Tuomas Pylkkö
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View article: Bioprospecting of inhibitors of EPEC virulence from metabolites of marine actinobacteria from the Arctic Sea
Bioprospecting of inhibitors of EPEC virulence from metabolites of marine actinobacteria from the Arctic Sea Open
A considerable number of antibacterial agents are derived from bacterial metabolites. Similarly, numerous known compounds that impede bacterial virulence stem from bacterial metabolites. Enteropathogenic Escherichia coli (EPEC) is a notabl…
View article: Virtual Screening Assisted Search for Inhibitors of the Translocated Intimin Receptor of Enteropathogenic <i>Escherichia Coli</i>
Virtual Screening Assisted Search for Inhibitors of the Translocated Intimin Receptor of Enteropathogenic <i>Escherichia Coli</i> Open
This study aimed to identify inhibitors of the translocated intimin receptor (Tir) of enteropathogenic Escherichia coli (EPEC). EPEC is an intestinal pathogen that causes diarrhea and is a major health concern worldwide. Because Tir is a k…
View article: Development and validation of a high-content screening assay for inhibitors of enteropathogenic E. coli adhesion
Development and validation of a high-content screening assay for inhibitors of enteropathogenic E. coli adhesion Open
Enteropathogenic E. coli (EPEC) causes intestinal infections leading to severe diarrhea. EPEC attaches to the host cell causing lesions to the intestinal epithelium coupled with the effacement of microvilli. In the process, actin accumulat…