Jie Zhang
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View article: Group B Streptococcus Sepsis with Cardiac Abscesses in a Neonate with Migrated Umbilical Catheter: Literature Review
Group B Streptococcus Sepsis with Cardiac Abscesses in a Neonate with Migrated Umbilical Catheter: Literature Review Open
Group B Streptococcus (GBS) is the leading cause of sepsis, pneumonia and/or meningitis in neonates. Insertion of umbilical catheter (UC) is a common practice in neonatal intensive care for primary central vascular access in extreme premat…
View article: Letter to the Editor regarding: ‘Anterior quadratus lumborum block at the lateral supra-arcuate ligament versus thoracic paravertebral block for postoperative analgesia after laparoscopic nephrectomy: a randomized non-inferiority trial’
Letter to the Editor regarding: ‘Anterior quadratus lumborum block at the lateral supra-arcuate ligament versus thoracic paravertebral block for postoperative analgesia after laparoscopic nephrectomy: a randomized non-inferiority trial’ Open
View article: A Study On The Symmetry Of The Anterior Mandibular Body
A Study On The Symmetry Of The Anterior Mandibular Body Open
Aim or purpose: This study aims to explore the optimal mandibular symphysis sagittal plane for patients with skeletal Class III mandibular asymmetry. Materials and methods: Thirty-three orthognathic surgery patients with the skeletal Class…
View article: Positive emotions and inhibitory control enhance prosocial sharing behavior in children under unequal resource conditions: An fNIRS study
Positive emotions and inhibitory control enhance prosocial sharing behavior in children under unequal resource conditions: An fNIRS study Open
Prosocial sharing in unequal contexts is a core issue in children's moral and social development, but the underlying neural mechanisms and the role of emotion regulation and inhibitory control of cognitive structures in them remain under-e…
View article: SugarcaneOmics: An integrative multi-omics platform for sugarcane research
SugarcaneOmics: An integrative multi-omics platform for sugarcane research Open
View article: Metabolomics and lipidomics combined with network pharmacology to reveal the hypolipidemic mechanism of Hippophae rhamnoides L. flavonoids
Metabolomics and lipidomics combined with network pharmacology to reveal the hypolipidemic mechanism of Hippophae rhamnoides L. flavonoids Open
View article: Non-linear association between serum levels of vitamins A and B12 and accelerated epigenetic aging
Non-linear association between serum levels of vitamins A and B12 and accelerated epigenetic aging Open
Background Serum vitamins A and B12, as essential micronutrients, play pivotal roles in maintaining physiological homeostasis; however, the association between these vitamins and aging remains unclear. Therefore, this study aims to investi…
View article: CEBPB regulates ERK1/2 activity through SOS1 and contributes to ovarian cancer progression
CEBPB regulates ERK1/2 activity through SOS1 and contributes to ovarian cancer progression Open
View article: United Minds or Isolated Agents? Exploring Coordination of LLMs under Cognitive Load Theory
United Minds or Isolated Agents? Exploring Coordination of LLMs under Cognitive Load Theory Open
Large Language Models (LLMs) exhibit a notable performance ceiling on complex, multi-faceted tasks, as they often fail to integrate diverse information or adhere to multiple constraints. We posit that such limitation arises when the demand…
View article: CEBPB promotes transformation of endometrial complex atypical hyperplasia to endometrial cancer
CEBPB promotes transformation of endometrial complex atypical hyperplasia to endometrial cancer Open
View article: Ejector Design and Structural Parameter Optimization Design of Vehicle-Mounted Hydrogen Supply Circulation System
Ejector Design and Structural Parameter Optimization Design of Vehicle-Mounted Hydrogen Supply Circulation System Open
View article: Small ubiquitin-like modifiers inhibitors lower blood pressure <i>via</i> ERK5/KLF2-dependent upregulation of the eNOS/NO pathway
Small ubiquitin-like modifiers inhibitors lower blood pressure <i>via</i> ERK5/KLF2-dependent upregulation of the eNOS/NO pathway Open
Background Small ubiquitin-like modifiers (SUMO)ylation is a dynamic and reversible post-translational modification playing pivotal roles in the regulation of cancer, diabetes, heart failure, and neurological diseases. However, whether SUM…
View article: Markers, Mechanisms and Metrics of Biological Aging: A Scoping Review
Markers, Mechanisms and Metrics of Biological Aging: A Scoping Review Open
Biological aging is a rapidly growing area of research, which entails characterizing the rate of aging independent of an individual’s chronological age. In this review, we analyze the results of biological aging research in 435 papers publ…
View article: Impact of residential solid fuel usage and fuel conversion on children’s lung function
Impact of residential solid fuel usage and fuel conversion on children’s lung function Open
Solid fuel combustion exposure is a leading global health risk factor, yet evidence on its effects, especially on vulnerable children, is sparse. This large-scale, multi-center prospective study aimed to address this gap by involving 9997 …
View article: Cambricon-LLM: A Chiplet-Based Hybrid Architecture for On-Device Inference of 70B LLM
Cambricon-LLM: A Chiplet-Based Hybrid Architecture for On-Device Inference of 70B LLM Open
Deploying advanced large language models on edge devices, such as smartphones and robotics, is a growing trend that enhances user data privacy and network connectivity resilience while preserving intelligent capabilities. However, such a t…
View article: InstInfer: In-Storage Attention Offloading for Cost-Effective Long-Context LLM Inference
InstInfer: In-Storage Attention Offloading for Cost-Effective Long-Context LLM Inference Open
The widespread of Large Language Models (LLMs) marks a significant milestone in generative AI. Nevertheless, the increasing context length and batch size in offline LLM inference escalate the memory requirement of the key-value (KV) cache,…
View article: Zosuquidar Promotes Antitumor Immunity by Inducing Autophagic Degradation of PD‐L1
Zosuquidar Promotes Antitumor Immunity by Inducing Autophagic Degradation of PD‐L1 Open
The intracellular distribution and transportation process are essential for maintaining PD‐L1 (programmed death‐ligand 1) expression, and intervening in this cellular process may provide promising therapeutic strategies. Here, through a ce…
View article: Exploring the bone marrow micro environment in thalassemia patients: potential therapeutic alternatives
Exploring the bone marrow micro environment in thalassemia patients: potential therapeutic alternatives Open
Genetic mutations in the β-globin gene lead to a decrease or removal of the β-globin chain, causing the build-up of unstable alpha-hemoglobin. This condition is referred to as beta-thalassemia (BT). The present treatment strategies primari…
View article: Evaluating the causal effect of circulating proteome on the risk of inflammatory bowel disease-related traits using Mendelian randomization
Evaluating the causal effect of circulating proteome on the risk of inflammatory bowel disease-related traits using Mendelian randomization Open
Objective This study sought to identify circulating proteins causally linked to Inflammatory Bowel Disease (IBD) traits through a Mendelian Randomization (MR) analytical framework. Methods Using a large-scale, two-sample MR approach, we es…
View article: Advances in the Pathogenesis of Steroid-Associated Osteonecrosis of the Femoral Head
Advances in the Pathogenesis of Steroid-Associated Osteonecrosis of the Femoral Head Open
Osteonecrosis of the femoral head (ONFH) is a refractory orthopedic condition characterized by bone cell ischemia, necrosis, bone trabecular fracture, and clinical symptoms such as pain, femoral head collapse, and joint dysfunction that ca…
View article: Exploring Prosocial Irrationality for LLM Agents: A Social Cognition View
Exploring Prosocial Irrationality for LLM Agents: A Social Cognition View Open
Large language models (LLMs) have been shown to face hallucination issues due to the data they trained on often containing human bias; whether this is reflected in the decision-making process of LLM Agents remains under-explored. As LLM Ag…
View article: SHIP1 modulation and proteome characterization of microglia
SHIP1 modulation and proteome characterization of microglia Open
View article: RETRACTED: GIPC1 remodels lipid metabolism by transporting DECR1 into mitochondria against ferroptosis during dilated cardiomyopathy (DCM)
RETRACTED: GIPC1 remodels lipid metabolism by transporting DECR1 into mitochondria against ferroptosis during dilated cardiomyopathy (DCM) Open
The authors have requested the removal of their preprint from Research Square, due to current circumstances that make preprinting challenging at this time. The author's request does not imply errors or misconduct.
View article: Association between metabolic syndrome severity score and cardiovascular disease: results from a longitudinal cohort study on Chinese adults
Association between metabolic syndrome severity score and cardiovascular disease: results from a longitudinal cohort study on Chinese adults Open
Objective This study aimed to quantify the severity of metabolic syndrome(MetS) and investigate its association with cardiovascular disease(CVD) risk on Chinese adults. Methods 13,500 participants from the Zhejiang Adult Chronic Disease St…
View article: Systematic proteome-wide Mendelian randomization using the human plasma proteome to identify therapeutic targets for lung adenocarcinoma
Systematic proteome-wide Mendelian randomization using the human plasma proteome to identify therapeutic targets for lung adenocarcinoma Open
View article: Qualitative and semiquantitative analyses of the chemical components of the seed coat and kernel of Ziziphi Spinosae Semen
Qualitative and semiquantitative analyses of the chemical components of the seed coat and kernel of Ziziphi Spinosae Semen Open
Ziziphi Spinosae Semen refers to the dried seed of Ziziphus jujuba Mill. var. spinosa (Bunge) Hu ex H. F. Chou. The seed is composed of a reddish brown coat and a yellow kernel. A comparative study was conducted to investigat…
View article: Causal association between genetically predicted circulating immune cell counts and frailty: a two-sample Mendelian randomization study
Causal association between genetically predicted circulating immune cell counts and frailty: a two-sample Mendelian randomization study Open
Background Despite the recognized link between immune responses and frailty, the association between immune cell counts and frailty based on previous observational studies remains disputed, with uncertain causal nexus. This study aimed to …
View article: Emerging Trends in Multi-Omics Data Integration: Challenges and Future Directions
Emerging Trends in Multi-Omics Data Integration: Challenges and Future Directions Open
View article: Surgical Treatment of Duplicated Collecting System in 185 Children: A Single-Center Experience
Surgical Treatment of Duplicated Collecting System in 185 Children: A Single-Center Experience Open
Background Duplicated collecting system (DCS) is a common congenital urinary tract anomaly in children. It can manifest as complete duplicated collecting system (CDS) or incomplete duplicated collecting system (IDS). While many DCS cases a…
View article: Systematic Mendelian randomization using the human plasma proteome to identify therapeutic targets for lung adenocarcinoma
Systematic Mendelian randomization using the human plasma proteome to identify therapeutic targets for lung adenocarcinoma Open
Background Lung adenocarcinoma (LUAD) is the most common histological subtype of lung cancer and the leading cause of cancer-related deaths. Identifying novel drug targets for LUAD is essential, with the proteome serving as a major source …