Twan Otten
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Functional and transcriptional senescence profiles of CD8+ T cells associate with the presence of carotid plaques in people living with HIV Open
Background People living with HIV (PLHIV) are at increased risk of atherosclerotic cardiovascular disease (ASCVD), but the immunological mechanisms driving plaque formation remain unclear. This study investigated the association between pe…
View article: Opposite effects of chronic HIV infection and antiretroviral medication on organismal and organ-specific biological aging
Opposite effects of chronic HIV infection and antiretroviral medication on organismal and organ-specific biological aging Open
People with HIV (PWH) on combination antiretroviral therapy have an elevated risk for aging-related non-AIDS comorbidities. We assessed whether HIV infection accelerates biological aging in two independent cohorts of PWH using six organ-sp…
View article: Impact of COVID-19, lockdowns and vaccination on immune responses in a HIV cohort in the Netherlands
Impact of COVID-19, lockdowns and vaccination on immune responses in a HIV cohort in the Netherlands Open
Introduction During the COVID-19 pandemic, major events with immune-modulating effects at population-level included COVID-19 infection, lockdowns, and mass vaccinations campaigns. As immune responses influence many immune-mediated diseases…
Risk of Non–AIDS–Defining Events Is Lower in Antiretroviral Therapy (ART)–Naive HIV Controllers Than in Normal Progressors on Suppressive ART Open
Background We aimed to compare the non-AIDS event (nADE) risk between normal progressors using antiretroviral therapy (NP-ART) and people with human immunodeficiency virus (HIV, PWH) who naturally control HIV infection (HIV controllers), a…
HIV immunological non-responders are characterized by extensive immunosenescence and impaired lymphocyte cytokine production capacity Open
Introduction Immunological non-responders (INR) are people living with HIV (PLHIV) who fail to fully restore CD4+ T-cell counts despite complete viral suppression with antiretroviral therapy (ART). INR are at higher risk for non-HIV relate…
Cardiometabolic Differences in People Living with HIV Receiving Integrase Strand Transfer Inhibitors Compared to Non-nucleoside Reverse Transcriptase Inhibitors: Implications for Current ART Strategies Open
In people living with HIV (PLHIV), integrase strand transfer inhibitors (INSTIs) are part of the first-line combination antiretroviral therapy (cART), while non-nucleoside reverse transcriptase inhibitor (NNRTI)-based regimens are alternat…
Identification of drug candidates targeting monocyte reprogramming in people living with HIV Open
Introduction People living with HIV (PLHIV) are characterized by functional reprogramming of innate immune cells even after long-term antiretroviral therapy (ART). In order to assess technical feasibility of omics technologies for applicat…