagnosis of blast-induced brain injury in a rat model Open
The diagnosis of blast-induced traumatic brain injury (bTBI) is of paramount importance for early care and clinical therapy. Therefore, the rapid diagnosis of bTBI is vital to the treatment and prognosis in clinic. In this paper, we report…
View article: Editorial: Neurovascular dysfunction after brain injury
Editorial: Neurovascular dysfunction after brain injury Open
EDITORIAL article Front. Pharmacol., 02 June 2023Sec. Neuropharmacology Volume 14 - 2023 | https://doi.org/10.3389/fphar.2023.1222328
View article: Acetylated α‐tubulin alleviates injury to the dendritic spines after ischemic stroke in mice
Acetylated α‐tubulin alleviates injury to the dendritic spines after ischemic stroke in mice Open
Background and Aim Functional recovery is associated with the preservation of dendritic spines in the penumbra area after stroke. Previous studies found that polymerized microtubules (MTs) serve a crucial role in regulating dendritic spine…
View article: Terahertz time-domain attenuated total reflection spectroscopy integrated with a microfluidic chip
Terahertz time-domain attenuated total reflection spectroscopy integrated with a microfluidic chip Open
The integration of a microfluidic chip into terahertz time-domain attenuated total reflection (THz TD-ATR) spectroscopy is highly demanded for the accurate measurement of aqueous samples. Hitherto, however little work has been reported on …
View article: Machine learning of flow cytometry data reveals the delayed innate immune responses correlate with the severity of COVID-19
Machine learning of flow cytometry data reveals the delayed innate immune responses correlate with the severity of COVID-19 Open
Introduction The COVID-19 pandemic has posed a major burden on healthcare and economic systems across the globe for over 3 years. Even though vaccines are available, the pathogenesis is still unclear. Multiple studies have indicated hetero…
View article: Intermolecular Vibration Energy Transfer Process in Two CL-20-Based Cocrystals Theoretically Revealed by Two-Dimensional Infrared Spectra
Intermolecular Vibration Energy Transfer Process in Two CL-20-Based Cocrystals Theoretically Revealed by Two-Dimensional Infrared Spectra Open
Inspired by the recent cocrystallization and theory of energetic materials, we theoretically investigated the intermolecular vibrational energy transfer process and the non-covalent intermolecular interactions between explosive compounds. …
View article: Stem cell differentiation with consistent lineage commitment induced by a flash of ultrafast-laser activation in vitro and in vivo
Stem cell differentiation with consistent lineage commitment induced by a flash of ultrafast-laser activation in vitro and in vivo Open
Recent technological advancements on stem cell differentiation induction have been making great progress in stem cell research, regenerative medicine, and therapeutic applications. However, the risk of off-target differentiation limits the…
View article: Revealing the Relationship between Electric Fields and the Conformation of Oxytocin Using Quasi-Static Amide-I Two-Dimensional Infrared Spectra
Revealing the Relationship between Electric Fields and the Conformation of Oxytocin Using Quasi-Static Amide-I Two-Dimensional Infrared Spectra Open
It is reported that the cis/trans conformation change of the peptide hormone oxytocin plays an important role in its receptors and activation and the cis conformation does not lead to antagonistic activity. Motivated by recent experiments …
View article: Terahertz technology applications in glioma diagnosis: From histological classification to molecular typing
Terahertz technology applications in glioma diagnosis: From histological classification to molecular typing Open
Terahertz wave is an electromagnetic wave, whose wavelength is located between microwave wavelength and infrared wavelength. Based on low ionization and fingerprint characteristics, it has great potential applications in biomedical field, …
View article: Inhibiting Microglia‐Derived NLRP3 Alleviates Subependymal Edema and Cognitive Dysfunction in Posthemorrhagic Hydrocephalus after Intracerebral Hemorrhage via AMPK/Beclin‐1 Pathway
Inhibiting Microglia‐Derived NLRP3 Alleviates Subependymal Edema and Cognitive Dysfunction in Posthemorrhagic Hydrocephalus after Intracerebral Hemorrhage via AMPK/Beclin‐1 Pathway Open
For posthemorrhagic hydrocephalus (PHH) patients, whether occur subependymal edema indicates poor outcomes, partially manifested as cognitive impairment. In the brain, NLRP3 inflammasome mainly derived from microglia/macrophages is involve…
View article: TRPV4-Activation Induced Nerve Fibers Injury Mediates the Memory Impairment After Noise Exposure
TRPV4-Activation Induced Nerve Fibers Injury Mediates the Memory Impairment After Noise Exposure Open
Background: Excessive exposure to high-intensity, low-frequency noise (HI-LFN) causes vibroacoustic disease (VAD). Memory deficits is one non-auditory symptomatic effect found in humans and rodents with VAD, but the mechanism is largely un…
View article: Long Non−Coding RNA H19 Regulates Glioma Cell Growth and Metastasis via miR-200a-Mediated CDK6 and ZEB1 Expression
Long Non−Coding RNA H19 Regulates Glioma Cell Growth and Metastasis via miR-200a-Mediated CDK6 and ZEB1 Expression Open
Long non-coding RNAs (lncRNAs) serve essential roles on various biological functions. Previous studies have indicated that lncRNAs are involved in the occurrence, growth and infiltration of brain tumors. LncRNA H19 is key regulator in the …
View article: Ferrostatin-1 Alleviates White Matter Injury via Decreasing Ferroptosis Following Spinal Cord Injury
Ferrostatin-1 Alleviates White Matter Injury via Decreasing Ferroptosis Following Spinal Cord Injury Open
Spinal cord injury (SCI), a devastating neurological impairment, ubiquitously imposes a long-term psychological stress and high socioeconomic burden for the suffers and their family. To date, recent researchers have paid arousing attention…
View article: Natural evolution mechanisms of the IDH mutant glioma revealed by multi-omics sequencing of a long-term survivor
Natural evolution mechanisms of the IDH mutant glioma revealed by multi-omics sequencing of a long-term survivor Open
Purpose Low-grade gliomas(LGG) almost invariably progress into secondary glioblastoma with limited therapeutic options. The currently proposed progression mechanisms were mainly based on treatment intervened patients, seldom is known about…
View article: NLRP3 Inflammasome Activation Attenuates Neuronal Apoptosis by Upregulating Autophagy through AMPK/Beclin-1 Pathway after Intracerebral Hemorrhage with Ventricular Extension in Rats
NLRP3 Inflammasome Activation Attenuates Neuronal Apoptosis by Upregulating Autophagy through AMPK/Beclin-1 Pathway after Intracerebral Hemorrhage with Ventricular Extension in Rats Open
BackgroundIn brain, NLRP3 inflammasome, mainly derived from macrophage/microglia, is involved in proinflammatory and neurodeficits after hemorrhage, and autophagy is vital for neuronal homeostasis and functions. Accumulating evidence sugge…
View article: Direct control of store-operated calcium channels by ultrafast laser
Direct control of store-operated calcium channels by ultrafast laser Open
Ca 2+ channels are essential to cell birth, life, and death. They can be externally activated by optogenetic tools, but this requires robust introduction of exogenous optogenetic genes for expression of photosensitive proteins in biologica…
View article: Graphene oxide-composited chitosan scaffold contributes to functional recovery of injured spinal cord in rats
Graphene oxide-composited chitosan scaffold contributes to functional recovery of injured spinal cord in rats Open
The study illustrates that graphene oxide nanosheets can endow materials with continuous electrical conductivity for up to 4 weeks. Conductive nerve scaffolds can bridge a sciatic nerve injury and guide the growth of neurons; however, whet…
View article: Monitoring Astrocytic Ca2+ Activity in Freely Behaving Mice
Monitoring Astrocytic Ca2+ Activity in Freely Behaving Mice Open
Monitoring astrocytic Ca 2+ activity is essential to understand the physiological and pathological roles of astrocytes in the brain. However, previous commonly used methods for studying astrocytic Ca 2+ activities can be applied in only an…
View article: Synchrotron Radiation-Based FTIR Microspectroscopic Imaging of Traumatically Injured Mouse Brain Tissue Slices
Synchrotron Radiation-Based FTIR Microspectroscopic Imaging of Traumatically Injured Mouse Brain Tissue Slices Open
Traumatic brain injury (TBI) is a health problem of global concern because of its serious adverse effects on public health and social economy. A technique that can be used to precisely detect TBI is highly demanded. Here, we report on a sy…