Tuong L. Nguyen
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View article: Development of a Machine Learning Model for Predicting Treatment-Related Amenorrhea in Young Women with Breast Cancer
Development of a Machine Learning Model for Predicting Treatment-Related Amenorrhea in Young Women with Breast Cancer Open
Treatment-induced ovarian function loss is a significant concern for many young patients with breast cancer. Accurately predicting this risk is crucial for counselling young patients and informing their fertility-related decision-making. H…
View article: Development of a Machine Learning Model for Predicting Treatment-Related Amenorrhea in Young Women with Breast Cancer
Development of a Machine Learning Model for Predicting Treatment-Related Amenorrhea in Young Women with Breast Cancer Open
Treatment-induced ovarian function loss is a significant concern for many young patients with breast cancer. Accurately predicting this risk is crucial for counselling young patients and informing their fertility-related decision-making. H…
View article: Genome-wide analysis highlights causal epigenetic link to age at menarche
Genome-wide analysis highlights causal epigenetic link to age at menarche Open
Age at menarche, a key milestone in female reproductive development, has declined globally and is associated with cancer and other health outcomes. We investigated epigenetic mechanisms underlying pubertal timing by analysing genome-wide D…
View article: Supplementary Table S6 from Region-Based Analyses of Existing Genome-Wide Association Studies Identifies Novel Potential Genetic Susceptibility Regions for Glioma
Supplementary Table S6 from Region-Based Analyses of Existing Genome-Wide Association Studies Identifies Novel Potential Genetic Susceptibility Regions for Glioma Open
Supplementary Table S6 shows the DEPTH posterior log odds in favour of association (PLO) score and the logistic regression p-value of the lowest p-value variant for each of the 34 known glioma risk regions using GliomaScan (S6a), AGOG (S6b…
View article: Supplementary Table S9 from Region-Based Analyses of Existing Genome-Wide Association Studies Identifies Novel Potential Genetic Susceptibility Regions for Glioma
Supplementary Table S9 from Region-Based Analyses of Existing Genome-Wide Association Studies Identifies Novel Potential Genetic Susceptibility Regions for Glioma Open
Supplementary Table S9 shows the generalised Berk-Jones statistic (GBJ) p-values for the potential novel glioma susceptibility regions by study, glioma type and sex.
View article: Supplementary Figure S2 from Region-Based Analyses of Existing Genome-Wide Association Studies Identifies Novel Potential Genetic Susceptibility Regions for Glioma
Supplementary Figure S2 from Region-Based Analyses of Existing Genome-Wide Association Studies Identifies Novel Potential Genetic Susceptibility Regions for Glioma Open
Supplementary Figure S2 shows the estimation of genetic ancestry of AGOG, GliomaScan and GICC samples by way of scatter plot of PC1 versus PC2.
View article: Supplementary Figure S1 from Region-Based Analyses of Existing Genome-Wide Association Studies Identifies Novel Potential Genetic Susceptibility Regions for Glioma
Supplementary Figure S1 from Region-Based Analyses of Existing Genome-Wide Association Studies Identifies Novel Potential Genetic Susceptibility Regions for Glioma Open
Supplementary Figure S1 is a stylised illustration of DEPTH’s use of sliding windows to identify genomic susceptibility regions.
View article: Supplementary Table S8 from Region-Based Analyses of Existing Genome-Wide Association Studies Identifies Novel Potential Genetic Susceptibility Regions for Glioma
Supplementary Table S8 from Region-Based Analyses of Existing Genome-Wide Association Studies Identifies Novel Potential Genetic Susceptibility Regions for Glioma Open
Supplementary Table S8 summarizes the supporting evidence for the potential novel glioma susceptibility regions.
View article: Supplementary Table S2 from Region-Based Analyses of Existing Genome-Wide Association Studies Identifies Novel Potential Genetic Susceptibility Regions for Glioma
Supplementary Table S2 from Region-Based Analyses of Existing Genome-Wide Association Studies Identifies Novel Potential Genetic Susceptibility Regions for Glioma Open
Supplementary Table S2 shows the number of samples excluded from the GliomaScan data and reasons for exclusion.
View article: Supplementary Table S1 from Region-Based Analyses of Existing Genome-Wide Association Studies Identifies Novel Potential Genetic Susceptibility Regions for Glioma
Supplementary Table S1 from Region-Based Analyses of Existing Genome-Wide Association Studies Identifies Novel Potential Genetic Susceptibility Regions for Glioma Open
Supplementary Table S1 shows the age characteristics of the UCSF/Mayo data (validation data).
View article: Supplementary Table S5 from Region-Based Analyses of Existing Genome-Wide Association Studies Identifies Novel Potential Genetic Susceptibility Regions for Glioma
Supplementary Table S5 from Region-Based Analyses of Existing Genome-Wide Association Studies Identifies Novel Potential Genetic Susceptibility Regions for Glioma Open
Supplementary Table S5 shows the generalised Berk-Jones statistic (GBJ) p-values for the candidate novel susceptibility regions for glioma by study and sex.
View article: Supplementary Table S3 from Region-Based Analyses of Existing Genome-Wide Association Studies Identifies Novel Potential Genetic Susceptibility Regions for Glioma
Supplementary Table S3 from Region-Based Analyses of Existing Genome-Wide Association Studies Identifies Novel Potential Genetic Susceptibility Regions for Glioma Open
Supplementary Table S3 shows the number of samples excluded from the AGOG autosomal data (S3a) and X-chromosome data (S3b) and reasons for exclusion.
View article: Supplementary Table S4 from Region-Based Analyses of Existing Genome-Wide Association Studies Identifies Novel Potential Genetic Susceptibility Regions for Glioma
Supplementary Table S4 from Region-Based Analyses of Existing Genome-Wide Association Studies Identifies Novel Potential Genetic Susceptibility Regions for Glioma Open
Supplementary Table S4 shows the number of samples excluded from the GICC data and reasons for exclusion.
View article: Supplementary Table S7 from Region-Based Analyses of Existing Genome-Wide Association Studies Identifies Novel Potential Genetic Susceptibility Regions for Glioma
Supplementary Table S7 from Region-Based Analyses of Existing Genome-Wide Association Studies Identifies Novel Potential Genetic Susceptibility Regions for Glioma Open
Supplementary Table S7 shows the DEPTH posterior log odds in favour of association (PLO) score and generalised Berk-Jones statistic (GBJ) p-value for TERT, EGFR, CCDC26, CDKN2BAS, TP53 and RTEL regions.
View article: Cancer incidence inconsistency between UK Biobank participants and the population: a prospective cohort study
Cancer incidence inconsistency between UK Biobank participants and the population: a prospective cohort study Open
Background While the UK Biobank has been widely used for cancer research, its representativeness of the population in terms of cancer incidence has not been thoroughly investigated. Methods We conducted a prospective cohort study of 466,16…
View article: Figure 3 from Region-Based Analyses of Existing Genome-Wide Association Studies Identifies Novel Potential Genetic Susceptibility Regions for Glioma
Figure 3 from Region-Based Analyses of Existing Genome-Wide Association Studies Identifies Novel Potential Genetic Susceptibility Regions for Glioma Open
DEPTH results for the 1p36.21 region. DEPTH PLO score for GICC (blue), AGOG (orange), and GliomaScan (green) for the 1p36.21 PRDM2 gene region for all-glioma male from the UCSC genome browser (https://genome.ucsc.edu/). The PLO score is on…
View article: Supplementary Table S8 from Region-Based Analyses of Existing Genome-Wide Association Studies Identifies Novel Potential Genetic Susceptibility Regions for Glioma
Supplementary Table S8 from Region-Based Analyses of Existing Genome-Wide Association Studies Identifies Novel Potential Genetic Susceptibility Regions for Glioma Open
Supplementary Table S8 summarizes the supporting evidence for the potential novel glioma susceptibility regions.
View article: Table 1 from Region-Based Analyses of Existing Genome-Wide Association Studies Identifies Novel Potential Genetic Susceptibility Regions for Glioma
Table 1 from Region-Based Analyses of Existing Genome-Wide Association Studies Identifies Novel Potential Genetic Susceptibility Regions for Glioma Open
Age and sex characteristics of the discovery datasets (GliomaScan, AGOG, and GICC) and validation dataset (UCSF/Mayo) by glioma type
View article: Table 2 from Region-Based Analyses of Existing Genome-Wide Association Studies Identifies Novel Potential Genetic Susceptibility Regions for Glioma
Table 2 from Region-Based Analyses of Existing Genome-Wide Association Studies Identifies Novel Potential Genetic Susceptibility Regions for Glioma Open
P values for candidate novel risk regions from the discovery, validation, and meta-analysis including the lowest P value SNP from each region
View article: Figure 2 from Region-Based Analyses of Existing Genome-Wide Association Studies Identifies Novel Potential Genetic Susceptibility Regions for Glioma
Figure 2 from Region-Based Analyses of Existing Genome-Wide Association Studies Identifies Novel Potential Genetic Susceptibility Regions for Glioma Open
DEPTH results for chromosome 1. Visualization of the DEPTH posterior log-odds in favor of association (PLO) score on the UCSC genome browser (https://genome.ucsc.edu/) for chromosome 1 for GICC (blue), AGOG (orange), and GliomaScan (green)…
View article: Supplementary Table S5 from Region-Based Analyses of Existing Genome-Wide Association Studies Identifies Novel Potential Genetic Susceptibility Regions for Glioma
Supplementary Table S5 from Region-Based Analyses of Existing Genome-Wide Association Studies Identifies Novel Potential Genetic Susceptibility Regions for Glioma Open
Supplementary Table S5 shows the generalised Berk-Jones statistic (GBJ) p-values for the candidate novel susceptibility regions for glioma by study and sex.
View article: Supplementary Table S1 from Region-Based Analyses of Existing Genome-Wide Association Studies Identifies Novel Potential Genetic Susceptibility Regions for Glioma
Supplementary Table S1 from Region-Based Analyses of Existing Genome-Wide Association Studies Identifies Novel Potential Genetic Susceptibility Regions for Glioma Open
Supplementary Table S1 shows the age characteristics of the UCSF/Mayo data (validation data).
View article: Supplementary Figure S1 from Region-Based Analyses of Existing Genome-Wide Association Studies Identifies Novel Potential Genetic Susceptibility Regions for Glioma
Supplementary Figure S1 from Region-Based Analyses of Existing Genome-Wide Association Studies Identifies Novel Potential Genetic Susceptibility Regions for Glioma Open
Supplementary Figure S1 is a stylised illustration of DEPTH’s use of sliding windows to identify genomic susceptibility regions.
View article: Supplementary Figure S2 from Region-Based Analyses of Existing Genome-Wide Association Studies Identifies Novel Potential Genetic Susceptibility Regions for Glioma
Supplementary Figure S2 from Region-Based Analyses of Existing Genome-Wide Association Studies Identifies Novel Potential Genetic Susceptibility Regions for Glioma Open
Supplementary Figure S2 shows the estimation of genetic ancestry of AGOG, GliomaScan and GICC samples by way of scatter plot of PC1 versus PC2.
View article: Supplementary Table S6 from Region-Based Analyses of Existing Genome-Wide Association Studies Identifies Novel Potential Genetic Susceptibility Regions for Glioma
Supplementary Table S6 from Region-Based Analyses of Existing Genome-Wide Association Studies Identifies Novel Potential Genetic Susceptibility Regions for Glioma Open
Supplementary Table S6 shows the DEPTH posterior log odds in favour of association (PLO) score and the logistic regression p-value of the lowest p-value variant for each of the 34 known glioma risk regions using GliomaScan (S6a), AGOG (S6b…
View article: Table 4 from Region-Based Analyses of Existing Genome-Wide Association Studies Identifies Novel Potential Genetic Susceptibility Regions for Glioma
Table 4 from Region-Based Analyses of Existing Genome-Wide Association Studies Identifies Novel Potential Genetic Susceptibility Regions for Glioma Open
Association of the genes within the potential novel risk regions with the synapse, neurodevelopment, neurological disorders, glioma tumor cell growth, and other cancers according to a PubMed search
View article: Figure 1 from Region-Based Analyses of Existing Genome-Wide Association Studies Identifies Novel Potential Genetic Susceptibility Regions for Glioma
Figure 1 from Region-Based Analyses of Existing Genome-Wide Association Studies Identifies Novel Potential Genetic Susceptibility Regions for Glioma Open
Methodology flowchart. An outline of the stages used to identify potential glioma risk regions. PLO, Bayesian posterior log odds in favor of association; PC, principal component.
View article: Supplementary Table S3 from Region-Based Analyses of Existing Genome-Wide Association Studies Identifies Novel Potential Genetic Susceptibility Regions for Glioma
Supplementary Table S3 from Region-Based Analyses of Existing Genome-Wide Association Studies Identifies Novel Potential Genetic Susceptibility Regions for Glioma Open
Supplementary Table S3 shows the number of samples excluded from the AGOG autosomal data (S3a) and X-chromosome data (S3b) and reasons for exclusion.
View article: Supplementary Table S9 from Region-Based Analyses of Existing Genome-Wide Association Studies Identifies Novel Potential Genetic Susceptibility Regions for Glioma
Supplementary Table S9 from Region-Based Analyses of Existing Genome-Wide Association Studies Identifies Novel Potential Genetic Susceptibility Regions for Glioma Open
Supplementary Table S9 shows the generalised Berk-Jones statistic (GBJ) p-values for the potential novel glioma susceptibility regions by study, glioma type and sex.
View article: Supplementary Table S7 from Region-Based Analyses of Existing Genome-Wide Association Studies Identifies Novel Potential Genetic Susceptibility Regions for Glioma
Supplementary Table S7 from Region-Based Analyses of Existing Genome-Wide Association Studies Identifies Novel Potential Genetic Susceptibility Regions for Glioma Open
Supplementary Table S7 shows the DEPTH posterior log odds in favour of association (PLO) score and generalised Berk-Jones statistic (GBJ) p-value for TERT, EGFR, CCDC26, CDKN2BAS, TP53 and RTEL regions.