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View article: Severe Fatal ARDS Due to Untreated Human Granulocytic Anaplasmosis in a 67-Year-Old Man: A Case Report
Severe Fatal ARDS Due to Untreated Human Granulocytic Anaplasmosis in a 67-Year-Old Man: A Case Report Open
BACKGROUND Anaplasmosis, or human granulocytic anaplasmosis (HGA), is a tick-borne diseased caused by a gram-negative, intracellular bacterium, Anaplasma phagocytophilum. HGA usually presents with mild symptoms but can be more severe. This…
View article: Molecular Evolution of GII.P31/GII.4_Sydney_2012 Norovirus over a Decade in a Clinic in Japan
Molecular Evolution of GII.P31/GII.4_Sydney_2012 Norovirus over a Decade in a Clinic in Japan Open
Norovirus (NoV) genogroup II, polymerase type P31, capsid genotype 4, Sydney_2012 variant (GII.P31/GII.4_Sydney_2012) has been circulating at high levels for over a decade, raising the question of whether this strain is undergoing molecula…
View article: Clinical evaluation of the Simplexa HSV 1 & 2 Direct assay for bronchoalveolar lavage specimens
Clinical evaluation of the Simplexa HSV 1 & 2 Direct assay for bronchoalveolar lavage specimens Open
Rapid laboratory testing is essential to detect HSV in the lower respiratory tract to allow rapid treatment decisions. We evaluated the clinical performance of the Simplexa HSV 1 & 2 Direct assay in bronchoalveolar lavage. This assay is hi…
View article: Clinical performance evaluation of HCV and HIV-1 assays on the fully automated molecular system Alinity m
Clinical performance evaluation of HCV and HIV-1 assays on the fully automated molecular system Alinity m Open
The demand for molecular virology testing continues to grow in clinical laboratories worldwide. The Alinity m system is a fully automated, continuous, random-access molecular diagnostic analyzer that was designed to streamline the laborato…
View article: A Comparative Study of Acute Gastroenteritis Symptoms in Single- versus Multiple-Virus Infections
A Comparative Study of Acute Gastroenteritis Symptoms in Single- versus Multiple-Virus Infections Open
Many different enteric viruses can cause acute gastroenteritis in humans worldwide. While a single virus can indeed cause disease, multiple-virus infections are commonly reported. However, data regarding a comparison between single- and mu…
View article: Mini-evaluation of the Lyra SARS-CoV-2 assay to detect Omicron BA.1 and BA.2 in nasopharyngeal swabs
Mini-evaluation of the Lyra SARS-CoV-2 assay to detect Omicron BA.1 and BA.2 in nasopharyngeal swabs Open
View article: Predictive model for severe COVID-19 using SARS-CoV-2 whole genome sequencing and electronic health record data, March 2020-May 2021
Predictive model for severe COVID-19 using SARS-CoV-2 whole genome sequencing and electronic health record data, March 2020-May 2021 Open
Background and Aim: We used SARS-CoV-2 whole-genome sequencing (WGS) and electronic health record (EHR) data to investigate the associations between viral genomes and clinical characteristics and severe outcomes among hospitalized COVID-19…
View article: Pasteurella multocida bacteremia in a patient with septic arthritis
Pasteurella multocida bacteremia in a patient with septic arthritis Open
Pasteurella multocida is a common commensal microorganism found in the nasopharynx of domestic and wild animals. Humans acquire P multocida infection primarily through contact with animals or their mucous secretions. P mul…
View article: Emergence of SARS‐CoV‐2 Omicron BA.5 variant of concern in Western Pennsylvania, United States
Emergence of SARS‐CoV‐2 Omicron BA.5 variant of concern in Western Pennsylvania, United States Open
The severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) Omicron variant of concern (B.1.1.529) was initially comprised of three lineages, BA.1, BA.2, and BA.3. Subsequently, BA.4 and BA.5 were detected in South Africa in January a…
View article: Detection of Enterococcus avium in a case of urinary tract infection and haematuria
Detection of Enterococcus avium in a case of urinary tract infection and haematuria Open
Enterococci have been recognized as major pathogens causing nosocomial and community-acquired infections. The emergence of antimicrobial-resistant enterococci is one of the major public health challenges worldwide. While many enterococcal …
View article: First detection of SARS‐CoV‐2 Omicron BA.4 variant in Western Pennsylvania, United States
First detection of SARS‐CoV‐2 Omicron BA.4 variant in Western Pennsylvania, United States Open
At the time of writing, the world continues to witness the extraordinarily rapid evolution and selection of SARS-CoV-2, with the Omicron variants comprising five lineages known as BA.1, BA.2, BA.3, BA.4, and BA.5.1 The Omicron variant show…
View article: Keratitis caused by Nocardia farcinica in a contact lens wearer
Keratitis caused by Nocardia farcinica in a contact lens wearer Open
Bacterial keratitis is an infection of the cornea. This kind of infection can progress quickly and if left untreated, it can eventually cause complete blindness. While Staphylococcus aureus and Pseudomonas aeruginosa are most…
View article: Whole genome sequencing and evolutionary analysis of G8P [8] rotaviruses emerging in Japan
Whole genome sequencing and evolutionary analysis of G8P [8] rotaviruses emerging in Japan Open
View article: Clinical evaluation of the Cue's COVID‑19 diagnostic test to detect SARS‐CoV‐2 in the upper respiratory tract
Clinical evaluation of the Cue's COVID‑19 diagnostic test to detect SARS‐CoV‐2 in the upper respiratory tract Open
View article: Evaluation of the ePlex Respiratory pathogen panel 2 to detect viral and bacterial pathogens, including SARS-CoV-2 Omicron in nasopharyngeal swabs
Evaluation of the ePlex Respiratory pathogen panel 2 to detect viral and bacterial pathogens, including SARS-CoV-2 Omicron in nasopharyngeal swabs Open
View article: Evaluation of the Cepheid Xpert Xpress SARS-CoV-2 test for bronchoalveolar lavage
Evaluation of the Cepheid Xpert Xpress SARS-CoV-2 test for bronchoalveolar lavage Open
View article: Development of a One-Step Qualitative RT-PCR Assay to Detect the SARS-CoV-2 Omicron (B.1.1.529) Variant in Respiratory Specimens
Development of a One-Step Qualitative RT-PCR Assay to Detect the SARS-CoV-2 Omicron (B.1.1.529) Variant in Respiratory Specimens Open
The first case of the new SARS-CoV-2 Omicron Variant of Concern (VOC) from South Africa was reported to WHO on November 24, 2021.…
View article: Development of the one-step qualitative RT-PCR assay to detect SARS-CoV-2 Omicron (B.1.1.529) variant in respiratory specimens
Development of the one-step qualitative RT-PCR assay to detect SARS-CoV-2 Omicron (B.1.1.529) variant in respiratory specimens Open
A new SARS-CoV-2 Omicron (B.1.1.529) Variant of Concern has been emerging worldwide. We are seeing an unprecedented surge in patients due to Omicron in this COVID-19 pandemic. A rapid and accurate molecular test that effectively differenti…
View article: Evaluation of Viral Loads in Patients With SARS-CoV-2 Delta Variant Infection: Higher Loads Do Not Translate Into Different Testing Scenarios
Evaluation of Viral Loads in Patients With SARS-CoV-2 Delta Variant Infection: Higher Loads Do Not Translate Into Different Testing Scenarios Open
The Delta SARS-CoV-2 variant is very infectious, and it is spreading quickly during this pandemic. In the study, we compared viral loads estimated by means of the Ct values emerging from RT-PCR swab tests in surging cases infected with the…
View article: Evaluation of the Cepheid Xpert Xpress SARS-CoV-2 test for bronchoalveolar lavage
Evaluation of the Cepheid Xpert Xpress SARS-CoV-2 test for bronchoalveolar lavage Open
Accurate and rapid laboratory tests are essential for the prompt diagnosis of COVID-19, which is important to patients and infection control. The Xpert Xpress SARS-CoV-2 test is a real-time RT-PCR intended for the qualitative detection of …
View article: Secondary syphilis as an initial presentation of HIV
Secondary syphilis as an initial presentation of HIV Open
Syphilis, a sexually transmitted infection caused by the spirochete Treponema pallidum, generally presents in distinct stages that sequentially progress in a predictable pattern. However, in the case of syphilis and HIV coinfection,…
View article: Detection of Enterococcus hirae in a case of acute osteomyelitis
Detection of Enterococcus hirae in a case of acute osteomyelitis Open
View article: One year into the pandemic: Short-term evolution of SARS-CoV-2 and emergence of new lineages
One year into the pandemic: Short-term evolution of SARS-CoV-2 and emergence of new lineages Open
View article: Vibrio mimicus wound infection in a burn patient
Vibrio mimicus wound infection in a burn patient Open
View article: A rare case of polymicrobial brain abscess involving Actinomyces
A rare case of polymicrobial brain abscess involving Actinomyces Open
View article: Tuberculosis of the rare azygos lobe of the right lung
Tuberculosis of the rare azygos lobe of the right lung Open
Mycobacterium tuberculosis is the etiological agent of tuberculosis in humans. Tuberculosis is not only a highly contagious infectious disease, but also one of the top causes of death globally, especially in developing countries. Tu…
View article: Septic Polyarthritis Caused by <i>Streptobacillus moniliformis</i>
Septic Polyarthritis Caused by <i>Streptobacillus moniliformis</i> Open
Streptobacillus moniliformis is a pleomorphic, fastidious gram-negative bacillus that colonizes rodent respiratory tracts and causes rat-bite fever in humans. Rat-bite fever is associated with septic arthritis, usually monoarticular or pau…
View article: Molecular epidemiology and surveillance of circulating rotavirus among children with gastroenteritis in Bangladesh during 2014–2019
Molecular epidemiology and surveillance of circulating rotavirus among children with gastroenteritis in Bangladesh during 2014–2019 Open
Acute gastroenteritis is one of the major health problems in children aged <5 years around the world. Rotavirus A (RVA) is an important pathogen of acute gastroenteritis. The burden of rotavirus disease in the pediatric population is still…
View article: Endophthalmitis resulting from gonococcal keratoconjunctivitis
Endophthalmitis resulting from gonococcal keratoconjunctivitis Open
Neisseria gonorrhoeae is a global pathogen with significant morbidity. This bacterium is one of the common causes of sexually transmitted diseases; however, ocular gonococcal infection is rare. The gonococcal ocular infection can le…
View article: SARS-CoV-2 and COVID-19: A genetic, epidemiological, and evolutionary perspective
SARS-CoV-2 and COVID-19: A genetic, epidemiological, and evolutionary perspective Open